This book considers deafness as a medical condition, exploring the neuronal consequences on the peripheral and the central nervous system as well as on cognition and learning, viewed from the standpoint of genetics, neuroanatomy and neurophysiology, molecular biology, systems neuroscience, and cognitive neuroscience.

Filling a gap in the anatomical and ENT literature, the authors show the various approaches to the middle ear which allow safe surgical manipulations, such as through the tympanic membrane or the Eustachian tube.

The question about the function ofsleep remains one ofthe major challenges scientists are faced with. Wherein lies the fascination with sleep? I am convinced that it is the necessity for sleep. No one has failed to experience the overpowering urge to fall asleep after a disturbed night's sleep or after sleep was curtailed or deprived, especially when our daily activities impose restrictions on motor activity. The demand ofour body and brain to sleep challenges our understanding ofwhy this is the case, and which are the benefits ofa night ofprofound sleep. Also in animals prolongation of waking consistently increases their attempts to fall asleep. It has been stated that sleep is more necessary to animals than even food! The need for sleep and some insight into the consequences of the preceding daily waking activities on subsequent sleep was wonderfully formulated by Shakespeare in Othello: Not poppy nor mandragora, Nor all the drowsy syrups ofthe world, Shall ever medicine thee to that sweet sleep Which thou owed'st yesterday It is interesting that the most powerful single intervention which invariably influences sleep in a positive and predictable manner is the prolongation of waking. The activities which people or animals engage in during the wakefulness episode are secondary in the magnitude oftheir effects on sleep.

This book, containing the proceedings of the 2000 Kyoto Symposium on Esophageal Cancer, is an important contribution for all types of physicians interested in both squamous and adenocarcinoma of the esophagus. The volume has great legitimacy and relevance. The symposia hosted by Professor Masayuki Imamura brought together the leaders in several disciplines from Japan with other acknowledged authorities from Europe, the United States, Australia, and other parts of Asia. Japan has long been a leader in making advances in understanding the pathology, diagnosis, and treatment of esophageal squamous cell carcinoma, for several decades originally led by Professor Komei Nakayama and his students. It is now clear that Japanese are also beginning to suffer from esophageal adenocarcinoma and Barrett's columnar lined epithelium, thus enabling the Japanese to formulate studies on the pathology, diagnosis, and treatment for the full spectrum of esophageal neoplasms. The authoritativeness of these proceedings is established not only by the long tradi tion of Japanese leadership in the field but by the contributions of the principal leaders from the Nakayama school participating in the honorary faculty and local scientific committee.

Throughout the world, head and neck cancer is a major threat to public health and a significant challenge to both clinicians and basic scientists. Despite extensive efforts in primary prevention, screening, early detection, and therapy, long-term survival rates have not improved substantially in the last three decades. This book covers a wide range of exciting new findings in both clinical and basic sciences as they are relevant to head and neck cancer. These findings have recently enhanced our understanding of head and neck carcinogenesis at the genetic and molecular levels, offering the promise of improved preventive and therapeutic strategies. This book will also present information on the important clinical advances that have been made in chemoprevention, organ preservation, and the simultaneous use of chemo therapy and radiotherapy. The first part provides an overview of the etiology and biology of head and neck cancer, including an examination of human papillomaviruses in both benign and malignant lesions. This section also discusses the carcinogenic process at the genetic and molecular levels, as well as aberrant squamous differentiation; increased understanding of these areas has great potential to translate into new strategies for cancer prevention. The second part describes recent advances in developing a risk model for head and neck cancer, as well as the application of genetic susceptibility data in chemoprevention. This section also includes overviews of the status of chemoprevention trials and of the process of invasion and metastasis in head and neck cancer."

MRI is assuming a dominant role in imaging of the larynx. Its superior soft tissue contrast resolution makes it ideal for differentiating invasion of tumors of the larynx from normal or more sharply circumscribed configuration of most of the benign lesions. Over ten years ago CT made a major impact on laryngeal examination because it was the first time that Radiologists were beginning to look at submucosal disease. All of the previous examinations duplicated the infor mation that was available to the clinician via direct and in-direct laryngo scopy. With the advent of rigid and flexible endoscopes, clinical examination became sufficiently precise that there was little need to perform studies such as laryngography which merely showed surface anatomy. The status of deep structures by these techniques was implied based on function. Fortunately laryngography is now behind us together with all of the gagging and contrast reactions which we would all like to forget. CT is still an excellent method of examining the larynx but it is unfortunately limited to the axial plane. With presently available CT techniques motion deteriorates any reformatting in sagittal or coronal projections. The latter two planes are extremely helpful in delineating the vertical extent of submucosal spreads. MRI has proven extremely valuable by producing all three basic projections, plus superior soft tissue contrast. Although motion artifacts still degrade the images in some patients, newer pulsing sequences that permit faster scanning are elimi nating most of these problems."

