Access the latest information available in the challenging area of HIV/AIDS management with Sande's HIV/AIDS Medicine, 2nd Edition. Authored by a veritable "who's who" of current global experts in the field, this medical reference book will provide you with all the practical, indispensable guidance you'll need to offer your patients the best possible care. Access reliable, up-to-the-minute guidance that addresses the realities of HIV/AIDS management in your geographical region, thanks to contributions from a global cast of renowned expert clinicians and researchers. Locate the clinically actionable information you need quickly with an organization that mirrors the current state of the AIDS epidemic and the different needs of Western vs. developing-world patients and clinicians. Diagnose AIDS manifestations confidently by comparing them to clinical images. Improve patient outcomes with the latest findings on the management of AIDS as a chronic illness. Efficiently review essential data through numerous at-a-glance tables. Get the most relevant information available on pediatric HIV and AIDS issues; anti-retroviral drugs, including integrase inhibitors; and the use of second- and third-line anti-retroviral drugs in resource-poor settings. Stay current on the latest actionable information, such as using antiretroviral therapy in patients with tuberculosis and drug-resistant tuberculosis; antiretroviral therapy; immune reconstitution inflammatory syndromes (IRIS); and implementation of the HPV vaccine. The very latest in HIV/AIDS management from global experts with a concise approach and a clinical/practical focus.

-Accessible introduction to the full spectrum of diseases and disasters for students of politics, human security studies and development studies -Case studies include Covid-19, Haiti Earthquake 2010, Hurricane Maria, Typhoon Haiyan, Second Congo War; Yemen Civil War; Tajikistan Civil War, AIDS in Africa, Malaria, SARS, and Ebola -Timely new textbook to address issues arising from the Covid-19 global pandemic

A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency.

"Models of Protection Against HIV/SIV" will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barre-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer.

This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike.
Providesextensive descriptions and comparisons onthe different models of protection agains HIV/AIDSComprehensive writing and illustrationsContributors are among the most eminent specialists in the field"

This book addresses the impact of HIV on populations of men who have sex with men in Africa and local responses to the issue. It documents the enduring existence of a rich variety of same-sex practices between men. More critically, it analyses how the denial and social rejection of same-sex sexuality, together with the legacy of criminalization by former colonial rulers, has not only fueled the transmission of HIV between men, but has also impeded an effective response. The book also documents some of the outstanding progress that has been made and acknowledges the differences between African countries. Through its focus on lived realities and grassroots activism in Africa, this book will appeal to researchers, policy makers and practitioners alike.

'This book will make you love her as much as I do' FORMER PRESIDENT BILL CLINTON 'Breath-taking courage and compassion [...]a beautiful book' THE SUNDAY TIMES 'A renegade Florence Nightingale cares for the ill in a remarkable tale of compassion and combating prejudice' GUARDIAN 'An extraordinary tale' EVENING STANDARD 'If I have one message with this book it's that we all have to care for one another. Today, not just in 1986. Life is about caring for each other, and I learned more about life from the dying than I ever learned from the living. It's in an elephant ride, it's in those wildflowers dancing on their way to the shared grave of two men in love, and it's in caring for that young man who just needed information without judgement.' In 1986, 26-year-old Ruth Coker Burks visits a friend in hospital when she notices that the door to one of the patient's rooms is painted red. The nurses are reluctant to enter, drawing straws to decide who will tend to the sick person inside. Out of impulse, Ruth herself enters the quarantined space and begins to care for the young man who cries for his mother in the last moments of his life. And in doing so, Ruth's own life changes forever. As word spreads in the community that she is the only person willing to help the young men afflicted by the growing AIDS crisis, Ruth goes from being an ordinary young mother to an accidental activist. Forging deep friendships with the men she helps, Ruth works to find them housing and jobs, and then funeral homes willing to take their bodies - often in the middle of the night. She prepares and delivers meals to 'her guys,' supplementing her own income with discarded food found in the dumpsters behind supermarkets. She defies local pastors and the medical community to store rare medications for her most urgent patients, and teaches sex education to drag queens after hours at secret bars. Emboldened by the weight of their collective pain, she fervently advocates for their safety and visibility, ultimately advising Governor Bill Clinton on the national HIV-AIDS crisis, and in doing so becomes a beacon of hope to an otherwise spurned group of ailing gay men on the fringes of society. Ruth kept her story a secret for years, fearful of repercussions within her deeply conservative community. But at a time when it's more important than ever to stand up for those who can't, Ruth has found the courage to have her voice - and the voices of those who were stigmatised, rejected and abandoned - heard.

