An Issue of Emergency Medicine Clinics of North A An Issue of Emergency Medicine Clinics of North A

This issue of Child and Adolescent Psychiatric Clinics, guest edited by Drs. Gabrielle A. Carlson and Manpreet Kaur Singh, is Part II of a two-part issue covering Emotion Dysregulation in Children. This issue is one of four selected each year by our series Consulting Editor, Dr. Todd Peters. Topics discussed in this issue include but are not limited to: Explosive Outbursts at School; Treatment of Childhood Emotional Dysregulation During Inpatient and Residential Interventions; Psychopharmacology of Treating Explosive Behavior; Treating explosive irritability in pediatric bipolar disorders; Evidence Base for Psychosocial Interventions for the Treatment of Emotion Dysregulation in Children and Adolescents; Preventing Irritability and Temper Outbursts in Youth by Building Resilience; Psychoeducational Treatments for Mood Dysregulation; A Modular, Transdiagnostic Approach to Treating Severe Irritability in Children and Adolescents; Longitudinal Outcome of Chronic Irritability; and the future of irritability in children, among others.

This issue of Dental Clinics focuses on Radiographic Interpretation for the Dentist and is edited by Dr. Mel Mupparapu. Articles will include: Fundamentals of Radiographic Interpretation for the Dentist; Radiology of Dental Caries; Radiographic Diagnosis of Periodontal Disease; Radiology in Endodontics; Imaging in Oral & Maxillofacial Surgery; Radiographic Interpretation in Oral Medicine and Hospital Dental Practice; Intraoral Scanning, Digital Dental Casts, Face Scans, and Cone Beam CT Integration for the Virtual Patient; Pathologic and Physiologic Calcifications of the Head and Neck Significant to the Dentist; Radiographic Diagnosis of Systemic Diseases Manifested in Jaws; Imaging in Prosthodontic Practice; Imaging in Orthodontics; Radiographic Diagnosis in the Pediatric Dental Patient; and more!

Phytochemical Profiling of Commercially Important South African Plants comprises a carefully selected group of plant species that are of interest to researchers and industry partners who would like to investigate the commercialization of plant species. The book presents 25 botanicals selected based on commercial relevance. For each of the species, the following topics are covered: botanical description and distribution, phytochemistry (including chemical structures), HPTLC fingerprint analysis, UPLC analysis, and GC analysis (the latter only in the case of essential oil-bearing species). Using standard methodology, high-level chromatographic fingerprints have been developed for better understanding. Different methods are succinctly summarized allowing for the rapid identification of botanical raw materials and formulated consumer products. This book will be extremely valuable to researchers in the field who wish to rapidly identify the constituents and for those who want to prepare formulations of plant material for commercial applications. This work will also be a valuable resource in the field of pharmacognosy.

"International Review of Research inDevelopmental Disabilities"is an ongoing scholarly look at research into the causes, effects, classification systems, syndromes, etc. of developmental disabilities. Contributors come from wide-ranging perspectives, including genetics, psychology, education, and other health and behavioral sciences. Volume43 of the series offers chapters on a variety of themes.
Provides the most recent scholarly research in the study of developmental disabilitiesA vast range of perspectives is offered, and many topics are covered An excellent resource for academic researchers"

Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and development of physiochemical characteristics such as aggregation, fragmentation, charge variants, identity, carbohydrate structure, and higher-order structure (HOS). This book dives deep into mAbs structure and the array of physiochemical testing and characterization methods that need to be developed and validated to establish a mAb as a therapeutic molecule. The main focus of this book is on physiochemical aspects, including the importance of establishing quality attributes such as glycosylation, primary sequence, purity, and HOS and elucidating the structure of new antibody formats by mass spectrometry. Each of the aforementioned quality attributes has been discussed in detail; this will help scientists in researching and developing biopharmaceuticals and biosimilars to find practical solutions to physicochemical testing and characterization.

