Personnel working in assisted reproductive technology often lack the opportunities for dedicated training in the specialized techniques and technologies required for the procedures. As such, success in the form of live birth rates can range from over 50% to less than 10% per treatment cycle. This comprehensive introductory textbook is an essential resource for trainee embryologists, medical students and nurses. The recent revolutions in biotechnology and molecular biology involved in delivering assisted reproductive services are thoroughly discussed. Basic knowledge such as the development and physiology of both male and female reproductive systems is covered, with practical aspects of IVF including gamete and embryo manipulation, cryopreservation and genetic testing explained in detail. A full description of the optimal structure and management of the IVF laboratory is given, helping ensure procedures are safe and effective. Extensive and highly detailed colour illustrations bring the content to life and aids readers in their understanding.

For counselor Nancy Wainer Cohen, this book is the sibling to "Silent Knife: Cesarean Prevention and Vaginal Birth after Cesarean "(Bergin & Garvey, 1983) her critically-acclaimed expose on America's growing reliance on cesarean sections. "Open Season "provides fresh insights and new information on the subject, offering guidance to childbearing couples, educators, health professionals, and scholars who value the natural path of childbirth.

Readers will find this book timely, informative, shocking, irreverent, and extremely readable. Cohen's intimate writing style presents a compendium of knowledge on childbirth in the fashion of a personal letter. Her aim is to lower America's alarming reliance on cesarean section, which is currently at 25 percent of all births, and to return the responsibility for childbirth to women by encouraging them to choose the kind of birthing experience they wish to have. In addition to cesarean section, Cohen discusses many other generally unnecessary interventions performed on women during pregnancy and childbirth--such as fetal monitoring and routinized hospital procedures.

Ever wondered what's really going on in your body as you age? Can you really eat to beat cancer or prevent heart disease? These questions and more are answered in Eat Better, Live Longer, helping you make achievable, sensible, science-based changes to your diet from day one. Discover the secrets of long life from centenarians around the world, and explore the 10 simple but meaningful adaptations you can make both to what you eat and to how you eat to follow in their footsteps. A four-week eating plan, with over 110 nutrient-packed recipes, helps you learn to make smarter choices about foods that can reduce your risk of certain diseases and lessen the effects of others. Use this new-found knowledge together with details on how each part of your body changes as you age and which nutrients you need to support support all-round health, helping you live a longer, happier life. Future-proof your life with this science-based superfood approach to discovering what is really happening to your body as you are aging.

..". glimpses of intriguing changes in social arrangements and cultural understandings in relation to surrogacy. Disturbing motherhood indeed." New Scientist

"Larry Gostin has put together the definitive collection of essays on one of the most perplexing and titillating topics in contemporary medical ethics. This book includes contributions from some of the leading scholars on the legal, ethical, and social aspects of surrogacy, as well as several critical perspectives on the famous Baby M case must reading for understanding the surrogate motherhood controversy." Robert M. Veatch

"Highly recommended... " Choice

..". a valuable resource for those concerned with an exceedingly difficult ethical, legal, and political problem." Ethics

"There is a wealth of information here on the current status questionis in the United States, and anyone involved in the surrogacy debate, in the U.S. or otherwise, will find working through this material very worthwhile." Canadian Philosophical Review

..". an excellent sample of some of the best and most varied thinking so far on the numerous conceptual, moral, social, and policy questions raised by contract motherhood." The Journal of Clinical Ethics"

In this new, revised edition of his landmark book, Montagu compels us to reevaluate the way we think about growth and development, in all its phases, throughout life. Humans are designed to grow and develop their childlike qualities, and not to become the ossified adults prescribed by society. Montagu demonstrates how our culture, schools, and families are in conspiracy against such childlike traits as the need to love, to learn, to wonder, to know, to explore, to think, to experiment, to be imaginative, creative and curious, to sing, dance, or play. He also reveals the many links between physical and mental aging and tells how to prevent psychosclerosis, the hardening of the mind, so that we can die young--as late as possible. The best statement ever written on the most important, neglected theme of human life and evolution. "Stephen Jay Gould, Harvard University"

In this new, revised edition of his landmark book, Montagu compels us to reevaluate the way we think about growth and development, in all its phases, throughout life. Humans are designed to grow and develop their childlike qualities, and not to become the ossified adults prescribed by society. Montagu demonstrates how our culture, schools, and families are in conspiracy against such childlike traits as the need to love, to learn, to wonder, to know, to explore, to think, to experiment, to be imaginative, creative and curious, to sing, dance, or play. He also reveals the many links between physical and mental aging and tells how to prevent psychosclerosis, the hardening of the mind, so that we can die young--as late as possible.