Set in the 1980s against a backdrop of the AIDS crisis, deindustrialization and the Reagan era, this book tells the story of one individual's defiant struggle against his community--the city of Kokomo, Indiana. At the same time as teenage AIDS patient Ryan White bravely fought against the intolerance of his hometown to attend public school, one of Kokomo's largest employers, Continental Steel, filed for bankruptcy, significantly raising the stakes of the fight for the city's livelihood and national image. This book tells the story of a fearful time in our recent history, as people in the heartland endured massive layoffs, coped with a lethal new disease and discovered a legacy of toxic waste. Now, some 30 years after Ryan White's death, this book offers a fuller accounting of the challenges that one city reckoned with during this tumultuous period.

The world continues to lose more than a million lives each year to the HIV epidemic, and nearly two million individuals were infected with HIV in 2017 alone. The new Sustainable Development Goals, adopted by countries of the United Nations in September 2015, include a commitment to end the AIDS epidemic by 2030. Considerable emphasis on prevention of new infections and treatment of those living with HIV will be needed to make this goal achievable. With nearly 37 million people now living with HIV, it is a communicable disease that behaves like a noncommunicable disease. Nutritional management is integral to comprehensive HIV care and treatment. Improved nutritional status and weight gain can increase recovery and strength of individuals living with HIV/AIDS, improve dietary diversity and caloric intake, and improve quality of life. This book highlights evidence-based research linking nutrition and HIV and identifies research gaps to inform the development of guidelines and policies for the United Nations' Sustainable Development Goals. A comprehensive approach that includes nutritional interventions is likely to maximize the benefit of antiretroviral therapy in preventing HIV disease progression and other adverse outcomes in HIV-infected men and women. Modification of nutritional status has been shown to enhance the quality of life of those suffering HIV/AIDS, both physically in terms of improved body mass index and immunological markers, and psychologically, by improving symptoms of depression. While the primary focus for those infected should remain on antiretroviral treatment and increasing its availability and coverage, improvement of nutritional status plays a complementary role in the management of HIV infection.

