This book offers a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various disorders. This book presents biomedical and anthropological data on the use of ayahuasca and provides critiques on how it is used for treating depression, PTSD, anxiety, substance dependence, and eating disorders. The volume also explores ayahuasca's role in the psychological well-being and quality of life of humans, and discusses possibilities of it enhancing cognition and coping with grief. The book examines ayahuasca's association with psychotherapy and also highlights the challenges of integrating plant medicines into psychiatry. Further, the book expands on some preliminary research with animals, suggesting that ayahuasca acts at multiple levels of neural complexity. The study on the neurogenic effects of ayahuasca alkaloids opens a new avenue of research with potential applications ranging from psychiatric disorders to brain damage and dementia. Psychologists, psychiatrists, and other mental health professionals will find this book relevant to their work regarding substance abuse and alternative medicine.

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. In this volume, invited experts provide authoritative reviews on various aspects of Monoamine Oxidase and its Inhibitors.
Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Flaviviruses are a diverse group of small RNA enveloped viruses, many of which are important human and animal pathogens. The best known include dengue virus, yellow fever virus, Japanese encephalitis virus, and West Nile virus. These viruses are endemic in many tropical and sub-tropical regions of the world. Dengue virus alone infects over 100 million people annually. In recent years, research on flaviviruses has progressed at a remarkable rate, leading to significant advances in our understanding of virus biology. This should ultimately lead to the development of better vaccine and antiviral strategies. This up-to-date and cutting-edge anthology contains contributions from the leading experts in the flavivirus field. Chapters are balanced by contributions from established investigators who have dedicated their careers to flavivirus research with those from newcomers who have recently made significant contributions to the flavivirus field. The book is divided into two sections: Molecular Virology and Virus Prevention. The first section on Molecular Virology covers: virion structure * virus replication * the NS1 glycoprotein * the NS3 protein * the NS5 protein * innate immunity and flavivirus infection * host responses to flavivirus infection * flavivirus fitness and transmission. The Virus Prevention section includes: vaccines * antibody therapy * small molecule antiviral development * flavivirus diagnostics * vector-virus interactions * vector control. The book represents an important update of flavivirus research and will serve as a reference to flavivirus researchers at the graduate level and beyond. It is a recommended text for all virology libraries.

Master the skills needed to perform basic radiography procedures! Written exclusively for limited radiography students, Radiography Essentials for Limited Practice, 6th Edition provides a fundamental knowledge of imaging principles, positioning, and procedures. Content reflects the most current practice, and incorporates all the subjects mandated by the American Society of Radiologic Technologists (ASRT) curriculum so you will be thoroughly prepared for the ARRT Limited Scope Exam. From radiologic imaging experts Bruce Long, Eugene Frank, and Ruth Ann Ehrlich, this book provides the right exposure to x-ray science, radiographic anatomy, technical exposure factors, and radiation protection, along with updated step-by-step instructions showing how to perform each projection. Concise coverage thoroughly prepares you for the ARRT Limited Scope Exam and clinical practice with the latest on x-ray science and techniques, radiation safety, radiographic anatomy, pathology, patient care, ancillary clinical skills, and positioning of the upper and lower extremities, spine, chest, and head. Expanded digital imaging concepts reflect today's practice and meet the requirements of the ASRT Limited Scope Content Specifications. Current information on state licensure and limited radiography terminology ensures that you understand exam requirements and the role of the limited practitioner. Step-by-step instructions provide guidance on how to position patients for radiographic procedures performed by limited operators. Math and radiologic physics concepts are simplified and presented at an easy-to-understand level. Bone Densitometry chapter provides the information you need to know to prepare for the ARRT exam and clinical practice. Learning objectives and key terms highlight important information in each chapter and can be used as review tools. Special boxes highlight information to reinforce important points in the text. NEW! Updated content reflects today's radiography for limited practice. NEW! Updated drawings, photos, and medical radiographs enhance your understanding of key concepts and illustrate current technology.

Applications of Nanobiotechnology for Neglected Tropical Diseases describes recent advances in nanobiotechnology that can be applied to reducing the global disease burden of neglected tropical diseases (NTDs). The book explores the application of nanotechnology on the development of safe, effective, and reliable tools to prevent, diagnose, and treat NTDs. Furthermore, Applications of Nanobiotechnology for Neglected Tropical Diseases includes multidisciplinary content, combining knowledge from biochemistry, medicinal chemistry, material sciences, pharmacology, and pharmaceutics. The book is divided into three main parts, each outlining one major type of approach: (1) nano-based approaches for prevention, (2) nano-diagnostics and detection, and (3) nanotherapeutics. Each part contains chapters that delve into the different applications of the type of approach being presented in that part. A discussion of other approaches against NTD follows these three parts. This book is remarkable in its ability to encompass and thoroughly explain the latest techniques in nanobiotechnology, from basic research to patient-oriented investigation.

Brucella Miletensis: Identification and Characterization of Potential Drug Targets presents a systematic approach to identifying and characterizing drug targets using bioinformatics. The book shows the potential of bioinformatic tools in the identification of virulence targets in pathogenic bacteria and viruses, in general, and in B. militensis 16M in particular. Chapters identify putative genes as potential drug targets, employ a subtractive genomic approach, consider the virulent genes of this bacteria that negatively affects humans, list twelve potential virulence genes as drug targets, and consider the screening of potential drugs against the bacteria's virulence genes through molecular modeling, computational screening, drug discovery and molecular docking studies. In addition, the book demonstrates in silico approaches that offer insights into the identification of drug targets in B.melitensis 16M. The title employs a step-by-step approach to understanding drug targets by identifying and characterizing vaccine targets for Brucella melitensis, in silico screening, and the identification of novel drug targets from the total Brucella melitensis proteome. Other sections cover computational modeling and evaluation of the best potential drug targets through comparative modeling, molecular docking, and dynamics simulations of novel drug targets and in silico validation and ADMET analysis for best lead molecules.

