The first book to teach physical assessment techniques based on evidence and clinical relevance. Grounded in an empirical approach to history-taking and physical assessment techniques, this text for advanced health care providers and students focuses on patient well-being and health promotion. It is based on an analysis of current evidence and up-to-date guidelines and recommendations and underscores the evidence, acceptability, and clinical relevance behind physical assessment techniques.Evidence-Based Health and Well-Being Assessment offers the unique perspective of teaching both a holistic and scientific approach to assessment. Chapters are consistently structured for ease of use to include anatomy and physiology, key history questions and considerations, physical examination, laboratory considerations, imaging considerations, evidence-based practice recommendations, and differential diagnoses related to normal and abnormal findings. Case studies, clinical pearls, and key takeaways aid retention and countless illustrations, images, and videos demonstrate advanced history-taking and assessment techniques. Instructor resources include PowerPoint slides, test bank with multiple-choice questions, essay questions, and an image bank. This is the physical assessment text of the future. Key Features: Delivers the evidence, acceptability, and clinical relevance behind advanced history-taking and assessment techniques Eschews "traditional" techniques that do not demonstrate evidence-based reliability Focuses on the most current clinical guidelines and recommendations from resources such as the US Preventative Services Task Force Focuses on the use of modern technology for assessment Aids retention through case studies, clinical pearls, and key takeaways Demonstrates advanced techniques with countless illustrations, images, and videos Includes robust instructor resources- PowerPoint slides, test bank with multiple-choice questions, essay questions, and an image bank Purchase includes access to the eBook for use on most mobile devices or computers

This book guides practitioners in the assessment of patients with a liver problem. The emphasis is on the role of macro- and microscopic pathology in elucidating pathogenesis as well as identifying confounding features of image findings that may lead to a more elaborate differential diagnosis. If appropriate, the role of light and electron microscopic examination, along with the role of specific stains and molecular techniques, is illustrated. In addition, the concept of each liver disease is summarized briefly and its up-to-data is provided, and unresolved problems in diagnosis, treatment, and pathogenesis are clearly described.The approach in this book is a practical one with a focus on the evaluation of illustrative cases, simultaneously demonstrating cross-sectional images (ultrasonography, computed tomography, magnetic resonance imaging, and angiography), pathological findings, and peritoneoscopic images. The diagnosis and therapy are summed up in helpful tables, and association of clinical manifestations with image analysis and pathological findings is shown to be important in differential diagnosis and treatment. With the authors comprising internationally renowned experts, this book will serve as a useful source of information for medical students, physicians, internists, hepatologists, gastroenterologists, radiologists, and pathologists worldwide.

The fifth edition of this best-selling Red Book (R) image companion aids in the diagnosis and treatment of more than 165 pediatric infectious diseases. Streamline disease recognition and clinical decision-making with more than 1,350 finely detailed color images, combined with step-by-step guidance. Featured in the Fifth Edition Updated guidance on every pediatric infectious disease New guidance on coronaviruses, including SARS-CoV-2 and MERS-CoV New Pseudomonas aeruginosa Infections chapter Images added for Chlamydia pneumoniae, hepatitis D virus, human herpesvirus 8, and more Extensively revised Gonococcal Infections chapter and Hepatitis B chapter New Clinical Manifestations added for human herpesvirus 8 in young children And much more . . . Concise text descriptions guide the reader through the diagnosis, evaluation, and essential management of each condition. Clinical Manifestations Etiology Epidemiology Diagnostic Tests Incubation Period Treatment

The increasing pressure upon clinicians to see more and more patients generates great concern as to how to offer a comprehensive and thorough diagnostic approach and yet maintain efficiency. Neurologic Differential Diagnosis is the answer. Unlike other texts which are divided into disease entities, this book uses a case study approach to focus on the patients' symptoms. Each chapter is dedicated to a specific presenting symptom or sign and includes a comprehensive, yet succinct table of clinical features to aid clarification of the broad list of diagnostic possibilities. This allows the clinician to quickly reference specific symptoms such as dizziness, mental status change or diplopia; or signs such as foot drop or psychotic behavior, and then immediately generate diagnostic possibilities. Written from the authors' extensive clinical experience, Neurologic Differential Diagnosis is an invaluable text for neurologists and psychiatrists at all stages of training.