The association between AIDS and cancer was recognized from the beginning of the AIDS epidemic, when the appearance of Kaposi sarcoma in a cluster of young men was one of the first signs of this new disease. It was soon recognized that AIDS was caused by infection with a novel virus (HIV) and that AIDS patients are prone to develop a number of "AIDS-defining" cancers: Kaposi sarcoma, lymphoma, and cervical cancer. The development of effective combination anti-HIV therapy starting around 1996 converted AIDS from a death sentence to a manageable disease and led to dramatic shifts in the epidemic. As this therapy was able to improve immune function in patients, the incidence of most "AIDS-defining" cancers decreased. There is a misconception, however, that AIDS has gone away. In fact, as AIDS patients are living longer, the number of AIDS patients has more than doubled in the United States since 1996, and the AIDS population overall has increased in age. Also, as AIDS patients are less likely to die of other complications, cancer is coming to the forefront as one of the most common causes of death in regions where AIDS drugs are widely available. Moreover, the three "AIDS-defining" cancers are now taking a back seat to a number of other HIV-associated cancers, such as Hodgkin lymphoma, lung cancer, and anal cancer. In the developing world, AIDS-associated cancers are a major public health problem, and in some regions of sub-Saharan Africa, Kaposi sarcoma is the most common tumor in men. In recent years, there has been a vast increase in our understanding of HIV-associated cancers. We now know, for example, that most are caused by other viruses and that the main role of HIV and immunodeficiency is to provide a supportive environment for the viruses to multiply and for the cancers to develop. But there remain a number of unanswered questions and a need for improved prevention and therapy. In the 28 chapters of this book, written by some of the most renowned experts in this field, we present up-to-date information on the cancers associated with HIV infection. The chapters cover the epidemiology of these cancers, their pathogenesis, their clinical presentation, and their treatment. The book will be of value to physicians, other medical professionals, students, and researchers with an interest in AIDS, viral-associated cancers, or HIV-associated malignancies. TABLE OF CONTENTS 1. HIV-associated Cancers: Overview Robert Yarchoan, Thomas Uldrick, Mark Polizotto 2. Epidemiology of AIDS-defining Malignancies William A. Blattner and Rebecca G. Nowak 3. Epidemiology of non-AIDS Defining Malignancies Andrew E. Grulich 4. HIV Cancers in Resource-Limited Regions Sam M. Mbulaiteye 5. Kaposi's Sarcoma-associated Herpesvirus (KSHV) Blossom Damania and Dirk P. Dittmer 6. Epstein Barr Virus (EBV) Lindsey Hutt-Fletcher 7. Human Papillomavirus (HPV) Zhi-Ming Zheng 8. Merkel Cell Polymavirus (MCV) Nicole Fischer and Adam Grundhoff 9. Presentation and Pathogenesis of Kaposi's Sarcoma Corey Casper 10. Management of Kaposi's Sarcoma Susan E. Krown 11. Presentation and Pathogenesis of HIV Lymphomas Richard F. Little, Stefania Pittaluga, Kieron Dunleavy 12. Diffuse Large B-Cell Lymphoma Neel K. Gupta and Lawrence D. Kaplan 13. Burkitt and Burkitt-Like Lymphoma Kishor Bhatia and Sam M. Mbulaiteye 14. Primary Effusion Lymphoma Giovanna Tosato 15. AIDS-related Central Nervous System Lymphoma Jan Davidson-Moncada and Thomas Uldrick 16. Plasmablastic and Other Lymphomas Huan-You Wang, Ida Wong-Sefidan, Erin Reid 17. Hodkin Lymphoma Michele Spina, Rosanna Ciancia, Accursio Augello 18. Multicentric Castelman Disease Mark N. Polizzotto, Thomas S. Uldrick, Robert Yarchoan 19. Cervical Cancer Elizabeth A. Stier 20. Anal Cancer Joel Palefsky 21. Other HPV-Associated Cancers Kristina R. Dahlstrom and Erich M. Sturgis 22. Lung Cancer in HIV Infection Deepthi Mani and David M. Aboulafia 23. Hepattocellular Carcinoma in HIV-positive Patients Massimiliano Berretta, Paolo De Paoli, Umberto Tirelli, Bruno Cacopardo 24. Merkel Cell Carcinoma and Other HIV-associated Skin Cancers Nathalie C. Zeitouni adn Bethany Lema 25. Conjuctival Carcinoma Kenneth O. Simbiri and Erle S. Robertson 26. Malignancies in Children with HIV Infection D. Cristina Stefan 27. cART and Supportive Care Ronald T. Mitsuyasu 28. Stem Cell Transplantation Christine Durand and Richard Ambinder

Social work practitioners active among those most directly involved with persons with AIDS/HIV need guidance and support. This volume offers both in a balanced analysis of key issues relating to their practice. The authors clearly and authoritatively establish that the demographics of the AIDS/HIV crisis are undergoing change rapidly and alarmingly.

Although there have been significant advances in education about AIDS and modifications in sexual practices among gay men resulting in a lowered rate of new infection, other groups are shown to be evidencing explosive levels of infection. Not only are the population parameters of AIDS defined, but the fundamental issues of social service delivery are addressed as are the special needs of the newly at-risk groups. Women, adolescents, substance abusers, minorities, and the mentally ill are all in the demographic patterns describing AIDS/HIV diffusion. The most compelling AIDS care issues are directly focused on and practical guidance is given to social work practitioners. AIDS/HIV poses a sometimes daunting challenge threatening to overwhelm service providers. This book will be of value due to its sensitive, insightful, experience-based guidance at the level of practice. It will also prove a useful resource for all in the caring professions who will appreciate its timely explanation of the complexities involved in framing effective responses to current and emerging needs associated with AIDS/HIV.

The study of viruses necessarily involves dissecting the intimate details of cellular pathways. Viruses have often been employed as tools in studying cellular pathways, as was done by early retrovirologists such as Peyton Rous in attempting to understand the mechanism of cellular transformation and oncogenesis. On the other side of the coin, virologists seek to de?ne those cellular elements interacting intimatelywiththeir virus ofinterestinorder to better understand viral replication itself, and in some cases to develop antiviral strategies. It is in the intersection of virology and cell biology that many of us ?nd the most rewarding aspects of our research. When a new discovery yields insights into basic cellular mechanisms and presents new targets for int- vention to ?ght a serious pathogen, the impact can be high and the excitement intense. HIV has been no exception to the rule that viruses reveal many basic aspects of cellular biology. In recent years, in part because of the importance of HIV as a major cause of human suffering, numerous cellular processes have been elucidated through work on processes or proteins of this human retrovirus. The excitement in this ?eld is especially well illustrated by the discovery of new innate means of resisting viral replication, such as the work on APOBEC3G, TRIM5a, and BST-2/ tetherin presented in this volume.

