The development of proteomic analyses using advanced mass spectrometry techniques has revolutionized the way proteins are studied, namely, as individual molecules within a complex system. HIV-1 Proteomics: From Discovery to Clinical Application comprehensively covers protein analysis from the early classic experimental days to current state-of-the-art HIV-1 proteomics in a clear informative style that brings expert-level understanding to the novice. Discussion of important clinical applications and future directions for the field also make this an ideal read for the expert. After finishing this book, the reader will have a complete and functional understanding of protein analysis from traditional biochemistry to modern proteomics.

Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS). The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.

Computational and Evolutionary Analysis of HIV Molecular Sequences is for all researchers interested in HIV research, even those who only have a nodding acquaintance with computational biology (or those who are familiar with some, but not all, aspects of the field). HIV research is unusual in that it brings together scientists from a wide range of disciplines: clinicians, pathologists, immunologists, epidemiologists, virologists, computational biologists, structural biologists, evolutionary biologists, statisticians and mathematicians. This book seeks to bridge the gap between these groups, in both subject matter and terminology. Focused largely on HIV genetic variation, Computational and Evolutionary Analysis of HIV Molecular Sequences covers such issues as sampling and processing sequences, population genetics, phylogenetics and drug targets.

Forty years ago, the age-old battle against infectious diseases as a major threat to human health was believed close to being won. However, by the late twentieth century, the increase of emerging and reemerging infectious diseases was evident in both low and high income countries. About 30 new infectious diseases have been identified in the last 20 years. Among the a oenewa diseases, and most importantly, the Human Immunodeficiency Virus (HIV) epidemic, with 40 million persons infected and 25 million deaths since its first description, presents one of the most significant health, societal and security challenges facing the global community. The interaction of HIV/AIDS with tuberculosis, malaria and bacterial infections have increased HIV-related morbidity and mortality, and in turn, the HIV pandemic has brought about devastating increases in tuberculosis.

Understanding the population impact and the dynamics of infection diseases in the most affected region is critical to efforts to reduce the morbidity and mortality of such infections, and for decisions on where to use limited resources in the fight against infections.

This book aims to contribute to these efforts by offering a demographic and epidemiological perspective on emerging and reemerging infections in sub-Saharan Africa.

Over the past decade, enormous progress has been made in understanding the late events in the HIV replication cycle. This has been made possible by major advances in cell biology, virology, and structural biology. The field continues to move forward rapidly, with important new discoveries being reported on a regular basis. The impact of this progress across a broad spectrum of biomedical research has been substantial. The increase in basic knowledge in the areas of HIV assembly, release, and maturation has been accompanied by new possibilities for therapeutic intervention.The work includes topics relating to basic molecular biology, cell biology, and structural biology of HIV assembly, coupled with more applied ideas of how this basic information can inform the field of antiretroviral research. The book coversall major topics pertaining to the late stages of HIV replication, with leaders in each area recruited to contribute chapters in their areas of expertise . The topics will be sufficiently focused to allow authors the opportunity to cover the latest developments in detail.

O'Brien describes the coping strategies that long-term survivors of HIV employ to promote positive quality of life. She also explores the impact of the virus on family members, friends, and caregivers; their strategies for dealing with HIV are identified as well.

This book has two unique features. First, the creative coping strategies developed to deal with HIV are explored primarily through the words of those living and/or working with the virus. O'Brien utilized more than 350 hours of tape-recorded interviews to glean the insightful and poignant anecdotes which describe their walk with HIV. Second, the HIV-positive individuals described are long-term survivors of the virus. Although that population consists primarily of gay men, the case is made that they are the first group of people with HIV to experience long-term survival; thus, their coping strategies and those of the people close to them provide a model for others moving into the survivor category. An important resource for nurses, social workers, chaplains, others in fields working with HIV/AIDs patients, and their families and friends.

This work identifies significant factors influencing, on the one hand, the historical pattern of sexually acquired diseases in 12 countries in Asia and the Pacific and, on the other hand, factors shaping the government and community responses to that pattern. Contributors analyze the role of supranational forces such as colonialism and economic modernization as well as distinctive national factors. The geographic scope is wide, extending from India in the west, to China in the east, to Australia in the south. The chronological scope is equally ambitious and contributors review two centuries or more of history, while also addressing the effect of the AIDS pandemic in a region of great social and economic dynamism. A number of factors including gender and economic inequality, as well as colonialism and economic growth, have been identified as important to the historical spread of sexually transmitted diseases and to the collective response of the spread. Quantitative data on disease incidence and mortality are used extensively throughout the book as are demographic, economic, and social statistics.

