This ambitious book provides a comprehensive history of the World Health Organization (WHO) Global Programme on AIDS (GPA), using it as a unique lens to trace the global response to the AIDS pandemic. The authors describe how WHO came initially to assume leadership of the global response, relate the strategies and approaches WHO employed over the years, and expound on the factors that led to the Programme's demise and subsequent formation of the Joint United Nations Programme on HIV/AIDS(UNAIDS). The authors examine the global impact of this momentous transition, portray the current status of the global response to AIDS, and explore the precarious situation that WHO finds itself in today as a lead United Nations agency in global health. Several aspects of the global response - the strategies adopted, the roads taken and not taken, and the lessons learned - can provide helpful guidance to the global health community as it continues tackling the AIDS pandemic and confronts future global pandemics. Included in the coverage: The response before the global response Building and coordinating a multi-sectoral response Containing the global spread of HIV Addressing stigma, discrimination, and human rights Rethinking global AIDS governance UNAIDS and its place in the global response The AIDS Pandemic: Searching for a Global Response recounts the global response to the AIDS pandemic from its inception to today. Policymakers, students, faculty, journalists, researchers, and health professionals interested in HIV/AIDS, global health, global pandemics, and the history of medicine will find it highly compelling and consequential. It will also interest those involved in global affairs, global governance, international relations, and international development.

When addressing the factors shaping HIV prevention programs in sub-Saharan Africa, it is important to consider the role of family planning programs that preceded the epidemic. In this book, Rachel Sullivan Robinson argues that both globally and locally, those working to prevent HIV borrowed and adapted resources, discourses, and strategies used for family planning. By combining statistical analysis of all sub-Saharan African countries with comparative case studies of Malawi, Nigeria, and Senegal, Robinson also shows that the nature of countries' interactions with the international community, the strength and composition of civil society, and the existence of technocratic leaders influenced variation in responses to HIV. Specifically, historical and existing relationships with outside actors, the nature of nongovernmental organizations, and perceptions of previous interventions strongly structured later health interventions through processes of path dependence and policy feedback. This book will be of great use to scholars and practitioners interested in global health, international development, African studies and political science.

HIV/AIDS remains a major global health problem, despite the progress made in its prevention and treatment. Addressing this problem is not only a matter of more and better drugs, they need to be widely accessible and be affordable to the poor. This book makes, with a much welcomed interdisciplinary approach, an excellent contribution to understanding how the intellectual property regime can influence health policies and the lives of millions of people affected by the disease. The analysis provided by the various authors that contributed to this book will be of relevance not only to those working in the area of HIV/AIDS, but to those more broadly interested in public health governance and the role of intellectual property rights.' - Carlos Correa, University of Buenos Aires, Argentina'This is an important, innovative and, at times, controversial collection. Inter-disciplinary in approach, this collection will have appeal to those concerned with the global injustice in the context of HIV/AIDS. Investigating the legal, political and economic determinants of access to essential medicines, this is thought provoking collection which will resonate with many in both the academic and public policy community.' - Bryan Mercurio, The Chinese University of Hong Kong This important book brings together leading scholars from multiple disciplines, including intellectual property, human rights, public health, and development studies, as well as activists to critically reflect on the global health governance regime. The Global Governance of HIV/AIDS explores the implications of high international intellectual property standards for access to essential medicines in developing countries. With a focus on HIV/AIDS governance, the volume provides a timely analysis of the international legal and political landscape, the relationship between human rights and intellectual property, and emerging issues in global health policy. It concludes with concrete strategies on how to improve access to HIV/AIDS medicines. This interdisciplinary, global, and up-to-date book will strongly appeal to academics in law, international relations, health policy and public policy, as well as students, policymakers and activists. Contributors include: F.M. Abbott, O. Aginam, T. Amin, L. Biron, A. Denburg, G.E. Evans, J. Harrington, J. Harrison, K. Lee, K.C. Shadlen, P.K. Yu

