This issue of Surgical Pathology Clinics, guest edited by Dr. Jessica Davis, is devoted to Challenges & Updates in Pediatric Pathology. Articles in this issue include: Advances and Pitfalls in the Diagnosis of Hirschsprungs Disease, Updates in Pediatric Enteropathies: Differential Diagnosis, Testing, and Genetics, Pediatric Liver Tumors: Updates in Classification, New Prognostic Indicators in Pediatric Adrenal Tumors: Neuroblastoma & Adrenal Cortical Tumors, Pediatric Cystic Lung Lesions, Strategies for the Neonatal Lung Biopsy: Histology to Genetics, Wilm's Tumor: Challenges and Newcomers in Prognosis, Pediatric Renal Tumors: Updates in the Molecular Era, Newcomers in Vascular Anomalies, Spindle Cell Rhabdomyosarcoma: Further Subcategorization, Pediatric & Infantile Fibroblastic/myofibroblastic Tumors in the Molecular Era, Round Cell Sarcomas: Newcomers and Diagnostic Approaches, CNS Embryonal Tumors: Testing Strategies for Integrated Diagnosis, Updates in Pediatric Gliomas, and more.

"Actually, suicidal persons dont want to die, they just want to stop living the way they have been up to now." People who suffer intensely and think about taking their life are experiencing a severe depression and high degree of hopelessness and confusion which darken and limit their vision of life. It is a perspective that only allows them to see death as the solution to heal the suffering their existence has become. Joseluis Canales (Dado) reveals in this book that suicide is not the only solution to pain. The text provides a searing reflection on this tragic subject while offering perspectives to overcome it. This expert on psychotrauma delicately unpacks the intricacies of the act so that those with a suicidal risk can begin to heal their pain and see the life options before them-options which right now seem unassailable. Dado accomplishes, through intelligent and thought-provoking arguments, an intimacy with readers who may be dealing with this life crisis, to help them find an escape from the haziness and confusion enveloping them. "My dream, my hope behind all this work, is that this book falls into the hands of someone that's considering suicide as the only way out from the hell they are suffering. This person may be you, and perhaps by reading this book you can overcome the existential crisis you are living through, and your life can go on. My fantasy is that someone at suicidal risk unable to imagine that this suffering can be left behind, decides to seek help...Maybe, just maybe, this book can save one life. That life may be yours and because of that and nothing else, it will have been worth it to write this book"-Dado

Global Perspectives on Astaxanthin: From Industrial Production to Food, Health, and Pharmaceutical Applications explores the range of practical applications for this molecule, focusing on nutraceutical, pharmaceutical and cosmeceutical products, along with food and feed. This volume brings together the most relevant research, background and future thinking on astaxanthin, focusing on its health benefits. Chapters cover phytopharmaceuticals, industrial production, feeds, downstream processing, regulations, products, color, pigment, cosmetics, bioactive compounds, relationships to other carotenoids, and skin care. The detailed information on its production, processing, utilization and future applications will be of particular use to academic and industry researchers in pharmaceutical sciences, pharmacology and nutrition.

The Man Who Crucified Himself is the history of a sensational nineteenth-century medical case. In 1805 a shoemaker called Mattio Lovat attempted to crucify himself in Venice. His act raised a furore, and the story spread across Europe. For the rest of the century Lovat's case fuelled scientific and popular debates on medicine, madness, suicide and religion. Drawing on Italian, German, English and French sources, Maria Boehmer traces the multiple readings of the case and identifies various 'interpretive communities'. Her meticulously researched study sheds new light on Lovat's case and offers fresh insights on the case narrative as a genre - both epistemic and literary.

The first book of its kind, Parenting Psychoanalysed: Letters to a Parent collates the musings of a thoughtful group of psychoanalysts with a series of candid letters, each addressing the aspect of parenthood they most want to share and what they wish they knew before becoming a parent.

Written in the simplest of terms, each contributor shares a letter that reflects both personally and professionally on parenthood, sharing their feelings, insights and psychoanalytic reflections with the parent-reader. Drawing on their deep understanding of the mind and the personal work done on themselves, each writer digests what it really means to be a parent, what they didn’t expect when they were expecting, the pleasures and anxieties of parenting, the ordinary ambiguities and ambivalence evoked by their children at various life stages, as well as many other gems that no other parenting books are talking about. This international collection begins an important conversation with mothers, fathers and caregivers; encouraging them to consider how their inner worlds, worries and wishes matter deeply and hold important clues about how to parent in an open and authentic way. Each letter shows how understanding this dynamic is key to raising a healthy, balanced family and living more freely.