Urban Action Networks is a study of how communities organize in response to threats to their lives and well being. As HIV/AIDS wreaked havoc on the worlds of some of the most marginal and disenfranchised people in New York, they came together to create a shared response, forming a new organizational field within which their various efforts were coordinated. This book traces the interorganizational processes by which the groups negotiated shared meanings, collective strategies, and a complex, shifting set of relations with local and national government. It covers the first decade of AIDS, when the organized community groups actively set the agenda. How the communities of the most affected people organized, reorganized, and redefined the social and political context of HIV/AIDS offers an encouraging glimpse into the way in which marginal communities can convert shared needs into collective action.

Since the time AIDS and HIV infection were first discovered, no medical cures have been developed. It became clear early on that education would be the cornerstone in the fight against AIDS, and that assessment remains true in the 1990s. This book describes how to tailor HIV education and prevention efforts to specific communities, including how to identify those most at risk, what types of interventions are most appropriate to those communities, how to engage those most at risk, and the role of participatory evaluation in determining the effectiveness of community education efforts.

This book delves into this almost unchartered territory, documenting the lived experiences of sex workers in Bangladesh, considering the complex realities of their day-to-day lives and the ways they negotiate their working conditions and relationships. Despite being the most common form of female deviance and criminality globally, we know very little about sex work in Asia and the global south. Drawing on feminist frameworks, it shows that the experiences of sex workers vary widely depending on the ways they enter the sex trade, their modes of operation, and relationships with significant others. Towards a Southern Approach to Sex Work contributes to feminist scholarship on sex work, by offering a much needed southern perspective, drawing on culturally specific data. It argues that the lived experience of sex workers comprises both victimhood and agency, deception and resilience, and that it is the management of these relationships that enable sex works to avoid social marginalization and alienation. An accessible and compelling read, this will appeal to students and scholars of criminology, sociology, gender studies, south Asian studies, cultural studies, social theory and policy makers. In addition, it will engage all those interested in learning more about how the sex trade operates in Bangladesh.

This book provides an overview of the current epidemiology of the HIV epidemic among young people in Eastern and Southern Africa (ESA) and examines the efforts to confront and reduce the high level of new HIV infections amongst young people. Taking a multi-dimensional approach to prevention, the contributors discuss the many challenges facing these efforts, in view of the slow progress in curbing the incidence of HIV amongst young people, focusing particularly on the structural and social drivers of HIV. Through an examination of these issues, chapters in this book provide valuable insights on how to mitigate HIV risk among young people and what can be regarded as the catalysts to mounting credible policy and programmatic responses required to achieve epidemic control in the region. The contributors draw on examples from a range of primary and secondary data sources to illustrate promising practices and challenges in HIV prevention, demonstrating links between conceptual approaches to prevention and lessons learnt from implementation projects in the region. Bringing together social scientists and public health experts who are actively engaged in finding effective solutions, the book discusses 'which interventions works', 'why they work', and the limitations and gaps in our knowledge to curb the pandemic amongst young people. As such it is an important read for researchers focusing on HIV/AIDS and public health. The Open Access version of this book, available at https://www.taylorfrancis.com/books/e/10.4324/9780429462818 has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

This book explores the thoroughly human dimension of the health care and prevention responses to the HIV crisis in the UK, and the impact that such initiatives had on the progression of the epidemic. This book presents a compelling account of the unfolding of the epidemic and the initiatives that made all the difference in the care and prevention of HIV in the UK from the early 1980s to the present time. Drawing on interviews with people with HIV, doctors and nurses involved in their care, leaders of AIDS charities, activists, and politicians, it identifies and describes the models of care developed in response to the onset of the HIV epidemic, and its impact on NHS and voluntary organisations. It goes on to explore the political responses, the evolution of HIV stigma, and the personal impact of the early high mortality rates. Finally, it discusses recent organisational changes in the provision of care and prevention services. In doing so, this volume identifies the lessons learnt from the care and prevention of HIV, both in relation to HIV infection and other conditions, such as COVID-19, and discusses future challenges. This book will be of great value to those working in services dealing with HIV, charities, and Clinical Commissioning Groups and GP organisations, as well as social historians and medical sociologists.