The global response to HIV/AIDS has been a major aspect of global health and development policy over the last three decades. The book illustrates the devastating health impacts of the epidemic, with life expectancy in some countries falling to the lowest levels observed anywhere, and the remarkable success of the global HIV/AIDS response in reversing such extreme outcomes. Concerns about the implications of HIV/AIDS for economic development have played a role in motivating the global HIV/AIDS response. However, evidence on the impacts of HIV/AIDS on economic growth or poverty is weak, and the magnitude and relevance of such economic effects appears trivial compared to the consequences for life and health. Because of the success in extending access to treatment globally, HIV/AIDS has effectively transitioned into a chronic disease. This means that HIV/AIDS absorbs not only a substantial chunk of current global and national financial resources, but that these spending needs are projected to persist over decades. The costs of the HIV/AIDS response thus resemble a long-term financial liability, shaped by past and current policies. Relatedly, the calculus of cost-effectiveness of HIV/AIDS interventions has changed. People who become infected with HIV can now expect to not die because of AIDS; at the same time, each HIV infection results in medical needs and expenditures extending over decades. The book presents a framework for integrating these financial consequences and the transmission dynamics of HIV in the analysis of cost-effectiveness of HIV/AIDS interventions and in the design of HIV/AIDS programs.

This text provides a clinical framework for the diagnosis and management of more than seventy potential neurological complications that may occur in the HIV infected patient. The clinical framework is designed to be "user friendly" so that even the most inexperienced clinician should be able to arrive at the correct diagnosis. The neurological complications of HIV disease have considerably changed in the last decade. Not only have more opportunistic conditions been described but other complications arising from antiretroviral drugs such as lipodystrophy and accelerated atherosclerosis have become problematic. Moreover, the pattern of complications has altered. Diseases such as cerebral toxoplasmosis, AIDS dementia complex and primary central nervous system lymphoma are now becoming uncommon to rare while peripheral neuropathy is becoming increasingly common. In line with these changes, there have been very significant advances in the therapy of HIV disease in general and in neurological complications in particular. Patients with AIDS dementia complex now have a variety of antiretroviral and adjuvant drugs available to them in contrast to the situation only five years ago where therapy was confined to two antiretroviral drugs at best.

In the short, turbulent history of AIDS research and treatment, the boundaries between scientist insiders and lay outsiders have been crisscrossed to a degree never before seen in medical history. Steven Epstein's astute and readable investigation focuses on the critical question of "how certainty is constructed or deconstructed," leading us through the views of medical researchers, activists, policy makers, and others to discover how knowledge about AIDS emerges out of what he calls "credibility struggles." Epstein shows the extent to which AIDS research has been a social and political phenomenon and how the AIDS movement has transformed biomedical research practices through its capacity to garner credibility by novel strategies. Epstein finds that nonscientist AIDS activists have gained enough of a voice in the scientific world to shape NIH--sponsored research to a remarkable extent. Because of the blurring of roles and responsibilities, the production of biomedical knowledge about AIDS does not, he says, follow the pathways common to science; indeed, AIDS research can only be understood as a field that is unusually broad, public, and contested. He concludes by analyzing recent moves to democratize biomedicine, arguing that although AIDS activists have set the stage for new challenges to scientific authority, all social movements that seek to democratize expertise face unusual difficulties. Avoiding polemics and accusations, Epstein provides a benchmark account of the AIDS epidemic to date, one that will be as useful to activists, policy makers, and general readers as to sociologists, physicians, and scientists.

