Since early-on in the epidemic, there has been much interest in the role that bisexual behaviour among men may play in HIV transmission. This text reviews from an international perspective what has been learned about male bisexuality in countries as diverse as Peru and Britain. Its authors examine the forms that bisexuality takes in different cultures, what it means to the men concerned, and whether or not such behaviour poses special risks. The implications of such enquiry for HIV prevention efforts are also examined.

A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world.

Primary schoolchildren are frequently shielded from education on sexuality and sexually transmitted diseases in an effort to protect their innocence. In countries like South Africa, where AIDS is particularly widespread, it is especially important to address prevention with younger boys and girls as active social agents with the capacity to engage with AIDS as gendered and sexual beings. This volume addresses the question of children's understanding of AIDS, not simply in terms of their dependence but as active participants in the interpretation of their social worlds. The volume draws on an interview and ethnographic based study of young children in two socially diverse South African primary schools, as well as interviews conducted with teachers and mothers of young children. It shows how adults sustain the production of childhood sexual innocence, and the importance of scaling up programs in AIDS intervention, gender and sexuality. It makes significant contributions to the global debate around childhood sexualities, gender and AIDS education.

'Positively Women smashes the invisibility of women with AIDS. By combining individual experiences with concrete analysis and implications for organizing, the authors treat each reader as a potential activist and inspire us to action.'

Contemporary feminist theory has moved into posthuman terrains as feminist theorists utilise human/nonhuman relations and a motley crew of nonhuman entities to reinvigorate feminist critique of nature/culture dichotomies. But what place is left for sex/gender relations in this move beyond the human? Materialities of Sex in a Time of HIV is written on the cusp of feminist theory of materiality and the analysis of an object at the heart of various sex/gender manifestations - the vaginal microbicide. Vaginal microbicides are female-initiated HIV prevention methods (currently tested in clinical trials) designed as creams, rings, gels and sponges that women can insert vaginally before having sex to protect themselves against HIV infection. The microbicide is developed as a tool for women's empowerment in the HIV epidemic, but what happens to feminist ideals when they materialise through biomedical practice? This book provides an analysis of the field of microbicide development to articulate the complexity of its promise and material effects; and utilises the microbicide as an analytical ally in a provocative debate with contemporary feminist theory.

Being Positive gives us the clearest picture we have of what life is like for people who have been diagnosed HIV positive. Based upon unique in-depth interviews with a broad cross-section of patients, the book is remarkable for its candor and compassionate analysis. The people speak for themselves. "Through these pages," Robert Klitzman writes, "I have tried to present a picture-a group portrait-and a sense of the fabric and texture of these individual's lives. Their stories taught me much about how people find meaning and cope with apparently overwhelming difficulties." In looking for patterns in these lives, Dr. Klitzman has focused first on the problems these new patients face-the uncertainties, losses, and taboos; then on how they adapt-their new life in "HIV-land," their spiritual beliefs, work and volunteerism, family relations, drugs and sex, and denial psychology. Finally he considers the implications of this major new medical problem and how it has forced us to examine so many personal, political, and institutional issues surrounding illness and the threat of death. Being Positive is not only a humanizing antidote to statistical studies of HIV and AIDS, it is an important benchmark in understanding the lives and experiences of the people who are affected.

