The sensory hair cells in the inner ear and vestibular system convert mechanical stimuli, sound and motion into neural activity that is responsible for the sensations of hearing, motion and head position. In mammals, the loss of hair cells from acoustic overstimulation, ototoxic drugs and aging is irreversible, leading to a permanent loss of function. However, it is now clear that hair cells in other vertebrates are capable of regenerating and recovering partial or complete function. Moreover, partially damaged hair cells can undergo self-repair or be protected from traumatic insults by external compounds.This volume provides a comprehensive survey of what is currently known about the regeneration, repair and protection of sensory hair cells and subsequent recovery of function in the auditory and vestibular system. The aim is to provide graduate students, postdoctoral fellows, clinicians and scientists in related disciplines with the biological bases of hair cells and with an understanding of the factors that contribute to their regeneration and repair.

Hearing and communication present a variety of challenges to the nervous system. To be heard and understood, a communication signal must be transformed from a time-varying acoustic waveform to a perceptual representation to an even more abstract representation that integrates memory stores with semantic/referential information. Finally, this complex, abstract representation must be interpreted to form categorical decisions that guide behavior. Did I hear the stimulus? From where and whom did it come? What does it tell me? How can I use this information to plan an action? All of these issues and questions underlie auditory cognition. Since the early 1990s, there has been a re-birth of studies that test the neural correlates of auditory cognition with a unique emphasis on the use of awake, behaving animals as model. Continuing today, how and where in the brain neural correlates of auditory cognition are formed is an intensive and active area of research. Importantly, our understanding of the role that the cortex plays in hearing has the potential to impact the next generation of cochlear- and brainstem-auditory implants and consequently help those with hearing impairments. Thus, it is timely to produce a volume that brings together this exciting literature on the neural correlates of auditory cognition. This volume compliments and extends many recent SHAR volumes such as Sound Source Localization (2005) Auditory Perception of Sound Sources (2007), and Human Auditory Cortex (2010). For example, in many of these volumes, similar issues are discussed such as auditory-object identification and perception with different emphases: in Auditory Perception of Sound Sources, authors discuss the underlying psychophysics/behavior, whereas in the Human Auditory Cortex, fMRI data are presented. The unique contribution of the proposed volume is that the authors will integrate both of these factors to highlight the neural correlates of cognition/behavior. Moreover, unlike other these other volumes, the neurophysiological data will emphasize the exquisite spatial and temporal resolution of single-neuron as opposed to more coarse fMRI or MEG data] responses in order to reveal the elegant representations and computations used by the nervous system.

This volume will serve as the first Handbook of its kind in the area of hearing aid research, often the least-defined, least-understood, part of the multi-disciplinary research process. Most scientific training is very advanced within the particular disciplines but provides little opportunity for systematic introduction to the issues and obstacles that prevent effective hearing-aid related research. This area has emerged as one of critical importance, as signified by a single specialized meeting (the International Hearing Aid Conference, IHCON) that brings together specialists from the disparate disciplines involved, including both university and industry researchers. Identification of the key steps that enable high-impact basic science to ultimately result in significant clinical advances that improve patient outcome is critical. This volume will provide an overview of current key issues in hearing aid research from the perspective of many different disciplines, not only from the perspective of the key funding agencies, but also from the scientists and clinicians who are currently involved in hearing aid research. It will offer insight into the experience, current technology and future technology that can help improve hearing aids, as scientists and clinicians typically have little or no formal training over the whole range of the individual disciplines that are relevant. The selection and coverage of topics insures that it will have lasting impact, well beyond immediate, short-term, or parochial concerns.

The third edition of ENT: An Introduction and Practical Guide provides an essential introduction to the clinical examination, treatment options and surgical procedures within ENT. It encompasses the most frequently encountered conditions in the emergency setting, on the ward and in the outpatient clinic. The text has been updated to include new content on implantation surgery for hearing loss. It also includes significant changes in the indications for surgery, patient assessment, management, and surgical techniques. The subject of dizziness and vertigo have also been updated to include novel interventions. With its highly practical step-by-step approach, this book will be invaluable to all surgical trainees studying for higher postgraduate examinations in ENT, and an essential guide for otorhinolaryngologists, primary care practitioners and specialist ENT nurses in their early years of training.

