A comprehensive health care system consists of services that are coordinated and integrated along the full continuum of care. For HIV patients, this includes physical health care, infectious disease management, crisis care, mental health care, substance abuse counseling, and social support services including housing, transportation, subsistence, and supports for dealing with multiple sources of stigma. This book highlights the dilemmas faced in providing comprehensive, integrated care to individuals living with HIV, providing both an understanding of existing efforts to integrate diverse systems of care, as well as insight into ways in which systems of care must be challenged in order to meet the needs of people living with HIV. Comprehensive Care for HIV/AIDS is the result of collaborative work with the county Health Department, numerous community-based organizations, and several planning boards in a metropolitan area, which have sought to provide integrated care to people living with HIV. It will be a valuable resource to the diverse community of HIV researchers, advocates and providers.

In a riveting portrait of the world's largest HIV/AIDS medical-care provider, award-winning journalist Patrick Range McDonald reveals AIDS Healthcare Foundation's unlikely rise from a feisty grassroots organization during the height of 1980s AIDS crisis to its position today as a global leader in the fight to control HIV and AIDS. This untold story highlights AHF's bold history of activism, its hard-charging advocacy on the behalf of vulnerable people, and its heroic efforts to provide free HIV drug treatment around the world. With insider access, McDonald follows AHF for a year as it clashes with the Obama administration, the state of Nevada, and the World Health Organization. He interviews AHF's key players, including firebrand president Michael Weinstein, and travels to AHF outposts around the globe. Along the way, McDonald discovers that AHF is a tenacious "people power" organization that brings hope and change to nearly all corners of the world.

Drawing on a rich set of interviews and surveys, this book shows how the global AIDS treatment advocacy movement helped millions in the developing world gain access to life-saving medication. The movement achieved this by transforming the market for AIDS drugs from one which was 'low volume, high price' to one based on access for all. The authors suggest that a movement's ability to transform markets depends upon whether: (1) markets are contestable; (2) they have framed their arguments to resonate across their target audiences; (3) the movement itself has a coherent goal; (4) the costs are low, or the benefit-to-cost ratio is favourable; and, finally, (5) institutions are present to reward continued achievement of the new market principle. These insights are applied to a range of other cases including malaria, maternal mortality, water/diarrheal disease, non-communicable diseases, education, climate change, the ivory trade, sex trafficking and the Atlantic slave trade.

The challenges faced by individuals and families at the end of life are still incredibly diverse, and many behavioural interventions and clinical approaches have been developed to address this great diversity of experiences in the face of dying and death, helping providers to care for their clients. Perspectives on Behavioural Interventions in Palliative and End-of-Life Care is an accessible resource that collates and explores interventions that can be used to address a wide range of behavioural, psychological, social and spiritual issues that arise when people are facing advanced chronic or life-limiting illness. With perspectives from experienced clinicians, providers, and caregivers from around the world, this book offers a strong foundation in contemporary evidence-based practice alongside seasoned practice insights from the field. Its chapters explore: Interventions to enhance communication and decision making The management of physical and mental health symptoms Meaning-Centred Psychotherapy for cancer patients Dignity Therapy Interventions embracing cultural diversity and intersectionality. Together with Perspectives on Palliative and End-of-Life Care: Disease, Social and Cultural Context, the book provides a foundation for collaborative international and interprofessional work by providing state-of science information on behavioural interventions addressing mental health and wellness. It is of interest to academics, researchers and postgraduates in the fields of mental health, medicine, psychology and social work, and is essential reading for healthcare providers and trainees from psychosocial and palliative medicine, social work and nursing.

This Brief presents preliminary findings from research in three prisons in Maharashtra, India on experiences of prison inmates there living with HIV. The study explores health care services in these prisons, and problems experienced by inmates in India living with HIV, as well as their staff and caregivers. Through this preliminary study, the researchers shed light on the experiences of inmates in Indian prisons, with an aim of presenting questions for future research. The author provides an overview of the global conditions of prison inmates living with HIV, as an international comparative context for examining the cases in India. Major problems highlighted in the cases include: living conditions, high risk behavior during incarceration, delivery of medical services and adherence to ethical guidelines. Results of the study reveal that overcrowding and inadequate nutrition were major concerns for inmates living with HIV; there were no support systems available inside the prisons to address the stress related issues of the inmates; and, the prison hospital did not have provisions to cater to the treatment needs of inmates living with AIDS. The study also found that confidentiality regarding the HIV positive status could not be maintained inside the prison. This Brief presents a window into the experience of inmates in India, and presents questions for future research to understand and improve living conditions and medical service delivery within the prison system. This work will be of interest to researchers in criminology and criminal justice, particularly interested in incarceration or health issues, public health and related areas such as public policy, international studies, and demography studies in India.

