This book can enhance everyone's understanding of how women experience loss and grief, and how they transition to resolution. It is an invaluable resource to women and everyone who supports them-spouses, partners, and family members as well as community and government. Women's grief is often a complex phenomenon-a natural, normal experience, but one that can seriously impact everyone-female or male-at every stage of life. Understanding Loss and Grief for Women: A New Perspective on Their Pain and Healing provides a way to look at how women experience loss through the lens of their socially constructed roles, and in light of the theories and practice of grief therapy and support. The book begins by explaining the social construction of women's traditional, transitional, and modern/postmodern roles, and then addresses the social construction of grief theory and practice in past eras and modern society. Several case studies enable readers to see how social constructs shape women's responses to various causes of grief, such as the death of a spouse or partner, child, marriage (divorce), and career (retirement). The final section of the book examines the health impacts of grief, offers suggestions to ameliorate negative health impacts, and emphasizes how loss and grief for women can be used as opportunities for self-growth. This book serves all members of the general population as well as educators, academics, scientists, and students of disciplines such as psychology, psychotherapy, medicine, sociology, and women's studies. It will enable all women to better understand, deal with, and heal from their loss and grief experience. Male readers will empathize with what their spouses/partners, mothers, grandmothers, siblings, and friends are experiencing in loss and grief and understand how to support healthy transition through grief to resolution. The community at large and care providers will learn how to create a more nurturing and supportive environment for women's grief response. Explicates the socially constructed roles of women, in the past and in modern society, to illustrate what has been considered "appropriate" expression and response to loss and grief for women, and to enable a unique understanding the phenomenal loss experience for women Presents an invaluable framework, as a scaffolding, that allows readers to interrogate their own and others' experiences of loss in a novel, more in-depth way-one that supports improved practice in the helping professions Includes women's real-life stories that tell their truths of the loss experience and how grief worked through them in transitioning to resolution Provides seminal information to professional grief counselors, physicians, nurses, clinical psychologists, and psychiatric social workers, as well as students of psychology, sociology, medicine, public health, and women's studies Allows family members, friends, or partners to better understand what a woman who is experiencing loss and grief is feeling, and instructs how to support healthy transition through grief to resolution

Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a new era for Chagas Disease drug discovery? and imaging in drug development.

Diversity and Functions of GABA Receptors: A Tribute to Hanns Moehler, Part B, a new volume of Advances in Pharmacology, presents the diversity and functions of GABA Receptors. The volume looks at research performed in the past 20 years, which has revealed specific physiological and pharmacological functions of individual GABAA receptor subtypes, providing novel opportunities for drug development.

Poor clinical trial designs result in failed studies wasting research funds and limiting the advancement of cures for disorders. Clinical Trial Design Challenges in Mood Disorders outlines classic problems researchers face in designing clinical trials and discusses how best to address them for the most definitive and generalizable results. Traditional trial designs are included as well as novel analytic techniques. The book examines information on high placebo response, the generalizability of studies conducted in the developing world, the duration of maintenance studies, and the application of findings into clinical practice. With representation from contributors throughout the world and from academia, industry, regulatory agencies, and advocacy groups, this book will contribute toward improved clinical trial design and valid, precise, and reliable answers about what works better and faster for patients.

Sleep and Affect: Assessment, Theory, and Clinical Implications synthesizes affective neuroscience research as it relates to sleep psychology and medicine. Evidence is provided that normal sleep plays an emotional regulatory role in healthy humans. The book investigates interactions of sleep with both negative and positive emotions, along with their clinical implications. Sleep research is discussed from a neurobiological, cognitive, and behavioral approach. Sleep and emotions are explored across the spectrum of mental health from normal mood and sleep to the pathological extremes. The book, additionally, offers researchers a guide to methods and research design for studying sleep and affect. This book will be of use to sleep researchers, affective neuroscientists, and clinical psychologists in order to better understand the impact of emotion on sleep as well as the effect of sleep on physical and mental well-being.

This new volume of Advances in Pharmacology presents the diversity and functions of GABA Receptors. The volume looks at research performed in the past 20 years which has revealed specific physiological and pharmacological functions of individual GABAA receptor subtypes, providing novel opportunities for drug development.

In this issue of Physical Medicine and Rehabilitation Clinics, guest editor Dr. Ameet Nagpal brings his considerable expertise to the topic of Interventional Procedures Used to Treat Chronic Pain using an evidence-based perspective. Top experts in the field cover key topics such as epidural steroid injections, radiofrequency ablation in the spine, sympathetic blocks for sympathetic and visceral pain, spinal cord stimulation, and more. Contains 14 relevant, practice-oriented topics including peripheral joint radiofrequency ablation, peripheral nerve stimulation, novel technologies, trigger point injections, peripheral nerve injections, and more. Provides in-depth clinical reviews on interventional procedures for chronic pain, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This book explores a wide range of mindfulness and meditative practices and traditions across Buddhism. It deepens contemporary understanding of mindfulness by examining its relationship with key Buddhist teachings, such as the Four Noble Truths and the Noble Eight-Fold Path. In addition, the volume explores how traditional mindfulness can be more meaningfully incorporated into current psychological research and clinical practice with individuals and groups (e.g., through the Buddhist Psychological Model). Key topics featured in this volume include: Ethics and mindfulness in Pali Buddhism and their implications for secular mindfulness-based applications. Mindfulness of emptiness and the emptiness of mindfulness. Buddhist teachings that support the psychological principles in a mindfulness program. A practical contextualization and explanatory framework for mindfulness-based interventions. Mindfulness in an authentic, transformative, everyday Zen practice. Pristine mindfulness. Buddhist Foundations of Mindfulness is an indispensable resource for clinical psychologists, and affiliated medical and mental health professionals, including specialists in complementary and alternative medicine as well as social work as well as teachers of Buddhism and meditation.

