This book recognizes Mexico's effects and challenges in a natural disaster and offers empirical risk-reduction methods in critical cases. The proposals considered here include real and detailed analysis, a set of models, frameworks, strategies, and findings in the three stages of the disaster (before-during-after). This book: describes the methodology to find secure locations for the Regional Humanitarian Response Depot; offers recommendations for the sites and creation of an Export Logistics Cluster; shows how to use available technology and information to locate volunteers in the right spots describes mathematical models to help to allocate procedure of resources for restoring the affected community and proposes actions to create resilience in the country's main economic sectors, including agriculture and industry. The processes applied at recent disasters such as the 19S earthquake and their results are used as case studies, identifying possibilities for further improvement. The book also describes new trends for Mexico due to climate change and makes suggestions for mitigating future disasters. The proposals are also replicable to other highly populated societies with similar socio-economic structures. Finally, this book is the basis for generating more innovative recommendations by researchers, graduate students, academics, professionals, and practitioners to obtain better planning and better collaboration between all the humanitarian chain actors. This book intends to be of interest as a fundamental tool for decision-makers, governments, non-governmental organizations, and enterprises.

Biopharmaceutics and Pharmacokinetics Considerations examines the history of biopharmaceutics and pharmacokinetics. The book provides a biopharmaceutics and pharmacokinetics approach to addressing issues in formulation development and ethical considerations in handling animals. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biopharmaceutics and pharmacokinetics within drug discovery and drug development. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to study the chemical and physical properties of drugs and the biological effects they produce.

In the early twenty-first century, trauma is seemingly everywhere, whether as experience, diagnosis, concept, or buzzword. Yet even as many scholars consider trauma to be constitutive of psychological modernity or the post-Enlightenment human condition, historical research on the topic has overwhelmingly focused on cases, such as World War I or the Holocaust, in which Western experiences and actors are foregrounded. There remains an urgent need to incorporate the methods and insights of recent historical trauma research into a truly global perspective. The chapters in Traumatic Pasts in Asia make just such an intervention, extending Euro-American paradigms of traumatic experience to new sites of world-historical suffering and, in the process, exploring how these new domains of research inform and enrich earlier scholarship.

In the United States alone, burns are the third leading cause of death among children 0 to 14 years of age. In addition, each year greater than 125,000 children suffer serious burn injuries, with a disturbing percentage of those through abuse. Yet the number of specialized burn centers in the U.S. is not near enough to be in proximity or even accessible to the majority of these patients. The situation is even worse in most other regions of the world. Therefore, it is critical that the information in this book reaches as many caregivers as possible because treatment of burn injuries has undergone dramatic changes over time in every area, from surgical procedures to respiratory and fluid resuscitation and even nourishment and metabolic support. The ability to recognize and react appropriately to pediatric injury can greatly affect the outcome and prognosis, up to and including the patient's future quality of life. It is in this context that this comprehensive guide for the diagnosis, treatment and follow up of the burned child from Time Zero through Long-term Rehabilitation was put together. This book is essential for the medical professional involved in attaining the most positive outcome possible for their patients and their families.

Extensively revised and updated, the new edition of this valuable reference work provides a comprehensive and up-to-date analysis of the current knowledge and new research in Bacillus molecular and cellular biology.

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer.

"International Review of Research inDevelopmental Disabilities"is an ongoing scholarly look at research into the causes, effects, classification systems, syndromes, etc. of developmental disabilities. Contributors come from wide-ranging perspectives, including genetics, psychology, education, and other health and behavioral sciences. Volume43 of the series offers chapters on a variety of themes.
Provides the most recent scholarly research in the study of developmental disabilitiesA vast range of perspectives is offered, and many topics are covered An excellent resource for academic researchers"

Spirituality, Theology and Mental Health provides reflections from leading international scholars and practitioners in theology, anthropology, philosophy and psychiatry as to the nature of spirituality and its relevance to constructions of mental disorder and mental healthcare. Key issues are explored in depth, including the nature of spirituality and recent debates concerning its importance in contemporary psychiatric practice, relationship between demons and wellbeing in ancient religious texts and contemporary practice, religious conversion, and the nature and importance of myth and theology in shaping human self understanding. These are used as a basis for exploring some of the overarching intellectual and practical issues that arise when different disciplines engage together with an attempt to better understand the relationship between spirituality and mental health and translate their findings into mental healthcare practice.

