Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) and allosteric modulation, presenting original research in the area and collectively providing a comprehensive description of key issues in GPCR allosteric modulation. The book provides background on core concepts of molecular pharmacology while also introducing the most important advances and studies in the area. It also discusses key methodologies. This is an essential book for researchers and advanced students engaged in pharmacology, toxicology and pharmaceutical sciences training and research. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signaling at a site apart from the endogenous ligand. Recent methodological and analytical advances have greatly improved our ability to understand the signaling mechanisms of GPCRs. We now know that allostery is a common regulatory mechanism for all GPCRs and not - as we once believed - unique to a few receptor subfamilies.

Cognitive enhancement offers a potential benefit to a variety of populations: neurologic and psychiatric disorders are associated with cognitive impairment, a growing population suffers from mild aging-related cognitive impairment, and those with normal functioning may desire improvement of intellectual performance.While there has been a substantial increase in research tools allowing for multiple-level analysis of cognition, building our knowledge of the molecular/cellular basis of cognitive function and offering the possibility technological development to enhance cognition, there is currently a gap in coverage in the research market. This volume addresses that gap, gathering multidisciplinary knowledge and providing tools for understanding the basics of cognitive enhancement and assistance in designing procedures/pharmacological approaches to further the use of novel cognitive enhancers. Separate sections are presented on enhancement drugs, environmental conditions and genetic factors, as well as on enhancement with regard to specific diseases. These topics are discussed in terms of both human and animal studies, and with regard to both healthy/young and aging/diseased individuals.
Offers readers coverage of the pharmacologic, environmental and genetic factors relevant to cognitive enhancementDiscusses cognitive enhancement from the perspective of both healthy and diseased or aging populationsTopics are discussed in terms of both human and animal studies"

This book addresses the need to view specific learning disorders (SLDs) within a mental health framework, as supported by their placement alongside autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). It describes how policy and practice point to a different perspective - specifically that SLDs are often treated as educational rather than psychological problems - and examines the implications of this dichotomy. The book reviews empirical research that suggests children need access to treatment for clinical components of SLDs that may respond to psychological intervention separately from, and in addition to, educational interventions. It provides a theoretical framework for organizing research findings and clinical perspectives that support understanding the clinical components of SLDs and addresses the need for a mental health framework within which to approach theory, treatment, and assessment of SLDs. Key areas of coverage include: Examining different theoretical orientations to learning disorders (e.g., cognitive, behavioral, neuropsychoeducational, psychoanalytic). Adapting evidence-based therapeutic techniques for use with children and adolescents who have learning disorders. The need for accurate and well characterized assessment of SLDs. How incorporating a cognitive neuroscience perspective into assessment can move LD treatment and research forward. Learning Disorders Across the Lifespan is an essential reference for clinicians, therapists, and other professionals as well as researchers, professors, and graduate students in school and clinical child psychology, special education, speech-language therapy, developmental psychology, pediatrics, social work as well as all interrelated disciplines.

This 2nd edition (of the original Successful Private Practice in Neuropsychology) provides an updated overview of key principles and processes for establishing, maintaining and developing neuropsychology practice and neuro-rehabilitation program (NRP) treatment in medical center and/or private practice settings. Essential elements of an entrepreneurial model that work well in the medical center context and the necessary role of variety and peer review in the private practice setting are also discussed.
How to gather and report NPE and other evaluation findings with a neuro- rehabilitation focus that lead to specific neuro-rehabilitation recommendations. Benefit this will make your evaluations and reports more desirable and sought after in the setting and community where you work.Updated billing/diagnostic code recommendations to accurately capture the actual time spent in evaluating and/or treating patients. Benefit increased appropriate billing and collections for your timeRecommendations for clinical neuropsychology postdoctoral fellowship training of a Navy psychologist. Benefit: you may be able to obtain funding for an experienced Navy clinical psychologist who wants formal training in neuropsychology. This can expand your clinical services, increase variety and quality of your training program and ultimately support improved care for returning American military personnel."

