This volume provides a unique collection of mathematical tools and industrial case studies in digital manufacturing. It addresses various topics, ranging from models of single production technologies, production lines, logistics and workflows to models and optimization strategies for energy consumption in production. The digital factory represents a network of digital models and simulation and 3D visualization methods for the holistic planning, realization, control and ongoing improvement of all factory processes related to a specific product. In the past ten years, all industrialized countries have launched initiatives to realize this vision, sometimes also referred to as Industry 4.0 (in Europe) or Smart Manufacturing (in the United States). Its main goals are * reconfigurable, adaptive and evolving factories capable of small-scale production * high-performance production, combining flexibility, productivity, precision and zero defects * energy and resource efficiency in manufacturing None of these goals can be achieved without a thorough modeling of all aspects of manufacturing together with a multi-scale simulation and optimization of process chains; in other words, without mathematics. To foster collaboration between mathematics and industry in this area the European Consortium for Mathematics in Industry (ECMI) founded a special interest group on Math for the Digital Factory (M4DiFa). This book compiles a selection of review papers from the M4DiFa kick-off meeting held at the Weierstrass Institute for Applied Analysis and Stochastics in Berlin, Germany, in May 2014. The workshop aimed at bringing together mathematicians working on modeling, simulation and optimization with researchers and practitioners from the manufacturing industry to develop a holistic mathematical view on digital manufacturing. This book is of interest to practitioners from industry who want to learn about important mathematical concepts, as well as to scientists who want to find out about an exciting new area of application that is of vital importance for today's highly industrialized and high-wage countries.

Disjunctive Programming is a technique and a discipline initiated by the author in the early 1970's, which has become a central tool for solving nonconvex optimization problems like pure or mixed integer programs, through convexification (cutting plane) procedures combined with enumeration. It has played a major role in the revolution in the state of the art of Integer Programming that took place roughly during the period 1990-2010. The main benefit that the reader may acquire from reading this book is a deeper understanding of the theoretical underpinnings and of the applications potential of disjunctive programming, which range from more efficient problem formulation to enhanced modeling capability and improved solution methods for integer and combinatorial optimization. Egon Balas is University Professor and Lord Professor of Operations Research at Carnegie Mellon University's Tepper School of Business.

Scheduling theory has received a growing interest since its origins in the second half of the 20th century. Developed initially for the study of scheduling problems with a single objective, the theory has been recently extended to problems involving multiple criteria. However, this extension has still left a gap between the classical multi-criteria approaches and some real-life problems in which not all jobs contribute to the evaluation of each criterion.

In this book, we close this gap by presenting and developing multi-agent scheduling models in which subsets of jobs sharing the same resources are evaluated by different criteria. Several scenarios are introduced, depending on the definition and the intersection structure of the job subsets. Complexity results, approximation schemes, heuristics and exact algorithms are discussed for single-machine and parallel-machine scheduling environments. Definitions and algorithms are illustrated with the help of examples and figures.

Very little has been published on optimization of pharmaceutical portfolios. Moreover, most of published literature is coming from the commercial side, where probability of technical success (PoS) is treated as fixed, and not as a consequence of development strategy or design. In this book there is a strong focus on impact of study design on PoS and ultimately on the value of portfolio. Design options that are discussed in different chapters are dose-selection strategies, adaptive design and enrichment. Some development strategies that are discussed are indication sequencing, optimal number of programs and optimal decision criteria. This book includes chapters written by authors with very broad backgrounds including financial, clinical, statistical, decision sciences, commercial and regulatory. Many authors have long held executive positions and have been involved with decision making at a product or at a portfolio level. As such, it is expected that this book will attract a very broad audience, including decision makers in pharmaceutical R&D, commercial and financial departments. The intended audience also includes portfolio planners and managers, statisticians, decision scientists and clinicians. Early chapters describe approaches to portfolio optimization from big Pharma and Venture Capital standpoints. They have stronger focus on finances and processes. Later chapters present selected statistical and decision analysis methods for optimizing drug development programs and portfolios. Some methodological chapters are technical; however, with a few exceptions they require a relatively basic knowledge of statistics by a reader.