The increasing prevalence of musical stimulation in our everyday environment makes studies of musical listening, comprehension and memory important. Music has simply become a pervasive aspect of the experienced environment for most of us; along with enhanced levels of machine sounds, musical sound sources are contributing to a virtual transformation of contemporary soundscapes occurring in many industrial countries. In spite of such trends, arguably the mainstream research in psychology and related fields has been slow to devote concentrated attention to this phenomenon and what it might mean. As a result, with respect to more established fields of research (e.g., visual perception, speech perception, attention and memory etc.), less is known about how people perceive and respond to complex, non-random, acoustic signals found in musical events. Although these topics reside in the domain of music research, this field is a relatively new one, with a history that dates back only about 25 years. Nevertheless, it is now a vibrant and rapidly growing field that draws from multiple disciplines (psychology, psychoacoustics, computer science, music theory, and so forth) to seek answers to questions about how we listen to musical events in our world. It tackles questions about pitch perception in complex patterns, about the role of tonal schemes as well as effects of metrical and rhythmic schemes on musical listening behaviors. It also examines abilities of children and adults to perceive and comprehend dynamic sound patterns. Emotional responses to music are also studied; and overarching all of this are exciting new neuroscience findings concerned with neural responses to musical events.

Music Perception introduces its audience to these and related basic issues concerned with listening to music. It also illustrates how knowledge about music perception may ultimately lead to a broader understanding of conventional concepts regarding perception, attention and memory.

This is a nearly complete collection of Chapters that provide an up to date overview of all aspects of Head and Neck cancer. It is written by professionals but is not only intended for other professionals, but students, patients, policy makers, etc. There are so many aspects to this group of diseases that even the most seasoned professional will learn something from having read this book.

At the age of four, Jaipreet Virdi's world went silent. A severe case of meningitis left her alive but deaf, suddenly treated differently by everyone. Her deafness downplayed by society and doctors, she struggled to "pass" as hearing for most of her life. Countless cures, treatments, and technologies led to dead ends. Never quite deaf enough for the Deaf community or quite hearing enough for the "normal" majority, Virdi was stuck in aural limbo for years. It wasn't until her thirties, exasperated by problems with new digital hearing aids, that she began to actively assert her deafness and reexamine society's--and her own--perception of life as a deaf person in America. Through lyrical history and personal memoir, Hearing Happiness raises pivotal questions about deafness in American society and the endless quest for a cure. Taking us from the 1860s up to the present, Virdi combs archives and museums in order to understand the long history of curious cures: hearing trumpets, violet-ray apparatuses, pneumomassages, electrotherapy machines, airplane diving, bloodletting, skull hammering, and many more. Hundreds of procedures and products have promised grand miracles but always failed to deliver--a legacy that is still present in contemporary biomedicine. Weaving Virdi's own experiences together with her exploration into the fascinating history of deafness cures, Hearing Happiness is a powerful story that America needs to hear.

Phonological Processes and Brain Mechanisms reviews selective neurolinguistic research relating brain structures to phonology. The studies in the volume report on a number of timely and important topics, such as a neuronal model for processing segmental phonology, the role of the thalamus and basal ganglia in language processing, and oral reading in dyslexia. Increasingly, phonology is considered a cognitive module whose brain correlates may be independently investigated. Given the modular nature of the phonological system and its direct linkage with peripheral components of the nervous system, research on phonology and the brain will undoubtedly flourish in the future. The chapters in this volume give substance to this future.

Language and Speech has been selected for the Fifth Convention of the Academia Eurasiana Neurochirurgica as a topic closely related to neurosurgery but also to philosophy, art, culture and humanity and treated by various experts of the field of this interdisciplinary subject. The volume has a certain structure: Language is evaluated as a tool of the Homo Artis in the introduction, which is followed by chapters focusing the language in history, in linguistics, as well as in music and that of the animals. In the next part speech is dealt with as a physiological process. It is followed by papers on three different but uniformly neurosurgical representation of speech in gliomas, AVMs, and focal epilepsies. Neurologists compiled papers on clinical forms of aphasia, and that among bilinguists as well as on lateralisation of speech centres in relation of handedness followed by rehabilitation of speech disorders. Two papers on language and computers complete the volume.

