Spermatogenesis is a tightly regulated cellular renovation and differentiation process. It consists of self-renewal and differentiation of spermatogonial stem cells (SSCs), spermatocytic meiosis and spermiogenesis; each of these processes is essential to the continuous, successful production of male gametes. During spermiogenesis, haploid spermatids undergo extensive cellular, molecular and morphological changes, including acrosome biogenesis, flagellum development, cytoplasmic reorganization and chromatin condensation. These changes ultimately result in mature spermatozoa with an acrosome-covered head and motile tail. In this book, Chapter One summarizes the progress that has been made in understanding the molecular mechanisms underlying acrosome biogenesis, and the authors discuss the potential directions of future investigations of this process. Chapter Two briefly addresses the basics of spermatogenesis and the synthesis of ncRNAs, and then the authors discuss the recent progress in understanding of the functions of miRNAs, endo-siRNAs, piRNAs and lncRNAs in the regulation of spermatogenesis. Chapter Three provides a review of the current literature on testicular immunoregulation and its underlying mechanisms, along with its effect on testicular functions.

Bestselling author and counselor Michael Gurian offers a comprehensive look at the emotional, spiritual, and cognitive dimensions of aging--and how to celebrate life after fifty.

Called "the people's philosopher" for his ability to apply scientific ideas to our ordinary lives, Michael Gurian, bestselling author of "The Wonder of Boys," sees life after fifty as an enormously fruitful, exciting, and fulfilling time. Drawing on scientific research as well as anecdotes that respond to the needs of his many clients, he goes beyond the physical-centered view of aging and presents a new, holistic paradigm embracing opportunities that come with life after fifty.

"The Wonder of Aging" focuses on the physical, mental, relational, and spiritual aspects of aging, discussing topics such as sex, how men and women age differently, the effects of aging on the brain, and what to expect in the last chapter of life. The book divides life after fifty into three stages: the Age of Transformation, from our late forties to sixty; the Age of Distinction, from sixty to seventy-five; and the Age of Completion, which involves completing one's life journey. In addition, this essential guide provides meditations and exercises to help you map out the aging process and is rich with case histories from Gurian's research and experience as a therapist.

Written with Gurian's contagiously optimistic outlook on life, "The Wonder of Aging" provides a full, constructive, and comforting roadmap to what to expect--and how to celebrate--the second half of your life.

"Living in an age of constant gratification, economic influx and fragile egos, happiness has become increasingly elusive, yet it remains the Holy Grail, we search for all our lives. The purpose of this book is to suggest a cure for the ordinary day to day unhappiness which most people suffer from in today's world due to no obvious reasons. Since the goal of every human being on this Earth is to attain Happiness, it is hoped that after reading the book thoroughly and analysing as well as grasping the seven most important and practical steps suggested by the author, such as: - Change is constant - Live in the present - Live free from Attachment - Good Health - You can stall ageing - Be Content which will lead to Happiness - Love and Cheer up to be contented in your day-to-day life - Always think Positively and have Happy thoughts- Laughter/Humour is God's gift to Happiness, one can successfully tackle one's problems in life and achieve one's ultimate goal, i.e., to Remain Happy and Cheerful!

Adopts an "issues approach" to teaching introductory biology Up-to-date on relevant topics like climate change, CRISPR, new hominids, and new cancer therapies Suitable for both a majors and non-majors course More succinct for ease in teaching and more affordable for students A large suite of student resources, such as questions to enable self-testing, simulations of key processes to aid learning, web links to encourage further reading Instructor resources to use in teaching, such as PowerPoint slides with figures from the book, activity and assignment ideas, and comprehensive lesson plans

This new edition of a groundbreaking book is now in two volumes, on 'Fundamentals, Symptoms, and Conditions' on 'Reconstructive and Fertility Preserving Surgery and Procedures. From a distinguished editorial team and internationally recognized contributors the text educates surgeons on the techniques and procedures now needed in gynecology, with a special focus on reconstructive vaginal, hysteroscopic, laparoscopic, and laparotomic surgery, including that designed to preserve or enhance fertility. The reader can now more readily understand pathogenesis, appropriate investigation, and application of both surgical and nonsurgical strategies and techniques. The two volumes contain over 20 new chapters and in the integral ebook, over 140 instructional videos; each chapter has Key Points summarized.