This book promotes the use of mathematical optimization and operations research methods in rail transportation. The editors assembled thirteen contributions from leading scholars to present a unified voice, standardize terminology, and assess the state-of-the-art. There are three main clusters of articles, corresponding to the classical stages of the planning process: strategic, tactical, and operational. These three clusters are further subdivided into five parts which correspond to the main phases of the railway network planning process: network assessment, capacity planning, timetabling, resource planning, and operational planning. Individual chapters cover: Simulation Capacity Assessment Network Design Train Routing Robust Timetabling Event Scheduling Track Allocation Blocking Shunting Rolling Stock Crew Scheduling Dispatching Delay Propagation

Transportation management in today's consumer goods industry can be characterized by a high proportion of outsourced transportation services. Due to rising freight costs consumer goods manufacturers are seeking opportunities to increase the efficiency of their transportation network. This book presents an operational transportation planning problem typical of the consumer goods industry focusing on a network of suppliers, production facilities and warehouses. With respect to the large share of outsourcing in these networks a detailed analysis of freight costs based on contractual agreements is provided. From this analysis a number of opportunities for efficiency gains are identified and consolidated in an operative transportation planning problem that is numerically investigated. Furthermore, an overview of processes and organizational requirements in transportation management is given with special focus on the integration of existing commercial Transportation Management Systems (TMS).

This book presents a collection of studies that have applied analytical methods to improve preparedness, planning, and a faster response to A&E and public health emergencies like epidemic and disease outbreak. It explores the application of quantitative Operational Research techniques such as Mathematical Modelling and Optimization, Maximum Likelihood Estimation, Multiple-Criteria Decision Analysis, Discrete-event Simulation, Data Mining, and Bayesian Decision Models. These techniques have been used for better management of emergency care, including first responders, ambulance services, A&E departments, and mass immunisation centres. This volume focuses on planning at the operational level whereas volume 2 focuses mainly on planning at the strategic level. The OR Essentials series presents a unique cross-section of high quality research work fundamental to understanding contemporary issues and research across a range of Operational Research (OR) topics. It brings together some of the best research papers from the highly respected journals of the Operational Research Society, also published by Palgrave Macmillan.

This book presents the proceedings of the Seventh International Conference on Management Science and Engineering Management (ICMSEM2013) held from November 7 to 9, 2013 at Drexel University, Philadelphia, Pennsylvania, USA and organized by the International Society of Management Science and Engineering Management, Sichuan University (Chengdu, China) and Drexel University (Philadelphia, Pennsylvania, USA). The goals of the Conference are to foster international research collaborations in Management Science and Engineering Management as well as to provide a forum to present current research findings. The selected papers cover various areas in management science and engineering management, such as Decision Support Systems, Multi-Objective Decisions, Uncertain Decisions, Computational Mathematics, Information Systems, Logistics and Supply Chain Management, Relationship Management, Scheduling and Control, Data Warehousing and Data Mining, Electronic Commerce, Neural Networks, Stochastic Models and Simulation, Fuzzy Programming, Heuristics Algorithms, Risk Control, Organizational Behavior, Green Supply Chains, and Carbon Credits. The proceedings introduce readers to novel ideas on and different problem-solving methods in Management Science and Engineering Management. We selected excellent papers from all over the world, integrating their expertise and ideas in order to improve research on Management Science and Engineering Management.

This book offers a comprehensive reference guide to operations research theory and applications in health care systems. It provides readers with all the necessary tools for solving health care problems. The respective chapters, written by prominent researchers, explain a wealth of both basic and advanced concepts of operations research for the management of operating rooms, intensive care units, supply chain, emergency medical service, human resources, lean health care, and procurement. To foster a better understanding, the chapters include relevant examples or case studies. Taken together, they form an excellent reference guide for researchers, lecturers and postgraduate students pursuing research on health care management problems. The book presents a dynamic snapshot on the field that is expected to stimulate new directions and stimulate new ideas and developments.

This book discusses key issues in the planning and operation of large-scale integrated energy systems (LSIES). It establishes individual-based models for LSIES and develops multi-objective optimization algorithms and multi-attribute decision making support systems, which are applied to the planning and optimal operation of LSIES. It is a valuable reference work for researchers, students and engineers who are interested in energy systems, operation research and decision theory.

The main objective of this book is to provide the necessary background to work with big data by introducing some novel optimization algorithms and codes capable of working in the big data setting as well as introducing some applications in big data optimization for both academics and practitioners interested, and to benefit society, industry, academia, and government. Presenting applications in a variety of industries, this book will be useful for the researchers aiming to analyses large scale data. Several optimization algorithms for big data including convergent parallel algorithms, limited memory bundle algorithm, diagonal bundle method, convergent parallel algorithms, network analytics, and many more have been explored in this book.

