This new edition describes the role of heat shock proteins in the life cycle of malaria parasites, particularly in the context of intracellular parasite stages. Thoroughly revised, this work provides a general introduction to the structural and functional features of heat shock proteins with a special focus on their role as molecular chaperones in ensuring protein quality control. The emphasis is on the heat shock protein families from Plasmodium falciparum, and their role in proteostasis and the development of malaria pathology. Moreover, the authors explore the latest prospects of targeting heat shock proteins in antimalarial drug discovery either directly or in combination therapies. Readers will experience a functional analysis of the individual families of heat shock proteins and their cooperation in functional networks, including both the parasite-resident proteome and the exportome released into host cells during intracellular stages. Subcellular and extracellular organelles such as the apicoplast and the Maurer's Clefts associated with Plasmodium species are discussed in detail. The book highlights the role of heat shock proteins in the development and function of these structures. Biochemical expertise and the inclusion of novel therapeutic solutions make this collection a unique reference for experts in heat shock protein research, parasitology and infectious diseases, cell stress, molecular biology and drug discovery. Not least, advances in malaria control will contribute to ending epidemics and ensuring healthy lives in line with the UN Sustainable Development Goals.

Neuroscience has made considerable progress in figuring out how the brain works. We know much about the molecular-genetic and biochemical underpinnings of sensory and motor functions, and recent neuroimaging work has opened the door to investigating the neural underpinnings of higher-order cognitive functions, such as memory, attention, and even free will. In these types of investigations, researchers apply specific stimuli to induce neural activity in the brain and look for the function in question. However, there may be more to the brain and its neuronal states than the changes in activity we induce by applying particular external stimuli.
In Volume 1 of Unlocking the Brain, Georg Northoff presents his argument for how the brain must code the relationship between its resting state activity and stimulus-induced activity in order to enable and predispose mental states and consciousness. By presupposing such a basic sense of neural code, the author ventures into different territories and fields of current neuroscience, including a comprehensive exploration of the features of resting state activity as distinguishable from and stimulus-induced activity; sparse coding and predictive coding; and spatial and temporal features of the resting state itself. This yields a unique and novel picture of the brain, and will have a major and lasting impact on neuroscientists working in neuroscience, psychiatry, and related fields.

Complementary and Integrative Therapies for Mental Health and Aging provides an up-to-date overview of integrative medicine that clinicians, researchers, and caregivers will require in order to address the major mental and physical disorders of aging. The chapters herein will increase clinicians' familiarity with the most recent research findings, and broaden their understanding of the use of these interventions in clinical practice. The discussion of the data is provided in easy-to-use format covering different fields of integrative medicine, and is written by an international group of leaders and researchers in their respective areas of expertise. This volume can be used for training by students of integrative medicine and gerontology, and individual chapters can be used as on-the-go references on a particular topic. Putting this work into a wider context, volume editors Helen Lavretsky, Martha Sajatovic, and Charles Reynolds III also provide a necessary framework for clinicians and public policy makers to understand the necessity of pursuing complementary, alternative, and integrative medicine for aging adults.

Optimize diagnostic accuracy with Problem Solving in Pediatric Imaging, a new volume in the Problem Solving in Radiology series. This concise title offers quick, authoritative guidance from experienced radiologists who focus on the problematic conditions you're likely to see-and how to reach an accurate diagnosis in an efficient manner. Addresses the practical aspects of pediatric imaging-perfect for practitioners, fellows, and senior level residents who may or may not specialize in pediatric radiology, but need to use and understand it. Integrates problem-solving techniques throughout, addressing questions such as, "If I see this, what do I need to consider? What are my next steps?" Presents content in a highly useful, real-world manner, with sections on conventional radiography in the ED, NICU, PICU, and CICU; fluoroscopy; body imaging; and neuroradiology. Imaging findings are merged with clinical, anatomic, developmental, and molecular information to extract key diagnostic and therapeutic information. Contains a section on special topics with chapters on radiation safety and quality assurance. Features hundreds of high-quality color images and anatomic drawings that provide a clear picture of what to look for when interpreting studies. Illustrations conveying normal anatomy help you gain an in-depth perspective of each pathology. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Edited by Michael Hoyt, PhD and Moshe Talmon, PhD. Could a single therapy session be not only helpful but even sufficient for some people? Numerous clinical examples and the research evidence support a definite "Yes!" Drawing from multiple theoretical approaches and cultural contexts, this is the book to read if you want to learn ways to help people as soon as possible - maybe even in one visit. It teaches you to be present in each and every session and offers you various ways of empowering your clients in the here and now. It includes contributions from over twenty experts including Ernest Rossi, Steven Andreas, Dawson Church, Chris Iveson, Douglas Flemons, James Gustafson, Rubin Battino, Bradford Keeney, Jeffrey Young, Arnold Slive, Monte Bobele, Michele Ritterman, Moshe Talmon, Michael Hoyt Bob Rosenbaum and others.