Facing up to AIDS is a novel and incisive study of a global plague which continues to threaten to engulf South Africa at this crucial moment in its history. Economists, demographers and health planners present a range of new methods of understanding the likely course of the disease, drawn from the most recent research and thinking by social scientists on the relationship between epidemic disease, economic growth and human resources. South Africa presents a unique opportunity for understanding AIDS, combining as it does Third World problems with a sophisticated infrastructure: the models of demographic projection and economic linkages which are explored here will be of major relevance for examining the socio-economic impact of AIDS in a range of countries in Asia and Latin America. Until medical science comes up with a miracle vaccine, the modification of behaviour is the only defence, and the essays in this volume make a powerful case for putting further resources into the research needed to bring this about.

The name "AIDS" is an accusation. It implies punishment for sin--homosexuality and promiscuity. AIDS is a moral judgement masquerading as a scientific name, which is at the very heart of discrimination against the infected. At the bottom are drug users, victims of the War On Drugs, condemned to contract AIDS by using contaminated syringes necessitated by scarcity resulting from restrictive policies. A rational way to control HIV is to liberalize drug paraphernalia policies as in Europe. The U.S. has not taken this simple step, thus unleashing the AIDS epidemic among drug users, their sexual partners, and neonates. While this policy neglect can be understood in the context of AIDS prevention dominated by moral, political, and religious ideologies rather than epidemiological facts, there are critical racial implications. The ethnic divide separating the white researchers and the infected who belong to minorities has fuelled comparisons of AIDS with the infamous Tuskegee Syphilis Study and some preventive strategies have been called genocidal plots. Recent research indicating the ineffectiveness of bleach to disinfect paraphernalia has exposed the deadly consequences of a nonchalant attitude to research and compromises for political expediency.

During the two years since the publication of the first edition of this book, the global spread of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) has continued. HIV was estimated by the World Health Organization (WHO) in 1993 to have at least 13 million individuals worldwide, with 1 million infected infected in the United States. HIV/AIDS in the United States has become the leading cause of death among men 25 to 44 years of age and the fifth leading cause of death among women of the same age group. Prevention of HIV infection remains a global challenge. Testing for HIV is the cornerstone for surveillance and prevention programs and for the provision of appropriate medical care for those who are infected. Such testing is equally essential to the search for effective antivirus drugs and vaccines. This second edition of AIDS Testing incorporates the most current thinking on test methodology and interpretation, some of which has changed considerably over the past two years. This edition also has been expanded to include a section consisting of six chapters on test applica tions and a section consisting of four chapters on management issues. This edition, like the first, describes in clear terms all the complex ele ments of testing, including applications, scientific principles, quality assurance, safety, and medical, ethical, and legal considerations."

The Radiology of AIDS is aimed at candidates for postgraduate examinations in all specialities and especially those doctors with some training in HIV disease who need to assess their knowledge of the subject. This book is particularly applicable to candidates for postgraduate examinations in radiology.

"AIDS is kind of like life, just speeded up. " JavonP., heroinaddictwithAIDS, Bronx, NewYork, 1988 "Now I'm not so much scared of dying as scared of living. " Mike D., heroin addict with AIDS, New Haven, Connecticut, 1998 Within little more than a decade, AIDS has been tranformed from an untreatable, rapidly fatal illness, into a manageable, chronic disease. Most of this tranformation has occurred in the past five years, accelerated by the advent of protease inhibitors and the proven benefits of combination antiretroviral therapy and prophylaxis against opportunistic infections. For people living with HIV/AIDS, these developments have offered unprecedented hope, and also new challenges. As reflected in the quotes above, some of the anxieties and anticipation of premature dying have been replaced by the uncertainties involved in living with a long-term, unpredictable illness. The role of caregivers for people with HIV/AIDS has also changed radically over this time. Earlier in the epidemic, we learned to accompany patients through illness, to bear witness, to advocate, to address issues of death, dying, and - reavement. The arrival of more effective therapy has brought with it new capabi- ties, but also new complexities, raising difficult problems concerning access to care, adherence, and toxicity.

This volume brings together a collection of essays from researchers engaged in, or concerned with, the politics of global health. It addresses the power relations which drive global health strategies, frustrate the possibility of effective engagement and operate to relegate billions of people to a vulnerable and bleak future. From a broad engagement with the global health system, the volume focuses on arguably the most pressing public health issue of modern times - the effective global governance of HIV/AIDS. The underlying objective is to help generate a timely debate and understanding of the impact of globalization on health and the plight of the vulnerable.