Preaching Prevention examines the controversial U.S. President's Emergency Plan for AIDS Relief (PEPFAR) initiative to "abstain and be faithful" as a primary prevention strategy in Africa. This ethnography of the born-again Christians who led the new anti-AIDS push in Uganda provides insight into both what it means for foreign governments to "export" approaches to care and treatment and the ways communities respond to and repurpose such projects. By examining born-again Christians' support of Uganda's controversial 2009 Anti-Homosexuality Bill, the book's final chapter explores the enduring tensions surrounding the message of personal accountability heralded by U.S. policy makers. Preaching Prevention is the first to examine the cultural reception of PEPFAR in Africa. Lydia Boyd asks, What are the consequences when individual responsibility and autonomy are valorized in public health initiatives and those values are at odds with the existing cultural context? Her book investigates the cultures of the U.S. and Ugandan evangelical communities and how the flow of U.S.-directed monies influenced Ugandan discourses about sexuality and personal agency. It is a pioneering examination of a global health policy whose legacies are still unfolding.

Preaching Prevention examines the controversial U.S. President's Emergency Plan for AIDS Relief (PEPFAR) initiative to "abstain and be faithful" as a primary prevention strategy in Africa. This ethnography of the born-again Christians who led the new anti-AIDS push in Uganda provides insight into both what it means for foreign governments to "export" approaches to care and treatment and the ways communities respond to and repurpose such projects. By examining born-again Christians' support of Uganda's controversial 2009 Anti-Homosexuality Bill, the book's final chapter explores the enduring tensions surrounding the message of personal accountability heralded by U.S. policy makers. Preaching Prevention is the first to examine the cultural reception of PEPFAR in Africa. Lydia Boyd asks, What are the consequences when individual responsibility and autonomy are valorized in public health initiatives and those values are at odds with the existing cultural context? Her book investigates the cultures of the U.S. and Ugandan evangelical communities and how the flow of U.S.-directed monies influenced Ugandan discourses about sexuality and personal agency. It is a pioneering examination of a global health policy whose legacies are still unfolding.

A sparkling satire on international aid and celebrity, Looking for Bono charts one man's accidental quest to bring water to his community. Baba is a semi-literate man living a simple life centred on the local auto repair shop in Palemo, how he will find his next meal and an obsession with his disinterested, Nollywood star-wannabe wife Munira and her voluptuous body. Baba is acutely aware of the water corruption that has left him, on occasion, without so much as a drop to even brush his teeth. One day on the news, a story about international humanitarian Bono flashes onscreen. Bono is in Africa to do good and like a thunderbolt, Baba decides that Bono is the answer to all of his problems. Once Bono hears about the local water issues he will want to step in and convince the president of Nigeria to end the corruption. Once the water is flowing, Baba can clean up and Munira will set her sights a little closer to home. Before he knows it, Baba is a celebrity being feted by the Lagos media and Munira has turned into his virtuous wife. Will the ensuing media storm engulf Baba as he is launched into a world of high stakes foreign aid dealings and competing interests? Or will he return to his simple life with water for his community and the renewed affections of his Munira?

Public Policy Lessons from the AIDS Response in Africa examines how the interplay between national state dynamics in Africa and the global political arena has shaped the global AIDS response, and in this context develops a framework for analysing public policy action more broadly in contemporary Africa. By applying comparative political sociology to AIDS public action, this book identifies four political models that are applicable to public initiatives. Fred Eboko goes on to test these in other domains - namely, the malaria and tuberculosis health subsectors, and the education and environment sectors. By articulating global and national connections and contributing a critical perspective grounded in African scholarship and French political science, the author builds a bold and ambitious framework with the potential to enable coherent and effective public policy action in Africa. This book will be of interest to scholars and students of public health, global health, political science, and development studies, as well as policy-level practitioners in the areas of global health and development.

This book considers the change in rhetoric surrounding the treatment of AIDS from one of crisis to that of 'ending AIDS'. Exploring what it means to 'end AIDS' and how responsibility is framed in this new discourse, the author considers the tensions generated between the individual and the state in terms of notions such as risk, responsibility and prevention. Based on analyses public health promotions in the UK and the US, HIV prevention science and engaging with the work of Foucault, this volume argues that the discourse of 'ending AIDS' implies a tension-filled space in which global principles and values may clash with localised needs, values and concerns; in which evidence-based policies strive for hegemony over local, tacit and communal regimes of knowledge; and in which desires compete with national and international ideas about what is best for the individual in the name of 'ending AIDS' writ large. As such, it will appeal to scholars of sociology and media studies with interests in the sociology of medicine and health, medical communication and health policy.