The disproportional loss of individuals to HIV/AIDS in their most productive years raises concerns over the welfare of surviving members of affected families and communities. One consequence of the rapid increase in adult mortality is the rise in the proportion of children who are orphaned. Sub-Saharan Africa, accounts for about 90 percent of these. Mainly due to the staggering toll of HIV/AIDS, research effort has focused on treatment and prevention. Children have received attention primarily in relation to 'mother to child transmission' and paediatric AIDS. These issues are important and compelling but fail to capture the whole story - the unprecedented surge in the number of children made vulnerable by HIV/AIDS. In this book we reflect on the plight of children classified as vulnerable, review interventions implemented to improve their welfare and grapple with the concept of vulnerability as it relates to human rights and the African child.

Liver disease has been identified as a leading cause of death in HIV-infected patients since the introduction of highly active antiretroviral therapy (HAART) in 1996. The HIV treatment community has been caught largely unaware of this emerging dilemma. Many HIV care providers are ill-equipped to understand and interpret liver injury patterns, or to provide comprehensive care and management for viral coinfections which they are not familiar with. HIV and Liver Disease provides a comprehensive update of the field covering the epidemiology, pathogenesis, management and treatment of liver disease in patients with HIV infection. The volume will help HIV care providers understand and interpret liver injury patterns, and/or provide comprehensive care and management for viral coinfections. Gastroenterologists and hepatologists will gain an understanding of complex drug regimens that are used to treat HIV and which may impact HCV and HBV treatment. Written by expert clinicians and researchers across multiple disciplines, HIV and Liver Disease will be of great value to gastroenterologists, hepatologists, infectious disease practitioners, as well as other health care providers who provide care or participate in research in the field of HIV.

In the seventeenth century, smallpox reigned as the world's worst killer. Luck, more than anything else, decided who would live and who would die. That is, until Lady Mary Wortley Montagu, an English aristocrat, moved to Constantinople and noticed the Turkish practice of "ingrafting" or inoculation, which, she wrote, made "the small- pox...entirely harmless." Convinced by what she witnessed, she allowed her six-year-old son to be ingrafted, and the treatment was a complete success--the young Montagu enjoyed lifelong immunity from smallpox. Lady Montagu's discovery would, however, remain a quiet one; it would be almost 150 years before inoculation (in the more modern form of vaccination) would become widely accepted while the medical community struggled to understand the way our bodies defend themselves against disease.
William Clark's At War Within takes us on a fascinating tour through the immune system, examining the history of its discovery, the ways in which it protects us, and how it may bring its full force to bear at the wrong time or in the wrong place. Scientists have only gradually come to realize that this elegant defense system not only has the potential to help, as in the case of smallpox, but also the potential to do profound harm in health problems ranging from allergies to AIDS, and from organ transplants to cancer. Dr. Clark discusses the myriad of medical problems involving the immune system, and he systematically explains each one. For example, in both tuberculosis and AIDS, the underlying pathogens take up residence within the immune system itself, something Clark compares to having a prowler take up residence in your house, crawling around through the walls and ceilings while waiting to do you in. He discusses organ transplants, showing how the immune system can work far too well, and touching on the heated ethical debate over the use of both primate and human organs. He explores the mind's powerful ability to influence the performance of the immune system; and the speculation that women, because they have developed more powerful immune systems in connection with childbearing, are more prone than men to contract certain diseases such as lupus. In a fascinating chapter on AIDS, arguably the most deadly epidemic seen on Earth since the smallpox, Clark explains how the disease originated and the ways in which it operates. And, in each section, we learn about the most recent medical breakthroughs.
At first glance, it may appear that our immune system faces daunting odds; it must learn to successfully fend off, not thousands, but millions of different types of microbes. Fortunately, according to Clark, it would be almost impossible to imagine a more elegant strategy for our protection than the one chosen by our immune system, and his At War Within provides a thorough and engaging explanation of this most complex and delicately balanced mechanism.