Progress in molecular and cellular biology has greatly enhanced our ability to accurately diagnose diseases that are caused by gene mutations, changes in genome structures, and altered gene expression; increased emphasis is now placed on translational research the clinical treatment of these genetically determined diseases. Seeking Cures outlines the progress and implications of science's quest to identify therapeutic targets and initiate novel treatments at the gene, RNA, protein, and physiological levels. Also considered are aspects of treatment at the cellular level (e.g., those with hematopoietic stem cells or induced pluripotent stem cells). Topics covered in this text include: * outline of the processes typical for identifying disease-modifying therapies * examples of newer therapeutic approaches in use or under investigation to treat lysosomal storage diseases, inborn errors of metabolism, mitochondrial functional defects, and specific monogenic diseases * therapeutic designs for specific complex common diseases, including Alzheimer's disease, cancer, and autism Through these specific examples, Seeking Cures provides a glimpse at the pursuit-and future-of personalized medicine.

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields. Chapter "Stationary and Non-Stationary Ion- and Water Flux Interactions in Kidney Proximal Tubule. Mathematical Analysis of Isosmotic Transport by a Minimalistic Model" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Tailor-Made Polysaccharides in Biomedical Applications provides extensive details on all the vital precepts, basics, and fundamental aspects of tailored polysaccharides in the pharmaceutical and biotechnological industries. This information provides readers with the foundation for understanding and developing high-quality products. The utilization of natural polymeric excipients in numerous healthcare applications demands the replacement of the synthetic polymers with natural polymers. Natural polymers are superior in terms of biocompatibility, biodegradability, economic extraction, and ready availability. Natural polymers are especially useful in that they are a renewable source of raw materials, as long as they are grown sustainably. Among these natural polymers, polysaccharides are considered as excellent excipients because they are nontoxic, stable, and biodegradable. Several research innovations have been carried out using polysaccharides in drug delivery applications. This book offers a comprehensive resource to understand the potential of these materials in forming new drug delivery methods. It will be useful to biomedical researchers, chemical engineers, regulatory scientists, and students who are actively involved in developing pharmaceutical products for biomedical applications by using tailor-made polysaccharides.

This issue of Radiologic Clinics of North America focuses on Imaging of the Mediastinum and is edited by Dr. Brett W. Carter. Articles will include: ITMIG Definition of Mediastinal Compartments; Imaging of the Anterior/Prevascular Mediastinum; Thymic Epithelial Neoplasms: Radiologic-Pathologic Correlation; Thymic Epithelial Neoplasms: TNM Staging; Added Value of MR Imaging in the Evaluation of Mediastinal Lesions; Imaging of the Middle/Visceral Mediastinum; Esophageal Cancer: Radiologic-Pathologic Correlation; Esophageal Cancer: TNM Staging; Cardiac Neoplasms: Radiologic-Pathologic Correlation; Potential Pitfalls in Imaging of the Mediastinum; Imaging-guided Biopsies and Interventions of Mediastinal Lesions; Imaging of the Posterior/Paravertebral Mediastinum; and more!

Guest edited by Dr. Justin Bishop, this issue of Surgical Pathology Clinics will cover several key areas of interest related to Head and Neck Pathology. This issue is one of four selected each year by our series Consulting Editor, Dr. Jason Hornick. Articles in this issue include but are not limited to: Intraductal Carcinomas of the Salivary Gland, Sclerosing polycystic adenoma,Basal Cell Adenoma and Basal Cell Adenocarcinoma, Sialadenoma papilliferum, Papillary Neoplasms of the Salivary Duct System: A review, Myoepithelial carcinoma, Lymphoepithelial carcinoma of salivary glands, Epithelial-myoepithelial carcinoma, Salivary Duct Carcinoma: An aggressive salivary gland carcinoma with morphological variants, newly identified molecular characteristics, and emerging treatment modalities, Polymorphous adenocarcinoma, Emerging Entities in Salivary Pathology: A Practical Review of Sclerosing Microcystic Adenocarcinoma, Microsecretory Adenocarcinoma, and Secretory Myoepithelial Carcinoma,Genomic analysis of salivary gland cancer and treatment of salivary gland cancers, and more.

This issue of the Atlas of the Oral and Maxillofacial Surgery Clinics of North America focuses on Orbital Surgery and is edited by Drs. Leander Dubois and A.G. (Eddy) Becking. Articles will include: Anatomy of the orbits; Orthoptic evaluation in orbital fractures; Standard preformed implants vs. patient specific implants; Implementation of an evidence-based clinical protocol for orbital fracture management; Ocular injury and emergencies around the globe; Secondary corrections of the orbit: Solitary fractures; Secondary corrections around the orbit: ZMC, NOE, panfacial; 3D virtual planning for orbital surgery; Orbital surgery navigation: The past, the present, and the future; Advanced concept of orbital reconstruction: Improving predictability of orbital reconstruction; Primary orbital fracture repair; Indications and timing of orbital surgery; and more!

COMPREHENSIVE PHARMACOLOGY for Clinical Dentistry is a unique collection of therapeutic drugs relevant to Dentistry. Salient features include: An "Introduction to pharmacology" that contains necessary information regarding General Pharmacology important for Dental students. A "Therapeutic Drugs Classification" that contains Classes of Drugs, which are important for Dental Students and Dental Practitioners. Special feature of 'Dental consideration' has been added at the end of most chapters so, that Dental Students must know how to deal with a patient using that particular Drug, during dental procedures in his office. And "Pharmacology in Dental Practice," contains information regarding Drugs that are directly used by Dentist in his office.