In the seventeenth century, smallpox reigned as the world's worst killer. Luck, more than anything else, decided who would live and who would die. That is, until Lady Mary Wortley Montagu, an English aristocrat, moved to Constantinople and noticed the Turkish practice of "ingrafting" or inoculation, which, she wrote, made "the small- pox...entirely harmless." Convinced by what she witnessed, she allowed her six-year-old son to be ingrafted, and the treatment was a complete success--the young Montagu enjoyed lifelong immunity from smallpox. Lady Montagu's discovery would, however, remain a quiet one; it would be almost 150 years before inoculation (in the more modern form of vaccination) would become widely accepted while the medical community struggled to understand the way our bodies defend themselves against disease.
William Clark's At War Within takes us on a fascinating tour through the immune system, examining the history of its discovery, the ways in which it protects us, and how it may bring its full force to bear at the wrong time or in the wrong place. Scientists have only gradually come to realize that this elegant defense system not only has the potential to help, as in the case of smallpox, but also the potential to do profound harm in health problems ranging from allergies to AIDS, and from organ transplants to cancer. Dr. Clark discusses the myriad of medical problems involving the immune system, and he systematically explains each one. For example, in both tuberculosis and AIDS, the underlying pathogens take up residence within the immune system itself, something Clark compares to having a prowler take up residence in your house, crawling around through the walls and ceilings while waiting to do you in. He discusses organ transplants, showing how the immune system can work far too well, and touching on the heated ethical debate over the use of both primate and human organs. He explores the mind's powerful ability to influence the performance of the immune system; and the speculation that women, because they have developed more powerful immune systems in connection with childbearing, are more prone than men to contract certain diseases such as lupus. In a fascinating chapter on AIDS, arguably the most deadly epidemic seen on Earth since the smallpox, Clark explains how the disease originated and the ways in which it operates. And, in each section, we learn about the most recent medical breakthroughs.
At first glance, it may appear that our immune system faces daunting odds; it must learn to successfully fend off, not thousands, but millions of different types of microbes. Fortunately, according to Clark, it would be almost impossible to imagine a more elegant strategy for our protection than the one chosen by our immune system, and his At War Within provides a thorough and engaging explanation of this most complex and delicately balanced mechanism.

Music at the Edge invites the reader to experience a complete music therapy journey through the words and music of the client, and the therapist's reflections. Francis, a musician living with AIDS, challenged Colin Andrew Lee, the music therapist, to help clarify his feelings about living and dying. The relationship that developed between them enabled Francis the opportunity to reconsider the meaning of his life and subsequent physical decline, within a musical context. First published in 1996, Music at the Edge is a unique and compelling music therapy case study. In this new edition of the highly successful book, Colin retains the force of the original text through the lens of contemporary music therapy theory. This edition also includes more detailed narrative responses from the author and his role as a therapist and gay man. Central to the book are the audio examples from the sessions themselves. The improvisations Francis played and his insightful verbal explorations provide an extraordinary glimpse into the therapeutic process when working in palliative and end-of-life care. This illuminating book offers therapists, musicians, related professionals and those working with, or facing, illness and death a unique glimpse into the transcendent powers of music. It is also relevant to anyone interested in the creative account of a pianist's discovery of life and death through music.

This book is a successor to the earlier and widely-used Business Organization. In this book the author helps the student to develop his or her own critical and conceptual understanding of the subject. As the author reviews the various approaches - classical, human relations, behavioural science, systems and contingency theories - he shows that none of them offers a simple progression from error to truth, but that all of them combine to contribute to a broader view of the field. The final chapter summarizes the author's viewpoint, applying the different approaches to a particular case study.

In the short, turbulent history of AIDS research and treatment, the boundaries between scientist insiders and lay outsiders have been crisscrossed to a degree never before seen in medical history. Steven Epstein's astute and readable investigation focuses on the critical question of "how certainty is constructed or deconstructed," leading us through the views of medical researchers, activists, policy makers, and others to discover how knowledge about AIDS emerges out of what he calls "credibility struggles." Epstein shows the extent to which AIDS research has been a social and political phenomenon and how the AIDS movement has transformed biomedical research practices through its capacity to garner credibility by novel strategies. Epstein finds that nonscientist AIDS activists have gained enough of a voice in the scientific world to shape NIH--sponsored research to a remarkable extent. Because of the blurring of roles and responsibilities, the production of biomedical knowledge about AIDS does not, he says, follow the pathways common to science; indeed, AIDS research can only be understood as a field that is unusually broad, public, and contested. He concludes by analyzing recent moves to democratize biomedicine, arguing that although AIDS activists have set the stage for new challenges to scientific authority, all social movements that seek to democratize expertise face unusual difficulties. Avoiding polemics and accusations, Epstein provides a benchmark account of the AIDS epidemic to date, one that will be as useful to activists, policy makers, and general readers as to sociologists, physicians, and scientists.