The endoscope with magnifying lens systems and retrotympanic sub-regions. During microsurgical pro angled view has, in all oto-rhino-laryngology, been cedures, the recognition of pathologic changes in developed from a basically diagnostical tool into a sur niches, recesses or occluded tunnels is considerably gical instrument. Earlier, it served to see what exists. facilitated. The disadvantages of the operating micro Nowadays, it is continuously changing what one does. scope -reduced brightness and bad focus with higher Jean-Marc Thomassin's book "Otoendoscopically magnifieations, no angled view- can be compensated guided surgey" appears as the first guide into this new by additional endoscopy with the instrument's tip field of otoendoscopic control of microsurgery of the close to the target and with the view "around the cor ear. The author has achieved to compile and codify ner". what, during recent years, was already looked at by While thus visualizing remote areas or hidden him and by a "happy few" of otological pilots. But, he spots by a rigid magnifying endoscope with an angled has also added new insights into this matter. One may view direction apparently no patho-anatomical secret say that he has provided a solid basis for both the remains undiscovered. What can be inspected can be scholars and the experts who want to enrich their cleaned, there are adequate instruments. This fact arsenal of otosurgical techniques. makes the analysis of surgical failures more plausible.

If we possessed a true, well established and undoubted theory concerning the function of the nerves in the human body, the principles of smell would be much easier to understand. So far, we do not know for certain whether the action of nerves takes place by means of a subtle fluid, which is instantaneously conveyed from the beginning of the nerves to their ends, or whether, as some think, some sort of vibratory movements is produced in them, or whether the stimulation should be considered as the only sufficient cause, to say nothing of the new opinion concerning the electrical force. Linnaeus Although much has been learned since the time of Linnaeus, it is still true that we do not yet possess "a true, well established and undoubted" theory of olfaction. The literature of the subject, however, has long been rather voluminous - the frequent assertions to the contrary are simply untrue - and is now growing rapidly. Moreover, quite a number of symposia on olfaction (or olfaction and taste) have been held during recent years. For example, in the U. S. A.

The sellar region and paranasal sinuses constitute the anatomical sections of the skull base in which pathological entities warrant interdisciplinary management. Processes originating in the paranasal sinuses can reach and involve the skull base in and around the sella, sometimes not respecting the natural dural boundary. On the other hand, lesions involving the sellar block, such as pituitary adenomas and meningiomas, can also extend downwards into the paranasal sinuses. The orbit and cavernous sinus may be subject to involvement and infiltration by both paranasal and sellar pathology. The advancement and new achievements of modern diagnostic procedures, such as high-resolution CT, three-dimensional reconstruc tion, MRI, and MRI angiography, as well as the detailed selective angiographic protocols and endovascular techniques, have increased the possibilities for surgical management of this type of pathology with extra- and intracranial involvement. Long-standing and intense inter disciplinary work has led to sophisticated operative approaches which for benign tumors allow total excision with preservation of structures and function, and for some malignant lesions permit an en bloc resec tion via a combined intracranial-extracranial approach. This volume reflects the work and scientific exchange which took place during the IV International Congress of the Skull Base Study Group, held in Hanover. Leading authorities in the basic sciences including anatomy joined with diagnosticians, clinicians, and surgeons from different fields to evaluate the state of the art of this topic in skull base surgery."

This volume brings together noted scientists who study presbycusis from the perspective of complementary disciplines, for a review of the current state of knowledge on the aging auditory system. Age-related hearing loss (ARHL) is one of the top three most common chronic health conditions affecting individuals aged 65 years and older. The high prevalence of age-related hearing loss compels audiologists, otolaryngologists, and auditory neuroscientists alike to understand the neural, genetic and molecular mechanisms underlying this disorder. A comprehensive understanding of these factors is needed so that effective prevention, intervention, and rehabilitative strategies can be developed to ameliorate the myriad of behavioral manifestations.

This book was not written for any particular audience; generally speaking, I believe its contents should be substantive for anyone who has an interest in the nature of normal language processes and their dysfunction. None theless, in writing the book I have had in mind that its contents will be of special interest and value to persons in several disciplines, most notably certain areas of psychology and linguistics, and especially where those in terests overlap. It should also be worthwhile to individuals involved in what has come to be known as neurolinguistics, and, of course, to persons having a particular interest in the disorder of stuttering. More has been written about stuttering than all the other speech disor ders combined, yet it has remained an enigma. In my view the major source of the continued failure to isolate the nature of stuttering lies in the matter of the questions asked about it. It is not simply that they were not the right questions, but rather that there have actually been so few bona fide questions Too much of what has been written and said about stutter ing has come in the form of declarative statement, which typically reflects some guiding concept and assumption(s). Moreover, most of what has passed as questions has been of a similar nature."