In 2008 it was believed that HIV/AIDS was without doubt the worst epidemic to hit humankind since the Black Death. The first case was identified in 1981; by 2004 it was estimated that about 40 million people were living with the disease, and about 20 million had died. Yet the outlook today is a little brighter. Although HIV/ AIDS continues to be a pressing public health issue the epidemic has stabilised globally, and it has become evident it is not, nor will it be, a global issue. The worst affected regions are southern and eastern Africa. Elsewhere, HIV is found in specific, usually, marginalised populations, for example intravenous drug users in Russia. Although there still remains no cure for HIV, there have been unprecedented breakthroughs in understanding the disease and developing drugs. Access to treatment over the last ten years has turned AIDS into a chronic disease, although it is still a challenge to make antiviral treatment available to all that require it. We also have new evidence that treatment greatly reduces infectivity, and this has led to the movement of 'Treatment as Prevention'. In this Very Short Introduction Alan Whiteside provides an introduction to AIDS, tackling the science, the international and local politics, the demographics, and the devastating consequences of the disease. He looks at the problems a developing international 'AIDS fatigue' poses to funding for sufferers, but also shows how domestic resources are increasingly being mobilised, despite the stabilisation of international funding. Finally Whiteside considers how the need to understand and change our behaviour has caused us to reassess what it means to be human and how we should operate in the globalizing world. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Drawing on a rich set of interviews and surveys, this book shows how the global AIDS treatment advocacy movement helped millions in the developing world gain access to life-saving medication. The movement achieved this by transforming the market for AIDS drugs from one which was 'low volume, high price' to one based on access for all. The authors suggest that a movement's ability to transform markets depends upon whether: (1) markets are contestable; (2) they have framed their arguments to resonate across their target audiences; (3) the movement itself has a coherent goal; (4) the costs are low, or the benefit-to-cost ratio is favourable; and, finally, (5) institutions are present to reward continued achievement of the new market principle. These insights are applied to a range of other cases including malaria, maternal mortality, water/diarrheal disease, non-communicable diseases, education, climate change, the ivory trade, sex trafficking and the Atlantic slave trade.

Das Acquired Immune Deficiency Syndrome - AIDS - ist eines der gro/3ten medizinischen Probleme unserer Zeit. Der Erreger, das HTLV III/LA V-Virus, dtirfte in Afrika entstanden sein; die Krank- heit AIDS wurde in den Vereinigten Staaten erstmals bekannt und definiert; sie greift nun auch auf den europaischen Kontinent tiber. Arzte, Soziologen, Epidemiologen und nicht zuletzt auch Politiker sind durch diese Infektionskrankheit und ihre infauste Prognose mit meist todlichem Ausgang, vor aHem aber durch ihre enorm rasche, einer geometrischen Reihe folgende Ausbreitung zutiefst beunru- higt. Die Medien haben sich aus verschiedenen Motiven heraus intensiv mit AIDS beschaftigt, und eine gewisse Beunruhigung in der Bevolkerung, aber auch in der Arzteschaft se1bst ausge1ost. Am 20. April 1985 hat in Wien ein Symposium stattgefunden, das sich mit der Problematik von AIDS auseinandergesetzt hat. Erste Fachleute aus Osterreich haben tiber die "AIDS-Lage" berichtet und die Manuskripte ihrer Vortrage zur VerfUgung gestellt; daraus ist dieser Band entstanden. Sicherlich wird dieses Buch dazu beitragen, die Probleme der AIDS-Forschung, deren Ergebnisse sich stan dig andern und vermehren, besser zu verstehen. Unser Dank gilt vor aHem den Vortragenden und Autoren, au/3erdem der Firma Bender + Co fUr die finanzieHe Untersttitzung und dem Verlag fUr die rasche VerOffentlichung. Wien, im November 1985 F. Gschnait und K. Wolff Inhaltsverzeichnis Gschnait, F., Hutterer, J.: AIDS 1985: Ein Uberblick ........ .

Witchcraft and a Life in the New South Africa reconstructs the biography of an ordinary South African, Jimmy Mohale. Born in 1964, Jimmy came of age in rural South Africa during apartheid, then studied at university and worked as a teacher during the anti-apartheid struggle. In 2005, Jimmy died from an undiagnosed sickness, probably related to AIDS. Jimmy gradually came to see the unanticipated misfortune he experienced as a result of his father's witchcraft and sought remedies from diviners rather than from biomedical doctors. This study casts new light on scholarly understandings of the connections between South African politics, witchcraft and the AIDS pandemic.

By drawing on the latest discoveries in virology, microbiology, and immunology, Mirko Grmek depicts the AIDS epidemic not as an isolated incident but as part of the long, but far from peaceful, coexistence of humans and viruses.

In an effort to go beyond immune-based therapies, researchers are now considering the implications of apoptosis dysregulation during HIV-induced immunodeficiency. This work provides the first comprehensive compendium of the progress made in understanding the process of cell death related to HIV and the potential breakthroughs in treatment that offer much promise. Combining the work of more than two-dozen top researchers, this seminal volume provides clinicians and researchers with an excellent reference, while also serving as an incubator to stimulate future research. It explains the fundamental biology involved with apoptosis, explains its clinical impact in HIV, and examines the newest therapeutic approaches.

