In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

In this issue of Facial Plastic Surgery Clinics, guest editors J. David Kriet and Clinton D. Humphrey bring their considerable expertise to the topic of Modern Approaches to Facial and Athletic Injuries. Top experts in the field cover key topics such as nasal fractures, orbital fractures, zygomaticomaxillary fractures, mandibular body injuries, and more. Contains 12 relevant, practice-oriented topics including Soft Tissue Injuries Including Auricular Hematoma Management; Concussion in the Athlete and Return to Play Guidelines; General Overview of Facial Trauma Patient Evaluation; and more. Provides in-depth clinical reviews on modern approaches to facial and athletic injuries, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Oral and Maxillofacial Surgery Clinics, guest editor Harry Dym brings his considerable expertise to the topic of Clinical Pharmacology for the Oral and Maxillofacial Surgeon. Top experts in the field cover key topics such as a review of sedation agents, acute pain management, and more. Contains 17 relevant, practice-oriented topics including Emergency Drugs for the Oral and Maxillofacial Surgeon Office; Update on Medications for Oral Sedation in the Oral and Maxillofacial Surgery Office; Pharmacologic Treatment for Tempromandibular and TMJ Disorders; and more. Provides in-depth clinical reviews on Clinical Pharmacology for the Oral and Maxillofacial Surgeon, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

The collective trauma of the COVID-19 pandemic. Digital shaming. Violence against women. Sexual bullying. Racial slurs and injustice. These are just some of the problems faced by today’s young adults. Liberating Shakespeare explores how adaptations of Shakespeare’s plays can be used to empower young audiences by addressing issues of oppression, trauma and resistance. Showcasing a wide variety of approaches to understanding, adapting and teaching Shakespeare, this collection examines the significant number of Shakespeare adaptations targeting adolescent audiences in the past 25 years. It examines a wide variety of creative works made for and by young people that harness the power of Shakespeare to address some of the most pressing questions in contemporary culture – exploring themes of violence, race relations and intersectionality. The contributors to this volume consider whether the representations of characters and situations in YA Shakespeare can function as empowering models for students and how these works might be employed within educational settings. This collection argues that YA Shakespeare represents the diverse concerns of today’s youth and should be taken seriously as art that speaks to the complexities of a broken world, offering moments of hope for an uncertain future.

Despite its ubiquity, revenge is a surprisingly understudied subject. We're all familiar with the urge for payback, but where does that urge come from? Why is it so hard to give up? And why can some people only satisfy it through extreme and brutal acts? This book addresses these questions, and by developing the concept of radical revenge it gives some meaning to what might otherwise appear to be senseless acts of violence. The author explores some of the most egregious examples of radical revenge in contemporary society, including mass shootings, internet trolling, revenge porn, and contemporary populist politics. Drawing on psychoanalytic ideas about shame, envy and thin-skinned narcissism, she discusses why some people feel compelled to engage in these sorts of destructive acts of radical revenge. She looks too at examples such as the work of Artemisia Gentileschi and David Holthouse, to show that in exceptional cases, revenge can be an act of creativity rather than destruction.

Current Progress in iPSC Disease Modeling, Volume Fourteen in the Advances in Stem Cell Biology series, is a timely and expansive collection of information and new discoveries in the field. This new volume addresses advances in research on how induced pluripotent stem cells are used for the creation of new tissues and organs. The creation of iPSC technology allowed the development of disease-specific human pluripotent stem cells. These cells allow researchers to study questions once impossible for some human diseases. This volume addresses iPSCs for vascular tissue engineering, bioprinting, derived lung organoids for pulmonary disorders, skeletal muscle engineering, human kidney organoids, and more. It is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors in the field.

Myofascial pain is the most common pain; it is estimated that 60-70 per cent of all pain is of myofascial origin. There are many common diagnoses - such as sciatica, lumbago, tendinitis, arthrosis, bursitis, tennis elbow, and frozen shoulder - that have a myofascial origin. They are not life threatening, but they abate the quality of life and reduce functional capacity, creating stress and depression. They are also a big sanitary cost and cause for early retirement. There is a regrettable lack of knowledge surrounding myofascial pain and the existing possibilities to cure. With this manual, I try to spread my long experience in treating and curing these pains with my combination method. For the manual techniques, videos are included on the companion DVD to make the study easier.

"Toxicological Survey of African Medicinal Plants" provides a detailed overview of toxicological studies relating to traditionally used medicinal plants in Africa, with special emphasis on the methodologies and tools used for data collection and interpretation. The book considers the physical parameters of these plants and their effect upon various areas of the body and human health, including chapters dedicated to genotoxicity, hepatotoxicity, nephrotoxicity, cardiotoxicity, neurotoxicity, and specific organs and systems.

