In this issue of Atlas of the Oral and Maxillofacial Surgery Clinics, guest editors Drs. Mark A. Miller and David M. Yates bring their considerable expertise to the topic of Common Procedures in Cleft and Craniofacial Surgery. Articles from top experts in the field include coverage of cleft lip surgery, different surgical approaches to craniosynostosis, and other craniofacial syndromes, as well as reconstruction and bone grafting. Contains 12 relevant, practice-oriented topics including primary cleft lip deformity; cleft nasal deformity; endoscopic approaches to craniosynostosis; open approaches to craniosynostosis; cranial deformities; and more. Provides in-depth clinical reviews on common procedures in cleft and craniofacial surgery, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This volume will provide an important contemporary reference on hearing development and will lead to new ways of thinking about hearing in children and about remediation for children with hearing loss. Much of the material in this volume will document that a different model of hearing is needed to understand hearing during development. The book is expected to spur research in auditory development and in its application to pediatric audiology.

Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

- Coverage of deaf people and cognition, neuroscience, bimodal/bilingualism, and education technology - Strong multicultural focus - Case studies from authors' clinical and educational practices - Three deaf and one hearing author-a deaf/hearing bilingual team

The field of cochlear mechanics has received an increasing interest over the last few decades. In the majority of these studies the researchers use linear systems analysis or linear approximations of the nonlinear (NL) systems. Even though it has been clear that the intact cochlea operates nonlinearly, lack of tools for proper nonlinear analysis, and widely available tools for linear analysis still lead to inefficient andpossiblyincorrect interpretation of the biophysics of the cochlea. An example is the presumption that a change in cochlear stiffness at hair cell level must account for the observed change in tuning (or frequency mapping) due to prestin application. Hypotheses like this need to be addressed in a tutorial that is lucid enough to analyze and explain basic differences.

"Cochlear Mechanics"presents a useful and mathematically justified/justifiable approach in the main part of the text, an approach that will be elucidated with clear examples. The book will be useful to scientists in auditory neuroscience, as well as graduate students in biophysics/biomedical engineering."

This issue of Otolaryngologic Clinics, guest edited by Drs. Cecelia E. Schmalbach and Kelly M. Malloy, is dedicated to Head and Neck Cutaneous Cancer. This issue is one of six selected each year by the series Consulting Editor, Dr. Sujana S. Chandrasekhar. Cutaneous cancer rates are growing at epidemic proportions and consequently lead to a significant health care burden. This issue opens with an overview of the related biology, epidemiology, and preventative measures. A contemporary review of cutaneous cancer management will be provided to include the roles of sentinel node biopsy, surgery, radiation therapy, and systemic therapy. Cutaneous cancers impact the geriatric patient population, so ethical considerations and non-surgical management are emphasized.

The major aim of this book is to introduce the ways in which scientists approach and think about a phenomenon -- hearing -- that intersects three quite different disciplines: the physics of sound sources and the propagation of sound through air and other materials, the anatomy and physiology of the transformation of the physical sound into neural activity in the brain, and the psychology of the perception we call hearing. Physics, biology, and psychology each play a role in understanding how and what we hear.
The text evolved over the past decade in an attempt to convey something about scientific thinking, as evidenced in the domain of sounds and their perception, to students whose primary focus is not science. It does so using a minimum of mathematics (high school functions such as linear, logarithmic, sine, and power) without compromising scientific integrity. A significant enrichment is the availability of a compact disc (CD) containing over 20 examples of acoustic demonstrations referred to in the book. These demonstrations, which range from echo effects and filtered noise to categorical speech perception and total more than 45 minutes, are invaluable resources for making the text come alive.

