Authored by Bengt Kallen, professor emeritus in embryology at Lund University in Sweden. The subject of this book is to describe the occurrence of congenital malformations among children born and what risk factors exist. Population data are presented for a number of malformations, ascertained with the use of data from the Swedish national health registers for the period 1998-2010 corresponding to some 1.3 million births, together with prospectively collected information on a group of exposures of possible interest. The structure of the analysis is such that it excludes studies of, for instance, nutrition, alcohol or street drug use and many other lifestyle factors where prospective information or independent register information is difficult or impossible to obtain. Epidemiology of Human Congenital Malformations culminates with a discussion on how the presence of malformations can be explained and various possibilities for the prevention of birth defects. Moreover, it will include a series of instructions on how to read epidemiological literature in this field making it an essential resource both for those currently working in the field of reproductive epidemiology or those intending to enter it. It will additionally be useful for doctors working with malformations, either as obstetricians, neonatologists or pediatricians.

This book is devoted solely to the tricuspid valve and its role in congenital heart disease. Tricuspid valve anomalies are part of the pathological spectrum in various congenital heart diseases, including Ebstein anomaly and tricuspid valve dysplasia, with different pathophysiology and clinical implications. This book covers all relevant aspects of such anomalies, including diagnosis, therapy and follow-up. Further topics addressed include the way in which the tricuspid valve may become the "systemic" valve in some congenital diseases, with important consequences and the involvement of the tricuspid valve in the right-sided heart complications often seen in adults with congenital heart disease. All of the chapters are written by internationally recognized experts and are designed to deliver state of the art knowledge of practical value. This book will be an important addition to the library for surgeons, cardiologists and other practitioners involved in the management of patients with congenital heart disease.

Until the 1990s, it was generally accepted that medicines were first developed for adults and their use in children was investigated later, if at all. One of the main tasks of hospital pharmacies was the manufacturing of child-appropriate formulations in a more or less makeshift way. The first change came in 1997 with U.S. legislation that rewarded manufacturers to do voluntary pediatric research. Ten years later, the European Union passed legislation that required manufacturers to discuss all pediatric aspects, including formulations, with the regulatory authorities as a condition of starting the registration procedure. In consequence, manufacturers must now cover all age groups, including the youngest ones. So far, pediatric formulations were more a focus for academic researchers. Through the changed regulatory environment, there is now a sudden high commercial demand for age-appropriate formulations. This book begins by highlighting the anatomical, physiological and developmental differences between adults and children of different ages. It goes on to review the existing technologies and attempts to draw a roadmap to better, innovative formulations, in particular for oral administration. The regulatory, clinical, ethical and pharmaceutical framework is also addressed.

Spinal Injuries and Conditions in Young Athletes provides a comprehensive, in-depth review of the mechanisms and management of back injuries and problems occurring in this ever-growing and active population. Led by Dr. Lyle Micheli and his co-editors, an award-winning group of orthopedists discusses and explores common adolescent spine injuries and procedures, in addition to breakthroughs in gene therapy, tissue engineering, and complex operations. As spine surgery is among the most complex and challenging procedures performed in orthopedics, special considerations and procedures are required in pediatric populations. Since many corrective surgeries run the risk of arthritis later in life, particular efforts must be made in young populations to prevent future injury in a child's adolescence and young adulthood while maximizing return-to-play potential. Chapters cover acute spinal injuries, concussions, overuse injuries, spinal malformations, tumors, infections and inflammatory diseases across the range of athletics, including swimming and combat sports. Spinal Injuries and Conditions in Young Athletes provides an immeasurable guide for back surgery in pediatric populations and will be a go-to resource for practitioners and residents in pediatric orthopedics and sports medicine.

There are growing questions regarding the safety, quality, risk management, and costs of PCC teams, their training and preparedness, and their implications on the welfare of patients and families. This innovative book, authored by an international authorship, will highlight the best practices in improving survival while paving a roadmap for the expected changes in the next 10 years as healthcare undergoes major transformation and reform. An invited group of experts in the field will participate in this project to provide the timeliest and informative approaches to how to deal with this global health challenge. The book will be indispensable to all who treat pediatric cardiac disease and will provide important information about managing the risk of patients with pediatric and congenital cardiac disease in the three domains of: the analysis of outcomes, the improvement of quality, and the safety of patients.