The creation of 'test--tube babiesa acted as a spur to public debate about the implications of research on embryos, in vitro fertilization, surrogate motherhood, and the whole range of technologies concerned with human reproduction. The scope of reproductive technologies examined in this volume -- from techniques for the medical 'managementa of childbirth, to genetic engineering -- is such that few women in the western world, and smaller and smaller numbers in the third world, escape their influence. What then is their impact: on the process of reproduction, on family life and particularly on women? 'Reproductive Technologiesa is a remarkable collection of original essays which attempts to place the current controversy over reproductive technologies in a political, legal and economic context. Contributors -- including Lesley Doyal, Ann Oakley, Ros Petchesky, Carol Smart, Hilary Rose, and Naomi Pfeffer -- examine systematically the technologies that have sparked off these debates. They explore the problem of infertility which is used to validate reproductive technologies; the way assumptions about the family and about biological parenthood continue to structure the arguments for and against; the impact of the medicalization of childbirth; the way debates are embedded in changing conceptions of paternal rights, maternal rights and embryo rights; the problems of providing adequate health care for women; and, above all, the urgency with which these issues raise problems about the accountability of science.

Take control of your hormones and feel happier and healthier, with this practical guide to re-balancing your body and getting your life back on track ____________ Hormones play a crucial role in our health and well-being, yet few of us understand the toll they take on our bodies when we don't achieve a balance. Whether you're riding the roller coasters of puberty, pregnancy or the menopause, we're all a slave to our hormones at some point in our lives, and they can leave you feeling tired, low and irritable. In It Must Be My Hormones, leading specialists in women's health Dr Marion Gluck and nutritionist Vicki Edgson, show you the role that each of our major hormones plays, how a deficiency can affect our well-being, and what we can do to restore the balance. In this book you'll discover: * How to keep the weight off with thyroid boosting mega-foods * Vitamins which work wonders for your skin * How herbs and spices can give you a caffeine-free energy kick * Which aromatherapy herbs are actually beneficial * Ways to improve cognitive function through mineral supplements From boosting fertility to easing symptoms of PMS, this practical, easy-to-implement guidance will restore mental and physical well-being. Filled with inspiring personal stories, nutritional suggestions and advice on bio-identical hormone therapy, this book will help you regain control of your hormones and your life.

It is the book for every woman who hopes for VBAC. In fact, many first-time cesareans could be avoided if this book were read first. It is thorough, it is compassionate. "Esther Zorn, Cesarean Prevention Movement"

A] landmark book. . . . These VBAC stories are inspiring, as well as very informative about the nature of labor and current U.S. obstetric practice. "Ina May Gaskin, The Birth Gazette"

This is not a dry text book remote from reality, but a powerful manual' that burns the knowledge women need in an indelible way on heart and mind. "AIMS Quarterly Journal"

Here for the first time are intimate stories of the VBAC (vaginal birth after cesarean) experience, as told by mothers, fathers, midwives, obstetricians, labor coaches, and others whose lives have been affected by VBAC. The stories demystify in a powerful way the idea of once a cesarean, always a cesarean. By example, each story is a telling critique of birthing practices in general and the cesarean outcome in particular, as well as a primer for mothers, fathers, and professionals on the VBAC experience.