Health is an often-overlooked issue in the touristic development of territories. However, the recent pandemic linked to Covid-19, by bringing the tourism sector to a halt, has revealed the importance of health issues for this economic sector. This book deals with the interaction between tourism and health in all its facets and offers a complete overview of the subject, the beginnings of which date back to Antiquity. The arguments presented here are based on a back-and-forth approach between tourism studies and health sciences. Various themes are thus addressed, such as health risks, health issues for travellers linked to tourism practices, medical tourism, health mobility and the global processes that accompany it, as well as the impact of tourism development on public health in destinations. A Back and Forth Between Tourism and Health highlights the need to include the health dimension in tourism planning and invites a paradigm shift in thinking about the tourism sector.

In ANOTHER WAY OF SEEING, Peter Gabel argues that our most fundamental spiritual need as human beings is the desire for authentic mutual recognition. Because we live in a world in which this desire is systematically denied due to the legacy of fear of the other that has been passed on from generation to generation, we exist as what he calls "withdrawn selves," perceiving the other as a threat rather than as the source of our completion as social beings. Calling for a new kind of "spiritual activism" that speaks to this universal interpersonal longing, Gabel shows how we can transform law, politics, public policy, and culture so as to build a new social movement through which we become more fully present to each other-creating a new "parallel universe" existing alongside our socially separated world and reaffirming the social bond that inherently unites us. "Peter Gabel is one of the grand prophetic voices in our day. He also is a long-distance runner in the struggle for justice. Don't miss this book " -Cornel West, The Class of 1943 Professor, Princeton University, and Professor of Philosophy and Christian Practice, Union Theological Seminary "Peter Gabel has delivered a set of unmatched phenomenological analyses of the profound alienation that pervades everyday life in America in the early 21st century. His insightful descriptions of the way things really are challenge us to open our eyes, minds and hearts to our own and one another's deepest longings, and together, to bring one another back home. ... Like a pick axe thrown ahead to anchor us all, to paraphrase one of his most evocative images, Gabel's polemic teaches and inspires us to 'think with our hearts, ' to genuinely and confidently love ourselves and our brothers and sisters on this very planet Earth, to lift ourselves and one another on the strength of our authentic Presence, and to move things forward together. Now." -Rhonda V. Magee, Professor of Law, University of San Francisco

Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) and allosteric modulation, presenting original research in the area and collectively providing a comprehensive description of key issues in GPCR allosteric modulation. The book provides background on core concepts of molecular pharmacology while also introducing the most important advances and studies in the area. It also discusses key methodologies. This is an essential book for researchers and advanced students engaged in pharmacology, toxicology and pharmaceutical sciences training and research. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signaling at a site apart from the endogenous ligand. Recent methodological and analytical advances have greatly improved our ability to understand the signaling mechanisms of GPCRs. We now know that allostery is a common regulatory mechanism for all GPCRs and not - as we once believed - unique to a few receptor subfamilies.

Cognitive enhancement offers a potential benefit to a variety of populations: neurologic and psychiatric disorders are associated with cognitive impairment, a growing population suffers from mild aging-related cognitive impairment, and those with normal functioning may desire improvement of intellectual performance.While there has been a substantial increase in research tools allowing for multiple-level analysis of cognition, building our knowledge of the molecular/cellular basis of cognitive function and offering the possibility technological development to enhance cognition, there is currently a gap in coverage in the research market. This volume addresses that gap, gathering multidisciplinary knowledge and providing tools for understanding the basics of cognitive enhancement and assistance in designing procedures/pharmacological approaches to further the use of novel cognitive enhancers. Separate sections are presented on enhancement drugs, environmental conditions and genetic factors, as well as on enhancement with regard to specific diseases. These topics are discussed in terms of both human and animal studies, and with regard to both healthy/young and aging/diseased individuals.
Offers readers coverage of the pharmacologic, environmental and genetic factors relevant to cognitive enhancementDiscusses cognitive enhancement from the perspective of both healthy and diseased or aging populationsTopics are discussed in terms of both human and animal studies"

This book addresses the need to view specific learning disorders (SLDs) within a mental health framework, as supported by their placement alongside autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). It describes how policy and practice point to a different perspective - specifically that SLDs are often treated as educational rather than psychological problems - and examines the implications of this dichotomy. The book reviews empirical research that suggests children need access to treatment for clinical components of SLDs that may respond to psychological intervention separately from, and in addition to, educational interventions. It provides a theoretical framework for organizing research findings and clinical perspectives that support understanding the clinical components of SLDs and addresses the need for a mental health framework within which to approach theory, treatment, and assessment of SLDs. Key areas of coverage include: Examining different theoretical orientations to learning disorders (e.g., cognitive, behavioral, neuropsychoeducational, psychoanalytic). Adapting evidence-based therapeutic techniques for use with children and adolescents who have learning disorders. The need for accurate and well characterized assessment of SLDs. How incorporating a cognitive neuroscience perspective into assessment can move LD treatment and research forward. Learning Disorders Across the Lifespan is an essential reference for clinicians, therapists, and other professionals as well as researchers, professors, and graduate students in school and clinical child psychology, special education, speech-language therapy, developmental psychology, pediatrics, social work as well as all interrelated disciplines.