Neurosurgical procedures are becoming more common and are taking place in the operating room and in interventional suites. Procedures that used to be performed only at major academic institutions are also being done in small community hospitals, and anesthesiologists in private practice are being asked to care for these patients. In many cases, treatment options are controversial or rapidly evolving. Close cooperation between the anesthesiologist and neurosurgeon is essential to achieve optimal outcomes and early recognition of any adverse events so appropriate therapy can be implemented. Fundamentals of Neuroanesthesia is a comprehensive guide to neuroanesthesia that discusses neurophysiology, neuroanatomy, and neurosurgical procedures and offers practical approaches and solutions to administering neuroanesthesia and providing perioperative care for neurosurgical patients. Chapters emphasize clinical management of neurosurgical problems that may be encountered in community practice as well as major academic medical centers. Highlighted key points, figures, algorithms, and management procedures supplement the text. This book is a must-have volume for general anesthesiologists, anesthesiology fellows, and subspecialists.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

"The Sacred Cauldron is truly a book to be read by both therapists and non-therapists, for it offers a thoughtful, intelligent, sensitive passage through the spiritual quarrels and complexities of our time and addresses our common summons, which is to treat the life of the spirit with the respect, the gravity, and the centrality it deserves. This book is instructive to all, for Corbett not only marshals a wealth of scholarship and clinical experience, but also expresses challenging insights through a calm, reasonable, and commonsense appeal. After this book, the reader will be more thoughtful, more considered, more sophisticated, more appreciative of the importance of therapy as a vehicle for healing and for engaging the numinous." -James Hollis, Ph.D., Jungian analyst and author of What Matters Most: Living a More Considered Life At a time when psychotherapy seems to be a purely secular pursuit with no connection to the sacred, The Sacred Cauldron makes the startling claim that, for both participants, psychotherapeutic work is actually a spiritual discipline in its own right. The psyche manifests the sacred and provides the transpersonal field within which the work of therapy is carried out. This book demonstrates some of the ways in which a spiritual sensibility can inform the technical aspects of psychotherapy. Dr. Lionel Corbett trained in medicine and psychiatry in England and as a Jungian analyst at the C.G. Jung Institute of Chicago. He is currently on the core faculty of Pacifica Graduate Institute in Santa Barbara, California, and the author of The Religious Function of the Psyche and Psyche and the Sacred, as well as various professional articles. His main interest is in the religious function of the psyche and the ways in which this function expresses itself through the structures of personality.

Neuroscience has made considerable progress in figuring out how the brain works. We know much about the molecular-genetic and biochemical underpinnings of sensory and motor functions, and recent neuroimaging work has opened the door to investigating the neural underpinnings of higher-order cognitive functions, such as memory, attention, and even free will. In these types of investigations, researchers apply specific stimuli to induce neural activity in the brain and look for the function in question. However, there may be more to the brain and its neuronal states than the changes in activity we induce by applying particular external stimuli.
In Volume 1 of Unlocking the Brain, Georg Northoff presents his argument for how the brain must code the relationship between its resting state activity and stimulus-induced activity in order to enable and predispose mental states and consciousness. By presupposing such a basic sense of neural code, the author ventures into different territories and fields of current neuroscience, including a comprehensive exploration of the features of resting state activity as distinguishable from and stimulus-induced activity; sparse coding and predictive coding; and spatial and temporal features of the resting state itself. This yields a unique and novel picture of the brain, and will have a major and lasting impact on neuroscientists working in neuroscience, psychiatry, and related fields.