The past decade has brought great advances in our understanding of the mechanisms underlying auditory pathologies. Molecular biology and genetics have primarily contributed to this enhanced understanding, which in turn has driven the design of novel rational therapeutic interventions. Auditory Trauma, Protection and Repair presents recent developments in auditory research and their potential translation to the clinical setting. In particular the authors address the major entities of peripheral auditory trauma, discuss the underlying mechanisms, the central nervous system consequences, protective interventions and finally explore the possibilities to restore cochlear morphology and function.

Two themes run through the chapters in this book: cellular homeostasis and cell death. In the broadest sense, all auditory pathologies are disorders of cellular homeostasis.

Contents:

• Auditory Pathology: When Hearing Is Out of Balance Jochen Schacht
• Genetics of Hearing Loss Ella Shalit and Karen B. Avraham
• Cochlear Homeostasis and Homeostatic Disorders Philine Wangemann
• Tinnitus: Theories, Mechanisms and Treatments Carol A. Bauer and Thomas J. Brozoski
• Autoimmune Inner Ear Disease Quinton Gopen, and Jeffrey P. Harris
• Age-Related Hearing loss and Its Cellular and Molecular Bases Kevin K. Ohlemiller and Robert D. Frisina
• The Patterns and Mechanisms of Noise-Induced Cochlear Pathology Donald Henderson, Bohua Hu, and Eric Bielefeld
• Drug-Induced Hearing Loss Leonard P. Rybak, Andrea E. Talaska, and Jochen Schacht
• Central Consequences ofCochlear Trauma D. Kent Morest and Steven J. Potashner
• Cell Death and Cochlear Protection Steven Green, Richard A. Altschuler, and Josef M. Miller
• Emerging Strategies for Restoring the Cochlea Stefan Heller and Yehoash Raphael

About the editors:

Jochen Schacht is Professor and Director of the Kresge Hearing Research Institute, University of Michigan, Ann Arbor. Arthur N. Popper is Professor in the Department of Biology and Co-Director of the Center for Comparative and Evolutionary Biology of Hearing at the University of Maryland, College Park. Richard R. Fay is Director of the Parmly Hearing Institute and Professor of Psychology at Loyola University of Chicago.

About the series:

The Springer Handbook of Auditory Research presents a series of synthetic reviews of fundamental topics dealing with auditory systems. Each volume is independent and authoritative; taken as a set, this series is the definitive resource in the field.

Specialist Periodical Reports provides systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemists, applying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

This book explores computational fluid dynamics in the context of the human nose, allowing readers to gain a better understanding of its anatomy and physiology and integrates recent advances in clinical rhinology, otolaryngology and respiratory physiology research. It focuses on advanced research topics, such as virtual surgery, AI-assisted clinical applications and therapy, as well as the latest computational modeling techniques, controversies, challenges and future directions in simulation using CFD software. Presenting perspectives and insights from computational experts and clinical specialists (ENT) combined with technical details of the computational modeling techniques from engineers, this unique reference book will give direction to and inspire future research in this emerging field.

Vertigo is the feeling that everything around is moving or spinning and is usually caused by a problem with the balance mechanisms in the inner ear. It can also be caused by problems in certain parts of the brain or vision disorders. Benign paroxysmal positional vertigo (BPPV) is one of the most common causes of vertigo causing brief episodes of mild to intense dizziness. BPPV is usually triggered by specific changes in the position of the head, when tipping the head up or down, when lying down, or when turning over or sitting up in bed. This book is a comprehensive guide to BPPV. Beginning with an introduction to anatomy, physiology and differential diagnosis, the following sections discuss the different types of BPPV - posterior, horizontal, anterior, subclinical, multicanal, secondary, migraine-associated and more. The final chapters examine medical and surgical management techniques and the book concludes with an atlas of diagnostic and therapeutic procedures for BPPV. The book is authored by recognised experts from Italy. Key Points Comprehensive guide to diagnosis and management of benign paroxysmal positional vertigo (BPPV) Covers all types of BPPV Includes atlas illustrating diagnostic and therapeutic procedures Recognised author team from Italy

This book considers deafness as a medical condition, exploring the neuronal consequences on the peripheral and the central nervous system as well as on cognition and learning, viewed from the standpoint of genetics, neuroanatomy and neurophysiology, molecular biology, systems neuroscience, and cognitive neuroscience.