Over the past few years, ever since the advent of HIV and AIDS, there has been increasing discussion of the concept of sexual health. This upsurge is especially noticeable not only in the field of health education and promotion but also in academic sources. The recent discourse on sexual health is paralleled by an upsurge in the debate on sexual rights. This book examines the social construction of sexual health in India through an analysis of HIV and AIDS messages. The broad objective of the chapters is to trace the growth and evolution of the concept of sexual health from a health communication perspective and to understand the role of the state in determining its form and structure. The methodology used includes comparative analysis of HIV and AIDS policies, document analysis on HIV and AIDS, poster and short films analysis, in depth and open-ended Interviews and case studies. The book shows that Sexual Health is constructed in various modes in India. The models that are elaborated are the Medical model that constructs HIV scientifically and in terms of a compromised immune system; the Epidemic model that identifies risk behaviours and transmission routes and the Moralistic model. Social constructions of AIDS as plague or punishment against society are advanced by moralists who equate HIV with taboo social and sexual behaviour and the political constructions highlights public health in the face of obstacles to treatment and the delivery of services to people living with HIV. Bringing together current research and discussions on the three areas of policy, practices and theoretical perspectives related to the use and social construction of sexual health through HIV and AIDS communication approaches with specific reference to India, this book will be of interest to academics in the field of health communication, HIV and AIDS, and South Asian Studies.

This edited collection brings together the social dimensions of three key aspects of recent biomedical advance in HIV research: Treatment as Prevention (TasP), new technologies such as Pre-Exposure Prophylaxis (PrEP), and the Undetectable equals Untransmittable (U=U) movement. The growth of new forms of biomedical HIV prevention has created hope for the future, signalling the possibility of a world without AIDS. In this context, the volume discusses the profound social, political and ethical dilemmas raised by such advances, which are to do with readiness, access, equity and availability. It examines how HIV prevention has been, and is, re-framed in policy, practice and research, and asks: How best can new biomedical technologies be made available in a profoundly unequal world? What new understandings of responsibility and risk will emerge as HIV becomes a more manageable condition? What new forms of blame will emerge in a context where the technologies to prevent HIV exist, but are not always used? How best can we balance public health's concern for adherence and compliance with the rights of individuals to decide on what is best for themselves and others? Few of these questions have thus far received serious consideration in the academic literature. The editors, all leaders in the social aspects of HIV, have brought together an innovative and international collection of essays by top thinkers and practitioners in the field of HIV. This book is an important resource for academics and professionals interested in HIV research. Chapters "Anticipating Policy, Orienting Services, Celebrating Provision: Reflecting on Scotland's PrEP Journey", "How the science of HIV treatment-as-prevention restructured PEPFAR's strategy: The case for scaling up ART in 'epidemic control' countries", "Stigma and confidentiality indiscretions: Intersecting obstacles to the delivery of Pre-Exposure Prophylaxis to adolescent girls and young women in east Zimbabwe" and "The drive to take an HIV test in rural Uganda: a risk to prevention for young people?" are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Despite major advances in HIV treatment, many areas require more study, in order to create efficacious, potent antiretrovirals that can suppress viral load completely and durably without toxic side effects, to define unknown drug targets and fine-tune known targets, and to better understand the interplay between viral and host factors. In "HIV Protocols, Second Edition", expert researchers provide clear, state-of-the-art methods for the study of HIV. Directed toward three specific goals, this text aims to document up-to-date protocols for select aspects of HIV biology, to bring together both virological and immunological approaches in a single, convenient volume, and to present a comprehensive account of a range of techniques not available in any existing HIV protocol book. As a volume in the highly successful Methods in Molecular Biology (TM) series, the chapters include brief introductions to the subject, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections containing priceless tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, "HIV Protocols, Second Edition" is an ideal guide to the wide array of techniques used in fundamental or applied research into the biology and pathogenesis of HIV-1.

This important work takes as its subject one of medicine 's most pressing arenas of ethical debate. There has been a consistent interest in ethical issues arising in the context of HIV research. Ongoing international and multi-site studies and the continuing search for an HIV vaccine continue to prompt examination of how this research is conducted. Also examined are how participants are engaged in the studies and the obligations of the researchers to individual participants and their communities during the course of and following the conclusion of the research. Each chapter of this book is authored primarily by one of the editors (secondarily by the other) and is accompanied by one to two case studies.