Managing Treatment-Resistant Depression: Road to Novel Therapeutics defines TRD for readers, discussing the clinical and epidemiological predictors, economic burden and neurobiological factors. In addition, staging methods for treatment resistance are fully covered in this book, including serotonin specific reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, other classes of antidepressants, including tricyclic antidepressants and monoamine oxidase inhibitors, augmentation strategies, and newer antidepressant treatments like ketamine and esketamine. In addition, evidence supporting the use of psychotherapies and neuromodulation strategies are also reviewed. Written by top experts in the field, this book is the first of its kind to review all methods of treatment for TRD.

Artificial Neural Network for Drug Design, Delivery and Disposition provides an in-depth look at the use of artificial neural networks (ANN) in pharmaceutical research. With its ability to learn and self-correct in a highly complex environment, this predictive tool has tremendous potential to help researchers more effectively design, develop, and deliver successful drugs. This book illustrates how to use ANN methodologies and models with the intent to treat diseases like breast cancer, cardiac disease, and more. It contains the latest cutting-edge research, an analysis of the benefits of ANN, and relevant industry examples. As such, this book is an essential resource for academic and industry researchers across the pharmaceutical and biomedical sciences.

Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology, containing comprehensive reviews of the most current research in applied microbiology. Users will find invaluable references and information on a variety of areas, including protozoan grazing of freshwater biofilms, metals in yeast fermentation processes, the interpretation of host-pathogen dialogue through microarrays, and the role of polyamines in bacterial growth and biofilm formation. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome.

How to Scale-Up a Wet Granulation End Point Scientifically provides a single-source devoted to all relevant information on the scale-up of a wet granulation end point. Contents include a general description, problem identification, and theoretical background with supporting literature, case studies, potential solutions, and more. By outlining issues related to scale-up and end-point determination, and then using practical examples and advice to address these issues, How to Scale-Up a Wet Granulation End Point Scientifically is a valuable and essential resource for all those pharmaceutical scientists and technologists engaged in the granulation process.

In this issue of Child and Adolescent Psychiatric Clinics, guest editors Drs. Lisa Fortuna, Cheryl S. Al-Mateen, Lisa M. Cullins, and W. David Lohr bring their considerable expertise to the topic of Systemic Racism and Disparate Mental Health Outcomes for Youth of Color. This issue represents a collaboration by American Academy of Child and Adolescent Psychiatry committee members and includes contributions by top experts in the field. It is an invaluable resource for practicing psychiatrists looking to address the unique needs and experiences of black and BIPOC youth in their practices. Contains 15 relevant, practice-oriented topics including the intersection of race and ethnicity with mental health service utilization in foster care youth; understanding systemic racism and racial inequity juvenile justice system involvement; racial disparities in the education system; suicide among minoritized and marginalized youth; trauma and youth of color; parenting and family-based care; and more. Provides in-depth clinical reviews on systemic racism and disparate mental health outcomes for youth of color, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Medicinal Plants as Anti-infectives: Current Knowledge and New Perspectives provides comprehensive and updated data on medicinal plants and plant-derived compounds used as antimicrobials in a range of locations (such as the Balkans, Colombia, India, Lebanon, Mali, Pakistan, Southeast Asia, South Africa, and West Africa). It also provides an overview on the most recent innovations and regulations in the field of drug discovery from ethnobotanical sources. This book will help readers to better appreciate the role of plants and phytomedicines as anti-infectives, to better assess the health benefits of plant-derived products, to help implement new methodologies for studying medicinal plants, and to guide future researchers in the field. Medicinal Plants as Anti-infectives: Current Knowledge and New Perspectives is a valuable resource for students, academic scientists, and researchers from the fields of ethnobotany, pharmacy, medicinal chemistry, and microbiology, as well as for professionals working in national or international health agencies, or in pharmaceutical industries.

In rural Mexico, people often say that Alzheimer's does not exist. ""People do not have Alzheimer's because they don't need to worry,"" said one Oaxacan, explaining that locals lack the stresses that people face ""over there"" - that is, in the modern world. Alzheimer's and related dementias carry a stigma. In contrast to the way elders are revered for remembering local traditions, dementia symbolizes how modern families have forgotten the communal values that bring them together. In Caring for the People of the Clouds, psychologist Jonathan Yahalom provides an emotionally evocative, story-rich analysis of family caregiving for Oaxacan elders living with dementia. Based on his extensive research in a Zapotec community, Yahalom presents the conflicted experience of providing care in a setting where illness is steeped in stigma and locals are concerned about social cohesion. Traditionally, the Zapotec, or ""people of the clouds,"" respected their elders and venerated their ancestors. Dementia reveals the difficulty of upholding those ideals today. Yahalom looks at how dementia is understood in a medically pluralist landscape, how it is treated in a setting marked by social tension, and how caregivers endure challenges among their families and the broader community. Yahalom argues that caregiving involves more than just a response to human dependency; it is central to regenerating local values and family relationships threatened by broader social change. In so doing, the author bridges concepts in mental health with theory from medical anthropology. Unique in its interdisciplinary approach, this book advances theory pertaining to cross-cultural psychology and develops anthropological insights about how aging, dementia, and caregiving disclose the intimacies of family life in Oaxaca.

This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route.

In September 2009, the format of the written Radiology FRCR Part 2A examinations changed. The previous negatively-marked true-false MCQs have become obsolete, replaced by 'single best answer' (SBA)questions, with candidates selecting 1 of 5 options, without negative marking. The author team have themselves recently successfully sat the FRCR exam, and have prior experience in the SBA format, making them ideally suited to write such a book, and have produced an excellent revision guide for the new format exam. There are 750 stem questions covering all 6 modules, including a separate section with a 75 questions-per-module 'mock' examination which readers can use to test themselves against the clock, under examination conditions, to hone their technique. The questions have been extensively researched and cross-checked, with relevant topics being drawn from major radiology textbooks, as well as current radiological journals such as Clinical Radiology and Radiographics. Answers are given with detailed explanations and references are provided, which can also be used for further reading as appropriate. As a bonus the authors pass on their own proven exam tips and techniques. Key Points - Authors recently sat exams themselves - Over 700 questions