Written for residents and practitioners of otolaryngology, medical oncology, radiation oncology, and maxiollofacial surgery, this book provides the reader with a comprehensive, concise discussion of the best evidence available on which to base clinical decisions needed when managing patients with squamous cell carcinomas of the oral cavity, pharynx and larynx. Because of its accessible and practical format, this book is considerably different than other related titles on the market. Formatted with questions at the beginning of each chapter that are then answered with evidence and best practices available for each case, each chapter addresses situations the clinician is likely to face in the diagnostic evaluation and treatment of a patient with cancer of the head and neck. Most clinical decisions in the management of cancers of the head and neck region are based on the results of a few controlled, randomized clinical trial trials (Evidence Level I). However, most decision-making is based on the results of case-control studies (Evidence Level II), descriptive studies, reports of expert committees, or opinions of respected authorities (Evidence Level III). This information is scattered throughout the literature and often comingled with information about other topics. Therefore, there is a need for a publication in which the evidence pertinent to making decisions regarding a particular clinical problem is distilled from the literature and presented in a single concise, clinical, situation-driven source. Cancer of the Oral Cavity, Pharynx and Larynx: Evidence-Based Decision Making is just such a resource.

Offering up-to-date, multidisciplinary coverage of this nuanced and evolving field, Cerebrospinal Fluid Rhinorrhea provides a comprehensive overview of the evaluation and diagnosis, as well as the medical and surgical management options, for all causes of cerebrospinal fluid (CSF) rhinorrhea. It covers all aspects of CSF leaks, synthesizing current knowledge on pathophysiology, diagnosis, perioperative care, and operative techniques for this complex group of patients. Leading experts in otolaryngology and neurosurgery, as well as ophthalmology, neurology, and radiology, provide detailed coverage of the distinctions between management of patients with differing etiologies of CSF rhinorrhea, including spontaneous, traumatic/iatrogenic, and tumor-related. Focuses exclusively on the comprehensive evaluation, and management of patients presenting with CSF leaks from the anterior cranial base, offering a reliable, one-stop resource for experienced clinicians as well as those in training. Covers the full breadth of cerebrospinal fluid rhinorrhea, with expert discussion of spontaneous CSF leaks, including evolving management techniques for patients with idiopathic intracranial hypertension; traumatic CSF leaks, including advanced management of complex anterior cranial base trauma; and up-to-date techniques for intraoperative skull base reconstruction after tumor resection. Includes tips and pearls on surgical approaches and postoperative management strategies for this complex and varied patient population. Features abundant high-definition images of anatomy, radiographic imaging, and intraoperative techniques, as well as videos that highlight intraoperative techniques in patients with spontaneous, traumatic, and tumor-related CSF leaks. Provides a detailed review of the different laboratory, examination (endoscopic nasal, as well as ophthalmologic) and imaging studies used to evaluate patients with CSF leaks. Discusses the evaluation and growing medical and procedural management options for patients with idiopathic intracranial hypertension. Offers state-of-the-art reconstruction options for CSF leaks and complex skull base defects, ranging from the nasoseptal flap and beyond. Addresses the controversial role of lumbar drains in CSF leak management, as will new and upcoming technological advances in operating room instrumentation. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Key Clinical Topics in Otolaryngology presents a brand new addition to the forthcoming Key Clinical Topics series. The book provides a comprehensive overview of the subject, comprising over 100 carefully selected topics in alpha order that together provide an extensive understanding of the management of head and neck disorders. This collection of highly practical guides systematically addresses management techniques for a large number of clinical settings. Edited by experienced specialists, with contributions from consultants who have recognised expertise in their field, this book provides an authoritative and up-to-date guide on head and neck disorders. Designed to enable rapid access to core information, Key Clinical Topics in Otolaryngology offers effective exam revision and the ideal quick reference for day-to-day practice. Over 100 topics presented in alpha order, from acute otitis media to voice disorders Effective exam revision for DOHNS and FRCS (ORL-HNS) candidates Succinct coverage of head and neck treatment modalities and complications Includes clinical photos and diagrams to improve understanding of concepts Contributions from experienced specialists to ensure authoritative, accurate content

The Oxford Handbook of Deaf Studies in Literacy brings together state-of-the-art research on literacy learning among deaf and hard of hearing learners (DHH). With contributions from experts in the field, this volume covers topics such as the importance of language and cognition, phonological or orthographic awareness, morphosyntactic and vocabulary understanding, reading comprehension and classroom engagement, written language, and learning among challenged populations. Avoiding sweeping generalizations about DHH readers that overlook varied experiences, this volume takes a nuanced approach, providing readers with the research to help DHH students gain competence in reading comprehension.