This thought-provoking book connects parents through personal stories and profound psychoanalytic insights, and is an essential read for every mother, father and caregiver.

Celebrating Fifty Years of Picador Books If a man has lost a leg or an eye, he knows he has lost a leg or an eye; but if he has lost a self - himself - he cannot know it, because he is no longer there to know it. In this extraordinary book, Dr. Oliver Sacks recounts the stories of patients struggling to adapt to often bizarre worlds of neurological disorder. Here are people who can no longer recognize everyday objects or those they love; who are stricken with violent tics or shout involuntary obscenities, and yet are gifted with unusually acute artistic or mathematical talents. If sometimes beyond our surface comprehension, these brilliant tales illuminate what it means to be human. A provocative exploration of the mysteries of the human mind, The Man Who Mistook His Wife for a Hat is a million-copy bestseller by the twentieth century's greatest neurologist. Part of the Picador Collection, a series showcasing the best of modern literature.

"Progress in Medicinal Chemistry" provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems.

*Presents the latest research in the field of drug discovery *Publishes on a twice yearly basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect

Toxicological Evaluation of Electronic Nicotine Delivery Products (ENDP) discusses the scientific basis for the toxicological assessment and evaluation of ENDPs. The book covers aerosol chemistry, in vitro and in vivo studies as well as clinical studies. It provides the basis for the evaluation of short and long term-effects, along with relative risks. It also examines the potential role of ENDPs in tobacco harm reduction and how they may reduce the risk of disease in smokers who switch to them. This book is a comprehensive resource for toxicologists, health practitioners and public health professionals who want the scientific information necessary to assess the relative risk of ENDPs when compared with cigarette smoking and cessation.

Preparation of Phytopharmaceuticals for the Management of Disorders: The Development of Nutraceuticals and Traditional Medicine presents comprehensive coverage and recent advances surrounding phytopharmaceuticals, nutraceuticals and traditional and alternative systems of medicines. Sections cover the concepts of phytopharmaceuticals, their history, and current highlights in phytomedicine. Also included are classifications of crude drugs, herbal remedies and toxicity, traditional and alternative systems of medicine, nanotechnology applications, and herbal cosmeticology. Final sections cover applications of microbiology and biotechnology in drug discovery. This book provides key information for everyone interested in drug discovery, including medicinal chemists, nutritionists, biochemists, toxicologists, drug developers and health care professionals. Students, professors and researchers working in the area of pharmaceutical sciences and beyond will also find the book useful.

As bacterial antibiotic resistance continues to exhaust the supply of effective antibiotics, a global public health disaster appears likely. Poor financial investment in antibiotic research has exacerbated the situation. A call to arms - raised by several prestigious scientific organizations a few years ago - rallied the scientific community and now the scope of antibacterial research has broadened considerably. Multi-disciplinary approaches have yielded a wealth of new data on areas ranging from the identification of novel antibacterial targets to the use of biological agents for antibacterial therapy. In this book, respected international experts summarize the most important concepts and pioneering strategies currently being used to develop novel antibacterials. The book opens with chapters on cellular processes that could be used as novel antibacterial targets. Examples include cell division, efflux pumps, metabolite-sensing riboswitches, and bacterial secretion systems. These are followed by excellent chapters on the identification of new, naturally occurring antibacterial agents, including phage and biosynthetically engineered compounds. Understanding the host-microbe interaction and microbial communities and how they can be exploited to develop new antibacterial strategies is discussed in subsequent chapters. Other topics include antibacterial vaccines adjuvants, host defense peptides, antibodies, within-host models, and diagnostics.

Sleep is a major component of good mental and physical health, yet over 40 million Americans suffer from sleep disorders. Edited by three prominent clinical experts, Behavioral Treatments for Sleep Disorders is the first reference to cover all of the most common disorders (insomnia, sleep apnea, restless legs syndrome, narcolepsy, parasomnias, etc) and the applicable therapeutic techniques. The volume adopts a highly streamlined and practical approach to make the tools of the trade from behavioral sleep medicine accessible to mainstream psychologists as well as sleep disorder specialists. Organized by therapeutic technique, each chapter discusses the various sleep disorders to which the therapy is relevant, an overall rationale for the intervention, step-by-step instructions for how to implement the technique, possible modifications, the supporting evidence base, and further recommended readings. Treatments for both the adult and child patient populations are covered, and each chapter is authored by an expert in the field.

