Cold atmospheric plasma is an auspicious new candidate in cancer treatment. Cold atmospheric plasma (CAP) is a partially ionized gas in which the ion temperature is close to room temperature. It contains electrons, charged particles, radicals, various excited molecules and UV photons. These various compositional elements have the potential to inhibit cancer cell activity whilst doing no harm to healthy cells. Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults; treatment including surgery, radio- and chemotherapy remains palliative for most patients as a cure remains elusive. The successful combination of the standard chemotherapeutic temozolomide (TMZ) and CAP treatment features synergistic effects even in resistant glioma cells. In particular in glioma therapy, CAP could offer an innovative approach allowing specific cancer cell / tumor tissue inhibition without damaging healthy cells. Thus CAP is a promising candidate for combination therapy especially for patients suffering from GBMs showing TMZ resistance.

This book explores the relaxation dynamics of inner-valence-ionized diatomic molecules on the basis of extreme-ultraviolet pump-probe experiments performed at the free-electron laser (FEL) in Hamburg. Firstly, the electron rearrangement dynamics in dissociating multiply charged iodine molecules is studied in an experiment that made it possible to access charge transfer in a thus far unexplored quasimolecular regime relevant for plasma and chemistry applications of the FEL. Secondly the lifetime of an efficient non-radiative relaxation process that occurs in weakly bound systems is measured directly for the first time in a neon dimer (Ne2). Interatomic Coulombic decay (ICD) has been identified as the dominant decay mechanism in inner-valence-ionized or excited van-der-Waals and hydrogen bonded systems, the latter being ubiquitous in all biomolecules. The role of ICD in DNA damage thus demands further investigation, e.g. with regard to applications like radiation therapy.

In this monograph the author presents the Canonical Profile Transport Model or CPTM as a rather general mathematical framework to simulate plasma discharges. The description of hot plasmas in a magnetic fusion device is a very challenging task and many plasma properties still lack a physical explanation. One important property is plasma self-organization. It is very well known from experiments that the radial profile of the plasma pressure and temperature remains rather unaffected by changes of the deposited power or plasma density. The attractiveness of the CPTM is that it includes the effect of self-organization in the mathematical model without having to recur to particular physical mechanisms. The CPTM model contains one dimensional transport equations for ion and electron temperatures, plasma density and toroidal rotation velocity. These equations are well established and in fact are essentially a reformulation the laws of energy, particle and momentum conservation. But the expressions for the energy and particle fluxes, including certain critical gradients, are new. These critical gradients can be determined using the concept of canonical profiles for the first time formulated in great detail in the book. This concept represents a totally new approach to the description of transport in plasmas. Mathematically, the canonical profiles are formulated as a variational problem. To describe the temporal evolution of the plasma profiles, the Euler equation defining the canonical profiles is solved together with the transport equations at each time step. The author shows that in this way it is possible to describe very different operational scenarios in tokamaks (L-Mode, H-Mode, Advanced Modes, Radiating Improved Modes etc…), using one unique principle. The author illustrates the application of this principle to the simulation of plasmas on leading tokamak devices in the world (JET, MAST, T-10, DIII-D, ASDEX-U, JT-60U). In all cases the small differences between the calculated profiles for the ion and electron temperatures and the experimental is rather confirm the validity of the CPTM. In addition, the model also describes the temperature and density pedestals in the H-mode and non steady-state regimes with current and density ramp up. The proposed model therefore provides a very useful mathematical tool for the analysis of experimental results and for the prediction of plasma parameters in future experiments.

This thesis presents neutron scattering data that contribute to the understanding of four distinct areas of condensed matter physics, including iso-compositional liquid-liquid phase transitions and the glass formation in rare earth doped BaTi2O5. In situ aerodynamic levitation with laser heating was combined with neutron scattering in order to study both liquid-liquid phase transitions in (Y2O3)x(Al2O3)1-x and the atomic and magnetic ordering in liquid Invar. Among several significant results, obtained in this case from small angle neutron scattering, was the absence of a phase transition across a range of temperatures and compositions in the yttria aluminates. As these are a principal system in which liquid-liquid phase transitions have been hypothesized, this is an important contribution in a contentious area.