Given rapid research progress and advance of the techniques in studying HIV interactions with host cells and factors, there is a critical need for a book on HIV interactions with DCs. The proposed book will aim for a broad readership to facilitate HIV/AIDS research and provide a practical tool for HIV researchers to continuously address novel questions. Specifically, the editors will summarize the literature in this field and provide critical analysis and future directions. International researchers will be invited as contributors of the book, highlighting authors who have contributed significantly to the field from different angles and aspects of virology, cell biology and immunology, etc.

The Handbook of AIDS Psychiatry is a practical guide for AIDS psychiatrists and other mental health professionals as well as for other clinicians who work with persons with HIV and AIDS and a companion book to the Comprehensive Textbook of AIDS Psychiatry (Cohen and Gorman, 2008). The Handbook provides insights into the dynamics of adherence to risk reduction and medical care in persons with HIV and AIDS as well as strategies to improve adherence using a biopsychosocial approach.
Psychiatric disorders can accelerate the spread of the virus by creating barriers to risk reduction. Risky sexual behaviors and sharing of needles in intravenous drug users account for the majority of new cases each year. Delirium, dementia, depression, substance dependence, PTSD, and other psychiatric disorders complicate the course and add considerably to the pain and suffering of persons with AIDS. HIV infection and AIDS also are risk factors for suicide, and the rate of suicide has been shown to be higher in persons with AIDS. Psychiatric care can help prevent HIV transmission through recognition and treatment of substance-related disorders, dementia, and mood disorders such as mania. Comprehensive, coordinated care by a multidisciplinary AIDS team, including AIDS psychiatrists, can provide a biopsychosocial approach that is supportive to patients, families, and clinicians. Psychiatric interventions are valuable in every phase of infection, from identification of risk behaviors to anticipation about HIV testing; from exposure and initial infection to confirmation with a positive HIV antibody test; from entry into systems of care to managing complex antiretroviral regimen; from healthy seropositive to onset of first AIDS-related illness; from late stage AIDS to end-stage AIDS and death.
There is no comprehensive handbook of AIDS psychiatry to guide clinicians in providing much needed care. The Handbook of AIDS Psychiatry is a practical pocket guide that provides protocols for the recognition and treatment of the psychiatric disorders most prevalent in persons with AIDS and most relevant for primary physicians, infectious disease specialists, and other caregivers because of their impact on health, adherence, behavior, and quality of life.

A comprehensive health care system consists of services that are coordinated and integrated along the full continuum of care. For HIV patients, this includes physical health care, infectious disease management, crisis care, mental health care, substance abuse counseling, and social support services including housing, transportation, subsistence, and supports for dealing with multiple sources of stigma. This book highlights the dilemmas faced in providing comprehensive, integrated care to individuals living with HIV, providing both an understanding of existing efforts to integrate diverse systems of care, as well as insight into ways in which systems of care must be challenged in order to meet the needs of people living with HIV. Comprehensive Care for HIV/AIDS is the result of collaborative work with the county Health Department, numerous community-based organizations, and several planning boards in a metropolitan area, which have sought to provide integrated care to people living with HIV. It will be a valuable resource to the diverse community of HIV researchers, advocates and providers.

The care paradigm for people with HIV has shifted from managing progressive illness with a poor prognosis to managing a chronic condition. Despite this improvement, people living with HIV continue to experience considerable stresses, so promoting their holistic wellbeing is a key aspect of long-term care. This book provides an accessible introduction for healthcare professionals who work with people living with HIV. It is designed to help readers understand how care in practice can be more person-centred and psychologically focused, whilst promoting compassion, health and wellbeing. Topics covered include self-awareness, attachment theories and communication as well as key aspects of providing care for people living with HIV, such as stigma in young adults, neurocognitive issues, the sexualized use of drugs, managing neuropathic pain, and the needs of older adults living with HIV. Invaluable reading for health professionals working within multidisciplinary teams that provide care for people living with HIV, this book is also a core text for those studying in the area.