This book explains how studies in brain development and epigenetics-the inextricable interplay of genes and environments-have led to breakthroughs in the understanding of children's psychological disturbances and serve to discredit the scientifically unsupported "chemical imbalance theory" of mental illness. Intended for mental health practitioners, concerned parents, and child advocates alike, this book presents a powerful new paradigm for understanding the causes of children's psychological disturbances-and as a result, the proper treatment of these symptoms. Based in cutting-edge research on the developing brain and epigenetics, this important volume serves to inform readers about the latest scientific conclusions and clinical practices that need to supplant pervasive and often dangerous drug prescriptions to millions of children. Sharna Olfman, PhD, and contributors including leading researchers, clinicians, and childhood advocates present their research findings and explain the implications for treatment of a range of symptoms, including autism spectrum disorders, attention deficit hyperactivity disorder (ADHD), concussion syndromes, and mood disorders. The book definitively lays to rest the "chemical imbalance theory" of mental illness, a theory that has been roundly discredited by the scientific community but kept alive by the pharmaceutical industry. Chapters focus on the real science of epigenetics and the sensitivity of the developing brain to environmental influences such as trauma and chemical toxins-legitimate research findings that are largely ignored by mental health practitioners and rarely influence practice. Presents a new paradigm for understanding the cause and treatment of children's psychological disturbances based in cutting edge research on the developing brain and epigenetics Addresses the latest groundbreaking research on the treatment of concussion syndromes as well as on the cause and treatment of autism spectrum disorders Offers strategies that promote healthy brain development and protect against childhood psychological disturbances Explains how 21st-century parents' excessive use of cell phones and other mobile devices undermines the quality of attachment and places children at risk for compromised brain development and psychological disturbance

"Principles of Clinical Pharmacology" is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science.

The Third Edition has been endorsed by the American Society for Clinical Pharmacology and Therapeutics

* Includes new chapters on imaging and the pharmacogenetic basis of adverse drug reactions. * Offers an expanded regulatory section that addresses US and international issues and guidelines. * Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers and also illustrates the impact of gender on drug response. * Presents a broadened discussion of clinical trials from Phase 1 to incorporate Phases II and III.

Evidence based or empirically supported psychotherapies are becoming more and more important in the mental health fields as the users and financers of psychotherapies want to choose those methods whose effectiveness are empirically shown. Cognitive-behavioral psychotherapies are shown to have empirical support in the treatment of a wide range of psychological/psychiatric problems. As a cognitive-behavioral mode of action, Problem Solving Therapy has been shown to be an effective psychotherapy approach in the treatment and/or rehabilitation of persons with depression, anxiety, suicide, schizophrenia, personality disorders, marital problems, cancer, diabetes-mellitus etc.

Mental health problems cause personal suffering and constitue a burden to the national health systems. Scientific evidence show that effective problem solving skills are an important source of resiliency and individuals with psychological problems exhibit a deficiency in effective problem solving skills. Problem solving therapy approach to the treatment and/or rehabilitation of emotional problems assumes that teaching effective problem solving skills in a therapeutic relationship increases resiliency and alleviates psychological problems.The book, in the first chapters, gives information on problem solving and the role of problem-solving in the etiology and the treatment of different forms of mental health problems. In the later chapters, it concentrates on psychotherapy, assessment and procedures of problem solving therapy. At the end it provides a case study.

This book integrates theory, research & practiceand provides a comprehensive appreciation of problem solving therapy.Itcontains empirical evidence and applied focus for problem solving therapy which provides a scientific base and best practices.The bookalso highlights the problem solving difficulties of persons with specific disorders and provides a better understanding of the relevance of problem solving therapy to a broad range of emotional problems. "

Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences brings together two very important fields in pharmaceutical sciences that have been mostly seen as diverging from each other: chemoinformatics and bioinformatics. As developing drugs is an expensive and lengthy process, technology can improve the cost, efficiency and speed at which new drugs can be discovered and tested. This book presents some of the growing advancements of technology in the field of drug development and how the computational approaches explained here can reduce the financial and experimental burden of the drug discovery process. This book will be useful to pharmaceutical science researchers and students who need basic knowledge of computational techniques relevant to their projects. Bioscientists, bioinformaticians, computational scientists, and other stakeholders from industry and academia will also find this book helpful.

This issue of Neuroimaging Clinics focuses on Evidence-Based Vascular Neuroimaging and is edited by Drs. Ajay Malhotra and Dheeraj Gandhi. Articles will include: Unruptured Intracranial Aneurysms: Duration, Frequency and Modality Used for Surveillance; Vasospasm: Role of Imaging in Detection and Monitoring Treatment; Extracranial Vascular Disease: Carotid Stenosis and Plaque Imaging; Subarachnoid Hemorrhage: Distribution and Role of Imaging; Acute Ischemic Stroke: MRI-based Paradigms; Imaging of Intracranial Hemorrhage (Non-subarachnoid Hemorrhage); Brain Arteriovenous Malformations: The Role of Imaging in Treatment Planning and Monitoring Response; Intracranial Vascular Disease and Vessel Wall Imaging; Acute Ischemic Stroke: CT/CTA/CTP and Their Role; Imaging for Treated Aneurysms (including clipping, coiling, stents, flow-diverters); and more!