The thesis represents the development of an entirely new experimental platform for generating and studying converging radiative shock waves. It was discovered that the application of large magnetic pressures to gas-filled cylindrical metallic tubes could sequentially produce three shocks within the gas. A comprehensive set of instrumentation was devised to explore this system in detail and an exceptionally thorough experimental and theoretical study was carried out in order to understand the source of the shock waves and their dynamics. The research is directed towards some of the most interesting topics in high energy density physics (HEDP) today, namely the interaction of HED material with radiation and magnetic fields, with broad applications to inertial confinement fusion (ICF) and laboratory plasma astrophysics. The work has already generated significant international interest in these two distinct research areas and the results could have significant importance for magnetic ICF concepts being explored at Sandia National Laboratories in the US and for our understanding of the very strong shock waves that are ubiquitous in astrophysics.

During the past century, world-wide energy consumption has risen dramatically, which leads to a quest for new energy sources. Fusion of hydrogen atoms in hot plasmas is an attractive approach to solve the energy problem, with abundant fuel, inherent safety and no long-lived radioactivity. However, one of the limits on plasma performance is due to the various classes of magneto-hydrodynamic instabilities that may occur. The physics and control of these instabilities in modern magnetic confinement fusion devices is the subject of this book. Written by foremost experts, the contributions will provide valuable reference and up-to-date research reviews for "old hands" and newcomers alike.

This thesis presents an experimental study of the ultrafast molecular dynamics of CO_2^+ that are induced by a strong, near-infrared, femtosecond laser pulse. In particular, typical strong field phenomena such as tunneling ionisation, nonsequential double ionisation and photo-induced dissociation are investigated and controlled by employing an experimental technique called impulsive molecular alignment. Here, a first laser pulse fixes the molecule in space, such that the molecular dynamics can be studied as a function of the molecular geometry with a second laser pulse. The experiments are placed within the context of the study and control of ultrafast molecular dynamics, where sub-femtosecond (10^-15 seconds) resolution in ever larger molecular systems represents the current frontier of research. The thesis presents the required background in strong field and molecular physics, femtosecond laser architecture and experimental techniques in a clear and accessible language that does not require any previous knowledge in these fields.

This book deals with solving mathematically the unsteady flame propagation equations. New original mathematical methods for solving complex non-linear equations and investigating their properties are presented. Pole solutions for flame front propagation are developed. Premixed flames and filtration combustion have remarkable properties: the complex nonlinear integro-differential equations for these problems have exact analytical solutions described by the motion of poles in a complex plane. Instead of complex equations, a finite set of ordinary differential equations is applied. These solutions help to investigate analytically and numerically properties of the flame front propagation equations.

This book introduces the basic concepts, synthesis techniques, and applications of vertically-oriented graphene. The authors detail emerging applications of vertically-oriented graphene such as field emitters, atmospheric nanoscale corona discharges, gas sensors and biosensors, supercapacitors, lithium-ion batteries, fuel cells (catalyst supports) and electrochemical transducers. They offer a perspective on current challenges to enabling commercial applications of vertically-oriented graphene.

The 11th International Conference on X-Ray Lasers had contributions in the following topical areas: Transient Collisional X-Ray Lasers, Table-Top High Repetition Rate X-Ray Lasers, Optical-Field Ionised (OFI) X-Ray Lasers, Theory and Simulation of X-Ray Lasers, High Order Harmonic Generation, XUV Optics and X-Ray Laser Applications, Capillary Discharge X-Ray Lasers, Alternative Sources of coherent XUV Radiation. The proceedings of this conference constitute a comprehensive source of reference for scientists involved in researching the development and application of coherent X-Ray sources.

This book covers the history of lasers with nuclear pumping (Nuclear Pumped Lasers, NPLs). This book showcases the most important results and stages of NPL development in The Russian Federal Nuclear Center (VNIIEF) as well as other Russian and international laboratories, including laboratories in the United States. The basic science and technology behind NPLs along with potential applications are covered throughout the book. As the first comprehensive discussion of NPLs, students, researchers, and application engineers interested in high energy lasers will find this book to be an extremely valuable source of information about these unique lasers.

