Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology. The series contains comprehensive reviews of the most current research in applied microbiology, and includes recent research on the roles of fungal communities in soil nutrient recycling, the microbial nitrogen cycle in soil, and the inter-kingdom associations between soil bacteria, fungi, and mycorrhizal fungi.

Volumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. This organizational structure meets the needs of the pharmaceutical community and allows for the development of a timely vehicle for publishing review materials on this topic. The scope of the Profiles series encompasses review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.

Pharmacological Mechanisms and the Modulation of Pain, the newest volume in the Advances in Pharmacology series, presents the pharmacological mechanisms and the modulation of pain. With a variety of chapters and the best authors in the field, this volume is an essential resource for pharmacologists, immunologists, and biochemists alike.

The Diverse Faces of Bacillus cereus elucidates all characteristics of this microorganism, from its environmental and ecologic relevance, to its veterinary involvement, its clinical settings, most common B. cereus associated food poisoning episodes, and the newest airway disease pictures mimicking the inhalation of anthrax. Due to its environmental distribution, B. cereus may cause serious, even fatal human diseases. The organism shows many diverse faces, as it is not only a veterinary pathogen, but also used as a biocontrol agent to control vegetable decay due to its natural antimicrobial properties. Once considered as a mere colonizer or contaminant, Bacillus cereus is nowadays acquiring increasing importance as an agent of nosocomial infections. The book's target audience is familiar with this opportunistic pathogen and will benefit from this clear compendium on the classical and molecular techniques and procedures that may be adopted or followed to correctly identify this intriguing multi-faceted microorganism.

Advances in technology permeates every aspect of life, including the healthcare system. Nanotechnology based systems have gained popularity based upon their promise, size, and other characteristics. Multifunctional Nanocarriers for Contemporary Healthcare Applications is a critical academic publication that explores advancements in nanostructured systems, applications of these systems in healthcare, and biomedical applications of these systems. Featuring coverage on a wide range of topics, such as hydrogels, controlled drug delivery systems, and nanomedicine, this book is geared toward researchers, students, and academicians seeking current research on advancements and applications of nanostructured systems in the healthcare industry.

Epi-Informatics: Discovery and Development of Small Molecule Epigenetic Drugs and Probes features multidisciplinary strategies with strong computational approaches that have led to the successful discovery and/or optimization of compounds that act as modulators of epigenetic targets. This book is intended for all those using or wanting to learn more about computational methodologies in epigenetic drug discovery, including molecular modelers, informaticians, pharmaceutical scientists, and medicinal chemists. With a better understanding of different molecular modeling and cheminformatic approaches, readers can incorporate these techniques into their own drug discovery projects that may involve chemical synthesis and medium- or high-throughput screening. In addition, this book highlights the significance of epigenetic targets to the public health for molecular modelers and chemoinformatians. The goal of this reference is to stimulate ongoing multidisciplinary research and to further improve current computational methodologies and workflows in order to accelerate the discovery and development of epi-drugs and epi-probes.

Managing Treatment-Resistant Depression: Road to Novel Therapeutics defines TRD for readers, discussing the clinical and epidemiological predictors, economic burden and neurobiological factors. In addition, staging methods for treatment resistance are fully covered in this book, including serotonin specific reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, other classes of antidepressants, including tricyclic antidepressants and monoamine oxidase inhibitors, augmentation strategies, and newer antidepressant treatments like ketamine and esketamine. In addition, evidence supporting the use of psychotherapies and neuromodulation strategies are also reviewed. Written by top experts in the field, this book is the first of its kind to review all methods of treatment for TRD.

Medicinal Plants as Anti-infectives: Current Knowledge and New Perspectives provides comprehensive and updated data on medicinal plants and plant-derived compounds used as antimicrobials in a range of locations (such as the Balkans, Colombia, India, Lebanon, Mali, Pakistan, Southeast Asia, South Africa, and West Africa). It also provides an overview on the most recent innovations and regulations in the field of drug discovery from ethnobotanical sources. This book will help readers to better appreciate the role of plants and phytomedicines as anti-infectives, to better assess the health benefits of plant-derived products, to help implement new methodologies for studying medicinal plants, and to guide future researchers in the field. Medicinal Plants as Anti-infectives: Current Knowledge and New Perspectives is a valuable resource for students, academic scientists, and researchers from the fields of ethnobotany, pharmacy, medicinal chemistry, and microbiology, as well as for professionals working in national or international health agencies, or in pharmaceutical industries.