Leading clinical experts survey the latest information available on the key rheumatic and allergic issues that physicians face in treating the HIV-infected patient. The physicians focus on the rheumatologic and dermatologic manifestations of HIV-1 infection, which include arthritis, myopathies, vasculitis, sicca syndrome, other autoimmune phenomena, and psoriasis. They also examine the question of allergic reactions in HIV patients, including drug hypersensitivity, with special attention given to adverse reactions to trimethoprim-sulfamethoxazole, the most frequently prescribed anti-infective. Practical advice for the diagnosis and treatment of these problems is given in full.

HIV/AIDS remains a major global health problem, despite the progress made in its prevention and treatment. Addressing this problem is not only a matter of more and better drugs, they need to be widely accessible and be affordable to the poor. This book makes, with a much welcomed interdisciplinary approach, an excellent contribution to understanding how the intellectual property regime can influence health policies and the lives of millions of people affected by the disease. The analysis provided by the various authors that contributed to this book will be of relevance not only to those working in the area of HIV/AIDS, but to those more broadly interested in public health governance and the role of intellectual property rights.' - Carlos Correa, University of Buenos Aires, Argentina'This is an important, innovative and, at times, controversial collection. Inter-disciplinary in approach, this collection will have appeal to those concerned with the global injustice in the context of HIV/AIDS. Investigating the legal, political and economic determinants of access to essential medicines, this is thought provoking collection which will resonate with many in both the academic and public policy community.' - Bryan Mercurio, The Chinese University of Hong Kong This important book brings together leading scholars from multiple disciplines, including intellectual property, human rights, public health, and development studies, as well as activists to critically reflect on the global health governance regime. The Global Governance of HIV/AIDS explores the implications of high international intellectual property standards for access to essential medicines in developing countries. With a focus on HIV/AIDS governance, the volume provides a timely analysis of the international legal and political landscape, the relationship between human rights and intellectual property, and emerging issues in global health policy. It concludes with concrete strategies on how to improve access to HIV/AIDS medicines. This interdisciplinary, global, and up-to-date book will strongly appeal to academics in law, international relations, health policy and public policy, as well as students, policymakers and activists. Contributors include: F.M. Abbott, O. Aginam, T. Amin, L. Biron, A. Denburg, G.E. Evans, J. Harrington, J. Harrison, K. Lee, K.C. Shadlen, P.K. Yu

What does it mean to oppose AIDS, to be at odds with AIDS? What kind of rupture with history does AIDS represent? How does AIDS and what is said about AIDS relate to gay identity? How does AIDS relate to thinking and acting, particularly deconstructive thinking? The author confronts these questions from a broad philosophical background that ranges from Kant, Nietzsche, Kierkegaard, and Heidegger to contemporary thought concerning gay activism and AIDS research, all brought together in an effort to find a philosophical language capable of doing justice to the singularity of lived experience in the shadow of AIDS.
In examining what AIDS reveals about the conditions of existence, Garcia Duttmann develops the idea of the "dis-unity" or "at-odds-ness" of existence, of the "non-belonging" that characterizes the marginalized, outcast, or abandoned, and exposes human existence itself. He analyzes what AIDS reveals about the character of history through two intertwined issues. First, he examines arguments bearing on the epochal significance of AIDS, the idea that AIDS reveals something uniquely characteristic of our time, hence that the epidemic marks a historical caesura. Second, he develops a theory of historical witnessing suggesting that the phenomena of historical event and bearing witness are not at all separate, but instead are co-originary, inhering in the same complex.

By tracing the shadow of the epidemic over the last 30 years in Uganda and more broadly in the region, HIV and East Africa investigates the impact of the epidemic on people's lives and livelihoods, placing the epidemic within the context of the social, political and economic changes that have occurred over the last three decades. Whilst it inevitably touches on loss and suffering, the message is also about managing the impact of an epidemic which has had a profound impact on many lives. When one looks for traces in southern Uganda, once thought to be the epicentre of the epidemic, it is hard to see any lasting impact at a community wide level. Delve deeper and there are scars to be found among families and patterns of change which are a direct result of the epidemic The book goes on to explore the effect of improved treatment and care on perceptions of the epidemic and concludes by putting HIV into the context of other disease outbreaks, reflecting on what we can learn from the history of other epidemics as well as the last 30 years of the HIV epidemic.