One message that comes along with ever-improving fertility treatments and increasing acceptance of single motherhood, older first-time mothers, and same-sex partnerships, is that almost any woman can and should become a mother. The media and many studies focus on infertile and involuntarily childless women who are seeking treatment. They characterize this group as anxious and willing to try anything, even elaborate and financially ruinous high-tech interventions, to achieve a successful pregnancy.

But the majority of women who struggle with fertility avoid treatment. The women whose interviews appear in "Not Trying" belong to this majority. Their attitudes vary and may change as their life circumstances evolve. Some support the prevailing cultural narrative that women are meant to be mothers and refuse to see themselves as childfree by choice. Most of these women, who come from a wider range of social backgrounds than most researchers have studied, experience deep ambivalence about motherhood and non-motherhood, never actually choosing either path. They prefer to let life unfold, an attitude that seems to reduce anxiety about not conforming to social expectations.

Clinical case studies have long been recognized as a useful adjunct to problem-based learning and continuing professional development. They emphasize the need for clinical reasoning, integrative thinking, problem-solving, communication, teamwork and self-directed learning - all desirable generic skills for health care professionals. This volume contains a selection of cases on assisted reproduction that will inform and challenge reproductive medicine practitioners at all stages in their careers. Both common and uncommon cases are included. The aim is to reinforce diagnostic skill through careful analysis of individual presenting patterns, and to guide treatment decisions. Each case consists of a clinical history, examination findings and special investigations, before a diagnosis is made. Clinical issues raised by each case are discussed and major teaching points emphasized. Selective references are provided. The book provides a useful complementary adjunct to existing textbooks of reproductive medicine, and an excellent resource for teaching and continuing professional development.

Challenging Concepts in Obstetrics and Gynaecology is a case-based guide to difficult scenarios faced in both fields, covering many of the major sub-speciality areas of each. The 24 cases have been selected to cover a spectrum of challenges in obstetrics and gynaecology. Recognising that any attempt to cover the whole curriculum is impossible, the authors have instead chosen specific, challenging scenarios that are commonly encountered in clinical practice, but by no means have simple answers or outcomes. Complex cases are examined from a multidisciplinary approach with consideration of diagnostic procedures, practical skills, evidence base, and the application of national and international guidelines. There is also a summary of evidence from the medical literature in various subspecialty areas of obstetrics and gynaecology, alongside current controversies in management. Cases are punctuated by easy-to-read "Learning Points", "Clinical Tips", and "Evidence Base" boxes, speeding the learning process as well as providing a handy dip-into guide for those just refreshing their memory. Each case is set off by an 'Expert Commentary' written by an internationally-renowned expert in each field, leaving the reader with both a solid base of knowledge and a nuanced view of current challenges in obstetrics and gynaecology. This collaboration between trainees and experts provides a unique insight into the management of complex and often rare but important obstetrics and gynaecology cases, within a highly user-friendly format and a ready-made means of self-learning and self-testing. Challenging Concepts in Obstetrics and Gynaecologymakes a useful, relevant and interesting read, enabling the reader to readily transfer the knowledge gained to everyday clinical practice.

Offering exceptional full color diagrams and clinical images, Langman's Medical Embryology , 13e helps medical, nursing, and health professions students develop a basic understanding of embryology and its clinical relevance. Concise chapter summaries, captivating clinical correlates boxes, clinical problems, and a clear, concise writing style make the subject matter accessible to students and relevant to instructors. The new edition is enhanced by over 100 new and updated illustrations, additional clinical images and photos of early embryologic development, and an expanded chapter on the cardiovascular system. Clinical Correlates boxes illustrated by cases and images cover birth defects, developmental abnormalities, and other clinical phenomena. More than 400 illustrations-including full-color line drawings, scanning electron micrographs, and clinical images-clarify key aspects of embryonic development. Basic genetic molecular biology principles are highlighted throughout the text to link embryology to other critical specialties. Chapter Overview figures provide a visually compelling introduction to each chapter. Problems to Solve (with detailed answers at the back of the book) help you assess your understanding. An expanded glossary defines key terms and concepts. Online learning resources for students include an interactive question bank and animations.