In this issue of Dental Clinics, guest editors Drs. Behnam Bohluli, Shahrokh C. Bagheri, and Omid Keyhan bring their considerable expertise to the topic of Smile Design. An all-new topic to Dental Clinics, smile design offers patients a custom-tailored plan that reflects their unique needs and personal goals. In this issue, top experts cover everything from the basics of treatment planning to specific techniques and treatments, ending with a discussion from three masters of the craft. Contains 13 relevant, practice-oriented topics including smile analysis: diagnosis and treatment plan; the gummy smile diagnosis and classification; digital smile design dentistry; smile management: a discussion with the masters; and more. Provides in-depth clinical reviews on smile design, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Is Attention Deficit Hyperactivity Disorder (ADHD), the most prevalent neuropsychiatric label in childhood, a valid medical condition? Should we really refer to the millions of children diagnosed with ADHD as children who suffer from the 'diabetes of psychiatry' - a chronic and harmful biological condition that must be treated regularly with powerful psychoactive substances? Building on previous critiques, this thorough, elegant, and mainly courageous book answers these questions through a step-by-step rebuttal of the scientific consensus about ADHD and its first-line treatment with stimulant medications.While maintaining scientific rigor, this book is written in a clear, creative, and flowing way, using colorful examples - some funny, some tragic - which sweep the reader and inspire social change. The book integrates key critiques into one consolidated source, uncovers massive evidence against the efficacy and safety of stimulant medications, and offers principal solutions to this burning socio-educational problem. But most importantly, this book reviews dozens of reliability and validity gaps in the overriding biomedical consensus. It exposes multiple biases and non-parsimonious bandages (unjustified rationalizations) aimed at hiding the scientific holes of the consensus and it redefines ADHD as a non-pathological quality/mode-of-thought that has both weaknesses and strengths. In this way, the book serves as the missing needle required to pierce the over-blown theoretical balloon commonly known as ADHD.

Biophotonic diagnostics/biomedical spectroscopy can revolutionise the medical environment by providing a responsive and objective diagnostic environment. This book aims to explain the fundamentals of the physical techniques used combined with the particular requirements of analysing medical/clinical samples as a resource for any interested party. In addition, it will show the potential of this field for the future of medical science and act as a driver for translation across many different biological problems/questions.

Advances in Nanotechnology-Based Drug Delivery Systems covers the core concepts and latest research regarding the use of nanoscale materials for the development and application of drug delivery systems. The book introduces the reader to nanotechnology in drug delivery, covering the synthesis, encapsulation techniques, characterization and key properties of nanoscale drug delivery systems. Later chapters review the broad range of target applications, including site-specific delivery of drugs for cardiovascular disease, cancer, bacterial infection, bone regeneration. and much more. This book helps translate advanced research into a clinical setting, analyzing the toxicity and health and safety challenges associated with utilizing nanotechnology in biomedicine. This will be a useful reference for those interested in nano-sized drug delivery in biomedicine, including academics and researchers in materials science, biomedical engineering, pharmaceutical science and related disciplines.

Emotions, Technology, and Health examines how healthcare consumers interact with health technology, how this technology mediates interpersonal interactions, and the effectiveness of technology in gathering health-related information in various situations. The first section discusses the use of technology to monitor patients' emotional responses to illness and its treatment, as well as the role of technology in meeting the fundamental human need for information. Section Two describes the use of technology in mediating emotions within and between individuals, and addresses the implications for the design and use of devices that gather behavioral health data and contribute to healthcare interventions. The final section assesses different situations in which technology is a key component of the health intervention-such as tablet use in educating elementary school students with social skills difficulty, physical activity monitoring for children at risk for obesity, and teleconferencing for older adults at risk of social isolation.

In September 2009, the format of the written Radiology FRCR Part 2A examinations changed. The previous negatively-marked true-false MCQs have become obsolete, replaced by 'single best answer' (SBA)questions, with candidates selecting 1 of 5 options, without negative marking. The author team have themselves recently successfully sat the FRCR exam, and have prior experience in the SBA format, making them ideally suited to write such a book, and have produced an excellent revision guide for the new format exam. There are 750 stem questions covering all 6 modules, including a separate section with a 75 questions-per-module 'mock' examination which readers can use to test themselves against the clock, under examination conditions, to hone their technique. The questions have been extensively researched and cross-checked, with relevant topics being drawn from major radiology textbooks, as well as current radiological journals such as Clinical Radiology and Radiographics. Answers are given with detailed explanations and references are provided, which can also be used for further reading as appropriate. As a bonus the authors pass on their own proven exam tips and techniques. Key Points - Authors recently sat exams themselves - Over 700 questions