HIV Treatment as Prevention: Primer for Behavior-Based Implementation provides the first practical guide to integrating behavioral prevention with antiretroviral therapies for people living with HIV infection. This brief book discusses the historical and social context embedding the shifting landscape in HIV prevention, where the use of effective treatments have become the focus of HIV prevention. While using treatments for prevention is promising, the history of HIV prevention offers several important pitfalls that must be avoided if HIV treatments are to ultimately succeed in preventing new HIV infections. Lessons learned from the successes and failures of other biomedical technologies used in HIV prevention, specifically syringes, condoms, and HIV testing are critical to the success of using HIV treatments for prevention. HIV Treatment as Prevention: Primer for Behavior-Based Implementation summarizes the scientific evidence for advancing the use of antiretroviral therapies for HIV prevention. The evidence makes clear that HIV treatments can prevent HIV transmission, but will fail if behavioral aspects of treatment and HIV transmission are ignored. Of greatest concern are medication adherence and risks for contracting other sexually transmitted infections. Placing HIV treatment within the context of behavioral interventions for maintaining medication adherence and reducing sexual risk behaviors is therefore essential to the future of HIV prevention. HIV Treatment as Prevention: Primer for Behavior-Based Implementation highlights two pioneering behavioral interventions aimed at maximizing the effects of antiretroviral therapies for preventing HIV transmission. One of the interventions, developed by the Author's research team, is discussed in detail and the intervention manual is included as an Appendix."

The study of viruses necessarily involves dissecting the intimate details of cellular pathways. Viruses have often been employed as tools in studying cellular pathways, as was done by early retrovirologists such as Peyton Rous in attempting to understand the mechanism of cellular transformation and oncogenesis. On the other side of the coin, virologists seek to de?ne those cellular elements interacting intimatelywiththeir virus ofinterestinorder to better understand viral replication itself, and in some cases to develop antiviral strategies. It is in the intersection of virology and cell biology that many of us ?nd the most rewarding aspects of our research. When a new discovery yields insights into basic cellular mechanisms and presents new targets for int- vention to ?ght a serious pathogen, the impact can be high and the excitement intense. HIV has been no exception to the rule that viruses reveal many basic aspects of cellular biology. In recent years, in part because of the importance of HIV as a major cause of human suffering, numerous cellular processes have been elucidated through work on processes or proteins of this human retrovirus. The excitement in this ?eld is especially well illustrated by the discovery of new innate means of resisting viral replication, such as the work on APOBEC3G, TRIM5a, and BST-2/ tetherin presented in this volume.

In the decade since AIDS was first recognised the enormous and worldwide social and medical implications of this disease have been increasingly recognised. The exponential increase in the number of people infected with HIV has been paralleled by the written literature on the subject. When this book was initially conceived the question was why another book? It seemed to me at that time and since, that as HIV presented ever more complex problems, they were best solved when considered within a wider context, using basic principles of individual medical specialties and applying them. For this reason, all the chapter authors were experienced in a particular field and applied that knowledge to HIV. All the authors were working at the Middlesex Hospital in London when the AIDS services there were expanding to fill a need, from 2 beds in 1986 to two wards today. The authors were frontline staff looking after all aspects of HIV infection within a wider general medical context. Many are now consultants or senior lecturers. It is the aim of the book to provide an insight into HIV and AIDS as a overview for someone starting to work in this field or who sees such patients occasionally and requires some basic guidelines. For this reason the chapters are based predominantly on organ systems and are divided into sections covering the presenta tion, methods of investigation and treatment or action required of relevant conditions."

In most countries, primary prevention programmes against the HIV / AIDS epidemic have been implemented. Broadly speaking, three levels of intervention can be identified: - national campaigns directed to the general population; most of them are multi phase campaigns aimed at providing information about HIV transmission and protective behaviour; they use the various mass media channels and are mainly directed to sexual behaviour modifi cation; - community-based interventions, addressed to specific target popula tions; these populations have been typically selected according to both the high risk of infection (gay men and prostitutes) and the difficulty to reach the members of these communities (intravenous drug users); - individual testing and counselling, often supported by public funds or large non-governmental organizations. Major efforts have been devoted to the development and the implemen tation of these preventive programmes, both in terms of human re sources and financial support. On the other hand, in most countries, far less energy has been put into the evaluation of these campaigns. This gap is not explained by the fact that evaluation of AIDS/HIV cam paigns is a totally new challenge in terms of methodology: there are classical methods, developed over twenty years and used in other fields of prevention."