Common forms of preventable hearing loss are drug and noise-induced hearing loss which are believed to be produced by a similar mechanism. The generation of reactive oxygen species appears to be a common mechanism mediating hearing loss produced by these different sources. As such, a number of laboratories have focused their research towards identifying the sources of ROS production in the cochlea following administration of chemotherapeutic agents or noise exposure. This led to the identification of ROS generating enzymes, such as xanthine oxidases, nitric oxide synthase, and NADPH oxidases which are activated and/or induced during the development of hearing loss. A consequence of these findings was the implementation of antioxidants in preclinical studies for the treatment of hearing loss. These antioxidants have provided different levels of protection in animal and human studies, but none of these have been approved by the US Food and Drug Administration for the treatment of hearing loss. More recently, it was shown that noise-induced hearing loss was associated with recruitment of inflammatory cells and mediators in the cochlea. This finding would suggest that noise could produce injury to the cochlea which stimulates local and/or circulating inflammatory cells. A similar finding was observed in the cochlea following administration of the anticancer drug, cisplatin. In addition, our laboratory and others have provided a plausible mechanism by which noise or chemotherapeutic agents could stimulate the inflammatory response. Surprisingly, this mechanism involves ROS activation of transcription factors linked to inflammatory processes in the cochlea. These studies have led to the use of anti-inflammatory agents for the treatment of hearing loss. Preliminary studies targeting inflammatory cytokines appear especially promising in preclinical studies. A primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this relates to cochlear inflammation. Several different aspects of the cochlear inflammatory process will be discussed in detail, ranging from the sources of inflammatory cells, chemokines, inflammatory cytokines, and cochlea resident immune cells. Molecular pathways leading to activation of the local inflammatory process will be highlighted and treatment options will be discussed. The relevance of certain clinically used anti-inflammatory interventions, such as trans-typmanic steroids will also be discussed. Furthermore, we will examine recent patents focusing on the use of anti-inflammatory agents for the treatment of drug and noise-induced hearing loss.

The Springer Handbook of Auditory Research presents a series of comprehensive and synthetic reviews of the fundamental topics in modern auditory research. The v- umes are aimed at all individuals with interests in hearing research including advanced graduate students, post-doctoral researchers, and clinical investigators. The volumes are intended to introduce new investigators to important aspects of hearing science and to help established investigators to better understand the fundamental theories and data in fields of hearing that they may not normally follow closely. Each volume presents a particular topic comprehensively, and each serves as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in pe- reviewed journals. The volumes focus on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beg- ning to develop. New research areas will be covered on a timely basis in the series as they begin to mature.

This book presents a consensus of internationally renowned authorities on the diagnosis and treatment of early esophageal cancer. Meeting at an international symposium held in Kyoto, Japan, pathologists, physicians, surgeons, and endoscopists presented and discussed the most recent results of molecular biological studies on esophageal neoplasm - its development, invasion, and metastasis.Topics included treatment modalities for early squamous cell carcinoma and early adenocarcinoma, the molecular basis of differentation of dysplasia from early cancer, and less invasive treatment for superficial esophageal neoplasm. Some 200 scientists and practitioners from Australia, Italy, Sweden, Germany, Thailand, France, the United States, and Japan participated in the symposium. This volume is a record of their presentations and discussions and will be of interest to all who are concerned with the pathology, diagnosis, and therapy of superficial esophageal cancer.

Hearing Science Fundamentals, Second Edition maintains the straightforward style of the previous edition, introducing the basic concepts in hearing science in an easy-to-understand format. With a wide variety of student-friendly features and instructor resources, this comprehensive textbook facilitates the absorption of technical material by both undergraduate and graduate students. The text is divided into four clear sections to cover everything from the physics of sound to the anatomy and physiology of the auditory pathway and beyond. The textbook begins by delving into the basics of acoustics and digital signal processing (DSP). In the next section, readers will find full coverage of the basic anatomy and physiology of the auditory mechanism. The third section contains eight chapters on psychoacoustics and how sound is perceived via the auditory pathways. The book wraps up with a brand-new section devoted to pathologies of the auditory mechanisms. New to the Second Edition New coauthor, Jeremy J. Donai, AuD, PhD, brings his extensive clinical and research experience to the concepts discussed Nine new chapters, including: Review of Speech Acoustics (Chapter 2) Digital Signal Processing (Chapter 3) Binaural Processing (Chapter 8) Temporal Processing (Chapter 10) Signal Detection Theory (Chapter 13) Auditory Perception and Hearing Impairment (Chapter 14) Clinical Notes intended to bridge the gap from classroom to hearing clinic have been added throughout the text Vocabulary Checks throughout all the chapters Evidence-based information incorporated throughout the text Updated Recommended Readings list Ancillary materials accessible on a PluralPlus companion website: a sample syllabus, test bank, and PowerPoint lecture slides for instructors, and practice quizzes, word-building and anatomy-labelling exercises, audio examples, and overview lecture videos for students

Loudness is the primary psychological correlate of intensity. When the intensity of a sound increases, loudness increases. However, there exists no simple one-to-one correspondence between loudness and intensity; loudness can be changed by modifying the frequency or the duration of the sound, or by adding background sounds. Loudness also changes with the listener 's cognitive state. Loudness provides a basic reference for graduate students, consultants, clinicians, and researchers with a focus on recent discoveries. The book begins with an overview of the conceptual thinking related to the study of loudness, addresses issues related to its measurement, and later discusses the physiological effects of loud sounds, reaction times and electrophysiological measures that correlate with loudness. Loudness in the laboratory, loudness of steady-state sounds and the loudness of time-varying sounds are also covered, as are hearing loss and models.

