The contributions in this book were presented at the fifth European-Japanese Joint Conference for Stroke Surgery, held in July 2010 in Duesseldorf, Germany. The topics treated are the management of cerebral and ventricular hemorrhage, extra-intracranial bypass surgery, surgical and endovascular treatment of cervical and intracranial arterial occlusive disease, and embolization and microsurgery of AVM and dural AV-fistulas.

Accurate interpretation of indications for treatment is the cornerstone of success in medicine. This book carefully examines the relation between clinical features, diagnosis, and choice of minimally invasive technique for a range of spine pathologies. It explains how selection of technique is intimately related to clinical and diagnostic aspects and how recognition of this relation forms the foundation for an optimal outcome. In addition to examining the various minimally invasive options, including the latest techniques, careful attention is paid to the role of medical treatment in avoiding recurrence after initial therapy. Nerve blocks, epidural injections, and intradiscal procedures are among the many options available in the armamentarium of the interventionalist, and advice is given on their use in different contexts. This volume will be of great value for neuroradiologists and others responsible for treating patients with spine disorders.

American Lobotomy studies a wide variety of representations of lobotomy to offer a rhetorical history of one of the most infamous procedures in the history of medicine. The development of lobotomy in 1935 was heralded as a "miracle cure" that would empty the nation's perennially blighted asylums. However, only twenty years later, lobotomists initially praised for their "therapeutic courage" were condemned for their barbarity, an image that has only soured in subsequent decades. Johnson employs previously abandoned texts like science fiction, horror film, political polemics, and conspiracy theory to show how lobotomy's entanglement with social and political narratives contributed to a powerful image of the operation that persists to this day. The book provocatively challenges the history of medicine, arguing that rhetorical history is crucial to understanding medical history. It offers a case study of how medicine accumulates meaning as it circulates in public culture and argues for the need to understand biomedicine as a culturally situated practice.

Computer-assisted techniques in the surgery of the facial skeleton including the skull base are depicted for the very first time in this atlas of navigational surgery. Experienced surgeons as well as trainees will benefit from the detailed and well-illustrated information on the use of computer technology in clinical routine, accompanied by the experimental basis of intraoperative accuracy. New methods of non-invasive referencing and the use of virtual models in the field of oral and cranio-maxillofacial surgery are demonstrated. Clinical cases illustrate the practical use of this new technique.

Once feared and misunderstood even among the medical community, epilepsy has since largely been demystified. Besides the characteristic seizures, various cognitive, behavioral, and emotional difficulties are recognized as associated with the condition, and patients are finding relief in medical management and/or surgical intervention. Not surprisingly, neuropsychology has emerged as a major component in treatment planning, program development, and assessment of surgical candidates. Geared toward beginning as well as veteran clinicians, the Handbook on the Neuropsychology of Epilepsy offers readers a skills-based framework for assessment and treatment, using current evidence and standardized terminology. Expert coverage reviews widely-used methods for evaluating key aspects of patient functioning (MRI, MEG, electrocortical mapping, the Wada test), and presents guidelines for psychotherapeutic and cognitive remediation strategies in treating comorbid psychiatric conditions. Given the diversity of the patient population, additional chapters spotlight issues specific to subgroups including high- and low-functioning as well as geriatric and pediatric patients. This integrative hands-on approach benefits a range of practitioners across medical and neurological settings. Topics featured in the Handbook: Neuropsychological assessment across the lifespan. Evaluating the epilepsy surgical candidate: methods and procedures. The Wada test: current perspectives and applications. Assessing psychiatric and personality disorders in the epilepsy patient. Evaluation and management of psychogenic non-epileptic attacks. Neuropsychological assessment with culturally diverse patients. Practical and flexible in its coverage, the Handbook on the Neuropsychology of Epilepsy serves not only neuropsychologists and neurologists but also primary care physicians such as internists, family physicians, and pediatricians.