The Handbook of AIDS Psychiatry is a practical guide for AIDS psychiatrists and other mental health professionals as well as for other clinicians who work with persons with HIV and AIDS and a companion book to the Comprehensive Textbook of AIDS Psychiatry (Cohen and Gorman, 2008). The Handbook provides insights into the dynamics of adherence to risk reduction and medical care in persons with HIV and AIDS as well as strategies to improve adherence using a biopsychosocial approach.
Psychiatric disorders can accelerate the spread of the virus by creating barriers to risk reduction. Risky sexual behaviors and sharing of needles in intravenous drug users account for the majority of new cases each year. Delirium, dementia, depression, substance dependence, PTSD, and other psychiatric disorders complicate the course and add considerably to the pain and suffering of persons with AIDS. HIV infection and AIDS also are risk factors for suicide, and the rate of suicide has been shown to be higher in persons with AIDS. Psychiatric care can help prevent HIV transmission through recognition and treatment of substance-related disorders, dementia, and mood disorders such as mania. Comprehensive, coordinated care by a multidisciplinary AIDS team, including AIDS psychiatrists, can provide a biopsychosocial approach that is supportive to patients, families, and clinicians. Psychiatric interventions are valuable in every phase of infection, from identification of risk behaviors to anticipation about HIV testing; from exposure and initial infection to confirmation with a positive HIV antibody test; from entry into systems of care to managing complex antiretroviral regimen; from healthy seropositive to onset of first AIDS-related illness; from late stage AIDS to end-stage AIDS and death.
There is no comprehensive handbook of AIDS psychiatry to guide clinicians in providing much needed care. The Handbook of AIDS Psychiatry is a practical pocket guide that provides protocols for the recognition and treatment of the psychiatric disorders most prevalent in persons with AIDS and most relevant for primary physicians, infectious disease specialists, and other caregivers because of their impact on health, adherence, behavior, and quality of life.

This book provides a comprehensive overview of the most important themes in German HIV/AIDS prevention and care from the beginning of the epidemic to the present. Multidisciplinary in approach, it highlights the unique contributions of Germany to AIDS work, making available for the first time knowledge which can be applied to other countries as well as to other fields of public health practice. Topics discussed include: *structural prevention, a concept which unites political and behavioural change *the synchronistic relationship between AIDS policy and gay politics *the dominance of love and intimacy over other 'risk factors' *an approach to prevention among drug users which emphasis human rights and accepts the using behaviour *a unique partnership between public authorities and the voluntary sector *services for women working in cross-national border prostitution *an AIDS survivor syndrome among gay men *HIV in the context of emotional risks taken by women in relationships. In addition, specifically German themes are described, including special needs of gay men from the former East Germany, the difficulties of providing adequate outpatient care for people with HIV/AIDS and the history of the AIDS prevention debate in Germany. The book offers medical, nursing, public health, sociological, psychological and social work perspectives on the German response to AIDS.

Originally published in 1997, Aids and Adolescents provided an insight into a wide range of adolescent issues which were rarely compiled in one volume at the time. Much of the HIV epidemic response had been at the individual level in the hope that this narrow focus would provide the key to containment and resolution of spread. However, over the ten years since the epidemic had taken hold, it was clear that paradigms were limited, input was uncritical and large cohorts were overlooked. In this text a series of contributions have been compiled to explore adolescent issues ranging from sexual behaviour and health education campaigns to HIV prevention and HIV/AIDS care. The chapters begin by giving an overview of adolescent problems, such as homelessness, pregnancy and gender, and explore why these problems are so often overlooked. We then move on to an examination of the facts and fictions associated with adolescent risk, challenging some of the basic current notions underpinning approaches to the subject at the time. Also included are particular focused studies of Australian adolescents' beliefs about HIV and STDs and also the American adolescents' perceptions of drug injection. Finally, the volume gives a focused view of those with HIV infection, with a review of findings of the time, neuropsychological and psychological factors. This overview provided some comments on merging issues and future directions. Today it can be read in its historical context.

First published in 2001. Routledge is an imprint of Taylor & Francis, an informa company.

