This book discusses new candidates for rapid-acting antidepressants, such as (R)-ketamine, (2R,6R)-hydroxynorketamine, scopolamine, mGluR2/3 antagonists and AMPA receptor agonists. There are serious limitations to currently available antidepressants, such as delayed onset and low rates of efficacy. The discovery that a single dose of ketamine, an NMDAR antagonist, can produce rapid antidepressant effects that are sustained has led to new research in this area. In this volume, a variety of novel pharmaceutical treatments are examined. This volume would be useful to both researchers and clinicians who work in the field of pharmacology, specifically CNS drug treatments.

In this issue of Magnetic Resonance Imaging Clinics, Guest Editor Mai-Lan Ho brings considerable expertise to the topic of Pediatric Neuroimaging. Top experts in the field cover key topics such as Magnetoencephalography of the Pediatric Brain, Magnetic Resonance Fingerprinting of the Pediatric Brain, Fetal and Placental Imaging, Chemical Exchange Saturation Transfer (CEST) MRI, and more. Provides in-depth, clinical reviews on Pediatric Neuroimaging, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 14 relevant, practice-oriented topics including Proton and Multinuclear Spectroscopy of the Pediatric Brain; Task-Based and Resting-State BOLD fMRI in Children; 3D Modeling, and Advanced Visualization of the Pediatric Brain, Neck and Spine; Contrast Pediatric Brain Perfusion: Dynamic Susceptibility Contrast and Dynamic Contrast-Enhanced MRI; and more.

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Advances in Anesthesia reviews the year's most important questions in anesthesiology. A distinguished editorial board identifies key areas of major progress and controversy and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in anesthesiology bring concepts to a clinical level and explore their everyday impact on patient care. Provides in-depth, clinical reviews in anesthesiology, providing actionable insights for clinical practice. Presents the latest information in the field under the leadership of an experienced editorial team; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Major depressive disorder is a common medical condition that can be disabling and can persist for months, even years. Many people experience depression symptoms that resist treatment. Although they try various combinations of medications, psychotherapy, or electroconvulsive therapy, their symptoms don't improve. What can people who have treatment-resistant depression do to overcome their depression and feel better? In Still Down, Dr. Dean F. MacKinnon, a psychiatrist at Johns Hopkins Medical School, presents nine composite stories drawn from patients he has seen in his twenty years as an expert in treatment-resistant mood disorders. The first section of the book features people diagnosed with depression who have not yet received appropriate treatment. The next section looks at misdiagnosis, focusing on people who feel and appear depressed but who have different mood disorders and need treatment for them. Finally, Dr. MacKinnon describes people who have severe depression that does not respond to any treatment, regardless of how finely tuned the treatment might be. These people, who suffer from true treatment-resistant depression (TRD), can benefit from a variety of treatments to feel better. Dr. MacKinnon provides commentary to explain and extend the discussion of the patients and situations in each case. He also discusses common obstacles to improvement, including overly conservative dosing, problems stemming from not adhering to treatment, antidepressant failure, and high sensitivity to side effects. By identifying aspects of the individual's qualities, behaviors, and experiences that may account for poor response to treatment, Still Down points the way for people with TRD and their families to find appropriate diagnoses and the best possible care.

"Integrative Anatomy and Pathophysiology in Traditional Chinese Medicine Cardiology" covers the structure, function, and pathology of the cardiovascular system from the TCM and western medical perspectives. It focuses specifically on western medicine anatomy and pathophysiology, along with TCM aspects of essence, qi, blood and body fluid concepts, production, and function to explain cardiovascular system dysfunction, its independent role and dependent interactions with the functions of other organ systems.

This book is designed for US-based licensed TCM practitioners as well as cardiology researchers.
Compares and contrasts the TCM basic theories and western medicine basic sciencesGives a specific connection between the heart dysfunction and the disease mechanisms of other organ systems using TCM and western medicine terms and diagnosesPrepares the practitioner to sit for the Niambi Wellness Integrative Anatomy and pathophysiology in cardiology final online exam

Chitosan in Drug Delivery provides thorough insights into chitosan chemistry, collection, chemical modifications, characterization and applications in the pharmaceutical industry and healthcare fields. The book explores molecular weight, degree of deacetylation and molecular geometry, emphasizing recent advances in the field as written by academic, industry and regulatory scientists. It will be a useful resource for pharmaceutical scientists, including industrial pharmacists, analytical scientists, postgraduate students, health care professionals and regulatory scientists actively involved in pharmaceutical product and process development in natural polymers containing drug delivery.