Sine syndromes (SSs) represent atypical forms of inflammatory rheumatic diseases, the courses of which are often severe. While the diagnosis of rheumatic diseases can be determined according to an established set of diagnostic criteria based on clinical characteristics and laboratory parameters, Sine Syndromes do not fulfill the standard criteria used to assist in the classification of patients with rheumatological disorders. This concise book gives an overview of atypical courses in common inflammatory rheumatic diseases such as Wegener's granulomatosis, systemic sclerosis, Sjoegren's syndrome, or systemic lupus erythematosus. Each chapter reviews similar cases reported in the literature and presents current data on treatment options. Drawing on their vast clinical experience, the editors provide a series of detailed case reports in order to illustrate the different types of disease. The book is intended to facilitate early diagnosis and effective therapy in patients where a schematic approach may not prove sufficient. Sine Syndromes in Rheumatology will serve as a useful and easily accessible reference for specialists in rheumatology as well as for practitioners in the fields of internal medicine, pediatrics, and orthopedics.

This book focuses on children and the impact of neurotoxins on the developing brain to guide the practice of psychologists working with children in clinical and school settings. Each chapter covers a distinct neurotoxin or group of neurotoxins, with particular emphasis on the impact of the neurotoxin exposure on the developing brain and long-term cognitive and psychosocial outcomes. This is more complex than studying neurotoxins with adults because of the rapid development occurring in the child's brain. Further, children are more susceptible than adults to the effects of neurotoxins due to their developmental status. Many of the effects discussed in this volume occur in utero, thus setting the stage for an altered developmental trajectory.

Although respiratory syncytial virus (RSV) has been a high priority for vaccine development for over 50 years now, still no vaccine is available and none has yet demonstrated sufficient promise to move to licensure. The success of RSV immune prophylaxis and the availability of ever more powerful tools to study the immune response and pathogenesis of disease, combined with the ability to construct a wide variety of vaccines using different vaccine platforms, give us grounds to believe that an RSV vaccine is within reach. This book brings together in one source what is currently known about the virus: its clinical and epidemiologic features; the host response and pathogenesis of the disease; vaccines, vaccine platforms, and treatment; and animal and tissue culture models of RSV infection. It is designed to organize the critical information relevant to RSV vaccine development, facilitate the assimilation of data, and speed progress toward producing a safe and effective vaccine.

Schools across the United States - as well as much of the world - are experiencing widespread change. Students are more diverse ethnically, academically, and emotionally. More attention is being paid to abuse and neglect, violence and bullying, and the growing inequities that contribute to student dropout. Within this changing landscape, cultural competence is imperative for school-based professionals, both ethically and as mandated by educational reform. The Handbook of Culturally Responsive School Mental Health explores the academic and behavioral challenges of an increasingly diverse school environment, offering workable, cost-effective solutions in an accessible, well-organized format. This timely volume updates the research on cultural competence in school-based interventions, describes innovative approaches to counseling and classroom life, and demonstrates how this knowledge is used in successful programs with children, adolescents, and their families. Populations covered range widely, from African American and Asian American/Pacific Islander families to forced migrants and children who live on military bases. By addressing issues of training and policy as well as research and practice, contributors present a variety of topics that are salient, engaging, and applicable to contemporary experience, including: - Adolescent ethnic/racial identity development. - Culturally responsive school mental health in rural communities. - Working with LGBT youth in school settings. - Cultural competence in work with youth gangs. - Culturally integrated substance abuse prevention and sex education programs. - Promoting culturally competent school-based assessment. - School-based behavioral health care in overseas military bases. - Developmental, legal, and linguistic considerations in work with forced migrant children. - Cultural considerations in work/family balance. The Handbook of Culturally Responsive School Mental Health is a must-have reference for researchers, scientist-practitioners, educational policymakers, and graduate students in child and school psychology; educational psychology; pediatrics/school nursing; social work; counseling/therapy; teaching and teacher education; and educational administration.

This book provides recommendations for evaluation and therapy in the area of acute pediatric neurology; these are presented didactically with frequent use of illustrations and algorithms. Chapters in the first part of the book discuss presenting symptoms of acute neurological conditions. The second part of the book covers major areas of acute pediatric neurology and each of these chapters has three key elements: description of presenting symptoms; recommended assessments; and recommended interventions. Acute Pediatric Neurology provides an accessible, clinically focused guide to assist physicians in the emergency ward or intensive care unit in decisions on diagnosis and therapeutic interventions in all major acute pediatric neurological diseases.

Bone Drugs in Pediatrics brings together in one place the evidence for the use of certain drugs in the treatment and prevention of bone loss in children, as well as the reservations still present in the pediatric community regarding their use. Beginning with a discussion of developmental pharmacokinetics and drug development for pediatric diseases where bone loss occurs, such as osteogenesis imperfecta, the physiology of pediatric bone and how best to monitor the safety and efficacy of these drugs is presented. The pros and cons of utilizing the drugs themselves - such as bisphosphonates, antiresorptives and anabolic agents - within the pediatric population are carefully considered, with an eye toward safe and effective integration. The potential use of drugs in future treatment is also highlighted. On the whole, Bone Drugs in Pediatrics is a cogent presentation of the ongoing debate surrounding the potential for pharmacological interventions in pediatric bone loss.