This study brings together health-care professionals and scholars from a variety of disciplines who seek to understand, and prevent, the transmission of HIV. The biological and social factors concerned with the spread and impact of HIV/AIDS has resulted in dedicated research from each of the disciplines and provided unique insights into the disease. By assembling their insights in one multidisciplinary volume, this book provides a more complete picture of the complex disease, and demonstrates why preventing the spread of HIV will require interdisciplinary collaboration.

In Viral Sex, leading AIDS researcher Jaap Goudsmit illuminates the origins and nature of the world's most lethal epidemic. This fascinating epidemiological whodunit, or...`howdunit' (The Lancet), takes us on a journey from the African rainforest, to ancient Egypt, to pioneering research labs in the U.S. and Europe.

The concept of `viral sex', Goudsmit explains, is central to understanding the AIDS crisis. HIV not only produces offspring that are almost exact copies of the parents, but also reproduces sexually, creating a recombinant population of variants. This `viral sex' gives HIV an edge in adapting to new hosts, enabling it to survive the leap from ape to man. Goudsmit argues that the man-made phenomenon of deforestation and human encroachment on the African monkey habitat provided the opportunity for the SIV virus to jump to its new host, human beings, who then brought HIV out of the Cameroon rainforest at the turn of the century.

Provocative, vividly written, and impeccably researched, Viral Sex instills readers with a new sense of the urgent need to contain HIV and other similarly lethal viruses before they spread beyond the grasp of even the most sophisticated science.

William Clark's At War Within takes us on a fascinating tour through the immune system, examining the history of its discovery, the ways in which it protects us, and how it may bring its full force to bear at the wrong time or in the wrong place.

Scientists have only gradually come to realize that this elegant defence system not only has the potential to help, as in the case of smallpox, but also the potential to do profound harm in health problems ranging from allergies to AIDS, and from organ transplants to cancer. Dr Clark discusses the myriad of medical problems involving the immune system, and systematically explains each one, making the complexities of this delicately balanced mechanism comprehensible to the lay reader.

Fifteen years ago the AIDS `epidemic' did not exist on the public agenda. In just over a decade the public and official response to the disease has resulted in the development of a whole network of organizations devoted to the study, containment, and practical treatment of AIDS. In this important and original analysis of AIDS policy, Virginia Berridge examines the speed and nature of the official (and unofficial) response to this new and critical historical event. The policy reaction in Britain passed through three stages. From 1981-1986 the outbreak of a new contagious disease led to public alarm and social stigmatization, with a lack of scientific certainty about the nature of the disorder. AIDS was a new and open policy area - there were no established departmental, local, or health authority mechanisms for dealing with the problem. This was a period of policy development from below, with relatively little official action and many voluntary initiatives behind the scenes. This phase was succeeded in 1986-1987 by a brief stage of quasi-wartime emergency, in which national politicians and senior civil servants intervened, and a high-level political response emerged. The response was a liberal one of `safe sex' and harm minimization rather than draconian notification or isolation of carriers. The author demonstrates that despite the `Thatcher revolution'in government in the 1980s, crisis could still stimulate a consensual response. The current period of `normalization' of the disease sees panic levels subsiding as the rate of growth slows and the fear of the unknown recedes. Official institutions have been established and formal procedures adopted and reviewed; paid professionals have replaced the earlier volunteers. The 1990s have seen change in the liberal consensus towards a harsher response and the partial repoliticization of AIDS. In this fascinating and scholarly account, Virginia Berridge analyses a remarkable period in contemporary British history, and exposes the reaction of the British political and medical elites, and of the British public to one of the most challenging issues of this century.

South African born-and-raised Hollywood screenwriter Helena Kriel is researching the ancient text of the Kama Sutra for a movie she’s writing. At the same time, she is travelling to India to meet with sages and find answers to the universal challenges of sex and love. While searching for love in her doomed relationships, little does she know she will find her answers in caring for her dying brother, Evan, in South Africa.