Stuart and his wife Julie decided they were ready to have a baby. She went on vitamins and they went on one last vacation, because they thought it would be no time at all before she was pregnant. But that's not exactly how things went. For nearly two years, they endured grueling fertility treatments, beginning with charting temperatures and predicting ovulation, on to oral fertility drugs, through a laparoscopy, a slew of IUIs, and multiple IVFs, and, finally, a course of homeopathic remedies. Catawampus tells this tale of the madness and confusion of fertility treatments and all that those treatments entail but, this time, it's Stuart that tells the story. So, specimen collecting? Sure. Syringes, large and small? Yes. Heartache, frustration, and anger? Of course, but Stuart also shows what else was going on at the time, because, despite the fact that the fertility process can dominate a couple's focus, life continues to unfold. As such, the book is about a relationship between husband and wife, between parent and child, about friendship, and, ultimately, about what it means to be a father. Oh, yeah, it's also very funny. And filled with a choice selection of rants about popular culture, references to movies ranging from the ridiculous to the mostly-still-ridiculous, citations of literary classics, and a little bit of Nashville thrown in for fun. In the end, it's entertaining and poignant writing, and a necessary and underrepresented perspective of an important, hot-button issue.

This book covers human female biology, how the menstrual cycle is controlled, how steroidogenesis is controlled and how the follicle and the egg are formed. This book covers male biology, and how steroid hormones are made, and how sperm are synthesised and matured. Then this book covers sex biology, such as how the brain deals with libido and sexual images, and how the brain controls erection and ejaculation. This book deals with how sperm are matured upon intercourse, how fertilisation takes place, and how the fertilised embryo is matured and implants in the uterus. The subjects of sexuality and homosexuality, chromosome disorders and hydatidiform moles are carefully discussed and considered. Sexual maturation of the foetus during pregnancy is carefully considered. This book carefully describes puberty, adrenarche and menarche. The subject of menopause is carefully considered. The subject of major bacterial and viral and sexual diseases is carefully considered as is the subject of reproductive cancers. In writing this book, care has been taken to update everything and check out the information available on medline and on the internet. This is a textbook for undergraduates, medical students and graduates describing all the details of human reproduction. It is also the only up-to-date book on the market. Having examined a total 70 books on human reproduction, obstetrics and gynaecology, they all, with no exceptions, include mostly out-of-date science. This is corrected in this book. This book is also a monograph for reproductive biology scientists, covering all the most recent findings in this field. It can also be sold as a general obstetrics and gynaecology information source for use by physicians, the general public and in libraries. This is a unique one-of-a-kind reference on human reproduction.

In this book the authors present current research in the study of spermatozoa. This compilation focuses on the biology, motility and function and chromosomal abnormalities of spermatozoa. Topics discussed are the epigenetic mechanisms in mammalian male germline; biological characteristics of sperm in two oyster species; sub-cellular dynamics occurring during capacitation of mammalian spermatozoa; new perspectives on the study of prion and prion-like proteins; meiotic segregation studies in spermatozoa of males carrying a structural chromosome abnormality; testicular germ cell apoptosis during orchitis; the influence of leukocytospermia on semen parameters; and spermatozoa motility and morphology.

In this book the authors present current research in the study of foetal development and its stages of growth, maternal influences and potential complications. Topics discussed in this compilation include the equine foetal development, fetomaternal interaction and potential complications during pregnancy; comparative anatomy, development and functional significance of the mammalian yolk sac; influence of exercise training on e-NOS expression, nitric oxide production and mitochondrial function in the human placenta; maternal melamine and foetal development; and immunolocalisation of syntaxin2 in sinusoidal endothelial cells during mouse liver development.