The bible of cesarean prevention. Wall Street Journal A landmark event, which will change the course of obstetric care by giving parents the informtion they need to make the decisions that are best for their own families. Comprehensive, highly readable, sensitive . . . should be read by everyone who cares about someone. Marian Tompson Director, Alternative Birth Crisis Coalition American Academy of Medicine Required reading for all childbirth professionals and prospective parents. Journal of Gynecological Nursing

In recent years increasing numbers of women from wealthy countries have turned to egg donation, egg freezing, and in vitro fertilization to become pregnant, especially later in life. This trend has created new ways of using, exchanging, and understanding oocytes-the reproductive cells specific to women. In The Oocyte Economy Catherine Waldby draws on 130 interviews---with scientists, clinicians, and women who have either donated or frozen their oocytes or received those of another woman---to trace how the history of human oocytes' perceived value intersects with the biological and social life of women. Demonstrating how oocytes have come to be understood as discrete and scarce biomedical objects open to valuation, management, and exchange, Waldby examines the global market for oocytes and the power dynamics between recipients and the often younger and poorer donors. With this exploration of the oocyte economy and its contemporary biopolitical significance, Waldby rethinks the relationship between fertility, gendered experience, and biomedical innovation.

This short volume selects and describes the main facts about the 'facts of life' and discusses their significance to man. It is only natural that it includes much information gleaned from mammalian reproductive patterns. It was their investigation that historically gave the clues to understanding what happens in human reproduction.

Selecting the best embryo to transfer to the uterus is key to successful in vitro fertilization (IVF). A huge amount of research has been devoted to this topic and there are numerous methods used, from simple morphological assessment to molecular biological techniques to assess the genome and metabolism of the newly fertilized embryo. For many of these techniques, an adequate evidence base is lacking, and expert opinion is valuable. Clinical imperatives require ranking all embryos in a cohort according to their viability, thereby enabling the selection of the best embryo to optimize live birth outcome: a key indicator used to measure and rate IVF Clinics worldwide. This clear and informative manual will provide embryologists and clinicians with an overview of the tools now available to assist in embryo selection, as well as evidence for their efficacy and safety and the broader considerations that must underlie these important clinical decisions.

Sexualfreundliche Sexualerziehung soll und muss sein, aber wem nutzt eine pro-aktiv sexualisierende Sexualerziehung und warum loest sie Widerstand aus? Ist die aktuell diskutierte Sexualpadagogik mit ihren Zielen und Methoden kindgerecht oder bedient sie Interessen von Erwachsenen? Diese Streitschrift bietet Interessierten und an Erziehung Beteiligten Informationen und Analysen, sowie persoenliche Einschatzungen der Autorin, die nachdenklich machen. Das Buch reflektiert alternative Herangehensweisen an das Thema Sexualitat in Kita und Schule und erklart, warum sich religioes begrundete und "moderne" sexual-padagogische Konzepte ahneln. Die Autorin nimmt die Leser mit in die Fragestellung und Besorgnis, ob die derzeit propagierte Sexualerziehung darauf hinauslauft, Kinder mit padagogischer Legitimation in die sexualisierte Erwachsenenwelt hineinzuziehen. Es oeffnet die Augen fur die Thematik und gibt Hinweise wie Kinder und Jugendliche motiviert werden koennen, sich vor dem Einfluss von Pornografie zu schutzen.

This book provides comprehensive information on Intracytoplasmic Sperm Injection (ICSI), its clinical considerations, outcomes and potential health effects. Male and female infertility is increasing all over the world. The basic techniques of assisted reproduction like ovulation control and intrauterine insemination are ineffective if the sperm quality or number is inadequate. The advanced fertilization techniques are in-vitro fertilization (IVF) and ICSI. In 15% cases of infertility, IVF results in total failed fertilization; therefore, ICSI must be used. Some clinics exclusively use ICSI for all infertility patients due to its reliability of fertilization outcome or to avoid total fertilization failure. ICSI was first used in humans in 1992. Since then, tremendous advances have been made in assisted reproductive technology. ICSI has enabled even those men who have rare sperm in their testes to father a biological child. If no sperm are observed in the ejaculate, in almost all cases, they can be recovered from the testicles. Such retrieved sperm can only be used by ICSI. Therefore, its understanding is essential not only for medical staff but also for patients suffering from infertility. This book is highly recommended for patients suffering from infertility or currently undergoing infertility treatment. It explains the factors affecting ICSI success rate. In ICSI, the embryologist picks a sperm for injection to fertilize oocytes whereas in intrauterine insemination and IVF, one sperm penetrates naturally. This manual selection of sperm has raised concerns especially in those patients suffering from severe male factor infertility. The nature of sperm defects varies and could be congenital, acquired or genetic. Children born through ICSI are, therefore, considered at higher risk of carrying the defect. Many investigations have been carried out to compare incidence of the defects between children conceived naturally and conceived through ICSI. Additional technologies have been developed to ensure the birth of a normal child. These include pre-implantation genetic testing and non-invasive prenatal testing. This book addresses these concerns and explains the health effects on children born through ICSI. This book is very useful for medical students, andrologists, embryologists, nurses or anyone else interested in learning basic or advanced knowledge of assisted reproductive technology, especially ICSI. The authors of the chapters of this book are highly experienced and from different parts of the world. Many of them are directing very busy ART laboratories at leading infertility clinics in the United States of America, Canada and the Middle East.