MRI can play an important role in identifying and localizing epileptogenic foci. This book aims to provide the clinical and imaging information required in order to decide whether an MRI scan is appropriate and whether it is likely to be sufficient to detect a lesion. The first part of the book presents background information on epilepsy patients and explains how to perform an MRI examination. Detailed attention is paid to functional MRI and post-processing, and the examination of subcategories of patients is also discussed. The second part of the book then documents the MRI findings obtained in the full range of epileptogenic lesions with the aid of high-quality images. Throughout, emphasis is placed on guiding the reader in the correct interpretation of the imaging findings. Both radiologists and referring physicians will find this book to be an indispensable guide to the optimal use of MRI in epilepsy.

More than 60 papers written by internationally recognized experts cover the broad spectrum of brain edema. The main topics treated are: ischemia & hemorrhage, trauma (experimental and clinical), cerebral hemorrhage, tumor, hydrocephlaus & intracranial pressure (ICP), neuromonitoring & neuroimaging, treatments, blood brain barrier, and miscellaneous.

The articles in this volume cover the various options of the optimal management of brain tumors, vascular lesions, and functional disorders. They provide a good balance between microneurosurgery and radiosurgery, presenting also alternative surgical and radiosurgical treatment options with discussions on their advantages and disadvantages. The presentation of multiple treatment methods will help to provide better service to patients. Some papers, specifically highlighting alternative treatment options, are accompanied by editorials prepared by recognized experts in the field. Additional emphasis is put on importance of the advanced neuroimaging techniques for radiosurgical treatment planning and subsequent follow-up.

This is the first comprehensive book about surgery on and around the vertebral artery all along its cervical and intracranial course. This vessel has been considered for long as out of surgical reach leaving many different pathologies not or incompletely treated. The surgical exposure and control of the vertebral artery not only permit to treat lesions of the vertebral artery wall or developed in contact to it but also to improve the access to the intervertebral foramen (tumors, osteophytes), to the anterior aspect of the spinal cord (tumors, spondylotic spurs), to the foramen magnum and to the jugular foramen. This book written by leading experts includes all aspects of vertebral artery surgery from anatomy to imaging, surgical techniques and pathologies; it is illustrated by many figures especially operative views and schematic drawings so that the beginner as well as the experienced surgeon find useful information. One of the editors of this book (B. GEORGE) was recently awarded the Olivecrona award for his work on the surgery of the vertebral artery.

Brain imaging and neurophysiological methods have been rapidly developed. The purpose of this book is to describe hearing problems which are caused by various kinds of brain diseases in central auditory pathway. Each topic is explained to use a lot of figures such as brain imaging and neurophysiological data comparing with neuropsychological tests. Readers will understand what happens in patients, when bilateral auditory nerve and auditory cortex are damaged in patients. Some patients can hear but cannot discriminate meanings of speech, music and environmental sounds. The author tries to explain why such a difference occurs.

This atlas gives careful step-by-step guidance for endoscopic sinus surgery. In doing so, it provides exciting firsthand accounts of modern advanced endoscopic sinus procedures. In the first part of the book the surgical anatomy of the nose and sinuses and the basic surgical techniques are described. The second part deals with advanced techniques and postoperative care. The detailed, step by step narratives - integrated with many intraoperative photographs - accurately convey both surgical fundamentals and nuances. For each procedure the authors give a piece of advice ("golden rules"), making it ideal for those who want to implement well-coordinated surgical approaches to sinus disease.