In spite of great advance made by ENT and maxillofacial surgeons as well as radiotherapists to improve therapy of cancer of the oral cavity and oropharynx, it has not been possible in the past 4 decades to raise the chances of patient survival above 40%-45%. However, recent studies with different combination therapies indicate that better results can be expected in the future. In this volume, the current status and results of therapeutic studies are presented by distinguished clinicians in the three disciplines. The book provides up-to-date information and encourages interdisciplinary cooperation.

Acquired aural cholesteatoma poses a unique procedural dilemma with regard to pathogenetic research and theory building. Because cholesteatoma spontane ously occurs only in the poorly pneumatized human ear, its pathogenesis is specific to humans. Nonetheless, because of the ethical questions surrounding human experimentation, pathogenetic study has almost exclusively involved nonhuman subjects. Indeed, attempts have failed in almost all animal expe riments except with the gerbil, and even here experimental designs have been improbable compared with human cholesteatoma. Cholesteatoma in the gerbil is useful, therefore, only for the study of pathology and not for human pathogenesis. I hold that the pathogenesis of cholesteatoma will be understood by studying the cholesteatomatous ear, that is, the malpneumatized ear of the human. The anatomical difference between the normal and malpneumatized ear is a probable cause of cholesteatoma. This difference may be found clinically in facial nerve decompression and cholesteatoma surgery, as, for example, facial nerve palsy occurs usually in the normal, well-pneumatized ear. Of course, conventional animal experimentation will not confirm this clinical difference since there is no ideal animal model for the poorly pneumatized human ear. Present surgical techniques for cholesteatoma vary greatly according to indi vidual otosurgeon's opinion. The most extreme difference of opinion is focused on whether to remove the external ear canal wall. Normally, the best option would be not to remove the canal wall if cholesteatoma recurrence can be prevented. Simply put, recurrence of cholesteatoma comes about when its cause has not been removed during primary surgery."

Since the respiratory airways branch to all parts of the lungs and ready access is provided through the nose or mouth, exploration of these passages for direct visualization or tissue sampling has long been a clinical challenge. This would be particularly helpful in diagnosing those pulmonary diseases that involve the bronchial tree or affect the surrounding lung parenchyma which prove difficult to diagnose or define by indirect methods. The pioneering efforts of Chevalier Jackson in 1918, using bismuth insufflation for radiologic visualization of the bronchial tree, and of Sicard and Forestier, who introduced poppy seed oil (lipiodol) in 1922, rapidly established bronchography as a practical radiologic diagnostic procedure. The initial enthusiasm was soon tempered by recognition of practical problems, and over the years the popularity of bronchography has waxed and waned as techniques were refined and new equipment, instrumentation and contrast agents evaluated. At the same time, alternative methods of diagnosis were being developed, notably sputum cytology, percutaneous needle aspira tion and biopsy, and bronchial brushing. In recent years, a number of medical and technologic developments have revived interest in transbronchial techniques and have made such a diagnostic approach more attractive. Improvements in topical airway anesthesia effectiveness have simplified passage of a variety of catheters, brushes, biopsy devices, fiberoptic or other bronchoscopic instruments along the bronchial passageways. Methods of guiding the catheter or other trans bronchial instrument toward the target site in the lung have also been refined.

Both the major and minor salivary glands can be the site of a wide variety of diseases and functional disturbances. This monograph covers both the common lesions and conditions of the salivary glands as well as the rare ones. Much attention is given to the problematic complaint of dry mouth and the even more cumbersome diagnostic aspects of Sjogren's syndrome. Emphasis is on the clinical aspects and the management of the various disorders. The vast experience of the authors is reflected in their clear and concise style. The illustrations are well chosen and updated references are provided, where appropriate."

This Atlas of Oral PathologV is intended primarily as a ances where appropriate and reproduce relevant radio graphs. Every pathologist who deals with bone specimens bench companion for the general diagnostic pathologist. especially the trainee. It has not been designed to cover will know the value of radiographs, and some indeed are the subject fully and in detail, nor does it enter into the reluctantto make a diagnosis in their absence. In addition, radiographs may give a good idea of the extent aFld other more theoretical aspects. Since the book is essentially an atlas the text has been features of a lesion that may be represented in the first kept to a minimum, but in it we have tried to adopt'a instance only by a small biopsy specimen. practical approach, with special regard to differential diag While many of the illustrations have been made from nosis. We have made some remarks about the clinical sections freshly cut and stained for the purpose, others features of the various conditions dealt with, since this have been prepared from stained sections already in our may help the pathologist to appreciate what is in the refer files and since, in addition, the material comes principally ring clinician's mind in an area with which the pathologist from two departments, as well as from outside sources, may not be particularly familiar."