Dynamics of Information Systems: Algorithmic Approaches presents recent developments and results found by participants of the Fourth International Conference on the Dynamics of Information Systems, which took place at the University of Florida, Gainesville FL, USA on February 20-22, 2012. The purpose of this conference was to bring together scientists and engineers from industry, government, and universities to exchange knowledge and results in a broad range of topics relevant to the theory and practice of the dynamics of information systems. Dynamics of Information plays an increasingly critical role in our society. The influence of information on social, biological, genetic, and military systems must be better understood to achieve large advances in the capability and understanding of these systems. Applications are widespread and include: detection of terrorist networks, design of highly efficient businesses, computer networks, quantum entanglement, genome modeling, multi-robotic systems, and industrial and manufacturing safety. The book contains state-of-the-art work on theory and practice relevant to the dynamics of information systems. It covers algorithmic approaches to numerical computations with infinite and infinitesimal numbers; presents important problems arising in service-oriented systems, such as dynamic composition and analysis of modern service-oriented information systems and estimation of customer service times on a rail network from GPS data; addresses the complexity of the problems arising in stochastic and distributed systems; and discusses modulating communication for improving multi-agent learning convergence. Network issues-in particular minimum-risk maximum-clique problems, vulnerability of sensor networks, influence diffusion, community detection, and link prediction in social network analysis, as well as a comparative analysis of algorithms for transmission network expansion planning-are described in later chapters.

This book provides an enduring response to modern economic problems and the consequent crises, dealing with the economic modelling of nations and the forecasting of economic growth. The main arguments embodied constitute the creation of jobs and the restoration of economic growth, using the implicit acceptance of analysis on differential models and neutral systems for controlling the wealth of nations.

This is the first book to offer a complete spectrum of the role that operations research has played and can play in the improvement of North American freight railroads. It explores how decisions are made at railroads, contains examples of the mathematical programming formulations to the complex problems, and provides insights into real-world applications. The handbook is divided into eleven chapters, covering topics including scheduling problems, empty railcar distribution, and intermodal rail. These topics have been specifically selected to offer a thorough examination of the application of operations research at freight railroads. The chapters are written by recognized award-winning scholars and practitioners with a deep knowledge and understanding of their specific topics. The Handbook of Operations Research Applications at Railroads is an ideal resource for academics, experienced researchers, and consultants in the field.

This book is an expository introduction to the methodology of sensitivity analysis of model output. It is primarily intended for investigators, students and researchers that are familiar with mathematical models but are less familiar with the techniques for performing their sensitivity analysis. A variety of sensitivity methods have been developed over the years. This monograph helps the analyst in her/his first exploration of this world. The main goal is to foster the recognition of the crucial role of sensitivity analysis methods as the techniques that allow us to gain insights from quantitative models. Also, exercising rigor in performing sensitivity analysis becomes increasingly relevant both to decision makers and modelers. The book helps the analyst in structuring her/his sensitivity analysis quest properly, so as to obtain the correct answer to the corresponding managerial question. The first part of the book covers Deterministic Methods, including Tornado Diagrams; One-Way Sensitivity Analysis; Differentiation-Based Methods and Local Sensitivity Analysis with Constraints. The second part looks at Probabilistic Methods, including Regression-Based methods, Variance-Based Methods, and Distribution-Based methods. The final section looks at Applications, including capital budgeting, sensitivity analysis in climate change modelling and in the risk assessment of a lunar space mission.

This book grows from a conference on the state of the art and recent advances in Efficiency and Productivity. Papers were commissioned from leading researchers in the field, and include eight explorations into the analytical foundations of efficiency and productivity analysis. Chapters on modeling advances include reverse directional distance function, a new method for estimating technological production possibilities, a new distance function called a loss distance function, an analysis of productivity and price recovery indices, the relation of technical efficiency measures to productivity measures, the implications for benchmarking and target setting of imposing weight restrictions on DEA models, weight restrictions in a regulatory setting, and the Principle of Least Action. Chapters on empirical applications include a study of innovative firms that use innovation inputs to produce innovation outputs, a study of the impact of potential "coopetition" or cooperation among competitors on the financial performance of European automobile plants, using SFA to estimate the eco-efficiency of dairy farms in Spain, a DEA bankruptcy prediction model, a combined stochastic cost frontier analysis model/mixture hazard model, the evolution of energy intensity in nine Spanish manufacturing industries, and the productivity of US farmers as they age.