Cook explores the development of clinical tropical medicine from the 19th century onwards by following the pioneering doctors in this discipline, their personalities, achievements and scientific breakthroughs.

The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval.

This essential book questions the psychological construct of Internet Addiction by contextualizing it within the digital technological era. It proposes a critical psychology that investigates user subjectivity as a function of capitalism and imperialism, arguing against punitive models of digital excesses and critiquing the political economy of the Internet affecting all users. Friedman explores the limitations of individual-centered remediations exemplified in the psychology of internet addiction. Furthermore, Friedman outlines the self-creative actions of social media users, and the data processing that exploits them to urge psychologists to politicize rather than pathologize the effects of excessive net use. The book develops a notion of capitalist imperialism of the social web and studies this using the radical methods of philosopher Gilles Deleuze and psychoanalyst Felix Guattari. By synthesizing perspectives on digital life from sociology, economics, digital media theory, and technology studies for psychologists, this book will be of interest to academics and students in these areas, as well as psychologists and counselors interested in addressing Internet Addiction as a collective, societal ill.

The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then, as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists has contributed to the informative, by critically interpreting it, and by pointing to whatever is misleading.

*Provides a critical yearly survey of new data and trends *Special reviews in this Annual include, among other topics: Epidemiology of the use of ecstasy, Paracetamol and the risk of asthma, Combination vaccines/multiple immunizations, Interactions of herbal medicines with warfarin, and Tyrosine kinase inhibitors.

Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful.

This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery.
Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics deliveryOf interest to researchers in both academia and industryHighlights what s currently known and where further research is needed"

This issue of Oral and Maxillofacial Surgery Clinics of North America is devoted to Dentoalveolar Surgery and is edited by Dr. Somsak Sittitavornwong. Articles will include: Preprosthetic Dentoalveolar Surgery; Management of Impacted Third Molars; Principles of Exodontia; Complications, Including Infections, in Dentoalveolar Surgery; Medical Management of Patient undergoing Dentoalveolar Surgery; Trigeminal Nerve Injury; Oral Soft Tissue Grafting; Current Concepts of Periapical Surgery; Surgical Exposure of Impacted Teeth; Dental Trauma; Tooth Transplantation; Socket Grafting; Maxillary Sinus Diseases; and more!

Without warning stroke can paralyze, blind, or kill. Some victims recover, but many do not and may even suffer another disabling or fatal attack. The drug known as tPA can drastically reduce the long-term disability associated with stroke, but despite its near-miraculous capabilities and the growing support of most neurologists, it has been slow to win acceptance as the standard of care in emergency departments nationwide.
tPA for Stroke chronicles how this remarkable drug came to be tested in stroke victims, its early years in development by the pharmaceutical giant Genentech, and its eventual marginalization due to a convergence of unfavorable political, fiscal, and medical circumstances. For instance, initially many stroke specialists were unconvinced that the drug's benefits outweigh its risks (tPA was originally developed and is still used for cardiac patients). Moreover, neurologists called upon to assess stroke patients have not typically been trained to make decisions in emergency settings--and tPA must be given within a scant few hours after stroke. These and other factors have continued to delay the drug's universal acceptance as the most effective treatment available, and to hamper the general public's awareness that such a treatment exists--a troubling state of affairs that Zivin and Simmons argue must be rectified. Instilling the knowledge that anyone, at any time, is susceptible to stroke, from the old and infirm to the young and healthy, tPA for Stroke is a clarion call to awareness in a rapidly changing healthcare environment in which stroke, long a disease in thrall to resignation and pessimism, must be neglected no longer.

"Dr. Feldmar's book is jam-packed with interesting information. You will get a basic understanding of how and why we, and the people around us, behave the way we do. A must-have book for any personal library." - Louis Puglisi, MA "I found Dr. Feldmar's book to be very informative. He cuts through the professional jargon, and makes it easily understandable for the lay person. It is an invaluable reference book for every household." - Gabor Kovacs, MD, FACS "After reading Dr. Feldmar's book, I feel it should be mandatory reading for all parents. In a world of confusion about psychological labels, this book gives the reader a clear understanding of the problems and conditions we all face. For those of us dealing with people under stress at work or home, this book is a valuable tool." - Edward M. Portnoy, DMD "As a health care professional, I know it is important for patients and their families to become educated consumers in recognizing and dealing with abnormal psychological or psychiatric conditions. With the assistance of Dr. Feldmar's comprehensive and easy-to-read book, individuals will hopefully seek professional treatment sooner and be willing to partner with their health care providers to achieve a more successful outcome." - Roberta Kiel, RN, MPH