This book gathers the proceedings of the 17th International Conference on Intracranial Pressure and Neuromonitoring, held in Leuven, Belgium in September 2019. It provides an overview of the current understanding, underlying research and future perspectives concerning pathophysiology, biophysics, monitoring and management in traumatic and non-traumatic acute brain injury, hydrocephalus and spinal cord injury, including cerebrovascular autoregulation impairment in neurological as well as non-neurological diseases. The peer-reviewed contributions were prepared by specialists in neurosurgery, neurointensive care and neuroanesthesiology, as well as prominent experts from the fields of physiology, clinical and biomedical engineering, mathematics and informatics. The book continues the time-honored tradition of publishing key presentations from the ICP Conferences in order to facilitate their dissemination within the clinical and research community.

The earliest human known to have the capability of walking erect on two legs is Sahelanphropus, who lived 6 million years ago. The ability to stand erect led to required extensive changes in the human skeleton, including significant changes in the cervical spine. In modern humans, the cervical spine holds the head upright and gives it great mobility. The combination of great mobility in this spinal segment combined with the requirement that it carry significant weight makes the cervical spine susceptible to a wide variety of pathologies. The cervical spine not only supports the head upright, but acts as a channel for the full set of neural elements connecting the brain with all near and distant parts of the body; thus, pathologies involving the spinal column in this segment directly affect the cervical spinal cord and exiting nerve roots. Today, excellence in spine surgery requires a thorough understanding of spinal anatomy, relevant neurology, and biomechanics, as well as skilled use of a variety of surgical techniques. The surgeon must master the ability to effectively select from a wide and constantly changing variety of alternative instrumentations and surgical approaches. In addition, the trend towards reducing the invasiveness of surgical procedures has led to the use of smaller and smaller tools and smaller surgical incisions with more limited views of the relevant anatomy. As a result of the rapid pace of change, the choice of an optimal technique in any given situation is increasingly complex. In this book, we begin with a basic review of anatomy, neurology, neurophysiology, and biomechanics. We also discuss clinical and radiological assessment required for a differential diagnosis, and present a thorough discussion of the importance of sagittal alignment of the spine and the utility of gait analysis. We proceed with a thorough discussion of nontraumatic pathologies causing cervical myelopathy, beginning with the craniocervical junction down through the subaxial spine, in pediatric and adult populations. This discussion includes steps in the differential diagnosis for specific pathologies, surgical techniques and nuances, radiation-based treatment alternatives, and special topics ranging from the use of stem cells to robotics and endoscopic surgery. We have attempted to provide both fundamental and state-of-the-art knowledge and to share the rich experience of some of the leading spine surgeons worldwide, with the aim of enabling surgeons at all levels to advance their own capabilities for performing safe and successful procedures in this area of complex anatomy.

Sir Victor Horsley (1857-1916) was a brilliant and pioneering neurosurgeon who also shaped the direction of clinical medicine through his work with the British Medical Association, Medical Defence Union, and General Medical Council. Before the nervous system could be imaged, Horsley operated successfully on the brain and spinal cord, and performed palliative procedures on patients dying from brain tumours. Nevertheless, he became a social pariah due to his support for nationalised health insurance, child welfare and women's rights, amongst other causes. In this fascinating biography, leading neurologist Dr Michael J. Aminoff places Horsley's life and work in the context of the society in which he lived and explores his influence on the development of neurosurgery and social policies still in effect. The many underlying themes to the book include the interplay of science and politics, and the responsibility of physicians to themselves and for the welfare of society.

This is the second in a sesries of books dealing with the enormous clinical problem of spinal cord dysfunction. Volume I discussed assessment; this book focuses on intervention. There are three main approaches to the restoration of function after damage to the spinal cord: the prevention of seconday pathological events; the identification of impaired or absent functions in nerve cells and processes that survive the initial injury; and restoration of severed neuronal connections. This book addresses the first two of these approaches. It contains a discussion of the arguments about early decompression of the spinal cord following injury, therapy of acute spinal injury, and the effects of early treatment and local cooling on spinal cord blood flow. The management of specific problems associated with spinal cord dysfunction is addressed; these problems include cardiovascular abnormalities due to autonomic dysfunction, bladder control, pain, and sexual function. Current procedures of rehabilitation (particularly the management of chronic problems and the treatment of complications) are summarized, and ideas on motor control and learning are discussed.

