In this issue of Physical Medicine and Rehabilitation Clinics, guest editor Dr. Ameet Nagpal brings his considerable expertise to the topic of Interventional Procedures Used to Treat Chronic Pain using an evidence-based perspective. Top experts in the field cover key topics such as epidural steroid injections, radiofrequency ablation in the spine, sympathetic blocks for sympathetic and visceral pain, spinal cord stimulation, and more. Contains 14 relevant, practice-oriented topics including peripheral joint radiofrequency ablation, peripheral nerve stimulation, novel technologies, trigger point injections, peripheral nerve injections, and more. Provides in-depth clinical reviews on interventional procedures for chronic pain, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Otolaryngologic Clinics, guest editors Drs. Joni K. Doherty and Michael Setzen bring their considerable expertise to the topic of Comprehensive Management of Headache for the Otolaryngologist. As many types of headache tend to masquerade as sinus headache, an understanding of the peripheral mechanisms of specific headache types is essential for otolaryngologists to effectively diagnose and treat patients, according to a study published in the American Journal of Otolaryngology. In this issue, top experts in the field address key issues such as novel devices for sinus headache, headache diagnosis in children and adolescents, headache and pregnancy, side-locked and nummular headaches, and much more. Contains 14 relevant, practice-oriented topics including the role of the otolaryngologist in the evaluation and management of headache; "Sinus headache:" rhinogenic headache, nonrhinogenic headache, or migraine; idiopathic intracranial hypertension; neuralgia and atypical facial, ear, and head pain; and more. Provides in-depth clinical reviews on comprehensive management of headache, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Advances in Structure and Activity Relationship of Coumarin Derivatives covers the structural behavior of various coumarin derivatives for various potential pharmaceutical applications. Based on substitution targeted for active sites, the book takes a rational approach for designing new and specific potent drugs, optimizing existing ones, and developing novel reactions. This focused primer describes the chemical structure and activity of coumarin derivatives to explore the effects of different substituents at specific positions, and their properties for effective bioactivity.

Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed.

The Pharmacological Potential of Cyanobacteria explores the bioactive compounds isolated from cyanobacteria and their relationship to human health and biotechnological applications. The book presents an overview of the chemistry and ecology of cyanobacteria, focusing on culture needs and techniques of biomass production. It is organized according to the different biological activities and biotechnological applications of compounds discovered in recent years. Besides biological activity, the mechanism of action of compounds is explained, along with molecular structure. Finally, compounds already used in therapeutics and biotechnology, as well as those in phases of approval or clinical trials are explored. Each chapter is written by a different research group with expertise in the field and publications in peer reviewed journals. Researchers and students in pharmaceutical academic research, pharmaceutical industrial sector personnel, health professionals, and nutritionists will find this book to be very useful.

In this issue of Immunology & Allergy Clinics, guest editor Dr. Elizabeth J. Phillips brings her considerable expertise to the topic of Drug Hypersensitivity. Top experts in the field cover key topics such as perioperative anaphylaxis; telemedicine in drug hypersensitivity; aspirin-exacerbated respiratory disease; pediatric drug allergy; and more. Contains 15 relevant, practice-oriented topics including excipient allergy; recognizing drug hypersensitivity in skin of color; allergy to radiocontrast dye; MRGRPX2 and its role in non-IgE-mediated mast cell activation; and more. Provides in-depth clinical reviews on drug hypersensitivity, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology. The series contains comprehensive reviews of the most current research in applied microbiology. Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome. Impact factor for 2013: 2.243

Case Studies in Nanotoxicology and Particle Toxicology presents a highly-illustrated analysis of the most prominent cases on the adverse effects of nanoparticles and their impact on humans and the environment. This comprehensive reference demonstrates the possible risks imposed by managing and handling nanoparticles, showing the effects of involuntary inhalation or ingestion during their use and after their incineration. Through the use of numerous examples, readers will discover the possible risks and effects of working with nanoparticles, along with best practices to prevent these effects. The text is an essential reference for anyone working in the risk assessment of nanoparticles, including nanosafety professionals, occupational toxicologists, regulatory toxicologists, and clinicians.

In this issue of Clinics in Geriatric Medicine, guest editor Dr. David Hunter brings his considerable expertise to the topic of Osteoarthritis. Top experts in the field cover key topics such as obesity and nutrition influences in osteoarthritis, the genesis of pain in osteoarthritis, overview of disease management, and more. Contains 14 relevant, practice-oriented topics including overview of disease management, concordance with guidelines, and strategies to increase implementation of best evidence; obesity and nutrition influences in osteoarthritis; pathogenesis of osteoarthritis; behavior change barriers and facilitators in people with osteoarthritis; suitable candidates and realistic expectations in surgery for osteoarthritis; and more. Provides in-depth clinical reviews on osteoarthritis, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This unprecedented work is an invaluable resource for therapists treating patients with obsessive-compulsive personality disorder (OCPD), for individuals suffering from OCPD, and for friends, family, and coworkers of those with OCPD. Although a significant number of individuals suffer from obsessive-compulsive personality disorder (OCPD), most of these people see themselves as being perfectly normal. In actuality, they are missing out in life due to their being compulsively prompt, counterproductively perfectionistic, and excessively penurious. This book explains what OCPD is, making it clear how it differs significantly from OCD; explains the thought processes and desires that give rise to the counterproductive defense mechanisms of OCPD; and identifies the approaches and methods that can allow such afflicted individuals to break through their character armoring and become rehumanized. In this book, Martin Kantor, MD, presents information to defuse the many manifested symptoms of OCPD: anxiety, indecision, unreasonable perfectionism, and difficulty in compromising. His explanations and methods will give the hopeless succor, move the stalled forward, and foster interpersonal cooperation and flexibility in the stubborn, while simultaneously enhancing the OCPD individual's social performance thus increasing his or her chances for interpersonal, relational, and occupational success. Kantor also identifies the social manifestations of OCPD and describes how to move idiosyncratic, rigid bureaucracies toward accomplishing what should be their most important mission: helping those who are in need and seeking comfort. Explains how OCPD compromises not only the quality of life of its sufferers but also the lives of many of the people that surround each OCPD individual Examines OCPD from multiple perspectives, documenting the author's eclectic treatment approach that views OCPD from multiple vantage points, including the psychodynamic, the interpersonal, and the cognitive-behavioral Extends the discussion of OCPD to include OCPD-inspired bureaucracies and how treating these toxic environments can lead to substantially improved socioeconomic functioning worldwide Serves therapists treating patients with OCPD; patients suffering from OCPD; friends, family, and coworkers of those with OCPD; and general readers interested in mental health issues Provides a bonus section on self-help methods that can be employed by the OCPD sufferer and those in the path of OCPD fallout