This pioneering book investigates how biographical evidence has been variously used, misused, or not used at all, by clinicians entirely reliant on biographical evidence for the influential posthumous diagnoses they have produced of Winston Churchill as a manic-depressive. Attention is paid, also, to the distinct question of Churchill and "nerves," otherwise known as neurasthenia. This question has a place alongside the manic-depression issue because, by ensuring there is a marked contrast between two lines of biographical inquiry, it facilitates a significant move in the direction of a more rounded, a more securely founded, understanding of how Churchill functioned psychologically, and how he did not. That goal of a more rounded understanding is important, and the contribution Diagnosing Churchill makes towards its achievement is worthwhile, because accuracy in the depiction of key elements in the functioning of a major historical figure, one of the heroes of Western democratic civilization, is enjoined by a principle Churchill expressed thus: "the meanest historian owes something to the truth."

This valuable reference and learning tool showcases 50 unique, real-life cases from NeoReviews popular "Index of Suspicion in the Nursery and "Visual Diagnosis". These 50 cases cover rare conditions or unusual clinical manifestations of common conditions that medical professionals see every day. Topic areas include cardiology, dermatology, endocrinology, fluids and electrolytes, gastroenterology, genetics, hematology and oncology, inborn errors of metabolism, maternal-fetal medicine, neurology, ophthalmology, orthopedics, otolaryngology, and pulmonology. More than 100 images provide assistance for visual learning.

The human genome study and genetics have emerged as a key concept and important aspect of public health and medicines. The complete characterization of genetic disorders and other related diseases can offer valuable information regarding the diagnosis of the patients. Moreover, the familial mutation identification, may lead to proper genetic counseling within families that may prevent genetic disorders in future pregnancies through possible preimplantation genetic diagnosis or prenatal diagnosis. In recent years the area of clinical molecular diagnostics has evolved considerably with the advances in fundamental research and technologies of human genetics. Earlier, the researchers used to depend on preliminary techniques to assess genetic mutations. Over the years more and more assay techniques were implemented for better utilization of clinical molecular diagnostic. Previously, the assays were usually targeted to more common disorders like cystic ?brosis and hemoglobinopathies using methods linked indirectly to mutation detection by linkage and haplotype analyses. These processes were very laborious, requiring a large amount of DNA from the patients and extensive knowledge of the region of the genome in question. Even then the results acquired were not very easily interpretable. However, those earlier analysis methods given the much-needed foundation for the molecular diagnostics and several of such techniques are still in use. The molecular diagnostic techniques got revolutionized with the advent of PCR or polymerase chain reaction which was first introduced by Mullis et al., 1986. It has the capability to produce numerous copies of any region of the target DNA enabling faster analysis as well as direct identification of mutations. In no time the earlier assays were modified to integrate the use of DNA amplified using PCR instead of the genomic DNA. Gradually, the assays dependent on allele-specific detection are developed into systems with high-throughput allowing larger scale analysis of patient samples. The discovery of PCR also enabled laboratories to identify rare disorders, along with the most common ones. In this regard, the NGS or next-generation sequencing methods are fetching more and more attention. But, the most common method for analysing many genetic disorders seems to be automated Sanger sequence analysis and is used in most of the molecular diagnostic laboratories for clinical purposes. The choice of assay, however, depends largely on the alleles or gene of interest and number of patients needed to be screened. In this book, an attempt is made to offer an insight on the common molecular techniques that are in use and recent advances in molecular diagnostics.

Molecular diagnosis has become one of the major forms of disease diagnosis. The biggest tools for this type of diagnosis are DNA and the Polymerase Chain Reaction (PCR).Molecular diagnostics is a collection of techniques used to analyze biological markers in the genome and proteome-the individual's genetic code and how their cells express their genes as proteins by applying molecular biology to medical testing. The technique is used to diagnose and monitor disease, detect risk, and decide which therapies will work best for individual patients. By analyzing the specifics of the patient and their disease, molecular diagnostics offers the prospect of personalized medicineThese tests are useful in a range of medical specialists, including infectious disease, oncology, human leucocyte antigen typing (which investigates and predicts immune function), coagulation, and pharmacogenomics, the genetic prediction of which drugs will work best They overlap with clinical chemistry (medical tests on bodily fluids).This book starts by introducing this tools followed by examples of the application of PCR to diagnosis of cancer and infectious diseases (section 1), genome sequencing applied to diagnostics (section 2) and RNA also applied to diagnosis of cancer and infectious diseases (Section 3). Section 4 shows examples of point of care assays diagnosis of Shigella and HIV. Section 5 gives examples of diagnosis based on proteomics and Mass Spectrometry. Several Molecular diagnosis assays and techniques are currently under development and being prepared for commercialization in a daily basis, making this type of diagnosis one of most promising and innovating ways of disease diagnostics.