Their frightened, angry faces are grim reminders of the reach of war. They are millions of children, orphaned, displaced, forced to flee or to fight. And just as they have myriad possibilities for trauma, their lives also hold great potential for recovery. The Handbook of Resilience in Children of War explores these critical phenomena at the theoretical, research, and treatment levels, beginning with the psychosocial effects of exposure to war. Narratives of young people's lives in war zones as diverse as Afghanistan, Sri Lanka, Columbia, and Sudan reveal the complexities of their experiences and the meanings they attach to them, providing valuable keys to their rehabilitation. Other chapters identify strengths and limitations of current interventions, and of constructs of resilience as applied to youth affected by war. Throughout this cutting-edge volume, the emphasis is on improving the field through more relevant research and accurate, evidence-based interventions, in such areas as: An ecological resilience approach to promoting mental health in children of war. Child soldiers and the myth of the ticking time bomb. The Child Friendly Spaces postwar intervention program. The role of education for war-zone immigrant and refugee students. Political violence, identity, and adjustment in children. The Handbook of Resilience in Children of War is essential reading for researchers, scientist-practitioners, and graduate students in diverse fields including clinical child, school, and developmental psychology; child and adolescent psychiatry; social work; counseling; education; and allied medical and public health disciplines.

This timely volume surveys the broad spectrum of interventions used in health promotion, and shows how they may be tailored to the developmental needs of children and adolescents. Its multilevel lifespan approach reflects concepts of public health as inclusive, empowering, and aimed at long- and short-term well-being. Coverage grounds readers in theoretical and ecological perspectives, while special sections spotlight key issues in social and behavioral wellness, dietary health, and children and teens in the health care system. And in keeping with best practices in the field, the book emphasizes collaboration with stakeholders, especially with the young clients themselves. Among the topics covered: Child mental health: recent developments with respect to risk, resilience, and interventions Health-related concerns among children and adolescents with ADD/ADHD Preventing risky sexual behavior in adolescents Violence affecting youth: pervasive and preventable Childhood and adolescent obesity Well-being of children in the foster care system Health Promotion for Children and Adolescents is a necessary text for graduate or advanced undergraduate courses in public health, education, medicine, psychology, health education, social work, curriculum, nutrition, and public affairs. It is also important reading for public health professionals; researchers in child health, health education, and child psychology; policymakers in education and public health; and teachers.

This book provides a step-by-step guide to integrating early childhood behavioral health care into primary care with hands-on advice for creating, implementing, and evaluating programs. It discusses the unique advantages of pediatric primary care as a setting for mental health services from birth into the early school years, particularly for addressing parent/child stress and trauma issues. Contributors illustrate in depth how bringing behavioral health into pediatric services can engender care that is replicable and sustainable, not only cost-effective but also clinically effective. Guidelines and case examples from frontline practitioners highlight typical challenges and workable recommendations. Among the featured topics: * The fit between early intervention programs and primary care.* Staffing, workforce development, and funding issues.* On-the-job teamwork concerns, from time constraints to continuity of care.* Culturally competent care geared toward key child care issues.* Intervening with parents of young children in the integrated pediatric setting. Integrated Early Childhood Behavioral Health in Primary Care is an essential resource for clinicians/practitioners, graduate students, and researchers in child and school psychology, pediatrics, and social work.

This book focuses on predictive, preventative and personalized medicine (PPPM) and how it is related to the healthcare of rare diseases. Readers will discover how advanced rare diseases healthcare provides an excellent "proof-of-principles" for the personalisation of healthcare systems on a global scale. Chapters look at national plans for rare disease, at biobanking, gene identification, rare cancers, virus gene therapy , induced pluripotency for cell therapy amongst other topics. There is a chapter dedicated to personalized medicine for hereditary deafness and another exploring the complexity of genotype-phenotype correlations. Specific diseases such as Fabry's, Gauchers and mitochondrial cytopathies are highlighted and we look at enzyme replacement therapy in lysosomal storage diseases. This work is part of a series, produced with the involvement of the European Association for Predictive, Preventive and Personalised Medicine. The series focusses on the concept of an integrative medical approach by PPPM. This volume is dedicated to all aspects related to the prediction, prevention and personalised treatments of rare diseases, and in doing so it explores developments relevant to all medical branches. The authors cover ethical considerations, the creation of a robust platform for professional communication, synergies with patient organisations, "doctor-patient" collaboration and a new philosophy of integrative medicine by PPPM. This volume serves as a reference source for scientific and medical centres in the field and can be used both at medical curricula and graduate level in the life sciences. Those who place a special emphasis on healthcare promotion and innovations intended to combat rare diseases, save the affected lives and enhance life quality will all find this book of great value.