The Clinician's Guide to Swallowing Fluoroscopy is a comprehensive resource for all dysphagia clinicians. This beautifully-illustrated text is intended for SLP, ENT, radiology, GI, and rehabilitation specialists interested in swallowing and addresses the need for an up-to-date, all-inclusive reference. Topics covered include radiation safety and protection, fluoroscopic oral, pharygeal, and esophageal phase protocols and abnormalities, and objective measures of timing and displacement.

This book comprehensively describes alkaptonuria and ochronosis. Beginning with the history, genetics, pathophysiology and diagnostics of the disease, the authors subsequently present a detailed characterization of its clinical manifestation in the spine, peripheral joints, eyes, ears, visceral organs and respiratory tract, its pathological anatomy and histology, as well as differential diagnosis. This is complemented by the latest data on therapy and experimental models of alkaptonuria, and supported by several case reports. Numerous pictures and radiological images document the clinical symptoms, giving the reader a solid understanding of the disease. On the basis of the editor's and authors' own extensive observations, the book offers an analysis of protein metabolism and aromatic amino acids in the context of alkaptonuria. Written by international experts in the field, the book offers a valuable reference guide for healthcare professionals working in rheumatology, dermatology, pulmonology, otolaryngology and histopathology.

Worship Sound Spaces unites specialists from architecture, acoustic engineering and the social sciences to encourage closer analysis of the sound environments within places of worship. Gathering a wide range of case studies set in Europe, Asia, North America, the Middle East and Africa, the book presents investigations into Muslim, Christian and Hindu spaces. These diverse cultural contexts demonstrate the composite nature of designing and experiencing places of worship. Beginning with a historical overview of the three primary indicators in acoustic design of religious buildings, reverberation, intelligibility and clarity, the second part of this edited collection offers a series of field studies devoted to perception, before moving onto recent examples of restoration of the sound ambiances of former religious buildings. Written for academics and students interested in architecture, cultural heritage, acoustics, sensory studies and sound. The multimedia documents of this volume may be consulted at the address: https://frama.link/WSS

Titles in the Pocket Tutor series give practical guidance on subjects that medical students and foundation doctors need help with 'on the go', at a highly-affordable price that puts them within reach of those rotating through modular courses or working on attachment. Topics reflect information needs stemming from today's integrated undergraduate and foundation courses: Common presentations Investigation options (e.g. ECG, imaging) Clinical and patient-orientated skills (e.g. examinations, history-taking) The highly-structured, bite-size content helps novices combat the 'fear factor' associated with day-to-day clinical training, and provides a detailed resource that students and junior doctors can carry in their pocket. Key points Ear, nose & throat disorders account for a high proportion of the problems that students and junior doctors see during GP, A&E, paediatric & surgical rotations, but they receive little formal ENT training Logical, building-block approach to content: initial chapter on relevant anatomy and physiology, followed by focus on ENT examination. Subsequent chapters describe specific disorders Fully-updated second edition contains brand new diagnostic algorithms for effective decision making, expanded rhinology chapter and full-colour illustrations

The only text of its kind for practicing clinicians, Quick Reference Guide: Otolaryngology is a comprehensive, quick-access reference written specifically for nurses, physician's assistants, and medical students. Not only is it useful as a pithy reference guide for clinicians, it is a learning system designed to foster retention and comprehension, and an in-depth review for written boards and ENT certification. The book is authored by a nurse practitioner with two practicing otolaryngologists, who are among the most highly respected professionals in their fields, as consultants. The guide is consistently organized by anatomical region and contains, for each topic, easy-to-follow tables, charts, diagrams, and algorithms to guide in the work-up, differential diagnosis, diagnostic methods, medical therapy, and treatment alternatives. The text includes procedure protocols used in clinical settings and staging criteria for common cancer diagnoses. Another important feature is the guide's overview of surgical management for specific conditions. Topics are covered on a "need-to-know" basis for written boards and certification review. Key Features: Provides key differential diagnosis guidelines Includes fifteen 'how-to' Procedure Protocols used in clinical settings and Staging Criteria for eight of the more common cancer diagnoses Presents Overview of Surgical Management for specific conditions Serves as a concise reference guide and review for written boards and ENT certification Designed for clinicians in general practice, those entering the ENT field, and for use as a diagnosis guide for referral purposes Includes six videos illustrating actual procedures, including nasal endoscopy, flexible laryngoscopy, and others