This book integrates multiple criteria concepts and methods for problems within the Risk, Reliability and Maintenance (RRM) context. The concepts and foundations related to RRM are considered for this integration with multicriteria approaches. In the book, a general framework for building decision models is presented and this is illustrated in various chapters by discussing many different decision models related to the RRM context. The scope of the book is related to ways of how to integrate Applied Probability and Decision Making. In Applied Probability, this mainly includes: decision analysis and reliability theory, amongst other topics closely related to risk analysis and maintenance. In Decision Making, it includes a broad range of topics in MCDM (Multi-Criteria Decision Making) and MCDA (Multi-Criteria Decision Aiding; also known as Multi-Criteria Decision Analysis). In addition to decision analysis, some of the topics related to Mathematical Programming area are briefly considered, such as multiobjective optimization, since methods related to these topics have been applied to the context of RRM. The book addresses an innovative treatment for the decision making in RRM, thereby improving the integration of fundamental concepts from the areas of both RRM and decision making. This is accomplished by presenting an overview of the literature on decision making in RRM. Some pitfalls of decision models when applying them to RRM in practice are discussed and guidance on overcoming these drawbacks is offered. The procedure enables multicriteria models to be built for the RRM context, including guidance on choosing an appropriate multicriteria method for a particular problem faced in the RRM context. The book also includes many research advances in these topics. Most of the multicriteria decision models that are described are specific applications that have been influenced by this research and the advances in this field. Multicriteria and Multiobjective Models for Risk, Reliability and Maintenance Decision Analysis is implicitly structured in three parts, with 12 chapters. The first part deals with MCDM/A concepts methods and decision processes. The second part presents the main concepts and foundations of RRM. Finally the third part deals with specific decision problems in the RRM context approached with MCDM/A models.

One of the central problems in operations research and management science is how to quantify the effects of uncertainty about the future. This, the second volume in a series of handbooks, is devoted to models where chance events play a major role. The thirteen chapters survey topics in applied probability that have been particularly useful in operations research and management science. Each chapter was written by an expert, both in subject matter and in its exposition.
The chapters fall into four groups. The first four cover the fundamentals of stochastic processes, and lay the foundation for the following chapters. The next three chapters are concerned with methods of getting numbers. This includes numerical solution of models, parameter estimation for models, and simulation of models. Chapters 8 and 9 describe the fundamentals of dynamic optimization. The last four chapters are concerned with the most important structured models in operations research and management science; queues, queueing networks, inventories, and reliability.

The storage yard is the operational and geographical centre of most seaport container terminals. Therefore, it is of particular importance for the whole terminal system and plays a major role for trade and transport flows. One of the latest trends in container-storage operations is the automated Rail-Mounted-Gantry-Crane system, which offers dense stacking, and offers low labour costs. This book investigates whether the operational performance of container terminals is influenced by the design of these storage systems and to what extent the performance is affected by the terminal's framework conditions, and discusses the strategies applied for container stacking and crane scheduling. A detailed simulation model is presented to compare the performance effects of alternative storage designs, innovative planning strategies, and other influencing factors. The results have useful implications future research, practical terminal planning and optimisation.

This book on constrained optimization is novel in that it fuses these themes: * use examples to introduce general ideas; * engage the student in spreadsheet computation; * survey the uses of constrained optimization;. * investigate game theory and nonlinear optimization, * link the subject to economic reasoning, and * present the requisite mathematics. Blending these themes makes constrained optimization more accessible and more valuable. It stimulates the student's interest, quickens the learning process, reveals connections to several academic and professional fields, and deepens the student's grasp of the relevant mathematics. The book is designed for use in courses that focus on the applications of constrained optimization, in courses that emphasize the theory, and in courses that link the subject to economics.

This work is devoted to the late Ukrainian computer scientist V. M. Glushkov on the 90th anniversary of his birthday. Dr. Glushkov is known for his contribution to the world computer science and technology and this volume analyzes the ideas and paths of development of informatics formulated by him and demonstrate their important role in constructing computer technologies of basic research in the fields of applied mathematics, theories of computer programming and computing systems. A significant portion of the monograph is devoted to the elucidation of new results obtained in the field of mathematical modeling of complicated processes, creation of new methods for solving and investigating optimization problems in different statements and development of computer technologies for investigations in the field of economy, biology, medicine and information security in systems. The monograph will be of particular interest to informatics specialists and experts using methods of informatics and computer technologies to investigate complicated processes of different natures and developing new information technologies. It may also be useful for both graduate students and postgraduates specializing in Computer Science.