This book reviews the phenomenology displayed by relativistic jets as well as the most recent theoretical efforts to understand the physical mechanisms at their origin. Relativistic jets have been observed and studied in Active Galactic Nuclei (AGN) for about half a century and are believed to be fueled by accretion onto a supermassive black hole at the center of the host galaxy. Since the first discovery of relativistic jets associated with so-called "micro-quasars" much more recently, it has seemed clear that much of the physics governing the relativistic outflows in stellar X-ray binaries harboring black holes and in AGN must be common, but acting on very different spatial and temporal scales. With new observational and theoretical results piling up every day, this book attempts to synthesize a consistent, unified physical picture of the formation and disruption of jets in accreting black-hole systems. The chapters in this book offer overviews accessible not only to specialists but also to graduate students and astrophysicists working in other areas. Covered topics comprise Relativistic jets in stellar systems Launching of AGN jets Parsec-scale AGN jets Kiloparsec-scale AGN jets Black hole magnetospheres Theory of relativistic jets The structure and dynamics of the inner accretion disk The origin of the jet magnetic field X-ray observations, phenomenology, and connection with theory

This course-tested textbook conveys the fundamentals of magnetic fields and relativistic plasma in diffuse cosmic media, with a primary focus on phenomena that have been observed at different wavelengths. Theoretical concepts are addressed wherever necessary, with derivations presented in sufficient detail to be generally accessible. In the first few chapters the authors present an introduction to various astrophysical phenomena related to cosmic magnetism, with scales ranging from molecular clouds in star-forming regions and supernova remnants in the Milky Way, to clusters of galaxies. Later chapters address the role of magnetic fields in the evolution of the interstellar medium, galaxies and galaxy clusters. The book is intended for advanced undergraduate and postgraduate students in astronomy and physics and will serve as an entry point for those starting their first research projects in the field.

The book, 'Laser Physics and Technology', addresses fundamentals of laser physics, representative laser systems and techniques, and some important applications of lasers. The present volume is a collection of articles based on some of the lectures delivered at the School on 'Laser Physics and Technology' organized at Raja Ramanna Centre for Advanced Technology during March, 12-30, 2012. The objective of the School was to provide an in-depth knowledge of the important aspects of laser physics and technology to doctoral students and young researchers and motivate them for further work in this area. In keeping with this objective, the fourteen chapters, written by leading Indian experts, based on the lectures delivered by them at the School, provide along with class room type coverage of the fundamentals of the field, a brief review of the current status of the field. The book will be useful for doctoral students and young scientists who are embarking on a research in this area as well as to professionals who would be interested in knowing the current state of the field particularly in Indian context.

This revised edition of the author's classic 2006 text offers a comprehensively updated review of the field of relativistic nonlinear electrodynamics. It explores the interaction of strong and super-strong electromagnetic/laser radiation with the electromagnetic quantum vacuum and diverse types of matter - including free charged particles and antiparticles, acceleration beams, plasma and plasmous media. The appearance of laser sources of relativistic and ultra-relativistic intensities over the last decade has stimulated investigation of a large class of processes under such super-strong radiation fields. Revisions for this second edition reflect these developments and the book includes new chapters on Bremsstrahlung and nonlinear absorption of superintense radiation in plasmas, the nonlinear interaction of relativistic atoms with intense laser radiation, nonlinear interaction of strong laser radiation with Graphene, and relativistic nonlinear phenomena in solid-plasma targets under supershort laser pulses of ultrarelativistic intensities. The only book devoted to the subject of relativistic nonlinear electrodynamics, this second edition will be a valuable resource for graduate students and researchers involved in any aspect of the field, including those working with intense x-ray - gamma-ray lasers, the new generation of small size laser-plasma accelerators of superhigh energies and high-brightness particle beams.