This book provides a comprehensive overview of the management of brain and skull base tumors. It features detailed insight into the intrinsic molecular biology, anatomical foundation, radiological planning, surgical execution, and the novel therapeutics that guide today's treatment regimens. The first section features concepts related to the epidemiology and pathological basis of disease processes, including relevant cellular and molecular biology. In the second section, integral anatomical foundations and principles are covered including microsurgical anatomy of the cerebrum, white matter tracts, ventricles, brainstem, skull base, advancements in radiological imaging, and cognitive examinations. Surgical approaches and how to execute these procedures are then subsequently discussed in the third part of the work. Principles of Neuro-Oncology: Brain & Skull Base is a practically applicable guide to the latest treatment techniques available to treat these patients. Therefore, it is an indispensable resource for all physicians who utilize these methodologies in their day-to-day practice.

This book is a comprehensive, focused resource on intraoperative neurophysiological monitoring (IOM). This rapidly evolving field has created a demand for an up-to-date book such as this that builds on foundational concepts necessary to the practice of IOM in the context of anatomy and physiology. Each chapter is designed to not only inform the reader, but to also test the reader on the information presented - therefore promoting practical, problem-based learning. Surpassing the quality of its successful predecessor, Principles of Neurophysiological Assessment, Mapping, and Monitoring, Second Edition, is positioned to suit the needs of residents and fellows studying for the IOM certificate programs, physicians and anesthesiologists practicing IOM, and neurotechnologists both experienced and in training.

The aim of this book is to educate and train practitioners in the safe and professional use of diagnostic ultrasound imaging in the visualization and interpretation of various cerebral conditions not only in neurointensive care, but also in the operating room and, in general, cardiothoracic and neurocritical care settings. It is chiefly intended for anaesthetists and intensivists with a basic knowledge of ultrasound physics, but also for neurosurgeons and neurologists. All chapters were coordinated by the Editors, with experiences in hands-on courses on Echography and Doppler of the Brain, and prepared by international experts. The book covers from basic principles to estimation of intracranial pressure and cerebral perfusion. The topics cover emergency department and prehospital brain US as part of POCUS and US multiorgan evaluation to general intensive care, neurointensive care and anesthesia, including special populations as pregnant and children and setting as LMIC. Clinical scenarios complete the book. An innovative and unique guide that equips readers to perform bedside and non-invasive assessments for a range of cerebrovascular diseases.

The quintessential guide to state-of-the-art instrumentation in minimally invasive spine surgery In recent decades, technological innovations in minimally invasive surgery (MIS) have revolutionized spine surgery. The integration of devices tailored to MIS spine techniques has allowed spine surgeons to tackle more complex spinal pathologies and generate new ways to improve clinical outcomes. Instrumentation for Minimally Invasive Spine Surgery by renowned orthopaedic surgeon Kern Singh and esteemed collaborators, provides practical, evidence-based insights into important surgical decisions spine surgeons face every day. The primary goal of this book is to help spine surgeons navigate a daunting number of available devices and leverage the optimal ones to achieve improved patient outcomes. Organized in 3 parts and 16 chapters, the text starts with the past, present, and future of MIS spinal instrumentation. The first two parts detail cutting-edge posterior and lateral approaches with discussion of required devices. The final part covers percutaneous cement augmentation, biologics, and navigation systems. The text combines a thorough review of empirical literature with expert experience and manufacturer specifications to elucidate the advantages and capabilities of currently available instrumentation. Key Highlights Discussion of commonly used MIS spinal instrumentation including retractors; percutaneous pedicle, cortical, and facet screw systems; interbody cages; and fixation systems Concise, yet in-depth technical descriptions include an introduction and potential complications, followed by design features, modular aspects, applicable procedures, and compatible devices for each type High-quality detailed images provide greater understanding of techniques This unique book is an essential surgical companion for orthopaedic and neurosurgical residents and fellows, as well as spine surgeons who wish to incorporate MIS techniques into clinical practice. This book includes complimentary access to a digital copy on https://medone.thieme.com.