This 2nd edition (of the original Successful Private Practice in Neuropsychology) provides an updated overview of key principles and processes for establishing, maintaining and developing neuropsychology practice and neuro-rehabilitation program (NRP) treatment in medical center and/or private practice settings. Essential elements of an entrepreneurial model that work well in the medical center context and the necessary role of variety and peer review in the private practice setting are also discussed.
How to gather and report NPE and other evaluation findings with a neuro- rehabilitation focus that lead to specific neuro-rehabilitation recommendations. Benefit this will make your evaluations and reports more desirable and sought after in the setting and community where you work.Updated billing/diagnostic code recommendations to accurately capture the actual time spent in evaluating and/or treating patients. Benefit increased appropriate billing and collections for your timeRecommendations for clinical neuropsychology postdoctoral fellowship training of a Navy psychologist. Benefit: you may be able to obtain funding for an experienced Navy clinical psychologist who wants formal training in neuropsychology. This can expand your clinical services, increase variety and quality of your training program and ultimately support improved care for returning American military personnel."

Neurosurgical procedures are becoming more common and are taking place in the operating room and in interventional suites. Procedures that used to be performed only at major academic institutions are also being done in small community hospitals, and anesthesiologists in private practice are being asked to care for these patients. In many cases, treatment options are controversial or rapidly evolving. Close cooperation between the anesthesiologist and neurosurgeon is essential to achieve optimal outcomes and early recognition of any adverse events so appropriate therapy can be implemented. Fundamentals of Neuroanesthesia is a comprehensive guide to neuroanesthesia that discusses neurophysiology, neuroanatomy, and neurosurgical procedures and offers practical approaches and solutions to administering neuroanesthesia and providing perioperative care for neurosurgical patients. Chapters emphasize clinical management of neurosurgical problems that may be encountered in community practice as well as major academic medical centers. Highlighted key points, figures, algorithms, and management procedures supplement the text. This book is a must-have volume for general anesthesiologists, anesthesiology fellows, and subspecialists.

What are the elements upon which a healthy personality is built? This fascinating book identifies the key components and shares vivid case studies that demonstrate what happens when those elements are missing. What is "normal" when it comes to human personality? And is it possible to achieve emotional health through intended effort, just like physical health? Clinical psychologist Camay Woodall, PhD, addresses these complex questions and many more in this work that cogently discusses the parameters of emotional health. This book covers historical concepts; examines personality at its formative stages and beyond; explains how "normal behavior" varies widely, yet emotional symptoms are definable; and pinpoints the common aspects of normality in human personality, such as the need for social connection, the struggle for realism, and the ability to come to terms with guilt. Covering topics that include anxiety; self-esteem; depression; food (and the abuses of it), sex, love, and intimacy; shame and guilt; and spirituality, this book identifies common sources of dysfunctional personality traits and stresses the importance of individual responsibility in each area. Each chapter is richly illustrated by actual case studies from the author's 30 years of experience. The book will be of interest and highly useful to undergraduate or graduate-level students of psychotherapy, individuals undergoing therapy, parents who are concerned about their own or their family's behavior, and general readers. Underscores the universal and key importance of healthy relationships in achieving emotional health and happiness Provides clear, accessible, and educational text that includes vignettes in each chapter to illustrate key points Identifies parallels between emotional health and subjective feelings of "happiness" and well-being Examines the root causes for common personality traits and behaviors such as aggression, eating disorders, guilt, intolerance, narcissism, and shame

This volume, Toxicology in Antiquity II, continues to tell the story of the roots of toxicology in ancient times. Readers learn that before scientific research methods were developed, toxicology thrived as a very practical discipline. Toxicologists are particularly proud of the rich and storied history of their field and there are few resources available that cover the discipline from a historical perspective. People living in ancient civilizations readily learned to distinguish safe from hazardous substances, how to avoid these hazardous substances and how to use them to inflict harm on enemies. Volume II explores the use of poison as weapons in war and assassinations, early instances of air pollution, the use of hallucinogens and entheogens, and the role of the snake in ancient toxicology.