Set in the mid-1990s, South Africa is just emerging from the darkness of apartheid and bursting with vibrant chaos. The story zooms in on an intense year in the narrator’s life. It centres around the lively and eccentric South African Kriel family: Maya, the combative but inspired mother; Lexi, the sister recently returned from living in a temple in India; Ross, the younger brother diving with sharks; and Helena, the narrator, herself on a journey to understand love and death. At the heart of the story is Evan, her terminally ill 30-year-old gay brother, who has been keeping his illness a shameful secret. Conscious, sensitive, terrified and trying to hang onto sanity as his world changes, Evan becomes paralysed then finally goes blind as death draws ever closer. But it is Evan who leads the family through the fire.

In living through her brother’s fight to stay alive, the narrator finds herself at the heart of a savage story, one she would not have chosen. How could she know when she set out to India to find ancient solutions to the modern problems of our age that her brother’s approaching death would be her greatest teacher? How could she imagine that dying brings everything to life?

The Year Of Facing Fire is an astoundingly written memoir by one of South Africa’s finest writers. It traverses universal themes including love, death and sex, and finds value in the ordinary and great beauty in the uncertain.

THE PIONEERING WORK IN HIV MEDICINE, COMPLETELY REVISED FOR THE FIRST TIME SINCE 2012 The 17th edition of Bartlett's Medical Management of HIV Infection offers the best-available clinical guidance for treatment of patients with HIV. Edited by preeminent and pioneering authorities in HIV research and clinical care, it has earned its status as the definitive work for physicians, physician assistants, nurse practitioners, pharmacists, and anyone working in the care of persons with HIV. Updated to reflect the most recent innovations in HIV prevention and therapy, this text balances new and old approaches to produce a guide to clinical management in any setting. Coverage includes: * New approaches to prevention of HIV and prevention of infection in patients with HIV * Laboratory protocols for screening and treatment * Antiretroviral therapies (including dosage and adverse effects and drug interactions ) * HIV treatment in resource-limited settings * Management of infections A portable, navigable guide to an exquisitely complex field, Bartlett's Medical Management of HIV Infection is the continuing standard for practice and education in the field of HIV.

The past few years have witnessed an explosive increase in our collective knowledge of the biology of the human immunodeficiency virus (HIV). Researchers have acquired new understanding of the virus's biochemistry, molecular biology, pathogenesis, genetics, and immunobiology. Resulting therapeutic advances have significantly prolonged the lives of thousands. Yet, the need to develop better therapies is ever more acute and--given the virus's continued spread through the human population--the need for an effective vaccine is urgent.

These goals can be accomplished only through the experienced synthesis of information from the many disciplines participating in HIV research and through the insights of new investigators. This volume is designed to lower the barriers imposed on investigators by the sheer volume of available information--information that often can be found only in far-flung and specialized journals. It provides, in a single resource, an in-depth overview of the diverse areas that constitute HIV research. The result is a broad introduction for students and researchers new to the field as well as an integrated overview for researchers specialized in particular areas of HIV investigation. The volume will also benefit those seeking technical understanding of the virus's biology, including physicians treating HIV-infected patients.

Each chapter is a comprehensive presentation of one area of current AIDS research--including work on the virus life cycle, epidemiology, genetics, protease and reverse transcriptase inhibitors, receptor and co-receptor interactions, therapeutic targets, clinical treatment, immunobiology, and vaccines--written by a leading researcher in that area. The contributors are Jon P. Anderson, Jan Balzarini, Elana Cherry, Thomas J. Coates, Chris Collins, Jon H. Condra, Mark B. Feinberg, Richard B. Gaynor, Matthias Gotte, Daria J. Hazuda, Spyros Kalams, Nathaniel R. Landau, Gerald H. Learn, Norman L. Letvin, James I. Mullins, Willscott E. Naugler, David Nickle, Matthew Rain, Allen G. Rodrigo, Daniel Shriner, Shalom Spira, Mario Stevenson, Todd Summers, Catherine Ulich, Joseph P. Vacca, Mark A. Wainberg, Bruce D. Walker, and Yang Wang."