The development of the placenta was a pivotal event in evolution. Without it, we would still be laying eggs instead of giving birth to live offspring. It represents the critical link between the foetus and the mother, but its character is extraordinary - it is, in effect, a foreign tissue that invades the mother's body. Compared to many other animals, the human placenta represents a particularly aggressive body. But how is it managed and controlled? How did such an organ evolve in the first place? And why is it tolerated by the mother? Y.W. Loke explores the nature of the placenta and what it can tell us about evolution, development, and genetics.

The world often falls short of how we'd like it to be, and our ability to make even just a little difference can seem limited. Sometimes it feels like you need to be a super-hero to achieve anything meaningful. But what if by re-conceiving what you do, you could change the world for the better? In THE REGENERATIVE LIFE, Carol Sanford shows you how to fundamentally change the roles you play in society, enabling you to do more than you ever believed possible; grow yourself and others, provide astounding innovations for your clients, children and students, generate extraordinary social returns, become more creative, and bring new life and opportunity to everything around you. THE REGENERATIVE LIFE teaches you to see your roles differently: stripping away all preconceptions of how it should be done, understanding what your role is at its core, and building yourself back up to become something new; something so grounded, inspiring, and resilient, it can change the world.

Studies of mammary gland biology are essential in the fight against breast cancer. Moreover, the mammary gland represents an excellent model system for investigation of physiological and pathological processes that occur throughout the body. The branching morphogenesis that occurs during puberty and the alveogenesis processes during pregnancy, for example, recapitulate steps that occur in many tissues during embryogenesis and are also relevant to tumor invasion and metastasis. Similarly, analyses of breast cancer progression and the cell types that contribute to it yield findings applicable not only to breast cancer but widely to other cancers as well.
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews our understanding of mammary gland development, physiology, and tumor formation, emphasizing the value of the organ as a model system. The contributors examine the roles of hormones, growth factors, oncogenes, and the extracellular matrix in normal development and cancer. In addition, they discuss the nature of the mammary gland stem cell population and review the gene expression programs activated and chromatin modifications that occur as the different cell lineages present differentiate. The book also contains chapters covering the many experimental approaches that have been used in this field, including transplantation, genetic engineering, RNA interference and genomics, three dimensional culture models, and live cell imaging. It will thus be of interest to all researchers working in cell, developmental, and cancer biology, as well as those focused specifically on mammary gland biology and breast cancer.

'Quite simply the best book about science and life that I have ever read' - Alice Roberts How does life begin? What drives a newly fertilized egg to keep dividing and growing until it becomes 40 trillion cells, a greater number than stars in the galaxy? How do these cells know how to make a human, from lips to heart to toes? How does your body build itself? Magdalena Zernicka-Goetz was pregnant at 42 when a routine genetic test came back with that dreaded word: abnormal. A quarter of sampled cells contained abnormalities and she was warned her baby had an increased risk of being miscarried or born with birth defects. Six months later she gave birth to a healthy baby boy and her research on mice embryos went on to prove that - as she had suspected - the embryo has an amazing and previously unknown ability to correct abnormal cells at an early stage of its development. The Dance of Life will take you inside the incredible world of life just as it begins and reveal the wonder of the earliest and most profound moments in how we become human. Through Magda's trailblazing research as a professor at Cambridge - where she has doubled the survival time of human embryos in the laboratory, and made the first artificial embryo-like structures from stem cells - you'll discover how early life is programmed to repair and organise itself, what this means for the future of pregnancy, and how we might one day solve IVF disorders, prevent miscarriages and learn more about the dance of life as it starts to take shape. The Dance of Life is a moving celebration of the balletic beauty of life's beginnings.