This book explains how studies in brain development and epigenetics-the inextricable interplay of genes and environments-have led to breakthroughs in the understanding of children's psychological disturbances and serve to discredit the scientifically unsupported "chemical imbalance theory" of mental illness. Intended for mental health practitioners, concerned parents, and child advocates alike, this book presents a powerful new paradigm for understanding the causes of children's psychological disturbances-and as a result, the proper treatment of these symptoms. Based in cutting-edge research on the developing brain and epigenetics, this important volume serves to inform readers about the latest scientific conclusions and clinical practices that need to supplant pervasive and often dangerous drug prescriptions to millions of children. Sharna Olfman, PhD, and contributors including leading researchers, clinicians, and childhood advocates present their research findings and explain the implications for treatment of a range of symptoms, including autism spectrum disorders, attention deficit hyperactivity disorder (ADHD), concussion syndromes, and mood disorders. The book definitively lays to rest the "chemical imbalance theory" of mental illness, a theory that has been roundly discredited by the scientific community but kept alive by the pharmaceutical industry. Chapters focus on the real science of epigenetics and the sensitivity of the developing brain to environmental influences such as trauma and chemical toxins-legitimate research findings that are largely ignored by mental health practitioners and rarely influence practice. Presents a new paradigm for understanding the cause and treatment of children's psychological disturbances based in cutting edge research on the developing brain and epigenetics Addresses the latest groundbreaking research on the treatment of concussion syndromes as well as on the cause and treatment of autism spectrum disorders Offers strategies that promote healthy brain development and protect against childhood psychological disturbances Explains how 21st-century parents' excessive use of cell phones and other mobile devices undermines the quality of attachment and places children at risk for compromised brain development and psychological disturbance

"Principles of Clinical Pharmacology" is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science.

The Third Edition has been endorsed by the American Society for Clinical Pharmacology and Therapeutics

* Includes new chapters on imaging and the pharmacogenetic basis of adverse drug reactions. * Offers an expanded regulatory section that addresses US and international issues and guidelines. * Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers and also illustrates the impact of gender on drug response. * Presents a broadened discussion of clinical trials from Phase 1 to incorporate Phases II and III.

This title highlights the current and topical areas of research in this rapidly growing field. Expert authors from around the world provide the latest insights into the mechanisms these fascinating organisms use to survive.

Evidence based or empirically supported psychotherapies are becoming more and more important in the mental health fields as the users and financers of psychotherapies want to choose those methods whose effectiveness are empirically shown. Cognitive-behavioral psychotherapies are shown to have empirical support in the treatment of a wide range of psychological/psychiatric problems. As a cognitive-behavioral mode of action, Problem Solving Therapy has been shown to be an effective psychotherapy approach in the treatment and/or rehabilitation of persons with depression, anxiety, suicide, schizophrenia, personality disorders, marital problems, cancer, diabetes-mellitus etc.

Mental health problems cause personal suffering and constitue a burden to the national health systems. Scientific evidence show that effective problem solving skills are an important source of resiliency and individuals with psychological problems exhibit a deficiency in effective problem solving skills. Problem solving therapy approach to the treatment and/or rehabilitation of emotional problems assumes that teaching effective problem solving skills in a therapeutic relationship increases resiliency and alleviates psychological problems.The book, in the first chapters, gives information on problem solving and the role of problem-solving in the etiology and the treatment of different forms of mental health problems. In the later chapters, it concentrates on psychotherapy, assessment and procedures of problem solving therapy. At the end it provides a case study.

This book integrates theory, research & practiceand provides a comprehensive appreciation of problem solving therapy.Itcontains empirical evidence and applied focus for problem solving therapy which provides a scientific base and best practices.The bookalso highlights the problem solving difficulties of persons with specific disorders and provides a better understanding of the relevance of problem solving therapy to a broad range of emotional problems. "

This book addresses the structural and biological properties of dental and peridental tissue structures and covers their mineralization process. The book contains a description of dentines, cementum, enamel and bone, including collagens, as well as non-collagenous proteins (SIBLINGs, SLRPs, GAGs, PGs, lipids, and MMPs). The mechanisms of mineralization are described in detail and the book is focused on matrix vesicles, collagen mineralization and the role of non-collagenous extracellular matrix components either as promoters or inhibitors of mineralization. In addition, the matrix components (non-collagenous) of enamel (amelogenin, ameloblastin, enamelin, MMP4, MMP20 and other proteases) are reviewed and their respective roles in dental tissues biomineralizations and tissue turnover are discussed. Additionally, environmental factors involved in enamel / dentin defects are adressed. With state-of-the-art contributions from experts in the respective domains, the book is a useful introduction to the field for junior scientists, interested in dental and peridental tissue biomineralization. It is also an interesting read for advanced scientists and clinicians working in dental research, giving them a broader view of the topic beyond their area of specialization. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.

This issue of Child and Adolescent Psychiatric Clinics, guest edited by Drs. Gabrielle A. Carlson and Manpreet Kaur Singh, is Part II of a two-part issue covering Emotion Dysregulation in Children. This issue is one of four selected each year by our series Consulting Editor, Dr. Todd Peters. Topics discussed in this issue include but are not limited to: Explosive Outbursts at School; Treatment of Childhood Emotional Dysregulation During Inpatient and Residential Interventions; Psychopharmacology of Treating Explosive Behavior; Treating explosive irritability in pediatric bipolar disorders; Evidence Base for Psychosocial Interventions for the Treatment of Emotion Dysregulation in Children and Adolescents; Preventing Irritability and Temper Outbursts in Youth by Building Resilience; Psychoeducational Treatments for Mood Dysregulation; A Modular, Transdiagnostic Approach to Treating Severe Irritability in Children and Adolescents; Longitudinal Outcome of Chronic Irritability; and the future of irritability in children, among others.