"Motor Learning and Performance: From Principles to Application, Fifth Edition With Web Study Guide," describes the principles of motor performance and learning in a style that is accessible even to students with little or no knowledge of physiology, psychology, statistical methods, and other basic sciences. Constructing an easy-to-understand conceptual model of motor performance along the way, this text outlines the principles of motor skill learning, building a strong understanding of how skills are acquired and perfected with practice and showing students how to apply the concepts to a variety of real-world settings. Incorporating familiar scenarios brings the material to life for students, leading to better retention of information and greater interest in practical application of motor performance and learning in their everyday lives and future careers.

The fifth edition of "Motor Learning and Performance" features a more streamlined organization, with practice situations integrated directly into chapters rather than appearing at the end of the text, facilitating a stronger link between principles derived from research and practical applications. The addition of author Timothy Lee adds a fresh perspective to the text. Other key changes include the following:

- An improved web study guide offers a principles-to-application exercise and multiple interactive activities for each chapter, ensuring that students will be able to transfer core content from the book to various applied settings.

- A full-color interior provides a more engaging presentation.

- Focus on Research and Focus on Application sidebars deliver more detailed research information and make connections to real-world applications in areas such as teaching, coaching, and therapy.

- Updates to instructor ancillaries feature the addition of lab activities to the instructor guide and new chapter quizzes that assess students' mastery of the most important concepts covered in the textbook.

- Pedagogical aids such as learning objectives, glossary of terms, and Check Your Understanding questions throughout help students stay on track with learning in each chapter.

"Motor Learning and Performance, Fifth Edition," provides optimal student comprehension, offering a strong conceptual understanding of skills and then building on this with the intricacies of skilled motor performance. Part I investigates the principles of human performance, progressively developing a conceptual model of human actions. The focus is mainly on human performance as based on an information-processing perspective. In part II, the text uses the conceptual model to impart an understanding of human motor learning processes. The presentation style remains simple and straightforward for those without extensive backgrounds in motor performance.

The fifth edition of "Motor Learning and Performance: From Principles to Application" goes beyond simply presenting research, challenging students not only to grasp but also to apply the fundamental concepts of motor performance and learning. The fifth edition is a valuable tool for anyone who appreciates high-level skilled activity or would like to learn more about how such performances occur.

The most important and the largest sex organ is located between the ears....and is commonly referred to as "the brain." Libido is a function of testosterone and erection is a function of free radicals. The very spark of life is fed by oxygen If you put out your free radical, oxidative fire, you extinguish your life If you douse your inner life-force spark, you smother your elan vital (life force). You can not live without your inner oxidative flame. Antioxidants pose a threat to the oxidative fire within. Oxygen and its electronically modified oxygen derivative (EMOD) progeny are the sine qua non (the essential condition) of man's very existence. This is an inarguable fact. Contrary to the common mantra of many authors, oxygen free radicals perform many crucial beneficial roles in sexual function and reproduction. Also contrary to popular claims, antioxidants are not the cure-all for sexual and reproductive problems. I have often said, "Man is the craziest critter on the planet." To back this up, I had suggested that all one had to do was to turn on the evening news or grab a newspaper. However, if you really want to see how crazy man is, just come with me through the history of aphrodisiacs and sexual prowess. So, let's undergo a reality check and scope out the history of these agents that claim to put more "zang in your wang," "zing in your thing" or greater "zippedy in your doo-da "

Few of us know much about the biology of sex determination, but what could be more interesting than to discover how we are shaped into males and females? In this book, Elof Carlson tells the incredible story of the difficult quest to understand how the body forms girls and boys. Carlson s history takes us from antiquity to the present day to detail how each component of human reproduction and sexuality was identified and studied, how this knowledge enlarged our understanding of sex determination, and how it was employed to interpret such little understood aspects of human biology as the origin of intersex births."

This personal scientific memoir describes how a chance observation concerning artery disease in children with rare inherited abnormalities of metabolism, often called experiments of Nature, led to the discovery of a new theory of heart disease, cancer and diseases of ageing. As explained in subsequent chapters, this new theory places the amino acid homocysteine at the heart of altered metabolism of diseases of ageing. Not only does this theory illuminate and explain the origin of these diseases, development of this theory logically leads to a novel and revolutionary metabolic and nutritional program for disease prevention and treatment, potentially benefiting individuals and populations.