This book presents the proceedings of the Seventh International Conference on Management Science and Engineering Management (ICMSEM2013) held from November 7 to 9, 2013 at Drexel University, Philadelphia, Pennsylvania, USA and organized by the International Society of Management Science and Engineering Management, Sichuan University (Chengdu, China) and Drexel University (Philadelphia, Pennsylvania, USA). The goals of the Conference are to foster international research collaborations in Management Science and Engineering Management as well as to provide a forum to present current research findings. The selected papers cover various areas in management science and engineering management, such as Decision Support Systems, Multi-Objective Decisions, Uncertain Decisions, Computational Mathematics, Information Systems, Logistics and Supply Chain Management, Relationship Management, Scheduling and Control, Data Warehousing and Data Mining, Electronic Commerce, Neural Networks, Stochastic Models and Simulation, Fuzzy Programming, Heuristics Algorithms, Risk Control, Organizational Behavior, Green Supply Chains, and Carbon Credits. The proceedings introduce readers to novel ideas on and different problem-solving methods in Management Science and Engineering Management. We selected excellent papers from all over the world, integrating their expertise and ideas in order to improve research on Management Science and Engineering Management.

Multiple criteria decision aid (MCDA) methods are illustrated in this book through theoretical and computational techniques utilizing Python. Existing methods are presented in detail with a step by step learning approach. Theoretical background is given for TOPSIS, VIKOR, PROMETHEE, SIR, AHP, goal programming, and their variations. Comprehensive numerical examples are also discussed for each method in conjunction with easy to follow Python code. Extensions to multiple criteria decision making algorithms such as fuzzy number theory and group decision making are introduced and implemented through Python as well. Readers will learn how to implement and use each method based on the problem, the available data, the stakeholders involved, and the various requirements needed. Focusing on the practical aspects of the multiple criteria decision making methodologies, this book is designed for researchers, practitioners and advanced graduate students in the applied mathematics, information systems, operations research and business administration disciplines, as well as other engineers and scientists oriented in interdisciplinary research. Readers will greatly benefit from this book by learning and applying various MCDM/A methods. (Adiel Teixeira de Almeida, CDSID-Center for Decision System and Information Development, Universidade Federal de Pernambuco, Recife, Brazil) Promoting the development and application of multicriteria decision aid is essential to ensure more ethical and sustainable decisions. This book is a great contribution to this objective. It is a perfect blend of theory and practice, providing potential users and researchers with the theoretical bases of some of the best-known methods as well as with the computing tools needed to practice, to compare and to put these methods to use. (Jean-Pierre Brans, Vrije Universiteit Brussel, Brussels, Belgium) This book is intended for researchers, practitioners and students alike in decision support who wish to familiarize themselves quickly and efficiently with multicriteria decision aiding algorithms. The proposed approach is original, as it presents a selection of methods from the theory to the practical implementation in Python, including a detailed example. This will certainly facilitate the learning of these techniques, and contribute to their effective dissemination in applications. (Patrick Meyer, IMT Atlantique, Lab-STICC, Univ. Bretagne Loire, Brest, France)

The objective of this book is to provide a valuable compendium of problems as a reference for undergraduate and graduate students, faculty, researchers and practitioners of operations research and management science. These problems can serve as a basis for the development or study of assignments and exams. Also, they can be useful as a guide for the first stage of the model formulation, i.e. the definition of a problem. The book is divided into 11 chapters that address the following topics: Linear programming, integer programming, non linear programming, network modeling, inventory theory, queue theory, tree decision, game theory, dynamic programming and markov processes. Readers are going to find a considerable number of statements of operations research applications for management decision-making. The solutions of these problems are provided in a concise way although all topics start with a more developed resolution. The proposed problems are based on the research experience of the authors in real-world companies so much as on the teaching experience of the authors in order to develop exam problems for industrial engineering and business administration studies.

"Advances in Bio-inspired Combinatorial Optimization Problems" illustrates several recent bio-inspired efficient algorithms for solving NP-hard problems. Theoretical bio-inspired concepts and models, in particular for agents, ants and virtual robots are described. Large-scale optimization problems, for example: the Generalized Traveling Salesman Problem and the Railway Traveling Salesman Problem, are solved and their results are discussed. Some of the main concepts and models described in this book are: inner rule to guide ant search - a recent model in ant optimization, heterogeneous sensitive ants; virtual sensitive robots; ant-based techniques for static and dynamic routing problems; stigmergic collaborative agents and learning sensitive agents. This monograph is useful for researchers, students and all people interested in the recent natural computing frameworks. The reader is presumed to have knowledge of combinatorial optimization, graph theory, algorithms and programming. The book should furthermore allow readers to acquire ideas, concepts and models to use and develop new software for solving complex real-life problems.