This book presents, in a stepwise and interactive fashion, approximately 75 cases that reflect the wide spectrum of pathology encountered in this region. Each case description commences with a concise clinical scenario. High-quality radiologic, laboratory, and histopathologic images depicting the differentiating features of the lesion subtype in question are then presented, and key operative and clinical management pearls are briefly reviewed. The interdisciplinary nature of this easy-to-use color atlas and textbook reflects the fact that the management of patients with sellar and parasellar lesions is itself often interdisciplinary. The format is unique in that no similar interdisciplinary book is available on lesions of this region of the brain. Atlas of Sellar and Parasellar Lesions: Clinical, Imaging, and Pathologic Correlations is of great value for practitioners and trainees in a range of medical specialties, including radiology, neurology, endocriniology, pathology, oncology, radiation oncology, and neurosurgery.

Nearly 80 short papers originating from the 14th International Symposium on Intracranial Pressure and Brain Monitoring held in Tuebingen, Germany, in September 2010 present experimental as well as clinical research data related to the naming topics of the conference. The papers have undergone a peer-reviewing and are organized in the following sections: methods of brain monitoring and data analysis, methods of invasive and non-invasive ICP assessment, the role of autoregulation, the role of tissue oxygenation and near-infrared spectroscopy, hydrocephalus/IIH imaging and diagnosis, management and therapy of hydrocephalus, management and therapy of traumatic brain injury, management and therapy of subarachnoid and intracranial hemorrhage, experimental approaches to acute brain disease. The book gives a good overview on the latest research developments in the field of ICP and related brain monitoring and on management and therapy of relevant acute brain diseases.

Unique neurointerventional surgery resource analyzes landmark literature to inform optimal patient management The field of neurointerventional surgery is rapidly expanding with an ever-accelerating pace of technological innovations. While industry plays a significant role in designing new technology and defining indications for its use, practitioners need to evaluate and determine the most efficacious treatments for their patients. Neurointerventional Surgery: An Evidence-Based Approach by renowned endovascular neurosurgeons Min Park, M. Yashar S. Kalani, and Michael F. Stiefel examines the most common disease states in neurointerventional surgery through a critical lens. The unique text leverages evidenced-based data to inform treatment decisions and improve patient outcomes. The text is organized by 5 sections and 32 chapters, including the latest state-of-the-art interventions. Each of the chapters provides critical analysis of the "landmark papers" that established the foundation and standards for modern neurointerventional practice. An example is the rapidly changing understanding of large vessel occlusions in ischemic stroke that now strongly supports mechanical thrombectomy as a viable and important part of the treatment armamentarium. Key Highlights Contributions from internationally recognized leaders in academic neurointerventional surgery provide insightful and analytic perspectives Encompasses the full continuum of neurointerventional procedures in one resource, from hemorrhagic and ischemic stroke to neoplasms and spine conditions The reader-friendly structure and chapter formatting facilitates understanding of often complicated decision-making The evidenced-based, multifaceted approach to neurointerventional surgery presented in this textbook makes it vital reading for residents, fellows, and practitioners in neurosurgery, as well as fellows in interventional neuroradiology and interventional neurology. This book includes complimentary access to a digital copy on https://medone.thieme.com.

MRI can play an important role in identifying and localizing epileptogenic foci. This book aims to provide the clinical and imaging information required in order to decide whether an MRI scan is appropriate and whether it is likely to be sufficient to detect a lesion. The first part of the book presents background information on epilepsy patients and explains how to perform an MRI examination. Detailed attention is paid to functional MRI and post-processing, and the examination of subcategories of patients is also discussed. The second part of the book then documents the MRI findings obtained in the full range of epileptogenic lesions with the aid of high-quality images. Throughout, emphasis is placed on guiding the reader in the correct interpretation of the imaging findings. Both radiologists and referring physicians will find this book to be an indispensable guide to the optimal use of MRI in epilepsy.

More than 60 papers written by internationally recognized experts cover the broad spectrum of brain edema. The main topics treated are: ischemia & hemorrhage, trauma (experimental and clinical), cerebral hemorrhage, tumor, hydrocephlaus & intracranial pressure (ICP), neuromonitoring & neuroimaging, treatments, blood brain barrier, and miscellaneous.

The articles in this volume cover the various options of the optimal management of brain tumors, vascular lesions, and functional disorders. They provide a good balance between microneurosurgery and radiosurgery, presenting also alternative surgical and radiosurgical treatment options with discussions on their advantages and disadvantages. The presentation of multiple treatment methods will help to provide better service to patients. Some papers, specifically highlighting alternative treatment options, are accompanied by editorials prepared by recognized experts in the field. Additional emphasis is put on importance of the advanced neuroimaging techniques for radiosurgical treatment planning and subsequent follow-up.