Over the last 20 years, pediatric otolaryngology has become a recognized subspecialty within otolaryngology head and neck surgery. Organizing the growth of clinical practice and knowledge in this area now is Pediatric Otolaryngology for the Clinician, a user-friendly resource for practicing general otolaryngologists, pediatricians and family practice physicians. This important title is divided into five sections: general ENT topics, otology, rhinology, head and neck disorders, and emergencies. Each chapter is authored by a recognized expert in the field and is concise and highly informative. Designed as a quick reference guide on a variety of topics such as antibiotic treatment of ear infections, sleep disorders in children, cochlear implantation, and airway management, to name just several, the book serves as a comprehensive yet succinct guide to caring for children with ear, nose and throat problems and will stand as an invaluable resource for any busy pediatric clinic.

For courses in Introductory Audiology A comprehensive introduction to hearing and balance disorders. This comprehensive, well-organized introduction to hearing and balance disorders gives students a number of vital tools to help them better understand, retain, and analyze the material. The book continues to update the material to keep content current with recent research, while retaining and improving a user-friendly approach to the topics and an abundance of how-to information, which shows the rewarding, fascinating aspects of a career in audiology. This text is designed to provide the ultimate teaching and learning experience. * Organized to ensure maximum teaching and learning effectiveness and success through a highly useful, unique chapter arrangement, flexible depth of coverage, and helpful chapter organization. * Includes features designed to facilitate learning, including illustrative visual tools, clinical commentaries, evolving case studies, footnoted material, review tables, a comprehensive glossary, and 20 new video clips interspersed throughout.

Language development, and the challenges it can present for individuals who are deaf or hard-of-hearing, have long been a focus of research, theory, and practice in D/deaf studies and deaf education. Over the past 150 years, but most especially near the end of the 20th and beginning of the 21st century, advances in the acquisition and development of language competencies and skills have been increasing rapidly. This volume addresses many of those accomplishments as well as remaining challenges and new questions that have arisen from multiple perspectives: theoretical, linguistic, social-emotional, neuro-biological, and socio-cultural. The contributors comprise an international group of prominent scholars and practitioners from a variety of academic and clinical backgrounds. The result is a volume that addresses, in detail, current knowledge, emerging questions, and innovative educational practice in a variety of contexts. The volume takes on topics such as discussion of the transformation of efforts to identify a "best" language approach (the "sign" versus "speech" debate) to a stronger focus on individual strengths, potentials, and choices for selecting and even combining approaches; the effects of language on other areas of development as well as effects from other domains on language itself; and how neurological, socio-cognitive, and linguistic bases of learning are leading to more specialized approaches to instruction that address the challenges that remain for deaf and hard-of-hearing individuals. This volume both complements and extends The Oxford Handbook of Deaf Studies and Deaf Education, Volumes 1 and 2, going further into the unique challenges and demands for deaf or hard-of-hearing individuals than any other text and providing not only compilations of what is known but setting the course for investigating what is still to be learned.

Cochlear implants are currently the standard treatment for profound sensorineural hearing loss. In the last decade, advances in auditory science and technology have not only greatly expanded the utility of electric stimulation to other parts of the auditory nervous system in addition to the cochlea, but have also demonstrated drastic changes in the brain in responses to electric stimulation, including changes in language development and music perception. Volume 20 of SHAR focused on basic science and technology underlying the cochlear implant. However, due to the newness of the ideas and technology, the volume did not cover any emerging applications such as bilateral cochlear implants, combined acoustic-electric stimulation, and other types of auditory prostheses, nor did it review brain plasticity in responses to electric stimulation and its perceptual and language consequences. This proposed volume takes off from Volume 20, and expands the examination of implants into new and highly exciting areas. This edited book starts with an overview and introduction by Dr. Fan-Gang Zeng. Chapters 2-9 cover technological development and the advances in treating the full spectrum of ear disorders in the last ten years. Chapters 10-15 discuss brain responses to electric stimulation and their perceptual impact. This volume is particularly exciting because there have been quantum leap from the traditional technology discussed in Volume 20. Thus, this volume is timely and will be of real importance to the SHAR audience.