This book is about life in the time of the HIV epidemic in Eastern Africa. By tracing the shadow of the epidemic over the last 30 years in Uganda and more broadly in the region, the author explores the impact of the epidemic on people's lives and livelihoods, placing the epidemic within the context of the social, political and economic changes that have occurred over the last three decades. While the story inevitably touches on loss and suffering, the message is also about managing the impact of an epidemic which, at one time, was expected to wipe out communities. When one looks for traces of the in southern Uganda, once thought to be the epi-centre of the epidemic, it is hard to see any lasting impact at a community wide level. Delve deeper and there are scars to be found among some families and some patterns of change that are a direct result of the epidemic. However, that is not the whole story. The book goes on to explore the effect of improved treatment and care on perceptions of the epidemic and the fragile hope that now exists as governments and donors struggle to scale-up anti-retroviral therapy. The threats to this hope are examined not only from drug shortages but also from the signs of rising rates of new infections among some communities in the region. The book concludes by putting HIV into the context of other epidemics, and reflecting on what we can learn from Spanish flu and the Black Death about the lasting impact, or not, of HIV.

This issue of Endocrinology and Metabolism Clinics, guest edited by Dr. Paul Hruz, is devoted to HIV and Endocrine Disorders. Articles in this issue include: Dyslipidemia and cardiovascular risk in HIV infection; Changes in nutritional concerns in HIV/AIDS; HIV Lipodystrophy: Lessons learned about adipose tissue and metabolic disorders; Hypogonadism in the HIV infected male; Gonadal function and reproductive health in women with HIV; Osteopenia, osteoporosis, and fracture risk with HIV infection and treatment; HIV-associated calcium and vitamin D abnormalities; Alterations in pancreatic islet function in HIV; Insulin resistance, glucose intolerance, and diabetes in HIV; Thyroid abnormalities in HIV; HPA axis/adrenal pathology in HIV; and Endocrinopathies in HIV-infected children.

Critical health communication scholars point out that the acceptance of HIV risk prevention methods are bound inside inequitable structures of power and knowledge. Nicola Bulled's in-depth ethnographic account of how these messages are selected, transmitted and reacted to by young adults in the AIDS-torn population of Lesotho in southern Africa provides a crucial example of the importance of a culture-centered approach to health communication. She shows the clash between traditional western perceptions of how increased knowledge will increase compliance with western ideas of prevention, and mixed messages offered by local religious, educational, and media institutions. Bulled also demonstrates how structural and geographical forces prevent the delivery and acceptance of health messages, and how local communities shape their own knowledge of health, disease and illness. This volume will be of interest to medical anthropologists and sociologists, to those in health communication, and to researchers working on issues related to HIV.

According to the Centers for Disease Control and Prevention, young people aged 18 to 25 are at a significant risk for acquiring and transmitting HIV (Human Immunodeficiency Virus) and other STIs (sexually transmitted infections). Primary developmental processes that place college students particularly at risk include the experience of intimacy, sexual desires and the centrality of the peer group. During these routine developmental processes, college students experiment with unprotected sex, multiple sex partners and alcohol and illicit drugs, all of which are contributing risk factors for HIV/STI infections.

Early diagnosis, treatment and prevention of HIV and other STIs is germane to promoting the sexual health of college students and reducing high HIV/STI infection rates among young people. This edited volume will provide innovative and cutting-edge approaches to prevention for college students and will have a major impact on advancing the interdisciplinary fields of higher education and public health. It will explore core ideas such as hooking up culture, sexual violence, LGBT and students of color, as well as HIV and STI prevention in community colleges, rural colleges and minority serving institutions."

"

In 1999, investigators announced that a single dose of nevirapine, a new antiviral drug, could stop the spread of the AIDS virus from infected mothers to their newborn babies. It was a discovery that ""changed the face of AIDS globally"" but it came at a high price, after years of scientific research, political conflict, social unrest and the loss of many thousands of lives. This book is the historical account of pediatric AIDS from the first reported cases in the early 1980s to the first effective treatments in the 1990s and then to the prevention of HIV infections altogether. It tells the story through the experiences of individual children infected with HIV, their families and the physicians who treated them, as well as the scientists who sought to understand the virus, discovered nevirapine's unique properties, and worked tirelessly to get it to the patients who needed it.