In keeping with the aims of other books in this Series the Editors have concentrated on the practical aspects of management -in this case of the urinary tract in patients with spinal cord injury. It is well accepted that the management of such patients is best done by those with special experience in this field. Nevertheless, it is essential that urologists should be well informed on matters relating to the neuropathic urinary tract since not all patients will be managed in special centres and, whether their problems are acute or chronic, the wrong clinical decision can lead them into a lifetime of problems. The plan of this book is directed towards examining particular problems and providing definitive answers. Even in this enlightened age of medical progress there are many clinical situations where there is often a choice of treatment. Readers of this Series will be aware that, despite an apparent abundance of information on a topic, it is sometimes not possible to reach a firm conclusion on a management problem. Keith Parsons and John Fitzpatrick are to be congratulated on ensuring that for this subject there are good clear guidelines. The data in the book are up to date and the excellent approach to the subject makes it a valuable addition to Clinical Practice in Urology.

This volume contains the proceedings of the Second International Symposium on Biology of Brain Tumour. The first Symposium was held in 1979 at Gardonne Riviera, Italy. This meeting was planned in order to coincide with the lOOth Anniversary of the first reported operation for glioma in London on November 25, 1884. Since the first meeting, the field of neuro-oncology has made remarkable progress in understanding both basic and clinical factors of significance to patients with brain tumor. While the earlier meeting dealt to a large extent with clinically oriented studies, this symposium was more heavily weighted toward the biology of brain tumour and improving our understanding at the physiologic, biochemical, pharmacologic, and cellular level. The meeting was divided according to scientific content into presentations and discussions as well as posters for more leisurely viewing, so as to allow the main themes of the meeting to sequentially develop. The first session dealt extensively with neuro-oncology at the molecular level and included considerable discus sion of material related to the babic biochemical milieu in which tumors originate, proliferate, and eventually destroy the brain. Classic neuropathology has been the mainstay of tumor identification and characteriza tion, however, the process of classification has become much more complex. The availability of a variety of new tools has allowed investigation into the validity of the more traditional classification systems as well as the development of newer biologically related concepts."

The Sixth International Meeting on Cholinesterases and Related Proteins, Choli nesterases '98, was organized by Palmer Taylor and his associates at the University of California-San Diego and convened in La Jolla, California, USA, in March of 1998. This was the first conference of the series to be held in the United States, let alone on the Pa cific Rim. Nearly 200 delegates from twenty countries-from Asia, Australia, Europe, and North and South America-heard 75 oral presentations and viewed 90 posters on current research on cholinesterases and related proteins. The meeting framework was structured to include two days of plenary sessions, followed by two days of concurrent sessions and workshops in specific areas. Communication at the concurrent sessions was facilitated by the conference settings of the Martin Johnson House, on a scenic bluff overlooking the blue Pacific Ocean, and the San Diego Supercomputer Center, which enabled projection and rotation of protein structures in three dimensions for a large audience. This book is the compilation of the presentations at the Sixth International Meeting on Cholinesterases and Related Proteins into a volume that describes recent investigations on the structure, catalytic and non-catalytic functions of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and related proteins, as well as studies on the molecular and cellular biology of these enzymes and the genes that encode them.

Over the past two decades researchers and clinicians in the neurosciences have witnessed a literal information explosion in the area of brain imaging and neuropsychological functioning. Until recently we could not view the nervous system except through the use of invasive procedures. Today, a variety of imaging techniques are available, but this technology has advanced so rapidly that it has been difficult for new information to be consolidated into a single source. The goal of this volume is to present information on technological advances along with current standards and techniques in the area of brain imaging and neuropsychological functioning. The quality of brain imaging techniques has improved dramatically. In 1975 one had to be content with a brain image that only offered a gross distinction between ventricular cavities, brain, and bone tissue. Current imaging techniques offer considerable precision and approximate gross neuroanatomy to such an extent that differentiation between brain nuclei, pathways, and white gray matter is possible. These technological advances have progressed so rapidly that basic and clinical research have lagged behind. It is not uncommon, particularly in longitudinal research, for the technical meth odology of a study to become obsolete while that study is still in progress. This has hampered certain aspects of systematic research and has also produced the need for a textbook that could address contemporary issues in brain imaging and neuropsychology."