As an objective of human security, it is important to understand the social system and to make more appropriate policies for people based on the bio-psycho-social viewpoint of health advocated by the World Health Organization (WHO). For countries with increasingly large populations of older adults, aging-related disorders cause many social handicaps. A comprehensive approach for integrating not only medical, but also psychosocial and spiritual viewpoints is needed for better health policy planning.During a risky situation such as a major disaster, which can critically affect peoples lives, people should utilize their brains more fully in order to survive; i.e., to understand the situation around them, to make a proper judgment call, and to choose their behaviors. All of these approaches are associated with brain functions. Understanding the situation primarily requires the posterior part of the brain, especially the parietal lobe.Briefly, the occipital, temporal, parietal, and frontal lobes are related to visual, auditory, other sensory, and motor functions, respectively. Each lobe has primary and secondary areas: The former is associated with primary function, whereas the latter is related to association functions, which add meaning to the primary information. In particular, visual and auditory information should be fully integrated to understand the situation and make a judgment call, which is the function of the parietal lobe.Human Security: Social Support for the Health of an Aging Population Based on Geriatric Behavioral Neurology is meant to help readers understand the bio-psycho-social viewpoint and bioethics of social support for elderly people. The second aim is to understand the social support system and Quality of Life (QOL) for handicapped and elderly people. Especially, the long-term care insurance system for elderly people in Japan, which is a well-organized system to support well-being in the elderly, needs to be understood. Also, dementia is one of the important age-related disorders that can affect not only patients themselves, but also their families, community residents, and society. The third objective is to understand dementia and dementing diseases, not only from a medical perspective, but in terms of psychosocial and spiritual aspects. Following the Great East Japan Earthquake of 2011, various cases of weakness due to the disaster were analyzed. Most of them were previously assessed as a borderline condition between healthy and dementia. Therefore, it is important to routinely screen community residents for security.All risky situations such as a disaster should be treated internationally. The author recalls that one student told them that the Indonesian government faces difficulties in preparing for a disaster with a unified language. Indeed, more than 700 regional languages are spoken in Indonesias numerous islands. However, disasters do not select a language. The author is certain that there are some lessons from their history that have not been recorded in a common language. It is important to establish a network based not only on local culture and language, but also a global proposal based on a common language.The author hopes that young scientists in the next generation will have an integrated perspective and will apply science to human security worldwide.

Il dolore cronico vulvare, o vulvodinia, e una patologia diffusa che puo avere un forte impatto sul benessere della donna. Nonostante sia frequentemente osservata nella pratica clinica quotidiana, resta un disturbo trascurato e puo richiedere anche molti anni per essere correttamente

diagnosticato. Il volume offre un panorama conciso delle ultimissime acquisizioni sulla diagnosi e la cura della vulvodinia e delle sue numerose comorbilita, ha un formato facile da leggere, con molti consigli pratici, e aiuta ad affrontare rapidamente ed efficacemente tutte le complesse e delicate problematiche

che sottendono il disturbo. Questo libro si rivolge ai medici motivati a migliorare la qualita di vita delle donne che soffrono di vulvodinia, e in particolare ai Ginecologi e ai Medici di Medicina Generale.

With the conclusion of adolescence, a child develops into a teenager that may experiment with dating, smoking and drinking, and they may make important decisions without parental knowledge or guidance. These teenagers may also engage in risky behaviour, which may pose as a threat to their well-being and successful transition into adulthood. With this in mind, how can we can prevent adolescent risk behaviour? Traditionally, prevention scientists propose three forms of prevention. Primarily, attempts to reduce the harmful consequences of risk behaviour, such as treatment of risk behaviour (ie: mental disorders or substance abuse) are ideal. For some problematic behaviour which has already occurred, a better approach is to identify those who are at-risk as early as possible (ie: secondary prevention). For example, youth workers may identify those who have suicidal ideation and intervene as early as possible so that they will not harm themselves. In this book, the authors assess whether a community-based program in Hong Kong was effective in promoting adolescent development and explore what factors were associated with the program effects. The authors hope that the studies included in this book can help to reveal the successful experience of the project and provide some pointers for the development of programs for adolescents with greater psychosocial needs.