A gripping and triumphant tale of human compassion, is the true story of Ruth Coker Burks, a young single mother in Hot Springs, Arkansas, who finds herself driven to the forefront of the AIDS crisis, and becoming a pivotal activist in America's fight against AIDS. In 1986, 26-year old Ruth visits a friend at the hospital when she notices that the door to one of the hospital rooms is painted red. She witnesses nurses drawing straws to see who would tend to the patient inside, all of them reluctant to enter the room. Out of impulse, Ruth herself enters the quarantined space and immediately begins to care for the young man who cries for his mother in the last moments of his life. Before she can even process what she's done, word spreads in the community that Ruth is the only person willing to help these young men afflicted by AIDS, and is called upon to nurse them. As she forges deep friendships with the men she helps, she works tirelessly to find them housing and jobs, even searching for funeral homes willing to take their bodies . . . often in the middle of the night. She cooks meals for tens of people out of discarded food found in the dumpsters behind supermarkets, stores rare medications for her most urgent patients, teaches sex-ed to drag queens after hours at secret bars, and becomes a beacon of hope to an otherwise spurned group of ailing gay men on the fringes of a deeply conservative state. Throughout the years, Ruth defies local pastors and nurses to help the men she cares for: Paul and Billy, Angel, Chip, Todd and Luke. Emboldened by the weight of their collective pain, she fervently advocates for their safety and visibility, ultimately advising Governor Bill Clinton on the national HIV-AIDS crisis. This deeply moving and elegiac memoir honors the extraordinary life of Ruth Coker Burks and the beloved men who fought valiantly for their lives with AIDS during a most hostile and misinformed time in America.

This NIH-supported study of HIV's physical and psychosocial impacts offers both practical and inspiring accounts of how individuals living with HIV respond and cope with the disease and its progressive stages and impacts. The longitudinal approach of the research and the rich resources offered by extensive interviews with the persons with HIV and those closest to them avail the reader of insights and responses that should improve others' coping and caring abilities.

The author's professional experience and extensive research informs the work throughout and fashions a remarkable and moving synthesis of the themes that will help those living with AIDS as well as all who relate to them. From the first awareness of infection to coping with bereavement, this book honestly, sensitively, and substantively addresses the essential concerns that any and all who are touched by the HIV pandemic must reflect on.

Three decades into the HIV pandemic, the goals remain clear: reduce the number of infections, improve the health outcomes of those who are infected, and eliminate disparities in care. And one observation continues to gain credence: families are a powerful resource in preventing, adapting to, and coping with HIV. Recognizing their complex role as educators, mentors, and caregivers, Family and HIV/AIDS assembles a wealth of findings from successful prevention and intervention strategies and provides models for translating evidence into effective real-world practice. Chapters spotlight the differing roles of mothers and fathers in prevention efforts, clarify the need for family/community collaborations, and examine core issues of culture, ethnicity, gender, and diagnosis (e.g., minority families, adolescents with psychological disorders). Throughout, risk reduction and health promotion are shown as a viable public health strategy A reference with considerable utility across the health, mental health, and related disciplines, Family and HIV/AIDS will be a go-to resource for practitioners working with families, researchers studying at-risk populations, administrators seeking to create new (or evaluate existing)prevention and care programs, and policymakers involved in funding such programs."

Since the early 20th century, when HIV began to circulate among humans, blood exposures during healthcare have contributed to the transmission of the virus. Despite all the money and attention directed at HIV/AIDS in the past several decades, these risks have remained. The book asks why, and seeks answers to a number of crucial questions: How much of the worst HIV epidemics are from blood exposures? Why have these risks persisted? And what is to be done? Points To Consider looks to the future and recommends new strategies that people and governments can adopt to ensure that healthcare and cosmetic services do not transmit HIV, and to reliably stop the worst HIV/AIDS epidemics. _______________________________ David Gisselquist has published more than a dozen articles in medical journals on HIV epidemics in Africa and India, with special attention to risks to transmit HIV through health care. He has traveled and worked in Africa and Asia, and has assisted field research on HIV in India and Kenya. He co-edited a collection of country studies on injection practices (Pilot-Testing the WHO Tools to Assess and Evaluate Injection Practices, published by WHO, 2003), and has spoken at WHO and at international AIDS conferences. Dr Gisselquist holds a PhD in economics, with experience in anthropology and rural development. He is an independent consultant

The author of the bestselling The City of Joy presents the tender, inspiring adventure of the scientists, doctors, nurses, victims, and Sisters of Mother Teresa who are battling against the dread epidemic of AIDS. LG Featured Alternate.