This is the first comprehensive book about surgery on and around the vertebral artery all along its cervical and intracranial course. This vessel has been considered for long as out of surgical reach leaving many different pathologies not or incompletely treated. The surgical exposure and control of the vertebral artery not only permit to treat lesions of the vertebral artery wall or developed in contact to it but also to improve the access to the intervertebral foramen (tumors, osteophytes), to the anterior aspect of the spinal cord (tumors, spondylotic spurs), to the foramen magnum and to the jugular foramen. This book written by leading experts includes all aspects of vertebral artery surgery from anatomy to imaging, surgical techniques and pathologies; it is illustrated by many figures especially operative views and schematic drawings so that the beginner as well as the experienced surgeon find useful information. One of the editors of this book (B. GEORGE) was recently awarded the Olivecrona award for his work on the surgery of the vertebral artery.

Brain imaging and neurophysiological methods have been rapidly developed. The purpose of this book is to describe hearing problems which are caused by various kinds of brain diseases in central auditory pathway. Each topic is explained to use a lot of figures such as brain imaging and neurophysiological data comparing with neuropsychological tests. Readers will understand what happens in patients, when bilateral auditory nerve and auditory cortex are damaged in patients. Some patients can hear but cannot discriminate meanings of speech, music and environmental sounds. The author tries to explain why such a difference occurs.

Ideal for both neurosurgical residents and recertifying neurosurgeons, Neurosurgery Self-Assessment: Questions and Answers offers the most comprehensive, up to date coverage available. Over 1,000 clinically relevant multiple-choice questions across 46 topic areas test the candidate's knowledge of basic neuroscience and neurosurgical subspecialties to an unparalleled degree and provide detailed answer explanations to facilitate learning and assessment. Over 700 histology, pathology, radiology, clinical and anatomical images serve as an index of routinely tested-on images in neurosurgical examinations with high-yield summaries of each pathology to reinforce and simplify key concepts. Includes only multiple choice questions in both single-best-answer and extended matching item (10-20 options) format increasingly adopted by neurosurgery certification boards worldwide. Questions are organized by topic and classified by degree of difficulty through a highly visual "traffic light system" which codes each question in green, amber, or red. Includes coverage of the landmark studies in areas such as vascular, stroke, spine and neurooncology. Practical tips facilitate study with test-taking strategies and things to consider before sitting for an exam. Utilizes Imperial and SI units throughout. Expert Consult eBook version included with purchase. This enhanced eBook experience acts an interactive question bank which automatically scores and provides immediate answer feedback, as well as allowing you to search all of the text, figures, and references from the book.

This atlas gives careful step-by-step guidance for endoscopic sinus surgery. In doing so, it provides exciting firsthand accounts of modern advanced endoscopic sinus procedures. In the first part of the book the surgical anatomy of the nose and sinuses and the basic surgical techniques are described. The second part deals with advanced techniques and postoperative care. The detailed, step by step narratives - integrated with many intraoperative photographs - accurately convey both surgical fundamentals and nuances. For each procedure the authors give a piece of advice ("golden rules"), making it ideal for those who want to implement well-coordinated surgical approaches to sinus disease.

In keeping with the aims of other books in this Series the Editors have concentrated on the practical aspects of management -in this case of the urinary tract in patients with spinal cord injury. It is well accepted that the management of such patients is best done by those with special experience in this field. Nevertheless, it is essential that urologists should be well informed on matters relating to the neuropathic urinary tract since not all patients will be managed in special centres and, whether their problems are acute or chronic, the wrong clinical decision can lead them into a lifetime of problems. The plan of this book is directed towards examining particular problems and providing definitive answers. Even in this enlightened age of medical progress there are many clinical situations where there is often a choice of treatment. Readers of this Series will be aware that, despite an apparent abundance of information on a topic, it is sometimes not possible to reach a firm conclusion on a management problem. Keith Parsons and John Fitzpatrick are to be congratulated on ensuring that for this subject there are good clear guidelines. The data in the book are up to date and the excellent approach to the subject makes it a valuable addition to Clinical Practice in Urology.

This volume contains the proceedings of the Second International Symposium on Biology of Brain Tumour. The first Symposium was held in 1979 at Gardonne Riviera, Italy. This meeting was planned in order to coincide with the lOOth Anniversary of the first reported operation for glioma in London on November 25, 1884. Since the first meeting, the field of neuro-oncology has made remarkable progress in understanding both basic and clinical factors of significance to patients with brain tumor. While the earlier meeting dealt to a large extent with clinically oriented studies, this symposium was more heavily weighted toward the biology of brain tumour and improving our understanding at the physiologic, biochemical, pharmacologic, and cellular level. The meeting was divided according to scientific content into presentations and discussions as well as posters for more leisurely viewing, so as to allow the main themes of the meeting to sequentially develop. The first session dealt extensively with neuro-oncology at the molecular level and included considerable discus sion of material related to the babic biochemical milieu in which tumors originate, proliferate, and eventually destroy the brain. Classic neuropathology has been the mainstay of tumor identification and characteriza tion, however, the process of classification has become much more complex. The availability of a variety of new tools has allowed investigation into the validity of the more traditional classification systems as well as the development of newer biologically related concepts."