Neuroscience has made considerable progress in figuring out how the brain works. We know much about the molecular-genetic and biochemical underpinnings of sensory and motor functions. Recent neuroimaging work has opened the door to investigating the neural underpinnings of higher-order cognitive functions, such as memory, attention, and even free will. In these types of investigations, researchers apply specific stimuli to induce neural activity in the brain and look for the function in question. However, there may be more to the brain and its neuronal states than the changes in activity we induce by applying particular external stimuli. In Volume 2 of Unlocking the Brain, Georg Northoff addresses consciousness by hypothesizing about the relationship between particular neuronal mechanisms and the various phenomenal features of consciousness. Northoff puts consciousness in the context of the resting state of the brain thereby delivering a new point of view to the debate that permits very interesting insights into the nature of consciousness. Moreover, he describes and discusses detailed findings from different branches of neuroscience including single cell data, animal data, human imaging data, and psychiatric findings. This yields a unique and novel picture of the brain, and will have a major and lasting impact on neuroscientists working in neuroscience, psychiatry, and related fields.

This volume, Toxicology in Antiquity II, continues to tell the story of the roots of toxicology in ancient times. Readers learn that before scientific research methods were developed, toxicology thrived as a very practical discipline. Toxicologists are particularly proud of the rich and storied history of their field and there are few resources available that cover the discipline from a historical perspective. People living in ancient civilizations readily learned to distinguish safe from hazardous substances, how to avoid these hazardous substances and how to use them to inflict harm on enemies. Volume II explores the use of poison as weapons in war and assassinations, early instances of air pollution, the use of hallucinogens and entheogens, and the role of the snake in ancient toxicology.

Edited by Michael Hoyt, PhD and Moshe Talmon, PhD. Could a single therapy session be not only helpful but even sufficient for some people? Numerous clinical examples and the research evidence support a definite "Yes!" Drawing from multiple theoretical approaches and cultural contexts, this is the book to read if you want to learn ways to help people as soon as possible - maybe even in one visit. It teaches you to be present in each and every session and offers you various ways of empowering your clients in the here and now. It includes contributions from over twenty experts including Ernest Rossi, Steven Andreas, Dawson Church, Chris Iveson, Douglas Flemons, James Gustafson, Rubin Battino, Bradford Keeney, Jeffrey Young, Arnold Slive, Monte Bobele, Michele Ritterman, Moshe Talmon, Michael Hoyt Bob Rosenbaum and others.

The second edition of Forensic Toxicology: Principles and Concepts takes the reader back to the origins of forensic toxicology providing an overview of the largely unchanging principles of the discipline. The text focuses on the major tenets in forensic toxicology, including an introduction to the discipline, principles of forensic toxicology including pharmacokinetics, pharmacodynamics, drug interactions and toxicogenomics, fundamentals of forensic toxicology analysis, types of interpretations based on analytical forensic toxicology results, and reporting from the laboratory to the courtroom. Also included in the second edition is a Unit focused on the forensic toxicology of individual drugs of abuse.

Complementary and Integrative Therapies for Mental Health and Aging provides an up-to-date overview of integrative medicine that clinicians, researchers, and caregivers will require in order to address the major mental and physical disorders of aging. The chapters herein will increase clinicians' familiarity with the most recent research findings, and broaden their understanding of the use of these interventions in clinical practice. The discussion of the data is provided in easy-to-use format covering different fields of integrative medicine, and is written by an international group of leaders and researchers in their respective areas of expertise. This volume can be used for training by students of integrative medicine and gerontology, and individual chapters can be used as on-the-go references on a particular topic. Putting this work into a wider context, volume editors Helen Lavretsky, Martha Sajatovic, and Charles Reynolds III also provide a necessary framework for clinicians and public policy makers to understand the necessity of pursuing complementary, alternative, and integrative medicine for aging adults.

iPSC Derived Progenitors, Volume Thirteen in the Advances in Stem Cell Biology series is a timely collection of information and new discoveries in the field of stem cell biology. The book addresses the importance of induced pluripotent stems cells and how can they be differentiated into different progenitors. Progenitors cells are often the first-step to making more differentiating cell types. This volume addresses iPSCs derived from bone, dental pulp, craniofacial, neural stem cells, otic, cardiac, and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine, organ transplantation, and is contributed by world-renowned authors.