This book presents a comprehensive interdisciplinary team approach to the rehabilitation of acquired brain injury (ABI) survivors. Medical and clinical specialists will receive a deeper understanding of not only each other's roles but of their complementary functions in this field. Many case examples are provided, illustrating a wide range of challenges and stages of recovery. This edition features 3 entirely new chapters and multiple updated chapters by new and returning authors. Featured in the coverage: The role of Robotics in acquired brain injury A comprehensive chapter on physical therapy in ABI Outstanding recoveries woven together by a video news producer who recovered from a meningioma State of the art updates on neurosurgery, neurology, physiatry, neuropsychiatry and neuro-optometry. Updated chapters on neuropsychology, speech-language and occupational therapies including new technology and approaches as well as evidence based practices Psychosocial challenges and treatment following ABI The importance of family as team members Post rehabilitation options and experiences Acquired Brain Injury: An Integrative Neuro-Rehabilitation Approach, 2nd edition provides clarity and context regarding the rehabilitation goals and processes for rehabilitation specialists, interdisciplinary students of neuro-rehabilitation as well as practicing clinicians interested in developing their knowledge in their field.

The quintessential guide to endoscopic skull base reconstruction from multidisciplinary experts Due to close collaboration between otorhinolaryngologists and neurosurgeons, endoscopic endonasal brain surgery has become part of the surgical armamentarium for successful treatment of various cranial base pathologies. Today, it is considered the gold standard surgical technique for many types of skull base tumors. Techniques and Key Points for Endoscopic Cranial Base Reconstruction by pioneering otorhinolaryngologist Carlos D. Pinheiro-Neto and neurosurgeon Maria Peris-Celda, co-editor of Thieme's acclaimed Rhoton's Atlas of Head, Neck, and Brain, encompasses the most important endoscopic cranial base reconstruction techniques performed in the last two decades. The book features contributions from an impressive group of additional experts in this field. Comprised of 26 reader-friendly chapters divided into seven sections, the book starts with discussion of general principles of endoscopic cranial base reconstruction. Sections II through VI provide step-by-step descriptions of reconstructive approaches utilizing diverse flaps including nasoseptal, intranasal, extranasal, and free grafts, followed by free flaps. The final section details management of seven challenging cases that enrich practical clinical experience, from free flap reconstruction to recalcitrant cerebrospinal fluid leak. Key Highlights Decision-making rationales and pearls regarding selection of the most efficacious reconstructive techniques. Consistently formatted chapters feature a succinct review of anatomical concepts integral to each procedure, detailed descriptions for each surgical step, and alternative options. High-quality and meticulous anatomical dissections performed at the editors' anatomy laboratory and beautiful illustrations depict the flow of operations essential to understanding surgical nuances. Nineteen narrated videos visually demonstrate techniques and consolidate learning. This must-have, comprehensive resource will help skull base surgeons master the latest techniques, avoid complications, and achieve improved outcomes for their patients. This book includes complimentary access to a digital copy on https://medone.thieme.com.

'A SUPERB ACHIEVEMENT' IAN MCEWAN * * * * * What is it like to be a brain surgeon? How does it feel to hold someone's life in your hands, to cut through the stuff that creates thought, feeling and reason? How do you live with the consequences when it all goes wrong? DO NO HARM offers an unforgettable insight into the highs and lows of a life dedicated to operating on the human brain, in all its exquisite complexity. With astonishing candour and compassion, Henry Marsh reveals the exhilarating drama of surgery, the chaos and confusion of a busy modern hospital, and above all the need for hope when faced with life's most agonising decisions. * * * * * Winner: PEN Ackerley Prize South Bank Sky Arts Award for Literature Shortlisted: Costa Biography Award Duff Cooper Prize Wellcome Book Prize Guardian First Book Award Slightly Foxed Best First Biography Prize Longlisted: Samuel Johnson Prize for Non-Fiction

Updated and expanded to provide the neurologic, intensive and critical care communities a comprehensive guide to common critical care illnesses and seizures, this third edition remains the premier resource on seizures in critical care. In addition to covering etiology, pathophysiology, diagnosis, differential diagnosis and treatment options, chapters feature the latest technologies and treatments and integrate current literature. This unique and specialized text offers neurologists, intensivists, neurosurgeons, trauma surgeons, epileptologists, electrophysiologists and residents in various specialties clarity on this challenging set of comorbidities.