Plague. The word itself is like a blow, connoting misery, miasma and death. Plague takes many forms: influenza, typhus, cholera, the Black Death, and, recently, AIDS. AIDS has reminded us that epidemic infectious disease is not simply a historical phenomenon--or one limited like famine to remote continents --and is a vivid and painful illustration of how epidemics take place at a number of levels --biological event, social perception, collective response, and, finally, the individual, the existential and the moral.

"In Time of Plague"examines the many ways in which catastrophic infectious and contagious diseases are both biologically and socially defined. In the politically charged age of AIDS, "In Time of Plague" analyzes what past epidemics tell us about this new, deadly virus: How has the definition of disease differed throughout history? How have new technologies and advances in epidemiology changed our perception and response to disease? When has quarantine been appropriate or effective? What norms should govern our thinking about responsibility, culpability, legality, and confidentiality? What does society owe the victims? What, in turn, are the responsibilities of the carrier population?

Featuring essays by such distinguished scholars as Lewis Thomas, Joshua Lederberg, Dorothy Nelkin, Sander Gilman, Barbara Guttmann Rosenkrantz, Baruch S. Blumberg, George Kateb, and David A. J. Richards, among others, from a wide range of disciplines, this work seeks to answer some of these pressing questions.

Despite major advances in HIV treatment, many areas require more study, in order to create efficacious, potent antiretrovirals that can suppress viral load completely and durably without toxic side effects, to define unknown drug targets and fine-tune known targets, and to better understand the interplay between viral and host factors. In "HIV Protocols, Second Edition," expert researchers provide clear, state-of-the-art methods for the study of HIV. Directed toward three specific goals, this text aims to document up-to-date protocols for select aspects of HIV biology, to bring together both virological and immunological approaches in a single, convenient volume, and to present a comprehensive account of a range of techniques not available in any existing HIV protocol book. As a volume in the highly successful Methods in Molecular Biology series, the chapters include brief introductions to the subject, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections containing priceless tips on troubleshooting and avoiding known pitfalls.

Comprehensive and cutting-edge, "HIV Protocols, Second Edition" is an ideal guide to the wide array of techniques used in fundamental or applied research into the biology and pathogenesis of HIV-1."

Series Information:
Social Aspects of AIDS

As soon as US media and politicians became aware of AIDS in the early 1980s, fingers were pointed not only at the gay community but also at other countries and migrant communities, particularly Haitians, as responsible for spreading the virus. Evangelical leaders, public health officials, and the Reagan administration quickly capitalized on widespread fear of the new disease to call for quarantines, immigration bans, and deportations, scapegoating and blaming HIV-positive migrants-even as the rest of the world regarded the US as the primary exporter of the virus. In The Borders of AIDS, Karma Chavez demonstrates how such calls proliferated and how failure to impose a quarantine for HIV-positive citizens morphed into the successful enactment of a complete ban on the regularization of HIV-positive migrants-which lasted more than twenty years. News reports, congressional records, and AIDS activist archives reveal how queer groups and migrant communities built fragile coalitions to fight against the alienation of themselves and others, asserting their capacity for resistance and resiliency. Building on existing histories of HIV/AIDS, public health, citizenship, and immigration, Chavez establishes how politicians and public health officials treated different communities with HIV/AIDS and highlights the work these communities did to resist alienation.

Forty years ago, the age-old battle against infectious diseases as a major threat to human health was believed close to being won. However, by the late twentieth century, the increase of emerging and reemerging infectious diseases was evident in both low and high income countries. About 30 new infectious diseases have been identified in the last 20 years. Among the "new" diseases, and most importantly, the Human Immunodeficiency Virus (HIV) epidemic, with 40 million persons infected and 25 million deaths since its first description, presents one of the most significant health, societal and security challenges facing the global community. The interaction of HIV/AIDS with tuberculosis, malaria and bacterial infections have increased HIV-related morbidity and mortality, and in turn, the HIV pandemic has brought about devastating increases in tuberculosis.

Understanding the population impact and the dynamics of infection diseases in the most affected region is critical to efforts to reduce the morbidity and mortality of such infections, and for decisions on where to use limited resources in the fight against infections.

This book aims to contribute to these efforts by offering a demographic and epidemiological perspective on emerging and reemerging infections in sub-Saharan Africa.