An Issue of Emergency Medicine Clinics of North A An Issue of Emergency Medicine Clinics of North A

Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 examines the challenges of delivering immuno-oncology therapies, focusing specifically on the multiple technologies of affective drug delivery strategies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses methods of targeting tumors, CRISPR technology, and vaccine delivery among many other delivery strategies. Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side.

"International Review of Research inDevelopmental Disabilities"is an ongoing scholarly look at research into the causes, effects, classification systems, syndromes, etc. of developmental disabilities. Contributors come from wide-ranging perspectives, including genetics, psychology, education, and other health and behavioral sciences. Volume43 of the series offers chapters on a variety of themes.
Provides the most recent scholarly research in the study of developmental disabilitiesA vast range of perspectives is offered, and many topics are covered An excellent resource for academic researchers"

Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and development of physiochemical characteristics such as aggregation, fragmentation, charge variants, identity, carbohydrate structure, and higher-order structure (HOS). This book dives deep into mAbs structure and the array of physiochemical testing and characterization methods that need to be developed and validated to establish a mAb as a therapeutic molecule. The main focus of this book is on physiochemical aspects, including the importance of establishing quality attributes such as glycosylation, primary sequence, purity, and HOS and elucidating the structure of new antibody formats by mass spectrometry. Each of the aforementioned quality attributes has been discussed in detail; this will help scientists in researching and developing biopharmaceuticals and biosimilars to find practical solutions to physicochemical testing and characterization.

"Principles of Clinical Pharmacology" is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science.

The Third Edition has been endorsed by the American Society for Clinical Pharmacology and Therapeutics

* Includes new chapters on imaging and the pharmacogenetic basis of adverse drug reactions. * Offers an expanded regulatory section that addresses US and international issues and guidelines. * Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers and also illustrates the impact of gender on drug response. * Presents a broadened discussion of clinical trials from Phase 1 to incorporate Phases II and III.

Evidence based or empirically supported psychotherapies are becoming more and more important in the mental health fields as the users and financers of psychotherapies want to choose those methods whose effectiveness are empirically shown. Cognitive-behavioral psychotherapies are shown to have empirical support in the treatment of a wide range of psychological/psychiatric problems. As a cognitive-behavioral mode of action, Problem Solving Therapy has been shown to be an effective psychotherapy approach in the treatment and/or rehabilitation of persons with depression, anxiety, suicide, schizophrenia, personality disorders, marital problems, cancer, diabetes-mellitus etc.

Mental health problems cause personal suffering and constitue a burden to the national health systems. Scientific evidence show that effective problem solving skills are an important source of resiliency and individuals with psychological problems exhibit a deficiency in effective problem solving skills. Problem solving therapy approach to the treatment and/or rehabilitation of emotional problems assumes that teaching effective problem solving skills in a therapeutic relationship increases resiliency and alleviates psychological problems.The book, in the first chapters, gives information on problem solving and the role of problem-solving in the etiology and the treatment of different forms of mental health problems. In the later chapters, it concentrates on psychotherapy, assessment and procedures of problem solving therapy. At the end it provides a case study.

This book integrates theory, research & practiceand provides a comprehensive appreciation of problem solving therapy.Itcontains empirical evidence and applied focus for problem solving therapy which provides a scientific base and best practices.The bookalso highlights the problem solving difficulties of persons with specific disorders and provides a better understanding of the relevance of problem solving therapy to a broad range of emotional problems. "

Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences brings together two very important fields in pharmaceutical sciences that have been mostly seen as diverging from each other: chemoinformatics and bioinformatics. As developing drugs is an expensive and lengthy process, technology can improve the cost, efficiency and speed at which new drugs can be discovered and tested. This book presents some of the growing advancements of technology in the field of drug development and how the computational approaches explained here can reduce the financial and experimental burden of the drug discovery process. This book will be useful to pharmaceutical science researchers and students who need basic knowledge of computational techniques relevant to their projects. Bioscientists, bioinformaticians, computational scientists, and other stakeholders from industry and academia will also find this book helpful.

* Helps the reader conceptualize interpersonal dynamics in the special education process, provide examples of effective oral communication, and describe essential meeting facilitation practices that collectively make facilitation a professional art * School psychologists from around the country share how they structure meetings, provide examples of language they use to communicate important educational and psychological concepts, and describe the persona they present to support the meeting process * Highlights meeting facilitation as a unique professional skillset and art, probing practitioners' experiences in the setting where school psychologists advocate for students, empower families, build consensus among team members, and make meaningful change for individuals they serve