Hearing loss is the most common form of sensory impairment in humans, affecting 360 million persons worldwide. In parallel, tinnitus disorder, the perception of a phantom sound often described as a ringing or buzzing, affects around 10-15% of the general population and interferes with daily life. Hyperacusis, defined as a hypersensitivity to moderate-intensity sounds often co-occurs with tinnitus suggesting a common mechanism of dysfunction for these two perceptual disorders. Whereas some drug candidates are in the process of being developed, nowadays no effective treatment exists to cure hearing loss and tinnitus. The topic of this book was selected with the goal of emphasizing mechanisms that induce hearing loss and tinnitus which lead the selection of promising targets for hearing disorder treatment. Hair cells (HC) are the sensory cells of the inner ear required for both auditory and vestibular functions in all vertebrates. HC are progressively lost during ageing and they are in addition sensitive to physical and acoustic traumas, infectious diseases and chemicals present in commonly used treatments such as anticancer, antimalarial or antibiotics. As adult mammals--including humans--cannot regenerate dead HC, all the possible injury could result in irreversible and permanent hearing loss. It has been shown, however, that a limited capacity to regenerate HC exists in mouse at an early stage of development. The regenerative capacity of HC then appears simply "repressed" in adult mammals, and one could expect it will be possible to re-activate it with an appropriate therapeutic approach which is still to be defined. Immune-mediated inner ear disease has been introduced and accepted as one SNHL pathophysiology; it responds to immunosuppressive therapy and is one of the few reversible forms of bilateral SNHL. Macrophages are always present in the spiral ligament of the lateral wall and are activated in response to various types of stimuli, including noise exposure, ischemia, mitochondrial damage, and surgical stress. Recent studies have also revealed another type of immune cell, called perivascular melanocyte-like macrophages (PVM/Ms), in the stria vascularis. The book will include a review of inflammatory/immune cells in the cochlear lateral wall, the pathways involved in cochlear damage and their potential as therapeutic targets. The final chapter provides an overview of current animal model of tinnitus and hyperacusis. Nowadays no effective treatment exists to cure tinnitus and hyperacusis. One major obstacle to arises from the fact that tinnitus is a subjective phenomenon, the only possible diagnosis relies on self-reports of the subjects. The main constraint of the use of animal models is the subjective character of tinnitus. This chapter describe the advancement in animal models which play an important role in revealing the underlying mechanisms and treatment for tinnitus and hyperacusis.

Cochlear implants have instigated a popular but controversial revolution in the treatment of deafness. This book discusses the physiological bases of using artificial devices to electrically stimulate the brain to interpret sounds. As the first successful device to restore neural function, the cochlear implant serves as a model for research in neuroscience and biomedical engineering. These and other auditory prostheses are discussed in the context of historical treatments, engineering, psychophysics and clinical issues as well as implications for speech, behavior, cognition and long-term effects on people.

Obstructive Sleep Apnea (OSA) is the most prevalent sleep disordered breathing disorder. It has become apparent that in more than half the patients with OSA, the frequency and duration of apneas are influenced by body position. To treat patients with Position Dependent OSA (POSA), positional therapy can be considered for preventing patients from sleeping in the worst sleeping position. Treatment of POSA has advanced dramatically recently with the introduction of a new generation of positional therapy. Positional Therapy in Obstructive Sleep Apnea presents improved OSA diagnostic methods and the tools needed to implement positional therapy in clinical practice. This includes patient work-up, positional therapy with or without other treatments, consequences of guidelines and future developments. Clinicians, students and researchers will find this comprehensive guide to be an invaluable resource for evaluating and treating sleep breathing disorders.

This book encompasses many different diagnoses as well as several specialties of practicing surgeons in the United States. Over the last ten years many advances have been made in preoperative assessment including imaging and diagnostic techniques, operative approaches including "minimally invasive" and robotic surgery, and post operative care. Controversies in Thyroid Surgery explores some of the controversies that arise as the result of these new findings and applications. The book is divided into the two categories of benign diagnosis and cancer topics. Both of these areas lend themselves to separate analysis of specific problems in the areas mentioned above. The text reviews recent data about advances in diagnostic techniques as well as outcomes with specific regards to the newer operative techniques. The textbook will serve as a resource for medical and surgical colleagues involved in the treatment of a wide variety of thyroid diseases. Authors that are experts in their field and have published extensively provide balanced and non-biased views of topics that are admittedly controversial. Controversies in Thyroid Surgery will be of great value and utility to practicing endocrinologists, general surgeons and otolaryngologists.

This is a nearly complete collection of Chapters that provide an up to date overview of all aspects of Head and Neck cancer. It is written by professionals but is not only intended for other professionals, but students, patients, policy makers, etc. There are so many aspects to this group of diseases that even the most seasoned professional will learn something from having read this book.