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This book presents, in two parts, a review concerning the use of Rattus norvegicus as a model for the study of neurological disorders and oncological diseases (mammary cancer). In the first part, the neurological disorders are addressed in important neurological diseases, such as: Autism, Parkinsons, Huntingtons and Alzheimers disease, and two neuromotor dysfunctions (amyotrophic lateral sclerosis and ataxia). The second part reveals the importance of the rat as a model for the study of mammary cancer, presenting the diversity of rat strains and models available for the study of this oncological disease. This part is mainly focused on the chemically-induced models of mammary cancer and on the importance of the rat for the development of new prophylactic and therapeutic strategies to fight this disease.For many years and up to the present, rat models have allowed the study of innumerable diseases, as well as their etiology, pathogenesis, evolution and treatment. Due to this, the role of this species for the evolution of medicine is undoubtable.Since the information presented in this book was obtained from years of works of expertise in the field, we hope that it be useful for those researchers aiming to use Rattus norvegicus as a model to study human diseases, providing them with valuable information for the adequate selection and management of this species in their experiments.

The Oxford Textbook of Medical Mycology is a comprehensive reference text which brings together the science and medicine of human fungal disease. Written by a leading group of international authors to bring a global expertise, it is divided into sections that deal with the principles of mycology, the organisms, a systems-based approach to management, fungal disease in specific patient groups, diagnosis, and treatment. The detailed clinical chapters take account of recent international guidelines on the management of fungal disease. With chapters covering recent developments in taxonomy, fungal genetics and other "omics", epidemiology, pathogenesis, and immunology, this textbook is well suited to aid both scientists and clinicians. The extensive illustrations, tables, and in-depth coverage of topics, including discussion of the non-infective aspects of allergic and toxin mediated fungal disease, are designed to aid the understanding of mechanisms and pathology, and extend the usual approach to fungal disease. This textbook is essential reading for microbiologists, research scientists, infectious diseases clinicians, respiratory physicians, and those managing immunocompromised patients. Part of the Oxford Textbook in Infectious Disease and Microbiology series, it is also a useful companion text for students and trainees looking to supplement mycology courses and microbiology training.

For more than 65 years, this best-selling text by Drs. Barbara J. Bain, Imelda Bates, and Mike A. Laffan has been the worldwide standard in laboratory haematology. The 12th Edition of Dacie and Lewis Practical Haematology continues the tradition of excellence with thorough coverage of all of the techniques used in the investigation of patients with blood disorders, including the latest technologies as well as traditional manual methods of measurement. You'll find expert discussions of the principles of each test, possible causes of error, and the interpretation and clinical significance of the findings. A unique section on haematology in under-resourced laboratories. Ideal as a laboratory reference or as a comprehensive exam study tool. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. diagnosis, molecular testing, blood transfusion- and much more. Complete coverage of the latest advances in the field. An expanded section on coagulation now covers testing for new anticoagulants and includes clinical applications of the tests.

This text is a review of molecular immunohematology (MI). It draws from analyses and case studies around the world and details many techniques used in many labs. It is aimed at anyone interested in how MI is changing blood bank and transfusion medicine.

Genetically-engineered mouse models for cancer research have become invaluable tools for studying cancer biology and evaluating novel therapeutic approaches. This volume focuses on state-of-the-art methods for generating, analyzing and validating such models for studying aspects of human cancer biology. Additionally, these models are emerging as important pre-clinical systems in which to test cancer prevention and therapeutic strategies in order to select compounds for testing in clinical trials.

Breast cancer remains a disease of considerable public health importance worldwide, with over 800,000 new cases diagnosed globally each year. Considerable energy is currently being spent by researchers to further our understanding of this complex disease, however, keeping up with all of the new data is a real challenge given the sheer volume of information that becomes available on a daily basis. The purpose of this book would be to provide a comprehensive review of breast cancer epidemiology, covering the topics of disease burden, etiology, risk factors, prevention, early detection/screening, treatment, and outcomes. The book would be a single comprehensive source of the most recent information on breast cancer epidemiology, and it would serve as a valuable resource for breast cancer researchers across disciplines regardless of what stage of their career they are in. To the knowledge of the editor, no such resource is currently available.