Node.js, MongoDB and Angular Web Development The definitive guide to using the MEAN stack to build web applications Node.js is a leading server-side programming environment, MongoDB is the most popular NoSQL database, and Angular is the leading framework for MVC-based front-end development. Together, they provide an easy-to-implement, fully integrated web development stack that allows web programmers to create high-performance sites and applications built completely in JavaScript, from server to client. Updated for Angular 2, Angular 4, and subsequent versions, this new edition of Node.js, MongoDB and Angular Web Development shows you how to integrate these three technologies into complete working solutions. It begins with concise, crystal-clear tutorials on each technology and then quickly moves on to building common web applications. You'll learn how to use Node.js and MongoDB to build more scalable, high-performance sites, how to leverage Angular's innovative MVC approach to structure more effective pages and applications, and how to use all three together to deliver outstanding next-generation Web solutions. Implement a highly scalable and dynamic web server using Node.js and Express Implement a MongoDB data store for your web applications Access and interact with MongoDB from Node.js JavaScript code Learn the basics of TypeScript Define custom Angular directives that extend the HTML language Build server-side web services in JavaScript Implement client-side services that can interact with the Node.js web server Build dynamic browser views that provide rich user interaction Add authenticated user accounts and nested comment components to your web applications and pages Contents at a Glance Part I: Getting Started 1 Introducing the Node.js-to-Angular Stack 2 JavaScript Primer Part II: Learning Node.js 3 Getting Started with Node.js 4 Using Events, Listeners, Timers, and Callbacks in Node.js 5 Handling Data I/O in Node.js 6 Accessing the File System from Node.js 7 Implementing HTTP Services in Node.js 8 Implementing Socket Services in Node.js 9 Scaling Applications Using Multiple Processors in Node.js 10 Using Additional Node.js Modules Part III: Learning MongoDB 11 Understanding NoSQL and MongoDB 12 Getting Started with MongoDB 13 Getting Started with MongoDB and Node.js 14 Manipulating MongoDB Documents from Node.js 15 Accessing MongoDB from Node.js 16 Using Mongoose for Structured Schema and Validation 17 Advanced MongoDB Concepts Part IV: Using Express to Make Life Easier 18 Implementing Express in Node.js 19 Implementing Express Middleware Part V: Learning Angular 20 Jumping into TypeScript 21 Getting Started with Angular 22 Angular Components 23 Expressions 24 Data Binding 25 Built-in Directives Part VI: Advanced Angular 26 Custom Directives 27 Events and Change Detection 28 Implementing Angular Services in Web Applications 29 Creating Your Own Custom Angular Services 30 Having Fun with Angular

Intimate and medicalized, natural and technological, reproduction poses some of the most challenging ethical dilemmas of our time. Reproduction presses the boundaries of humanity and ethical respect, the permissible limits of technology, conscientious objection by health care professionals, and social justice. This volume brings together scholars from multiple perspectives to address both traditional and novel questions about the rights and responsibilities of human reproducers, their caregivers, and the societies in which they live. Among issues treated in the volume are what it is to be a parent, the responsibilities of parents, and the role of society in facilitating or discouraging parenting. May gamete donors be anonymous? Is surrogacy in which a woman gestates a child for others ethically permissible when efforts are made to prevent coercion or exploitation? Should it be mandatory to screen newborns for potentially serious conditions, or permissible to sequence their genomes? Are both parties to a reproductive act equally responsible to support the child, even if one deceived the other? Are there ethical asymmetries between male and female parents, and is the lack of available contraceptives for men unjust? Should the costs of infertility treatment be socially shared, as they are for other forms of health care? Do parents have a duty to try to conceive children under the best circumstances they can-or to avoid conception if the child will suffer? What is the status of the fetus and what ethical limits constrain the use of fetal tissue? Reproduction is a rapidly changing medical field, with novel developments such as mitochondrial transfer or uterine transplantation occurring regularly. And there are emerging natural challenges, too, with Zika virus just the latest. The volume gives readers tools not only to address the problems we now know, but ones that may emerge in the future as well.