Following this discussion of the effects of medicinal plants is a critical review of the guidelines and methods in use for toxicological research as well as the state of toxicology studies in Africa. With up-to-date research provided by a team of experts, "Toxicological Survey of African Medicinal Plants" is an invaluable resource for researchers and students involved in pharmacology, toxicology, phytochemistry, medicine, pharmacognosy, and pharmaceutical biology.
Offersa critical review of the methods used in toxicological survey of medicinal plantsProvides up-to-date toxicological data on African medicinal plants and familiesServes as a resource tool for students and scientists in the various areas of toxicology"

"Toxicology in Antiquity" is the first in a series of short format works covering key accomplishments, scientists, and events in the broad field of toxicology, including environmental health and chemical safety. This first volume sets the tone for the series and starts at the very beginning, historically speaking, with a look at toxicology in ancient times. The book explains that before scientific research methods were developed, toxicology thrived as a very practical discipline. People living in ancient civilizations readily learned to distinguish safe substances from hazardous ones, how to avoid these hazardous substances, and how to use them to inflict harm on enemies.It also describes scholars who compiled compendia of toxic agents.
Provides the historical background for understanding modern toxicologyIllustrates the ways ancient civilizations learned to distinguish safe from hazardous substances, how to avoid the hazardous substances and how to use them against enemiesDetails scholars who compiled compendia of toxic agents"

Nanoparticle therapeutics: Production Technologies, Types of Nanoparticles, and Regulatory Aspects employs unique principles for applications in cell-based therapeutics, diagnostics and mechanistics for the study of organ physiology, disease etiology and drug screening of advanced nanoparticles and nanomaterials. The book focuses on the extrapolation of bioengineering tools in the domain of nanotechnology and nanoparticles therapeutics, fabrication, characterization and drug delivery aspects. It acquaints scientists and researchers on the experiential and experimental aspects of nanoparticles and nanotechnology to equip their rational application in various fields, especially in differential diagnoses and in the treatment of diverse diseased states. This complete resource provides a holistic understanding of the principle behind formation, characterization, applications, regulations and toxicity of nanoparticles employing myriad principles of nanotechnology. Investigators, pharmaceutical researchers, and advanced students working on technology advancement in the areas of designing targeted therapies, nanoscale imaging systems and diagnostic modalities in human diseases where nanoparticles can be used as a critical tool for technology advancement in drug delivery systems will find this book useful.

iPSC Derived Progenitors, Volume Thirteen in the Advances in Stem Cell Biology series is a timely collection of information and new discoveries in the field of stem cell biology. The book addresses the importance of induced pluripotent stems cells and how can they be differentiated into different progenitors. Progenitors cells are often the first-step to making more differentiating cell types. This volume addresses iPSCs derived from bone, dental pulp, craniofacial, neural stem cells, otic, cardiac, and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine, organ transplantation, and is contributed by world-renowned authors.

Our mind is one of the most extraordinary wonders of mankind! We use it to think critically and creatively, it stores our treasured memories, it helps us make friends and look after our loved ones, and it can transform our impossible dreams into reality.Sometimes we encounter glitches in our life's journey. The brain may not advance as fast as expected. This book delves into both the normal as well as the abnormal functioning of a child's mind. Topics covered include intelligence, creativity, consciousness, memory and normal development. It also gives practical advice on how to manage children's mental health and problems like ADHD, dyslexia, autism and depression.The book is timely because of the recent surge in interest of the human mind during the Covid-19 pandemic where there has been a dramatic worldwide increase in mental problems brought about by isolation, economic slowdown, unemployment, and loss of our loved ones.This book is suitable for everyone who is fascinated by the human mind.

Sampson Davis is best known as one of three friends from inner-city Newark who made a pact in high school to become doctors. Their book 'The Pact' and their work through the Three Doctors Foundation have inspired countless young men and women to strive for goals they otherwise would not have dreamed they could attain. In this book, Dr Davis looks at the healthcare crisis in the inner city from a rare perspective: as a doctor who works on the front line of emergency medical care in the community where he grew up, and as a member of that community who has faced the same challenges as the people he treats every day. He also offers invaluable practical advice for those living in such communities, where conditions like asthma, heart disease, stroke, obesity, and AIDS are disproportionately endemic.

The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.

This book discusses new candidates for rapid-acting antidepressants, such as (R)-ketamine, (2R,6R)-hydroxynorketamine, scopolamine, mGluR2/3 antagonists and AMPA receptor agonists. There are serious limitations to currently available antidepressants, such as delayed onset and low rates of efficacy. The discovery that a single dose of ketamine, an NMDAR antagonist, can produce rapid antidepressant effects that are sustained has led to new research in this area. In this volume, a variety of novel pharmaceutical treatments are examined. This volume would be useful to both researchers and clinicians who work in the field of pharmacology, specifically CNS drug treatments.

In this issue of Magnetic Resonance Imaging Clinics, Guest Editor Mai-Lan Ho brings considerable expertise to the topic of Pediatric Neuroimaging. Top experts in the field cover key topics such as Magnetoencephalography of the Pediatric Brain, Magnetic Resonance Fingerprinting of the Pediatric Brain, Fetal and Placental Imaging, Chemical Exchange Saturation Transfer (CEST) MRI, and more. Provides in-depth, clinical reviews on Pediatric Neuroimaging, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 14 relevant, practice-oriented topics including Proton and Multinuclear Spectroscopy of the Pediatric Brain; Task-Based and Resting-State BOLD fMRI in Children; 3D Modeling, and Advanced Visualization of the Pediatric Brain, Neck and Spine; Contrast Pediatric Brain Perfusion: Dynamic Susceptibility Contrast and Dynamic Contrast-Enhanced MRI; and more.