Chitosan in Biomedical Applications provides a thorough insight into the complete chitosan chemistry, collection, chemical modifications, characterization and applications of chitosan in biomedical applications and healthcare fields. Chitosan, a biopolymer of natural origin, has been explored for its variety of applications in biomedical research, medical diagnostic aids and material science. It is the second most abundant natural biopolymer after cellulose, and considered as an excellent excipient because of its non-toxic, stable, biodegradable properties. Several research innovations have been made on applications of chitosan in biomedical applications. The book explores key topics, such as molecular weight, degree of deacetylation, and molecular geometry, along with an emphasis on recent advances in the field written by academic, industry, and clinical researchers. Chitosan in Biomedical Applications will be of interest to those in biomedical fields including the biomaterials and tissue engineering community investigating and developing biomaterials for biomedical applications, particularly graduate students, young faculty and others exploring chitosan-based materials.

This issue of Child and Adolescent Psychiatric Clinics, guest edited by Drs. Suzie Nelson, Jessica Jeffrey, Mark Borer, and Barry Sarvet, will focus on Collaborative Partnerships to Advance Practice within Child and Adolescent Psychiatry. This issue is one of four selected each year by our series Consulting Editor, Dr. Todd Peters. Topics discussed in this issue include but are not limited to: Formation of Partnerships; Ethical Imperative for Participation in Integrated Care Engaging our Primary Care Partners; The Role of Child Psychiatrist in Systems of Care; Interprofessional Education; Incorporating Pharmacists into Your Clinical Team; Collaboration with Schools and School Wellness Centers; Training Community Partners in Trauma-Informed Care; Rating Scales for Mental Health Screening System within Primary Care; Collaborating with Psychologists; Models of Practice for Advanced Practice Nurses. Provides in-depth, clinical reviews on collaborative partnerships, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Medical and technological organizations have recently developed therapy and assistance solutions that venture beyond what is considered conventional for individuals with various mental health conditions and behavioral disorders such as autism, Down syndrome, Alzheimer's disease, anxiety disorders, phobias, and learning difficulties. Through the use of virtual and augmented reality, researchers are working to provide alternative therapy methods to treat these conditions, while studying the long-term effects the treatment has on patients. Virtual and Augmented Reality in Mental Health Treatment provides innovative insights into the use and durability of virtual reality as a treatment for various behavioral and emotional disorders and health problems. The content within this publication represents the work of e-learning, digital psychology, and quality of care. It is designed for psychologists, psychiatrists, professionals, medical staff, educators, and researchers, and covers topics centered on medical and therapeutic applications of artificial intelligence and simulated environment.

In ANOTHER WAY OF SEEING, Peter Gabel argues that our most fundamental spiritual need as human beings is the desire for authentic mutual recognition. Because we live in a world in which this desire is systematically denied due to the legacy of fear of the other that has been passed on from generation to generation, we exist as what he calls "withdrawn selves," perceiving the other as a threat rather than as the source of our completion as social beings. Calling for a new kind of "spiritual activism" that speaks to this universal interpersonal longing, Gabel shows how we can transform law, politics, public policy, and culture so as to build a new social movement through which we become more fully present to each other-creating a new "parallel universe" existing alongside our socially separated world and reaffirming the social bond that inherently unites us. "Peter Gabel is one of the grand prophetic voices in our day. He also is a long-distance runner in the struggle for justice. Don't miss this book " -Cornel West, The Class of 1943 Professor, Princeton University, and Professor of Philosophy and Christian Practice, Union Theological Seminary "Peter Gabel has delivered a set of unmatched phenomenological analyses of the profound alienation that pervades everyday life in America in the early 21st century. His insightful descriptions of the way things really are challenge us to open our eyes, minds and hearts to our own and one another's deepest longings, and together, to bring one another back home. ... Like a pick axe thrown ahead to anchor us all, to paraphrase one of his most evocative images, Gabel's polemic teaches and inspires us to 'think with our hearts, ' to genuinely and confidently love ourselves and our brothers and sisters on this very planet Earth, to lift ourselves and one another on the strength of our authentic Presence, and to move things forward together. Now." -Rhonda V. Magee, Professor of Law, University of San Francisco