An ideal companion to the groundbreaking TILLS test! Screen with SLS, and then follow up and diagnose with TILLS. For use on its own or with the Test of Integrated Language and Literacy Skills™ (TILLS™), the Student Language Scale (SLS) reliably screens students ages 6—18 years for language/literacy disorders, including dyslexia. Filled out by parents, teachers, and students, the screener is a quick, cost-effective way to see how students are performing on academic tasks as compared to their same-age peers. Use the SLS to: Screen for language/literacy disorders, including dyslexia, by gathering teachers' and parents' ratings of students Gather input about a struggling student's strengths and needs from multiple sources Enhance home—school communication by gaining new insight into the student's performance and the teacher's and the parents' and student's perspectives on it, whether or not everyone agrees and whether or not there are concerns Whether used with an entire classroom or with individual students, the SLS is the tool you need to quickly gather valuable information about strengths and needs—and plan next steps for students at risk for disorders. Why use the SLS? Expert developed: The SLS developers are highly respected for their test-building skills and evidence-based work in the field of language and literacy assessment and school social work. Fast and easy: The three-part SLS can be completed in just 3 minutes or less. Administration and scoring is simple—a pencil and paper are all you need. Strong sensitivity and specificity. Sensitivity of the SLS to risk of language/literacy disorder is .90 for teachers and .85 for parents, and specificity (correct identification of typical learners) is .90 for teachers and .83 for parents. Cost effective. The SLS helps you screen effectively at a lower cost than comparable tools on the market. Simple scoring: The 12-item rating scale section of the SLS incorporates descriptive statements that are rated on a scale of 1 to 7 from not good to very good. The first eight items on the scale ask about core language and literacy abilities that represent the 2 language levels x 4 language modalities assessed with TILLS. When teachers or parents rate more than two areas on items 1-8 as less than 5, SLS screening results indicate the student is at risk and needs further assessment. Perfect for use with TILLS!: The SLS is an ideal companion to the groundbreaking TILLS test, which assesses oral and written language skills in students ages 6—18 years. Gather teacher and parent ratings for whole classes of students with the SLS, and if results indicate that a student is at risk, follow up with TILLS assessment and other forms of language/literacy assessment. What's in this kit?: One SLS User's Manual One gummed tablet of 50 TILLS™ Student Language Scale forms One SLS Quick Start Guide with basic instructions on administering and scoring

Early detection of breast cancer is critical. Yet efforts to cut back on mammography or even stop screening altogether have been gaining ground in the medical community's decades-long debate over testing and treatment. It is not a purely scientific debate-back-room politics and hidden agendas have played as much a role as clinical data, leading to some surprising conclusions. Written by one of the first physicians in the country to specialize in breast cancer risk assessment, genetic testing and high-risk interventions, this book focuses on the screening controversy and explains the arguments used on both sides. The author covers the history of screening, from the first mobile unit on the streets of Manhattan to the cutting edge imaging technology of today.

Since the publication of the first edition of the Handbook in 2002, optical methods for biomedical diagnostics have developed in many well-established directions, and new trends have also appeared. To encompass all current methods, the text has been updated and expanded into two volumes. Volume 1: Light - Tissue Interaction features eleven chapters, five of which focus on the fundamental physics of light propagation in turbid media such as biological tissues. The six following chapters introduce near-infrared techniques for the optical study of tissues and provide a snapshot of current applications and developments in this dynamic and exciting field. Topics include the scattering of light in disperse systems, the optics of blood, tissue phantoms, a comparison between time-resolved and continuous-wave methods, and optoacoustics.

Since the publication of the first edition of the Handbook in 2002, optical methods for biomedical diagnostics have developed in many well-established directions, and new trends have also appeared. To encompass all current methods, the text has been updated and expanded into two volumes. Volume 2: Methods begins by describing the basic principles and diagnostic applications of optical techniques based on detecting and processing the scattering, fluorescence, FT IR, and Raman spectroscopic signals from various tissues, with an emphasis on blood, epithelial tissues, and human skin. The second half of the volume discusses specific imaging technologies, such as Doppler, laser speckle, optical coherence tomography (OCT), and fluorescence and photoacoustic imaging.