The Sixth International Meeting on Cholinesterases and Related Proteins, Choli nesterases '98, was organized by Palmer Taylor and his associates at the University of California-San Diego and convened in La Jolla, California, USA, in March of 1998. This was the first conference of the series to be held in the United States, let alone on the Pa cific Rim. Nearly 200 delegates from twenty countries-from Asia, Australia, Europe, and North and South America-heard 75 oral presentations and viewed 90 posters on current research on cholinesterases and related proteins. The meeting framework was structured to include two days of plenary sessions, followed by two days of concurrent sessions and workshops in specific areas. Communication at the concurrent sessions was facilitated by the conference settings of the Martin Johnson House, on a scenic bluff overlooking the blue Pacific Ocean, and the San Diego Supercomputer Center, which enabled projection and rotation of protein structures in three dimensions for a large audience. This book is the compilation of the presentations at the Sixth International Meeting on Cholinesterases and Related Proteins into a volume that describes recent investigations on the structure, catalytic and non-catalytic functions of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and related proteins, as well as studies on the molecular and cellular biology of these enzymes and the genes that encode them.

Over the past two decades researchers and clinicians in the neurosciences have witnessed a literal information explosion in the area of brain imaging and neuropsychological functioning. Until recently we could not view the nervous system except through the use of invasive procedures. Today, a variety of imaging techniques are available, but this technology has advanced so rapidly that it has been difficult for new information to be consolidated into a single source. The goal of this volume is to present information on technological advances along with current standards and techniques in the area of brain imaging and neuropsychological functioning. The quality of brain imaging techniques has improved dramatically. In 1975 one had to be content with a brain image that only offered a gross distinction between ventricular cavities, brain, and bone tissue. Current imaging techniques offer considerable precision and approximate gross neuroanatomy to such an extent that differentiation between brain nuclei, pathways, and white gray matter is possible. These technological advances have progressed so rapidly that basic and clinical research have lagged behind. It is not uncommon, particularly in longitudinal research, for the technical meth odology of a study to become obsolete while that study is still in progress. This has hampered certain aspects of systematic research and has also produced the need for a textbook that could address contemporary issues in brain imaging and neuropsychology."

The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than 50 participants. including investigators in basic neuroscience, physicians. and stu dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain."

Brain Injury is the second volume in the book series, Molecular and Cellular Biology of Critical Care Medicine. In this volume, a group of internationally regarded experts in important areas of neuroscience and neurointensive care research address the molecular and cellular basis of acute brain injury. This text covers acute brain injury within a context relevant to the care of patients with critical neurologic injuries such as cardiac arrest, trauma and stroke. It includes recent data pertaining to established pathways such as neurotransmission, exitotoxicity, ionic-mechanisms, oxidative stress, inflammation, and cerebral vascular injury. In addition, rapidly developing areas such as cell signaling, adenosine pharmacology, apoptosis, mitochondrial dysfunction, neurocytoskeletal changes, and the role of trophic factors are reviewed from the level of in vitro modeling to human data. Other topics covered that are highly clinically relevant include the effect of genetic background and gender differences in outcome after brain injury, preconditioning, and the effects of currently used anesthetics and sedative agents in patients with brain injury.

Injury of the spinal cord has been known since antiquity. There is no cure for the injury and until modern times patients died rapidly from a combination of pressure sores and urinary tract infection. Treatment consists of preventing complications until the spine has stabilised and the patient can be rehabilitated to an independent life. History of the Treatment of Spinal Injuries explores how this treatment developed in the Ancient World, the Middle Ages, in Europe, Great Britain and latterly in the United States. It describes how these principles of treatment were recognised and explores the relationship and rivalry of the powerful personalities of the doctors who developed this treatment against the social background at different times.