Providing practical, multidisciplinary coverage of the latest diagnostic and multidisciplinary therapeutic approaches for head and neck cancer, the 5th Edition of this award-winning text helps you achieve the best possible surgical outcomes and preserve and restore form and function. Internationally renowned surgeon Dr. Jatin P. Shah, joined by colleagues Snehal G. Patel, Bhuvanesh Singh, and Richard Wong, guides you step by step through every aspect of this challenging field, helping you take advantage of every multidisciplinary management approach available for your patients. Offers complete coverage of the scalp, skull base, paranasal sinuses, oral cavity, pharynx, larynx, cervical lymph nodes, thyroid, salivary glands, and soft tissue and bone tumors - from incidence, diagnosis, and work up through treatment planning, operative techniques, rehabilitation, and outcomes. Features new diagnostic approaches, staging, algorithmic thought processes for therapy selection, and outcomes of treatment for head and neck tumors, allowing for a better overall understanding of head and neck oncology. Includes new information on multimodal management of head and neck cancer; a new Radiation Therapy Glossary; and hundreds of new surgical photographs presented in sequential order from the surgeon's point of view. Provides outcomes of therapy data from the NCDB, institutional data from MSKCC, and evidence-based information throughout. Covers key topics such as radiation oncology, medical oncology including targeted therapies, and maxillofacial prosthodontics and dental oncology. Addresses the day-to-day, practical care of patients with basic operating room techniques and technology, intraoperative decisions, and post-operative care for patients undergoing head and neck surgery. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

"Surgical Anatomy of the Head and Neck" was immediately hailed as indispensable when it was first published in 2001. In demand ever since, this classic surgical atlas packed with more than 700 exceptional drawings, 537 of them in full color, by an internationally noted medical illustrator is now available again, with an extensive new index, after years of being out of print.

Here is a surgeon s-eye view of all anatomic details, from the upper thorax to the crown. Ideal for both surgery and test preparation, this volume features special boxed sections that focus on the surgical significance of each anatomical structure. Every illustration is clearly labeled with key anatomic landmarks, and a user-friendly design allows quick reference. This volume is an invaluable resource for surgeons, residents, and medical students.

This comprehensive book pulls together the essential elements needed to assess sleep apnea patients for the transoral robotic surgical approach and how to optimize the surgery. Detailed information on patient selection, pre-operative work up, anesthesiological pre and post-operative management, surgery, complication prevention and management is provided along with background on sleep medicine and sleep surgery. Authored for ENT surgeons, head and neck specialists and neurologists, pneumonologists, sleep doctors as well for anesthesiologists, chapters offer solutions pulled from experts in the field of sleep surgery and information relevant to geographic areas worldwide.

This series has already become a classic. In general, one volume is published per year. The advances section presents fields of neurosurgery and related areas in which important recent progress has been made. The technical standards section features detailed descriptions of standard procedures to assist young neurosurgeons in their post-graduate training. The contributions are written by experienced clinicians and are reviewed by all members of the editorial board.

This volume provides a full explanation and technical details to perform surgical techniques properly on small and large animal models. The first six chapters of Experimental Neurosurgery in Animal Models focus primarily on the brain, while the next six chapters concern the spinal cord in rodents. The last four chapters provide a description of operative procedures in large animals. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory. Authoritative and practical, Experimental Neurosurgery in Animal Models aims to ensure successful results in the further study of this vital field.

The inaugural publication of the 7.0 Tesla MRI Brain Atlas: In Vivo Atlas with Cryomacrotome Correlation in 2010 provided readers with a spectacular source of ultra-high resolution images revealing a wealth of details of the brainstem and midbrain structures. This second edition contributes additional knowledge gained as a result of technologic advances and recent research. To facilitate identification and comparison of brain structures and anatomy, a detailed coordination matrix is featured in each image. Updated axial, sagittal, and coronal images are also included. This state-of-the-art and user-friendly reference will provide researchers and clinicians with important new perspectives.

This book is an up-to-date reference on all aspects of anticoagulation and hemostasis in neurosurgery. After an opening section on basic principles and drug classes in current use, detailed consideration is given to coagulation issues relevant to all patients, not just neurosurgical ones. The coverage includes, for example, deep vein thrombosis, pulmonary embolism, and disseminated intravascular coagulation. A variety of important issues specific to neurosurgical practice are then addressed, and a summary of current guidelines and best practices is provided. By bringing together the latest knowledge from across the discipline, this book will serve as a sound basis for informed decision making in surgical practice. It will be of daily value for neurosurgeons and trainees worldwide and will also be of interest to emergency room physicians, surgeons in general, critical care physicians, neurologists, and hospital medicine specialists.