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.

Despite effective approaches to prevention, STD and HIV infection rates remain fairly constant. Targeting, implementation, and monitoring of interventions have posed widespread problems, and the recent spate of cuts to prevention budgets has made these roadblocks even more challenging. It is clear that working in sexual health requires both a deeper understanding of STI/HIV epidemiology and an ongoing quest for up-to-date, realistic prevention strategies. The New Public Health and STD/HIV Prevention offers readers leading-edge access to both. Focusing on social determinants of sexual health, at-risk populations, critical factors in approaches to prevention, and reviews of new research, this authoritative volume explores areas as varied as HPV prevention, technology-based interventions, migration as a factor in disease transmission, and competencies key to effective leadership in the field. Dispatches from the frontlines of theory, research, and practice in the U.S. and abroad include: Personal risk, public impact: balancing individual rights and STD/HIV prevention. Distribution of prevention resources and its impact on sexual health. Prevention measures in diverse populations of women. Toward a better approach to preventive interventions with men who have sex with men. Adolescent sexual health and STIs. Reducing disparities in sexual health: lessons from the campaign to eliminate infectious syphilis. Public health professionals of all backgrounds interested in or working in improving sexual health will find The New Public Health and STD/HIV Prevention an indispensable guide to conceptualizing the problems and clarifying possible solutions.

The last decade has seen a huge amount of change in the area of sexually transmitted infection control and prevention, including the development of high-profile vaccines for preventing the spread of cervical cancer-causing human papillomavirus (HPV), novel control methods for HIV and AIDS, and even the discussion of more widespread use of controversial abstinence-only sex education programs. Fully revised and updated to reflect the changes of the past ten years, "Sexually Transmitted Diseases: Vaccines, Control and Prevention" 2nd Edition brings researchers, clinical investigators, clinicians, and students the most up-to-date research, findings and thought on sexual infection prevention, control and therapy available and serves as an essential reference for anyone working in the field.
Provides comprehensive coverage of epidemiology, physiology and immunology, featuringgeneral preventive strategies such as behavioural modification, barrier methods and topical microbicides Presents individual chapters on Herpes Simplex Virus, Papillomavirus, Hepatitis B, Chlamydia, Gonorrhea, Syphilis, and Bacterial VaginosisIncludes pathogenesis, microbiology and clinical manifestations of each STD, along with current advances in vaccine development"

When Communities Assess their AIDS Epidemics is a detailed ethnographic description of the AIDS epidemic in ten U.S. cities and the U.S. Virgin Islands. Employing a rapid ethnographic assessment methodology, cities from the Atlantic to the Pacific have implemented Project RARE (Rapid Assessment, Response, and Evaluation) efforts. These RARE projects examine the moving edge of the AIDS epidemic through descriptions of high-risk sites and identifications of segments of the populations at greatest risk. Utilizing a series of focus groups and street interviews, local field research teams gain an insider's perspective on HIV risk within social contexts. Dr. Benjamin P. Bowser, Dr. Ernest Quimby, and Dr. Merrill Singer have compiled these critical studies that analyze current conditions, challenges, and recommendations encountered by RARE. When Communities Assess their AIDS Epidemics is a powerful and engaging text that will appeal to those interested in public health and anthropology.

A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency.

"Models of Protection Against HIV/SIV" will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barre-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer.

This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike.
Providesextensive descriptions and comparisons onthe different models of protection agains HIV/AIDSComprehensive writing and illustrationsContributors are among the most eminent specialists in the field"

In 2003-2006, Patricia Henderson lived in the South African province of KwaZulu-Natal where she recorded the experiences of people living with HIV/AIDS. In this illuminating study, she recounts the concerns of rural people and explores local repertoires through which illness was folded into everyday life. The book spans a period when antiretroviral medication was not available, and moves on to a time when the treatment became accessible. Hope gradually became manifest in the recovery of a number of people through antiretroviral therapies and 'the return' of bodies they could recognise as their own. This research implies that protracted interaction with people over time, offers insights into the unfolding textures of everyday life, in particular in its focus on suffering, social and structural inequality, illness, violence, mourning, sensibility, care and intimacy.