This edited volume presents a detailed portrait of couples living with mixed HIV status, where one partner is HIV-positive and the other negative. Readers will come to understand the various and complex ways in which these mixed-status, or serodiscordant couples build a life together within the shadow of HIV-related stigma. Spanning the globe, coverage explores serodiscordance as a negotiated practice and process, inseparable from the social context in which it is situated. The book shows how couples draw on diverse and sometimes contradictory cultural discourses of medicine, romance, and "normality" to make sense of and manage their mixed HIV status and any perceived risks, not uncommonly in ways that depart from prevailing HIV prevention messages. Throughout, compelling personal stories accompany the empirical research, sharing the firsthand experiences of men and women in serodiscordant relationships. Bringing together research from diverse disciplines and geographical regions, this book contributes important insights for future HIV health promotion as well as offers new knowledge to scholarship on the cultural intersections of illness and intimacy. It will appeal to a broad audience working across the fields of HIV, health, gender, sexuality, development, and human rights.

In the mid-1990s new treatment options introduced a new era of AIDS. This book is a sophisticated study of the shaping of this new era. Well informed by ethnographic as well as statistical data, it reveals the complex and ambiguous processes of change in the field of HIV/AIDS and beyond. The investigation leads from the changing conceptions of disease and body to the re-defined roles of patients and physicians, and eventually treats the shifts in the production and diffusion of knowledge that the health care system underwent. In doing so, the book captures the new era of AIDS from multiple perspectives and through the voices of physicians as well as people with HIV. It offers an accessible and engaging account of the wide-ranging responses this illness caused.

As an original and timely contribution to questions of considerable currency in medicine and the social sciences, the book meets the interests of specialists, professionals, researchers and students alike.

The Culture of AIDS in Africa enters into the many worlds of expression brought forth across this vast continent by the ravaging presence of HIV/AIDS. Africans and non-Africans, physicians and social scientists, journalists and documentarians share here a common and essential interest in understanding creative expression in crushing and uncertain times. They investigate and engage the social networks, power relationships, and cultural structures that enable the arts to convey messages of hope and healing, and of knowledge and good counsel to the wider community. And from Africa to the wider world, they bring intimate, inspiring portraits of the performers, artists, communities, and organizations that have shared with them their insights and the sense they have made of their lives and actions from deep within this devastating epidemic.
Covering the wide expanse of the African continent, the 30 chapters include explorations of, for example, the use of music to cope with AIDS; the relationship between music, HIV/AIDS, and social change; visual approaches to HIV literacy; radio and television as tools for "edutainment;" several individual artists' confrontations with HIV/AIDS; various performance groups' response to the epidemic; combating HIV/AIDS with local cultural performance; and more. Source material, such as song lyrics and interviews, weaves throughout the collection, and contributions by editors Gregory Baz and Judah M. Cohen bookend the whole, to bring together a vast array of perspectives and sources into a nuanced and profoundly affective portrayal of the intricate relationship between HIV/AIDS and the arts in Africa.

Drugs into Bodies recounts the emergence and development of a globally oriented AIDS treatment activist movement that refused to accept that more than 40 million people with HIV in the developing world should simply be left to die. Rooted in earlier AIDS activist efforts, this new movement has forged a global network dedicated to providing universal access to life-saving medications. More than 40 million people are living with HIV/AIDS worldwide, yet only a small fraction have access to life-saving treatments. For many years, governments, pharmaceutical companies, and even some international relief agencies have called this a tragic but unavoidable situation, given the high cost of the medications used to fight HIV. A small but growing group of activists, however, have banded together to prove that the obstacles to universal HIV treatments are mostly human-made, and thus can be overcome by human actions. Drugs into Bodies chronicles the birth and expansion of the global AIDS treatment activist movement, focusing in particular on the U.S.-based organization Health GAP. Drawing on the legacy of the protest group ACT UP and other earlier AIDS activism, Health GAP and like-minded allies have forged a global network to combat the AIDS crisis in Africa and throughout the developing world. From the White House to the United Nations, from plush corporate offices to South African shantytowns, AIDS treatment activists have defied the dictates of globalization, altered government policies, shamed multinational corporations, secured funding for treatment, and brought hope to millions of people with HIV.