A state-of-the-art resource on current and future advances in the treatment of intradural spinal tumors Tumors of the spinal canal provide unique challenges in terms of surgical approaches and oncological treatment. Management requires in-depth knowledge of the intricate anatomical relationships between the tumors and normal spinal pathways, restricted corridors of entry, and limitations of drug penetration. Over the past few decades, significant strides have been made in the treatment of these tumors. Development of minimally invasive techniques and greater understanding of these pathologies has resulted in improved safety, precision, and outcomes. Tumors of the Spinal Canal: Surgical Approaches and Future Therapies by Ankit I. Mehta and esteemed contributors is the most comprehensive textbook written to date on this topic. The book starts with two opening chapters covering an overview and anatomy, followed by three sections and 11 chapters on intramedullary spinal tumors, intradural extramedullary tumors, and peripheral nerve tumors. The comprehensive review encompasses anatomy, pathophysiology, therapeutic and surgical advances, diverse surgical techniques, and future directions. Throughout the text, readers are provided with the necessary tools to master management of these clinically difficult tumors, from both a medical and surgical standpoint. Key Highlights Treatment algorithms, clinical study summaries, and differential diagnoses presented in reader-friendly tables enhance acquisition and retention of knowledge Comprehensive analyses and pearls from masters provide insights on how to manage complications and improve patient outcomes Discussion of current research innovations, clinical trials, and future directions that have the potential to change the treatment paradigm Neurosurgical residents, spine fellows, and complex spine surgeons will benefit from reading this resource, while the intradural spinal tumor treatment paradigms provide an invaluable clinical tool for neurooncologists and oncologists. This book includes complimentary access to a digital copy on https://medone.thieme.com.

This full-length translation of Professor Luria's book introduces to the English speaking world a major document in neuropsychology, summarizing Professor Luria's earlier contributions to that area for nearly a third of a century. It is a monumental contribution. Nothing of this scope exists in the Western literature of this field, with the possible exception of Ajuriaguerra and Hecaen's book (in French) on the cerebral cortex. Professor Luria's book thus marks a further and decisive step toward the eventual coalescence of neurology and psychology, a goal to which only a few laboratories in the East and West have been devoted over the last decades. The book is unique in its organization. The first half deals with observations and interpretations concerning the major syndromes of man's left cerebral hemisphere: those grievous distortions of higher functions traditionally described as aphasia, agnosia, and apraxia. There is also a detailed and brilliant analysis of the syndrome of massive frontal-lobe involvement. The entire second half of the book is given over to a painstaking description of Professor Luria's tests, many of them introduced by himself, and set out in such detail that anyone could repeat them and thus verify Professor Luria's interpretations."

This concise reference clarifies the gray areas between traumatic brain injury and PTSD while providing an empirically sound framework for neuropsychological evaluation and differential diagnosis. Its extended research review summarizes findings on key topics including the neuroanatomy of brain injury, test battery design and selection, and the salience of accurate diagnosis to ensuring appropriate specialized treatment. The authors offer the possibility of combined diagnosis as well as injuries that may fall through the diagnostic cracks, and consider possible relationships between TBI, PTSD, and the dementias, including Alzheimer's disease. This knowledge base and the practical guidelines it informs are presented so that readers can better: * Understand the clinical distinctions between TBI and PTSD, and among forms of TBI. * Recognize cognitive, behavioral, emotional, and social components of the disorders. * Identify skill areas for neuropsychological evaluation of patients. * Select appropriate instruments for individualized assessment.* Address test administration and interpretation concerns. * Make an accurate differential diagnosis between PTSD and TBI. With its sharp focus on the nuances of trauma and recovery, The Intercorrelation of Traumatic Brain Injury and PTSD in Neuropsychological Evaluations will find a wide, interested audience among psychologists, neuropsychologists, neurologists, psychiatrists, social workers, mental health counselors, undergraduate and graduate level students, and researchers. In addition, this text may be useful for those interested in psychology and neurology. <

Tumor Neurosurgery provides information on the basic knowledge and clinical management required for optimal care of neurooncology patients. Providing an up-to-date synopsis of the field of tumor neurosurgery, the book covers the most common sites and tumor pathologies encountered by neurosurgeons. The chapters are organized under broad topics, including investigative studies, perioperative care and the role of newer techniques. The clinical management of CNS tumors in adults and children is described, including spinal tumors, both intradural and extradural. This book provides coverage of relevant topics in the field of tumor neurosurgery, for residents and registrars in training, and for recent graduates of training programs.