This volume provides a thorough overview of the Wilms' Tumour Gene (WT1). The book begins with three review chapters that cover the involvement of WT1 in pediatric cancer, kidney disease, and tissue development and homeostasis. The next few chapters discuss cell marking and lineage tracing, epicardial cell methodology, colony forming assays for bone marrow stem cells, angiogenesis assays and zebrafish tools. The next group of chapters explores the latest tools in genomics, molecular biology, and biochemistry. They discuss dissecting transcription factor function in cell free systems, ChiP seq, proteomics, RNA interactome, and multiphoton imaging of lipids, measuring the binding constants of protein-nucleic acid interactions, and bioinformatics approaches for analyzing Next Generation Sequence data. The final chapter discusses protocols for clinical trials for immune therapy using anti-WT1 peptides. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, The Wilms' Tumour (WT1) Gene: Methods and Protocols is a valuable resource for anyone who is interested in the diverse methodologies used in WT1 research.

This handbook describes in detail different contemporary approaches to group work with children and adolescents. Further, this volume illustrates the application of these models to work with the youth of today, whether victims of trauma, adolescents struggling with LGBT issues, or youth with varying common diagnoses such as autism spectrum disorders, depression, and anxiety. It offers chapters presenting a variety of clinical approaches written by experts in these approaches, from classic (play therapy and dialectical behavior therapy) to cutting-edge (attachment-based intervention, mindfulness, and sensorimotor psychotherapy). Because of its broad scope, the book is suitable for a wide audience, from students to first-time group leaders to seasoned practitioners.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

With Bridging Worlds, you will learn to uncover the roots of teenage problems - the causes behind symptoms such as self-destructiveness, anger, recklessness, and violence. Originally published in 1998, this title shows you how to develop treatment guidelines and thoughtful frames of reference that address the problems of teenage violence, pregnancy, truancy, and delinquency. It will help you detect when the reckless, even frightening, behaviour of adolescents is a cry for help and show you what you can do to defuse the situation, make authentic and meaningful connections, and offer valuable help.

In this volume, Kathleen Nader has compiled an articulate and comprehensive guide to the complex process of assessment in youth and adolescent trauma. There are many issues that are important to evaluating children and adolescents, and it is increasingly clear that reliance on just one type of assessment does not provide the most accurate results. From history to recent advances, this book covers a wide range of methods and measures for assessing trauma, including case examples to illustrate the integration of these different facets. Altogether, the broad scope and inclusive depth of this work make it an essential addition to the field of trauma assessment.

Presenting a multidisciplinary approach to the prevention and management of injuries to young tennis players, this unique book considers multiple factors contributing to the increasing numbers of such sports-related injuries, such as increased young athlete participation in tennis, the pre-professionalization of younger players and misconceptions surrounding treating children in the same manner as adults. Beginning with the essentials for developing tennis players and their physical and mental growth with the sport, the text then turns to prevention and management techniques and strategies covering the upper and lower extremities, shoulder and elbow, hip and knee, and spine, as well as other acute medical conditions. Further consideration is given to proper nutrition, strength and conditioning, and rehabilitation and return to play. Edited by clinicians directly involved in the care of young tennis players and including contributions from physical therapists, nutritionists, sports psychologists, and physicians, it is an invaluable and comprehensive resource for any professional seeing and treating young tennis players.

This book offers a theoretical and practical overview of the specific ethical and legal issues in pediatric organ transplantation. Written by a team of leading experts, Ethical Issues in Pediatric Organ Transplantation addresses those difficult ethical questions concerning clinical, organizational, legal and policy issues including donor, recipient and allocation issues. Challenging topics, including children as donors, donation after cardiac death, misattributed paternity, familial conflicts of interest, developmental disability as a listing criteria, small bowel transplant, and considerations in navigating the media are discussed. It serves as a fundamental handbook and resource for pediatricians, transplant health care professionals, trainees, graduate students, scholars, practitioners of bioethics and health policy makers.

Written for pediatric dermatologists, fellows, dermatology residents and medical students rotating in pediatric dermatology, this book covers topics ranging from atopic dermatitis, drug eruptions, neonatal inpatient dermatology, abuse, and skin signs of other systemic diseases. Inpatient Pediatric Dermatology is an emerging subspecialty of Pediatric Dermatology, yet little has been written for the practicing physician treating these young patients in the hospital. Case-based Inpatient Pediatric Dermatology fills that void and uses case-based examples to highlight common and uncommon presentations of dermatologic disease in the hospitalized pediatric patient. Complete with useful color illustrations and photographs, this book is the go-to guide for clinicians treating hospitalized pediatric dermatology patients.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

In this issue of Clinics in Perinatology, guest editors KuoJen Tsao and Hanmin Lee bring their considerable expertise to the topic of Fetal and Neonatal Surgery. Provides in-depth reviews on the latest updates in Fetal and Neonatal Surgery, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.