The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than 50 participants. including investigators in basic neuroscience, physicians. and stu dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain."

The one-stop guide to microsurgical and endoscopic treatment of skull base lesions from global experts A deep knowledge of regional anatomy, improved understanding of pathologies and their behaviors, technological advances, and multidisciplinary collaboration have led to more effective treatments for once inoperable skull base lesions. Microsurgical and Endoscopic Approaches to the Skull Base: Anatomy, Tactics, and Techniques by renowned skull base neurosurgeons Luis A. B. Borba and Jean G. de Oliveira presents a balanced, anatomy-based perspective on microsurgical and endoscopic approaches to manage these highly challenging lesions. The text leverages the best current scientific literature on this topic and insights from global skull base surgery experts. Organized into 9 sections and 52 chapters, the book starts with discussion of microsurgical and endoscopic instrumentation and neurophysiological monitoring. The subsequent sections cover diverse approaches for skull base lesions involving the sphenoid and parasellar, orbit, anterior fossa, cavernous sinus, temporal bone and jugular foramen, and foramen magnum regions. Each of these sections starts with an introduction, followed by a microsurgical description of the anatomy of the impacted region. Key Highlights Contributions from an impressive group of internationally renowned neurosurgeons and otolaryngologists specializing in skull base pathologies Indications, preoperative and postoperative concerns, nuances, pitfalls, tactics, techniques, and references for further reading provide a comprehensive guide to treatment A stepwise description of the approach, high-quality four-color drawings, and illustrative cases facilitate acquisition and retention of knowledge High-quality figures provide greater visual insights and step-by-step guidance on how to perform specific procedures This unique textbook will help residents, fellows, and practitioners in neurosurgery and otolaryngology make an evidenced-based decision on using the most effective microsurgical and/or endoscopic approach to achieve the best outcomes in patients with skull base lesions. This book includes complimentary access to a digital copy on https://medone.thieme.com.

Brain Injury is the second volume in the book series, Molecular and Cellular Biology of Critical Care Medicine. In this volume, a group of internationally regarded experts in important areas of neuroscience and neurointensive care research address the molecular and cellular basis of acute brain injury. This text covers acute brain injury within a context relevant to the care of patients with critical neurologic injuries such as cardiac arrest, trauma and stroke. It includes recent data pertaining to established pathways such as neurotransmission, exitotoxicity, ionic-mechanisms, oxidative stress, inflammation, and cerebral vascular injury. In addition, rapidly developing areas such as cell signaling, adenosine pharmacology, apoptosis, mitochondrial dysfunction, neurocytoskeletal changes, and the role of trophic factors are reviewed from the level of in vitro modeling to human data. Other topics covered that are highly clinically relevant include the effect of genetic background and gender differences in outcome after brain injury, preconditioning, and the effects of currently used anesthetics and sedative agents in patients with brain injury.

Both a theoretic text book and a descriptive atlas, this standard reference in the field presents the individual steps of each surgical procedure. It represents the current perspective in the management of the childs nervous system and discusses at great length the individual pathological entities which may be treated surgically. Numerous illustrations highlight both the operative technique and theoretic principles sections of the book, whereas the neuroimages are used in the theoretic principle section - accentuating the correlation of imaging with surgical planning and decision making. Recent world literature has been systematically reviewed, analysing critically different perspectives.

Injury of the spinal cord has been known since antiquity. There is no cure for the injury and until modern times patients died rapidly from a combination of pressure sores and urinary tract infection. Treatment consists of preventing complications until the spine has stabilised and the patient can be rehabilitated to an independent life. History of the Treatment of Spinal Injuries explores how this treatment developed in the Ancient World, the Middle Ages, in Europe, Great Britain and latterly in the United States. It describes how these principles of treatment were recognised and explores the relationship and rivalry of the powerful personalities of the doctors who developed this treatment against the social background at different times.

