What should a Navy SEAL do when faced with evidence that representatives of the U.S. Government are secretly buying old Soviet tactical nuclear weapoons for purposes other than disarmament? In this thriller, Andy Carlson responds by throwing a monkey wrench into the deal and by resigning from the Navy. Hoping to settle down on his family's Virginia farm and resume his career as an emergency physician, Andy instead finds himself and those he loves the targets of his own governement and a Russian arms dealer. Although a capable warrior and field surgeon, Andy is disallusioned with his country and unprepared for the female operative sent to ensnare him. He's a binge drinker, never comfortable around women when he's sober and scarred by personal losses. Andy's antebellum plantation is a major player in the action, with its network of limestone caves, family treasures, historical surprises, and natural defenses. Andy enlists three unlikely allies in his defense--a pregnant CIA agent, a male descendant of a former slave on the Carlson plantation who shares a common ancestor with Andy, and a teenage Saudi girl. Some of the secrets of the plantation have never been discused in polite company. Some have heretofore been unspeakable. There were good reasons why the Indians, the British, and the Yankees had lost on this same ground in previous battles. But the Carlsons knew who their enemies were in those fights. And tactical nuclear weapons had never been in Farmville before.

How We Became Human: A Challenge to Psychoanalysis tackles the question of what distinguishes human beings from other animals. By interweaving psychoanalysis, biology, physics, anthropology, and philosophy, Julio Moreno advances a novel thesis: human beings are faulty animals in their understanding of the world around them. This quality renders humans capable of connecting with inconsistencies, those events or phenomena that their logic cannot understand. The ability to go beyond consistency is humans' distinctive trait. It is the source of their creativity and of their ability to modify the environment they inhabit. On the basis of this connective-associative interplay, Moreno proposes a new approach to the links human beings create amongst themselves and with the world around them. This theory focuses on a key question: What is the difference between human beings and the other animals? From this perspective, Moreno seeks to reformulate many of the classic psychoanalytic, psychological, and anthropological postulates on childhood, links, and psychic change.

This book offers a comprehensive overview of Alexander disease, a rare and devastating neurological disorder that often affects the white matter of the brain and spinal cord. Its distinctive neuropathology consists of abundant Rosenthal fibers within astrocytes (one of the four major cell types of the central nervous system). Nearly all cases are caused by variants in the gene encoding the intermediate filament protein GFAP, but how these changes in GFAP lead to the widespread manifestations of disease is poorly understood. Astrocytes, while discovered over a century ago, are themselves still much of a mystery. They exhibit considerable diversity, defy precise definition, and yet actively regulate many aspects of nervous system functioning. We also have incomplete understanding of Rosenthal fibers, odd structures that contain GFAP as just one of many components. Whether they are toxic or protective is unknown. Moreover, Rosenthal fibers are not absolutely unique to Alexander disease, and are seen sporadically in a wide variety of other conditions, including brain tumors and multiple sclerosis. GFAP is the third unknown. It is an ancient protein, arising early in the evolution of vertebrates, but its role in normal biology is still a matter of debate. Yet Alexander disease shows, without a doubt, that changing just a single of its 432 amino acids can lead to catastrophe, not just in the astrocytes where GFAP is produced but also in the other cells with which astrocytes interact. Despite all of the unknowns, much has been learned in the past 20 years, and it is time to share this knowledge. This book is intended for recently diagnosed patients and families, as well as non-specialist researchers interested in this neurological disease. It covers historical origins, the state of current knowledge, and prospects for what lies ahead, with citations to the primary literature given throughout.

A great deal of interest has been generated recently in the isolation, characterization, and biological activity of phytochemicals. Phytochemicals have the potential to enhance pharmaceuticals and drug discovery. As such, there is an urgent need for current research in the global scope of phytochemicals including the chemical and physical characteristics, analytical procedures, biological activity, safety, and industrial applications. The Handbook of Research on Advanced Phytochemicals and Plant-Based Drug Discovery examines the applications of bioactive molecules from a health perspective, examining the pharmacological aspects of medicinal plants, the phytochemical and biological activities of different natural products, and ethnobotany and medicinal properties. Moreover, it presents a novel dietary approach for human disease management. Covering topics such as computer-aided drug design, government regulation, and medicinal plant taxonomy, this major reference work is beneficial to pharmacists, medical practitioners, phytologists, hospital administrators, government officials, faculty and students of higher education, librarians, researchers, and academicians.