The first book of its kind to explore this timely topic in depth, Otologic and Lateral Skull Base Trauma addresses the many facets of temporal bone trauma, including its epidemiology, diagnosis, and medical and surgical management, and contemporary research. Ideal for both trainees and more advanced general practitioners and specialists, this text is a valuable resource for otolaryngologists and pediatric otolaryngologists, otologists and neurotologists, and audiologists, as well as neurosurgeons, neurologists, physical medicine and rehabilitation providers, and occupational and physical therapists. Covers the epidemiology, basic pathophysiology, diagnostic evaluation, and treatment of temporal bone trauma, including complex injuries of the lateral skull base.  Contains multiple chapters co-written by leading speciality experts: imaging of the temporal bone and brain following head injury (co-written by leading neuroradiologists); facial nerve injury management (co-written by leading facial nerve specialists); vascular injury management (co-written by leading neurosurgeons); soft tissue repair of auricular trauma (co-written by leading facial plastic surgeons); acoustic overexposure and blast injury management (co-written by leading experts in noise-induced hearing loss); rehabilitation following head trauma (co-written by leading physical medicine and rehabilitation providers, occupational therapists, and physical therapists) and more.  Includes detailed coverage of labyrinthine concussion diagnosis and management, medical and surgical management of temporal bone fractures, conductive and sensorineural hearing loss and rehabilitation after head injury, balance disturbance after head injury, and much more.  Discusses animal models of head injury and current research, with a focus on the auditory system.  Consolidates today's available information on this timely topic into a single, convenient resource. 

The Sense of Hearing is a highly accessible introduction to auditory perception, addressing the fundamental aspects of hearing. This fourth edition has been revised to include up-to-date research and references. In particular, Chapter 7 on Pitch and Periodicity Coding and Chapter 13 on Hearing Loss include new material to reflect the fast pace of research in these areas. The book introduces the nature of sound and the spectrum, and the anatomy and physiology of the auditory system, before discussing basic auditory processes such as frequency selectivity, loudness and pitch perception, temporal resolution, and sound localization. Subsequent chapters show how complex processes such as perceptual organization, speech perception, and music perception are dependent on the initial analysis that occurs when sounds enter the ear. The book concludes with a description of the physiological bases and perceptual consequences of hearing loss, as well as the latest diagnostic techniques and management options that are available. Featuring student-friendly resources, including an overview of research techniques, an extensive glossary of technical terms, and over 150 original illustrations, The Sense of Hearing offers a clear introduction and an essential resource for students in the fields of audiology and sound perception.

Until recently, the contribution of immunological knowledge to the under standingand management ofENTdisorders was slight, being largely confined to the appreciation that many rhinitic patients were allergic. Happily, this situation is rapidly changing: the immunological basis of many disorders of the ears, nose and throat is becoming recognized and the mechanisms of the reactions involved are being elucidated. From this, rational therapy should evolve. This book aims to highlight some of the areas in which immunological mechanisms are involved in otorhinolaryngology. It is written by experts in their respective fields of immunology and allergy, otology, rhinology and pathology. It opens with an overview ofthe pathways ofthe immune response and the cells and molecules involved, leading to an appreciation of the normal defence mechanisms of the upper respiratory tract and possible areas offailure. There is then a chapter on HIV infection and how this may present to otorhinolaryngologists. The normal function of the tonsil and the immunological effects oftonsillectomy are then considered. The varying roles of fungi in ENT disorders ranging from commensal through allergen to invasive organisms is assessed by Professor R. J. Hay. Perhaps the most obvious immunological contribution to management thus far lies in the immunocytochemical diagnosis of pathological conditions of the ears, nose and throat and this is covered in a chapter by Professor Leslie Michaels."