For more than three decades the methods for assessing cell pro liferation have been largely the preserve of experimental biologists, and in their hands such techniques have contributed greatly to our understanding of the dynamic organisation of normal and patho logical tissues. In recent years, with the advent of novel method ologies, there has been increased interest among both pathologists and clinicians, particularly oncologists and others interested in neoplasia, in assessing cell proliferation. This interest has been stimulated by the possibility that indices of cell proliferation may have direct clinical relevance, for example in being useful predictors of outcome in patients with certain forms of malignancy. In addi tion, interest in assessing cell proliferation has been fuelled by the tremendous advances in our understanding of the mechanisms of cell proliferation and their deregulation in pathological processes. Consequently, the time is ripe for a monograph critically reviewing the available methods for assessing cell proliferation, their potential and their problems. We have been particularly concerned to present a balanced view of the advantages and disadvantages of different methods currently available for assessing cell proliferation. The assessment of cell proliferation often requires some familiarity with mathematical methods, but in this book we have attempted to keep detailed mathematical analyses to a minimum. We have asked exponents of each of the well-recognised methods to critically review the tech niques and the ways in which they may be applied to clinical mate rial."

Hearing and communication present a variety of challenges to the nervous system. To be heard and understood, a communication signal must be transformed from a time-varying acoustic waveform to a perceptual representation to an even more abstract representation that integrates memory stores with semantic/referential information. Finally, this complex, abstract representation must be interpreted to form categorical decisions that guide behavior. Did I hear the stimulus? From where and whom did it come? What does it tell me? How can I use this information to plan an action? All of these issues and questions underlie auditory cognition. Since the early 1990s, there has been a re-birth of studies that test the neural correlates of auditory cognition with a unique emphasis on the use of awake, behaving animals as model. Continuing today, how and where in the brain neural correlates of auditory cognition are formed is an intensive and active area of research. Importantly, our understanding of the role that the cortex plays in hearing has the potential to impact the next generation of cochlear- and brainstem-auditory implants and consequently help those with hearing impairments. Thus, it is timely to produce a volume that brings together this exciting literature on the neural correlates of auditory cognition. This volume compliments and extends many recent SHAR volumes such as Sound Source Localization (2005) Auditory Perception of Sound Sources (2007), and Human Auditory Cortex (2010). For example, in many of these volumes, similar issues are discussed such as auditory-object identification and perception with different emphases: in Auditory Perception of Sound Sources, authors discuss the underlying psychophysics/behavior, whereas in the Human Auditory Cortex, fMRI data are presented. The unique contribution of the proposed volume is that the authors will integrate both of these factors to highlight the neural correlates of cognition/behavior. Moreover, unlike other these other volumes, the neurophysiological data will emphasize the exquisite spatial and temporal resolution of single-neuron as opposed to more coarse fMRI or MEG data] responses in order to reveal the elegant representations and computations used by the nervous system.

The purpose of this work is to review the current knowledge of laryngeal pathology in the light of my experience at the Institute of Laryngology and Otology, London. The role of histopathological investigations in the care of patients with diseases of the larynx is given special consideration. Radiologi cal study of the larynx has become more refined in recent years with the introduction of computerised tomography. Microlaryngoscopy with biopsy of the interior of the larynx is now a frequent procedure in the diagnosis of laryngeal disease. In the effort to interpret the findings resulting from these methods, the need for a monograph outlining the pathological basis of laryngeal disorders has arisen. To the best of my knowledge, such a work, devoted to the pathology of the larynx only, has never been written; a modern study in this field is certainly not available. I have aimed the text towards the practising pathologist in order to give it the broadest scope. It was necessary, therefore, to include an account of the basic anatomy of the larynx. For this purpose (and in subsequent descriptions throughout the book) I have not used the formal anatomical terminology for the two folds on either side of the ventricle of the larynx. There is some variation in the use of these terms, and they are not yet completely in general use."

A disease of unknown origin - this is the challenge presented by Meniere's disease and taken up by top clinicians and scientists, members and coworkers of The Vestibular Disorder Research Committee organized by The Ministry of Health and Welfare, Japan. They explore the pathophysiology, diagnosis and treatment of Meniere's disease to help physicians faced with treating this intractable ailment. Specialists investigating the etiology of the disease will welcome these reports which clear the picture for future research."