This convenient handbook is a comprehensive guide to the evaluation and treatment of more than 80 signs and symptoms. It is organized alphabetically, and each entry includes history and physical examinations; causes; differential diagnosis; diagnostic procedures; treatment approaches including when to refer and when to admit; ongoing care and follow-up; and prevention. Contents include: Abdominal pain Back pain Chest pain Diarrhea and steatorrhea Dizziness and vertigo Fatigue and weakness Fever Headache Heart murmurs Jaundice Rash Red eye/pink eye Sleep disturbances Speech and language concerns Vomiting Wheezing And more!

Uroscopy - the diagnosis of disease by visual examination of the urine - played a very prominent role in early modern medical practice and in the lives of ordinary people. Widely considered as the most reliable way to diagnose diseases and pregnancies it was taught at the best universities. Leading physicians prided themselves on their mastery in this field. Countless medical writings were dedicated to uroscopy and artists represented it in hundreds of illustrations and paintings. Based on a wide range of textual and visual sources, such as autobiographies, court records, medical treatises and genre painting, this book offers the first comprehensive study of the place of uroscopy in early modern medicine, culture and society and of the - gradually changing - ways in which medical practitioners, lay persons and, last but not least, artists perceived and used it.

Rather than categorizing vulvar disorders by standard classifications such as neoplastic, inflammatory, or infective, this book describes the disorders by key presenting symptoms-such as erythema, bullae, plaques, cysts, or ulcers. This approach allows clinicians to quickly formulate a correct diagnosis. Vulval Dermatologic Diagnosis: Diagnosis by Clinical Presenting Sign combines clinical images with short, concise descriptions to facilitate the timely and correct identification of various vulvar disorders. The book includes hundreds of color clinical photographs for ease of diagnosis. For many disorders, a clinical description, etiology, epidemiology, diagnosis, differential diagnosis, and treatment are also included. Written by leaders in the field with extensive clinical expertise in the area, these distinguished physicians and scientists consolidate decades of experience into one single volume. This book is a valuable and useful resource for dermatologists, gynecologists, family physicians, and medical students.

Our yesterdays have determined who we are today, and knowledge of our past has the potential to enhance both our understanding of the present and our predictions of the future. Diagnosing Giants traces the history of medicine through the illnesses of some of the most influential figures of the past. Standard biographies all too often pay scant attention to the health issues that affected their subjects. Yet, the diseases suffered by these figures had profound effects on their lives and their legacies. Each chapter opens with a detailed medical history of the patient. Facts relevant to the historical figure's life and legacy are woven into the case summary, and the mystery patient's identity is revealed at the conclusion of the case summary. The author then analyzes the medical history, offers a differential diagnosis and a final diagnosis. Where relevant, the potential effects of the subject's medical problems on his or her life and legacy are discussed. Diagnosing Giants is a must-own volume for medical professionals and history buffs alike.

In this volume, a team of internationally recognized experts provide an in-depth description of therapeutic biomarkers across a broad area of cancer research and oncology. With a wealth of information to specific therapies, each chapter focuses on a class of targeted chemotherapy agents. The book describes established and evolving diagnostic tests for therapeutic biomarkers that predict benefit, response, resistance, or drug side effects from specific therapeutic interventions. This volume is an essential handbook for health professionals and scientists researching current applicable biomarkers in oncology.

Providing authoritative and up-to-date medical and scientific information about Tourette syndrome, "A Family's Guide to Tourette Syndrome" speaks to patients, families, care providers, academic institutions, and medical centers in easy-to-understand language about this neurodevelopmental disorder that affects children, adolescents, and adults worldwide. Each chapter is authored by leading neurologists, psychiatrists, psychologists, scientists, and others with expertise and research interests in Tourette syndrome.
"Praise for A Family's Guide to Tourette Syndrome"

"I am delighted to see the breadth and wealth of valuable clinical and scientific findings that have been gathered together in this comprehensive resource for families. The information provided in this book is testimony to the talent, abiding intellectual curiosity, and dedication to compassionate care and sheer persistence of each of the professionals who have contributed chapters. Their common goal was clear and selfless-to uncover sound medical and scientific data that could provide much needed answers to the baffling complexities of Tourette syndrome. A mere two decades ago, it was clear to all in the field that the prospect of obtaining sufficient funding to explore more deeply the intriguing preliminary findings uncovered about the disorder was all but non-existent. Simply put-other research funding priorities prevailed at the time. And so we can appreciate that the decision by each of them to dedicate their professional efforts to the study of Tourette syndrome is especially laudable. And for this we all owe the contributing authors a profound debt of gratitude." -Sue Levi-Pearl, Emeritus TSA Vice President, Medical and Scientific Programs