The rapid urbanization and industrialization of developing countries across the globe have necessitated for substantial resource utilization and development in the areas of Healthcare, Environment, and Renewable energy. In this context ,this resourceful book serves as a definitive source of information for the recent developments in application of microbial enzymes in various sectors. It covers applications in fermentation processes and their products, extraction and utilisation of enzymes from various sources and their application in health and biomass conversion for production of value added products. Different chapters discuss various areas of bioprospecting in enzyme technology, and describe why these are the mainstays for industrial production of value added products. The rich compilation of the cutting-edge advances and applications of the modern industrial based techniques hold feasible solutions for a range of current issues in enzyme technology. This book will be of particular interest for scientists, academicians, technical resource persons, engineers and members of industry. Undergraduate and graduate students pursuing courses in the area of industrial biotechnology will find the information in the book valuable. General readers having interest towards biofuels, enzyme technology, fermented food and value added products, phytochemicals and phytopharmaceutical products will also find the book appealing. Readers will discover modern concepts of enzymatic bioprocess technology for production of therapeutics and industrial value added products.

"Taenia solium" cysticercosis is a parasitic disease caused by the dissemination of the larval form of the pork tapeworm and affects an estimated 50 million people worldwide. It is endemic in several developing countries, including many in Central and South America, Africa and South Asia. Through increased immigration and international travel, it is also of emerging significance in developed countries such as the USA. This book, written by international leading experts in the field, covers the basic science and clinical aspects of "Taenia solium," its pathology, investigational aspects of neurocysticercosis, therapy and prevention

Regular physical exercise is associated with substantial health benefits. Recent evidence not only holds for cardiovascular effects promoting "physical health," but also for the central nervous system believed to promote "brain health." Moderate physical exercise has been found to improve learning, memory, and attentional processing, with recent research indicating that neuroprotective mechanisms and associated plasticity in brain structure and function also benefit. Physical exercise is also known to induce a range of acute or sustained psychophysiological effects, among these mood elevation, stress reduction, anxiolysis, and hypoalgesia. Today, modern functional neuroimaging techniques afford direct measurement of the acute and chronic relation of physical exercise on the human brain, as well as the correlation of the derived physiological in vivo signals with behavioral outcomes recorded during and after exercise. A wide range of imaging techniques have been applied to human exercise research, ranging from electroencephalography (EEG), magnetoencephalography (MEG), near infrared spectroscopy (NIRS), magnetic resonance imaging (MRI) to positron emission tomography (PET). All of these imaging methods provide distinct information, and they differ considerably in terms of spatial and temporal resolution, availability, cost, and associated risks. However, from a "multimodal imaging" perspective, neuroimaging provides an unprecedented potential to unravel the neurobiology of human exercise, covering a wide spectrum ranging from structural plasticity in gray and white matter, network dynamics, global and regional perfusion, evoked neuronal responses to the quantification of neurotransmitter release. The aim of this book is to provide the current state of the human neuroimaging literature in the emerging field of the neurobiological exercise sciences and to outline future applications and directions of research.

Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a new era for Chagas Disease drug discovery? and imaging in drug development.

COMPREHENSIVE PHARMACOLOGY for Clinical Dentistry is a unique collection of therapeutic drugs relevant to Dentistry. Salient features include: An "Introduction to pharmacology" that contains necessary information regarding General Pharmacology important for Dental students. A "Therapeutic Drugs Classification" that contains Classes of Drugs, which are important for Dental Students and Dental Practitioners. Special feature of 'Dental consideration' has been added at the end of most chapters so, that Dental Students must know how to deal with a patient using that particular Drug, during dental procedures in his office. And "Pharmacology in Dental Practice," contains information regarding Drugs that are directly used by Dentist in his office.

Internationally-recognized pain expert Don Goldenberg helps readers better understand the intricacies of chronic pain through the lens of personal stories, including his own. One out of three Americans lives with chronic pain. Pain is the number one reason we seek medical care and accounts for 40% of doctor visits. Chronic pain is the most common cause of work loss world-wide. The yearly cost of chronic pain in the United States is between $560-$630 billion, higher than that of heart disease, diabetes and cancer combined. Despite this, physicians and the public are woefully ill-informed about chronic pain. The litany of self-help books available to the public are largely misleading, quick-fix, junk-science. Although there is a major push to better inform primary health-care providers on chronic pain, they have been provided no authoritative treatment of the subject. The Pain Epidemic provides the latest medical information and pathways to better understanding and treatment of chronic pain. Dr. Don Goldenberg, an internationally known expert on pain, here discusses such hot topics as the opioid epidemic, mind/body interactions in chronic pain, and gender bias, as well as the role of cannabis and new potential pain treatment. Interested readers will come away with not only a better understanding of the pain epidemic but of pain itself.

This research volume examines the available alternative, complementary, pharmaceutical and vaccine methods for treating, mitigating, or preventing COVID-19. Coverage includes traditional Chinese medicine, herbal remedies, nutraceutical/dietary options, and drug/vaccine therapies. All the methods discussed will be critically examined to provide readers with a full, unbiased overview that includes pros/cons of each method. While the nature of COVID-19 is still being studied, and new research and theories are being published daily, this book endeavors to provide readers with a comprehensive summary of current research on alternative and mainstream treatment and prevention methods.