During the last decades, research on spinal cord has attracted a great deal of attention because of problems such as sensory-motor and autonomic dysfunctions associated with traumatic and other injuries. Recording of spinal cord evoked potentials is one of the most promising approaches to understand the spinal cord function. However, the details of the evoked potentials and their significance in various pathological conditions are not yet fully characterized. This book summarizes new findings in the field of electrophysiology and relates this knowledge to pathology and regeneration research. It is the first one which deals in great detail with various ways to monitor spinal cord function in experimental and clinical situations. It provides an up-to-date knowledge regarding spinal cord bioelectrical activity and its modification with pharmacological agents and covers new aspects of regeneration studies, particularly the role of myelin associated inhibitory molecules. A section is devoted to clinical studies dealing with electrical activity, pathology, and current therapeutic measures. This volume will be useful both to basic and clinical neuroscientists engaged in the field of neurology, neurophysiology, neurochemistry, neurosurgery, neuropathology, and related disciplines in order to understand basic functions of the spinal cord and to stimulate further research in this rapidly advancing field.

As an addition to the European postgraduate training system for young neurosurgeons we began to publish in 1974 this series of Advances and Technical Standards in Neurosurgery which was later sponsored by the European Association of Neurosurgical Societies. This series was first discussed in 1972 at a combined meeting of the Italian and German Neurosurgical Societies in Taormina, the founding fathers of the series being Jean Brihaye, Bernard Pertuiset, Fritz Loew and Hugo KrayenbtihI. Thus were established the principles of European co operation which have been born from the European spirit, flourished in the European Association, and have throughout been associated with this series. The fact that the English language is well on the way to becoming the international medium at European scientific conferences is a great asset in terms of mutual understanding. Therefore we have decided to publish all contributions in English, regardless of the native language of the authors. All contributions are submitted to the entire editorial board before publi cation of any volume. Our series is not intended to compete with the publications of original scientific papers in other neurosurgical journals. Our intention is, rather, to present fields of neurosurgery and related areas in which important recent advances have been made. The contributions are written by specialists in the given fields and constitute the first part of each volume.

Core Principles of Acute Neurology is a series of short volumes that handles major topics not found in sufficient detail elsewhere and provides useful context. Identifying Neuroemergencies provides practical information how to best manage and triage patients in the first hour of admission in the emergency department. Physicians consider a neurologic emergency when the patient has clearly worsened and their neurologic signs have changed. Correct decisions are imperative: any type of neurocritical illness demands immediate treatment in the emergency department. Neurologist can assist further with the successful triage of the neurologic emergency and this volume in the Core Principles of Acute Neurology will serve as a handy, concise, reference to both the neurologist and the emergency physician.

Since Harvey Cushing's extensive study on brain meningiomas no similar study has been conducted on spinal cord meningiomas. The high scientific value of this book is based on the careful elaboration of data from patients affected by spinal meningiomas who have been examined and operated on over the last 33 years (1962-1995) at the Neurosurgical School of the University of Florence, Italy. The main focus of this study was on the anatomic and clinical relationship that enabled early diagnosis of spinal meningiomas. More over this book emphasizes the interaction between neurology and neuroradiology in the form of "dynamic neurology." Myeloradiculographic findings are described together with those using more recent techniques such as CT and MRI.

The book gives the most up-to-date information for the expanding field of stereotactic and functional neurosurgery from European and international experts. The newest developments in neural transplantation and stereotactic irradiation are included together with the reports on extensive trials of analgesic surgery and new techniques used in the treatment of a variety of functional disorders.

In this first volume of the series Update in Plastic Surgery, internationally acknowledged experts give an up-to-date view of the clinical possibilities in plastic surgery which result from video-assisted microsurgery with the endoscope. Advantages and disadvantages are discussed, and reasons are presented why it can be assumed that this technique will be the standard in plastic surgery within a few years.

Of all the therapies that comprise psychiatric practice, the use of brain surgery to modify behaviour is the most contentious. That such behavioural neuro surgery, or psychosurgery, provokes opposition is far from surprising. The paramount status of the brain seems to belie mechanical intervention. The irreversible nature of the intervention seems to aggravate the outrage. Thus, opponents of the practice contend that psychosurgical procedures constitute a grievous assault on the integrity of the personality. Its proponents, on the other hand, confidently testify that it is a valid and efficacious form of treat ment for many seemingly intractable psychiatric disorders. Argument and counterargument have pursued the practice since its initial upsurge in the 1940s, although the decline in its popularity in the 1960s occasioned a tem porary cease-fire. However, the recent resurgence of psychosurgery has ensured that it is once again a matter of controversy. In the United Kingdom the characteristically subdued tenor of the debate frequently obscures the popularity of the practice and the commitment of its opposition. A recent application by the Royal College of Psychiatrists to the Medical Research Council for funds to mount a large controlled trial of psychosurgical procedures was turned down. Several opposition lobbyists might claim some credit for the proposal's lack of success. The Schizophrenia Association of Great Bri tain clearly and publicly expressed their disapproval of the trial. The Patient's Protection Law Committee presented Parliament with a petition condemning the Royal College's submission."