During the last decades, research on spinal cord has attracted a great deal of attention because of problems such as sensory-motor and autonomic dysfunctions associated with traumatic and other injuries. Recording of spinal cord evoked potentials is one of the most promising approaches to understand the spinal cord function. However, the details of the evoked potentials and their significance in various pathological conditions are not yet fully characterized. This book summarizes new findings in the field of electrophysiology and relates this knowledge to pathology and regeneration research. It is the first one which deals in great detail with various ways to monitor spinal cord function in experimental and clinical situations. It provides an up-to-date knowledge regarding spinal cord bioelectrical activity and its modification with pharmacological agents and covers new aspects of regeneration studies, particularly the role of myelin associated inhibitory molecules. A section is devoted to clinical studies dealing with electrical activity, pathology, and current therapeutic measures. This volume will be useful both to basic and clinical neuroscientists engaged in the field of neurology, neurophysiology, neurochemistry, neurosurgery, neuropathology, and related disciplines in order to understand basic functions of the spinal cord and to stimulate further research in this rapidly advancing field.

This monograph highlights modern concepts of brain ischemia and strategies of neuroprotective therapy. The first part of the book is devoted to mechanisms of ischemic brain damage. The authors present the results of their own clinical and experimental studies conducted in the last two decades, as well as the achievements of native and foreign neurological researches that open a new stage in understanding how reversible changes of blood flow and metabolism are transformed into a permanent morphological lesion, i.e. brain infarction. The most important advances in areas of ischemic energy failure, main mechanisms of the glutamate-calcium cascade, influence of metabolic acidosis on ischemic damage, delayed neuronal death connected with microglial activation, local inflammation, autoimmune reactions, trophic dysfunction, and apoptosis, as well as of reaction of the stress-mediating endocrine system to focal brain ischemia are shown in animals and humans, and the relevant literature is cited and critiqued.The book also explores topics that recently have experienced substantial growth, such as gene expression and subsequent molecular events in response to acute brain ischemia, connected with both tissue damage and reparation. The authors demonstrate not only universal features of the process of brain ischemia, but also individual peculiarities of its course in patients and analyse their reasons.

For the beginner or for the accomplished sinus surgeon, mastering the anatomy of the lateral nasal wall is an ongoing challenge. Even though there are excellent standard anatomical references and equally outstanding sinus courses with cadaver dissection, a reference depicting the surgical anatomy is needed. A step-by-step surgical approach on the anterior nasal spine to the anterior wall of the sphenoid is presented. The sinus surgeon is confronted with a wide range of different spaces created by the ethmoid bone. No other bone in the human body has so many anatomical variations. Four critical anatomical structures are emphasized as the foundation for a precise approach to surgery of the maxillary, anterior ethmoid, frontal, and posterior ethmoid sinuses. The goal of this book is to meet the tremendous challenge of offering an anatomical approach which will serve the sinus surgeon of every level of experience and expertise.

As an addition to the European postgraduate training system for young neurosurgeons we began to publish in 1974 this series of Advances and Technical Standards in Neurosurgery which was later sponsored by the European Association of Neurosurgical Societies. This series was first discussed in 1972 at a combined meeting of the Italian and German Neurosurgical Societies in Taormina, the founding fathers of the series being Jean Brihaye, Bernard Pertuiset, Fritz Loew and Hugo KrayenbtihI. Thus were established the principles of European co operation which have been born from the European spirit, flourished in the European Association, and have throughout been associated with this series. The fact that the English language is well on the way to becoming the international medium at European scientific conferences is a great asset in terms of mutual understanding. Therefore we have decided to publish all contributions in English, regardless of the native language of the authors. All contributions are submitted to the entire editorial board before publi cation of any volume. Our series is not intended to compete with the publications of original scientific papers in other neurosurgical journals. Our intention is, rather, to present fields of neurosurgery and related areas in which important recent advances have been made. The contributions are written by specialists in the given fields and constitute the first part of each volume.