This book analyses the clinical interaction between depression and personality dysfunction to help clinicians better understand and treat patients with complex depression. It proposes an innovative perspective to clinical work that moves away from a disorder-centered approach to a person-centered approach by analysing complex depression through the lens of functional domains related to personality functioning and applying Research Domain Criteria to diagnosis and treatment planning. By doing so, it aims to contribute to the development of precision psychotherapy by applying the principles of precision medicine to mental health care. The book is divided in two parts. Chapters in the first part review problems in five domains of personality dysfunction that drive complex depressive presentations - identity, affect regulation, self-other regulation, social dysfunction and self-criticism - and the neurobiological findings underlying them. In the second part, authors present integrative models of depression and personality dysfunction and their implications for diagnosis and treatment. Depression and Personality Dysfunction: An Integrative Functional Domains Perspective is a scientific and clinical guide for the understanding and treatment of patients with depression complicated by personality dysfunction. It will be a useful tool for clinicians looking for resources to develop a more person-centered and evidence-based approach to mental health care.

Major depressive disorder is a common medical condition that can be disabling and can persist for months, even years. Many people experience depression symptoms that resist treatment. Although they try various combinations of medications, psychotherapy, or electroconvulsive therapy, their symptoms don't improve. What can people who have treatment-resistant depression do to overcome their depression and feel better? In Still Down, Dr. Dean F. MacKinnon, a psychiatrist at Johns Hopkins Medical School, presents nine composite stories drawn from patients he has seen in his twenty years as an expert in treatment-resistant mood disorders. The first section of the book features people diagnosed with depression who have not yet received appropriate treatment. The next section looks at misdiagnosis, focusing on people who feel and appear depressed but who have different mood disorders and need treatment for them. Finally, Dr. MacKinnon describes people who have severe depression that does not respond to any treatment, regardless of how finely tuned the treatment might be. These people, who suffer from true treatment-resistant depression (TRD), can benefit from a variety of treatments to feel better. Dr. MacKinnon provides commentary to explain and extend the discussion of the patients and situations in each case. He also discusses common obstacles to improvement, including overly conservative dosing, problems stemming from not adhering to treatment, antidepressant failure, and high sensitivity to side effects. By identifying aspects of the individual's qualities, behaviors, and experiences that may account for poor response to treatment, Still Down points the way for people with TRD and their families to find appropriate diagnoses and the best possible care.

Handbook on the Toxicology of Metals, Volume II: Specific Metals, Fifth Edition provides complete coverage of 38 individual metals and their compounds. This volume is the second volume of a two-volume work which emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, pharmacologists, and environmental scientists in the fields of environmental, occupational and public health.

This book provides detailed and updated knowledge about medically important 'Big Four' venomous snakes of India (Indian spectacled cobra, Indian common krait, Indian Russell's viper, and Indian saw-scaled viper). This book essentially covers the snakebite problem in the world with particular reference to Asia and India. It discusses the evolution and systematics of venomous snakes, emphasizing 'Big Four' venomous snakes of India; the evolution and composition of venoms determined by traditional biochemical and modern proteomic analyses. It also describes the pharmacological properties of enzymatic and non-enzymatic toxins of 'Big Four' venomous snakes of India. Different chapters discuss exciting topics such as species-specific and geographical differences in venom composition and its impact on pathophysiology and clinical manifestations of snakebite envenomation in India, biomedical application of Indian snake venom toxins; production and quality assessment of commercial antivenom, prevention, and treatment of snakebite in India, adverse effects of antivenom including strategies to combat antivenom reactions inpatient. This book caters to toxinologists, pharmacologists, zoologists, antivenom manufacturers, biochemists, clinicians, evolutionary biologists, herpetologists, and informed non-specialists interested to know about the Indian snake venoms.

In this issue of Hand Clinics, guest editors Frederic Schuind, Fabian Moungondo, and Luc Van Overstraeten bring their considerable expertise to the topic of The Use of Sonography in Hand/Upper Extremity Surgery. Top experts in the field cover key topics such as Flexor Tendons Sonography, Sonographic Diagnosis of Carpal Tunnel Syndrome, Atlas of Sonographic Anatomy of the Hand and Wrist, and more. Contains 9 relevant, practice-oriented topics including Nerve Ultrasound-Assisted Surgery for Neuropathic Pain and Joint Denervation; Preoperative Evaluation of Thenar Muscles in Carpal Tunnel Syndrome by Ultrasonograph; Shear Wave Ultrasound Elastography for Hand Soft Tissue Assessment; and more. Provides in-depth clinical reviews on the use of sonography in Hand/Upper Extremity Surgery, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.