The past few years have witnessed an explosive increase in our collective knowledge of the biology of the human immunodeficiency virus (HIV). Researchers have acquired new understanding of the virus's biochemistry, molecular biology, pathogenesis, genetics, and immunobiology. Resulting therapeutic advances have significantly prolonged the lives of thousands. Yet, the need to develop better therapies is ever more acute and--given the virus's continued spread through the human population--the need for an effective vaccine is urgent.

These goals can be accomplished only through the experienced synthesis of information from the many disciplines participating in HIV research and through the insights of new investigators. This volume is designed to lower the barriers imposed on investigators by the sheer volume of available information--information that often can be found only in far-flung and specialized journals. It provides, in a single resource, an in-depth overview of the diverse areas that constitute HIV research. The result is a broad introduction for students and researchers new to the field as well as an integrated overview for researchers specialized in particular areas of HIV investigation. The volume will also benefit those seeking technical understanding of the virus's biology, including physicians treating HIV-infected patients.

Each chapter is a comprehensive presentation of one area of current AIDS research--including work on the virus life cycle, epidemiology, genetics, protease and reverse transcriptase inhibitors, receptor and co-receptor interactions, therapeutic targets, clinical treatment, immunobiology, and vaccines--written by a leading researcher in that area. The contributors are Jon P. Anderson, Jan Balzarini, Elana Cherry, Thomas J. Coates, Chris Collins, Jon H. Condra, Mark B. Feinberg, Richard B. Gaynor, Matthias Gotte, Daria J. Hazuda, Spyros Kalams, Nathaniel R. Landau, Gerald H. Learn, Norman L. Letvin, James I. Mullins, Willscott E. Naugler, David Nickle, Matthew Rain, Allen G. Rodrigo, Daniel Shriner, Shalom Spira, Mario Stevenson, Todd Summers, Catherine Ulich, Joseph P. Vacca, Mark A. Wainberg, Bruce D. Walker, and Yang Wang."

A sparkling satire on international aid and celebrity, Looking for Bono charts one man's accidental quest to bring water to his community. Baba is a semi-literate man living a simple life centred on the local auto repair shop in Palemo, how he will find his next meal and an obsession with his disinterested, Nollywood star-wannabe wife Munira and her voluptuous body. Baba is acutely aware of the water corruption that has left him, on occasion, without so much as a drop to even brush his teeth. One day on the news, a story about international humanitarian Bono flashes onscreen. Bono is in Africa to do good and like a thunderbolt, Baba decides that Bono is the answer to all of his problems. Once Bono hears about the local water issues he will want to step in and convince the president of Nigeria to end the corruption. Once the water is flowing, Baba can clean up and Munira will set her sights a little closer to home. Before he knows it, Baba is a celebrity being feted by the Lagos media and Munira has turned into his virtuous wife. Will the ensuing media storm engulf Baba as he is launched into a world of high stakes foreign aid dealings and competing interests? Or will he return to his simple life with water for his community and the renewed affections of his Munira?

Almost four decades after the discovery of HIV/AIDS, the world continues to grapple with this public health challenge. Thinking Differently about HIV/AIDS explores the limits of mainstream approaches to the HIV/AIDS epidemic and challenges readers to develop alternate solutions, emphasizing the value of critical social science perspectives. The contributors investigate traditions of inquiry - governmentality studies, institutional ethnography, and Indigenous knowledges, among others - to determine what these perspectives can bring to HIV/AIDS research, policy, and programming. Ultimately, this book demonstrates how and why critical social science is necessary for rethinking research and action required to address the epidemic.

In 2008 it was believed that HIV/AIDS was without doubt the worst epidemic to hit humankind since the Black Death. The first case was identified in 1981; by 2004 it was estimated that about 40 million people were living with the disease, and about 20 million had died. Yet the outlook today is a little brighter. Although HIV/ AIDS continues to be a pressing public health issue the epidemic has stabilised globally, and it has become evident it is not, nor will it be, a global issue. The worst affected regions are southern and eastern Africa. Elsewhere, HIV is found in specific, usually, marginalised populations, for example intravenous drug users in Russia. Although there still remains no cure for HIV, there have been unprecedented breakthroughs in understanding the disease and developing drugs. Access to treatment over the last ten years has turned AIDS into a chronic disease, although it is still a challenge to make antiviral treatment available to all that require it. We also have new evidence that treatment greatly reduces infectivity, and this has led to the movement of 'Treatment as Prevention'. In this Very Short Introduction Alan Whiteside provides an introduction to AIDS, tackling the science, the international and local politics, the demographics, and the devastating consequences of the disease. He looks at the problems a developing international 'AIDS fatigue' poses to funding for sufferers, but also shows how domestic resources are increasingly being mobilised, despite the stabilisation of international funding. Finally Whiteside considers how the need to understand and change our behaviour has caused us to reassess what it means to be human and how we should operate in the globalizing world. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Lucky Lupin is a poignant yet light-hearted story of survival against the odds, based on Charlie Mortimer's life with HIV/Aids during the early years (1984-1996), when there was neither treatment nor cure. Using a combination of good luck, gallows humour, Fray Bentos pies and copious quantities of Solpadeine, Charlie survived not only the illness but the hysteria that accompanied the so-called 'gay plague'. Anyone infected became a social pariah; had the local launderette got word of his illness they wouldn't have washed his sheets but burnt them. Whilst taking full responsibility for the consequences of his behaviour - 'The fact is you don't get AIDS from watching telly' - Charlie initially took to the sofa and prepared for death, but, in time, he found the inner strength required to confront his fatal diagnosis, becoming, among other things, an antiques dealer and contemporary art collector. With blistering and often hilarious candour Charlie also recounts his childhood where he developed a passion for cars, cultivated by his adventurous mother 'Nidnod', his dizzying array of careers and somewhat curious domestic arrangements including the 'adoption' of a bank robber for twelve years. He also confronts head on his experiences of coming to terms with confused sexuality, addiction, epilepsy and clinical depression before finding lasting contentment. Praise for Dear Lupin: 'As well as being the funniest book I've read in ages, it's also extremely touching. A delight then, on every front.' The Spectator 'Very, very funny.' Sunday Times 'Wry, trenchant, often extremely funny, but also charmingly forbearing and forgiving.' Country Life

"Randy Shilts and Laurie Garrett told the story of the HIV/AIDS epidemic through the late 1980s and the early 1990s, respectively. Now journalist-historian-activist Emily Bass tells the story of US engagement in HIV/AIDS control in sub-Saharan Africa. There is far to go on the path, but Bass tells us how far we've come." -Sten H. Vermund, professor and dean, Yale School of Public Health With his 2003 announcement of a program known as PEPFAR, George W. Bush launched an astonishingly successful American war against a global pandemic. PEPFAR played a key role in slashing HIV cases and AIDS deaths in sub-Saharan Africa, leading to the brink of epidemic control. Resilient in the face of flatlined funding and political headwinds, PEPFAR is America's singular example of how to fight long-term plague-and win. To End a Plague is not merely the definitive history of this extraordinary program; it traces the lives of the activists who first impelled President Bush to take action, and later sought to prevent AIDS deaths at the whims of American politics. Moving from raucous street protests to the marbled halls of Washington and the clinics and homes where Ugandan people living with HIV fight to survive, it reveals an America that was once capable of real and meaningful change-and illuminates imperatives for future pandemic wars. Exhaustively researched and vividly written, this is the true story of an American moonshot.