Infectious diseases have plagued man throughout history. In the era of modern medicine antibiotics and vaccines brought the hope of liberation from the great scourges of smallpox, polio, and tuberculosis. Yet, in the ensuing decades as we hoped to close the book on infectious diseases, we have instead been confronted by wave upon wave of new assailants. AIDS, SARS, pandemic influenza, and multi-drug resistant bacteria demonstrated how our technological advances have either fallen short in halting or even enhanced the spread of emerging pathogens. International air travel has collapsed geographic boundaries that once confined tropical infections to distant latitudes. Novel forms of immunosuppression, advances in organ transplantation, and victories in the cancer wars have led to an ever-expanding population at risk for opportunistic infections. In this collection of illustrated cases we give a cross-sectional view of the growing challenges that face the infectious diseases consultant. The modern physician is empowered by high resolution imaging and molecular diagnostic techniques that confer diagnostic capabilities Osler could have only dreamed of. Nevertheless we continue to grapple with the timeless struggles illuminated by Pasteur, Koch, and Fleming between man and the microscopic organisms of the world.
Part of the new Oxford American Infectious Disease Library series, this book of illustrative cases will appeal to anyone working in a busy infectious diseases consultation service or practice including students, residents, fellows, faculty and other ID practitioners. Featuring numerous high-quality images and illustrations guiding diagnosis and case discussion, the handbook is meant to serve as a highly practical guide covering current approaches and new developments in the diagnosis, treatment, and management of a cross section of infectious diseases, including community-acquired and healthcare-associated infections.

PET-CT imaging is a powerful tool in diagnosis and treatment of cancer. Its application as a prognostic tool in various malignancies is well established. This volume encompasses the latest trends and developments of PET-CT imaging in non-neoplastic disease along with its application in clinical decision-making. This volume will be of interest to internal medicine specialists and subspecialists, as well as neurologists, psychiatrists, general radiologists and Nuclear Medicine physicians. Topics include: PET myocardial perfusion imaging as an accurate and non-invasive means in the evaluation of ischemia and the assessment of myocardial viability as well as the potential for myocardial blood flow quantificationThe use of PET imaging in the early diagnosis and timely intervention in potentially devastating dementiasThe utility of PET imaging in the diagnosis of a variety of inflammatory diseases such as lupus and myositis

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The Oxford American Handbook of Clinical Examination and Practical Skills is a comprehensive pocket guide for medical, physician assistant, and nurse practitioner students. It is designed to help students transition from classroom to clinical internships, preceptorships, and clerkships. Providing clear and user-friendly guidance on all aspects of history taking, physical examination, common practical procedures, data interpretation and communication skills, it gives realistic advice on coping with and mastering common situations.
Each systems chapter follows a structured format covering applied anatomy, history, examination, and the presentation of common and important disorders. The procedures section includes approximately forty practical procedures that the final year medical student and senior nurse are expected to perform. The section on data interpretation covers the basics of chest x-rays, abdominal x-rays, ECGs, lung function tests and several other areas that the student is expected to carry out in their early years of training.

Undergraduate and postgraduate teaching increasingly favours a symptom-based approach to diagnosis. Unlike many other textbooks in acute medicine, this book reflects this shift in emphasis, presenting a logical and structured approach to the diagnosis and initial management of acutely unwell adults. It discusses the relevant pathophysiology of each clinical presentation, and provides a comprehensive table of differential diagnoses, highlighting common causes. The book's description of generic emergency management emphasises important diagnoses, and explains relevant history, examination findings and investigations involved in assessment or diagnosis. Senior medical students and junior doctors in their first four years after qualifying will find this an invaluable aid to honing their clinical practice. The logical systems of diagnostic thought will serve them throughout their careers. No book can replace hard work on the ward and in clinics but books can speed up the acquisition of skills by fostering sound basic principles and developing the right instincts. Diagnosis in Acute Medicine is particularly helpful in this regard. I strongly recommend it.A " - From the Foreword by Ian Pavord