This issue of Critical Care Clinics, guest edited by Drs. Michael Matthay and Kathleen Dori Lui, focuses on Acute Respiratory Distress Syndrome. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: Epidemiology, Environmental Factors, Clinical Diagnosis, Physiology of ARDS, including COVID-19, Pathogenesis Based on Clinical Studies, Genetics of ARDS, Ventilator Management and Rescue Therapy with ECMO, Acute Kidney Injury and ARDS, Pharmacologic Therapies and ARDS and Long Term Outcomes from ARDS. Provides in-depth, clinical reviews on ARDS, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

"Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases" is the second volume in the series, "Pharmaceutical Leads from Medicinal Plants." This book includes key pharmacological and chemical evidence to support the selection of promising pre-clinical candidates for the treatment of neurodegenerative diseases.

This important addition to the natural product and drug discovery literature contains the history, synonyms, medicinal uses, phytopharmacology, pre-clinical potential, and rationale for each plant selected. By providing critical evaluation of pharmacological data, mechanisms of action, and structural requirements for the development of future neuroprotective agents, this comprehensive reference is a beneficial resource for industry and academic scientists whose research focuses on neurodegenerative drug discovery and development.
Incorporates compelling biological activity data and preclinical structure-activity relationships to help you choose promising lead molecules for further research Includes primary source references to the most recent natural product discoveries in the field of neuroprotection in order to promote new drug discovery in this areaContains detailed discussions of important neurodegenerative diseases, including Alzheimer's disease and Parkinson's diseaseEach plant section includes a critical evaluation of pharmacological, chemical, and toxicological evidence to support the use of the compound in drug discovery research in neurodegeneration

Travel health nursing has evolved as a distinct and increasingly complex specialty over the past three decades, and in 2020, ANA officially recognized travel health nursing as a nursing specialty for the first time. This first edition of ANA and ATHNA's Travel Health Nursing: Scope and Standards of Practice is an important professional resource for nurses who strive to advance the well-being of all domestic and international travellers, and the communities to which they travel and return. Travel health nurses are specially educated and trained to promote the health and safety of travellers through comprehensive risk analysis, assessment, immunizations, health education, and therapeutic interventions. Nurses in this specialty provide services in three different clinical encounters: pre-travel, during travel ("in-transit"), and post-travel in a variety of settings that include college health, occupational health, public health, the military, primary care, and nurse-managed travel health clinics, among others.

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Herbal Biomolecules in Healthcare Applications presents extensive detailed information on all the vital principles, basics and fundamental aspects of multiple herbal biomolecules in the healthcare industry. This book examines important herbal biomolecules including alkaloids, glycosides, flavonoids, anthraquinones, steroids, polysaccharides, tannins and polyphenolic compounds, terpenes, fats and waxes, proteins and peptides, and vitamins. These herbal biomacromolecules are responsible for different bioactivities as well as pharmacological potentials. A systematic understanding of the extraction, purification, characterization, applications of these herbal biomolecules and their derivatives in healthcare fields is developed in this comprehensive book. Chapters explore the key topics along with an emphasis on recent research and developments in healthcare fields by leading experts. They include updated literature review of the relevant key topics, good quality illustrations, chemical structures, flow charts, well-organized tables and case studies. Herbal Biomolecules in Healthcare Applications will be useful for researchers working on natural products and biomolecules with bioactivity and nutraceutical properties. Professionals specializing in scientific areas such as biochemistry, pharmacology, analytical chemistry, organic chemistry, clinics, or engineering focused on bioactive natural products will find this book useful.

There is a growing literature in neuroethics dealing with cognitive neuro-enhancement for healthy adults. However, discussions on this topic tend to focus on abstract theoretical positions while concrete policy proposals and detailed models are scarce. Furthermore, discussions appear to rely solely on data from the US or UK, while international perspectives are mostly non-existent. This volume fills this gap and addresses issues on cognitive enhancement comprehensively in three important ways: 1) it examines the conceptual implications stemming from competing points of view about the nature and goals of enhancement; 2) it addresses the ethical, social, and legal implications of neuroenhancement from an international and global perspective including contributions from scholars in Africa, Asia, Australia, Europe, North America, and South America; and 3) it discusses and analyzes concrete legal issues and policy options tailored to specific contexts.

* Helps the reader conceptualize interpersonal dynamics in the special education process, provide examples of effective oral communication, and describe essential meeting facilitation practices that collectively make facilitation a professional art * School psychologists from around the country share how they structure meetings, provide examples of language they use to communicate important educational and psychological concepts, and describe the persona they present to support the meeting process * Highlights meeting facilitation as a unique professional skillset and art, probing practitioners' experiences in the setting where school psychologists advocate for students, empower families, build consensus among team members, and make meaningful change for individuals they serve