This book is a new edition of Roederer's classic Dynamics of Geomagnetically Trapped Radiation, updated and considerably expanded. The main objective is to describe the dynamic properties of magnetically trapped particles in planetary radiation belts and plasmas and explain the physical processes involved from the theoretical point of view. The approach is to examine in detail the orbital and adiabatic motion of individual particles in typical configurations of magnetic and electric fields in the magnetosphere and, from there, derive basic features of the particles' collective "macroscopic" behavior in general planetary environments. Emphasis is not on the "what" but on the "why" of particle phenomena in near-earth space, providing a solid and clear understanding of the principal basic physical mechanisms and dynamic processes involved. The book will also serve as an introduction to general space plasma physics, with abundant basic examples to illustrate and explain the physical origin of different types of plasma current systems and their self-organizing character via the magnetic field. The ultimate aim is to help both graduate students and interested scientists to successfully face the theoretical and experimental challenges lying ahead in space physics in view of recent and upcoming satellite missions and an expected wealth of data on radiation belts and plasmas.

James L. Burch*C. Philippe Escoubet Originally published in the journal Space Science Reviews, Volume 145, Nos 1-2, 1-2. DOI: 10. 1007/s11214-009-9532-7 (c) Springer Science+Business Media B. V. 2009 The IMAGE and CLUSTER spacecraft have revolutionized our understanding of the inner magnetosphere and in particular the plasmasphere. Before launch, the plasmasphere was not a prime objective of the CLUSTER mission. In fact, CLUSTER might not have ever observed this region because a few years before the CLUSTER launch (at the beginning of the 1990s), it was proposed to raise the perigee of the orbit to 8 Earth radii to make multipoint measu- ments in the current disruption region in the tail. Because of ground segment constraints, this proposal did not materialize. In view of the great depth and breadth of plasmaspheric research and numerous papers published on the plasmasphere since the CLUSTER launch, this choice certainly was a judicious one. The fact that the plasmasphere was one of the prime targets in the inner magnetosphere for IMAGE provided a unique opportunity to make great strides using the new and comp- mentary measurements of the two missions. IMAGE, with sensitive EUV cameras, could for the rst time make global images of the plasmasphere and show its great variability d- ing storm-time. CLUSTER, with four-spacecraft, could analyze in situ spatial and temporal structures at the plasmapause that are particularly important in such a dynamic system.

This monograph is dedicated to the derivation and analysis of fluid models occurring in plasma physics. It focuses on models involving quasi-neutrality approximation, problems related to laser propagation in a plasma, and coupling plasma waves and electromagnetic waves. Applied mathematicians will find a stimulating introduction to the world of plasma physics and a few open problems that are mathematically rich. Physicists who may be overwhelmed by the abundance of models and uncertain of their underlying assumptions will find basic mathematical properties of the related systems of partial differential equations. A planned second volume will be devoted to kinetic models. First and foremost, this book mathematically derives certain common fluid models from more general models. Although some of these derivations may be well known to physicists, it is important to highlight the assumptions underlying the derivations and to realize that some seemingly simple approximations turn out to be more complicated than they look. Such approximations are justified using asymptotic analysis wherever possible. Furthermore, efficient simulations of multi-dimensional models require precise statements of the related systems of partial differential equations along with appropriate boundary conditions. Some mathematical properties of these systems are presented which offer hints to those using numerical methods, although numerics is not the primary focus of the book.

The book presents results of a comprehensive study of various features of eigen electromagnetic waves propagating across the axis of plasma filled metal waveguides with cylindrical geometry. The authors collected in one book material on various features of surface flute waves, i.e. impact of waveguide design on wave dispersion, wave damping influenced by various reasons, impact of plasma density and external magnetic field inhomogeneity on the wave, and impact of waveguide corrugation and electric current on the wave. A variety of present surface waves applications and possible future applications is also included. Using the method of successive approximations it is shown how one can solve problems, which concern real experimental devices, starting from simple models. The book applies to both professionals dealing with problems of confined plasmas and to graduate and post-graduate students specializing in the field of plasma physics and related applications.

The two experimental studies reported in this thesis contribute important new knowledge about phase transitions in two-dimensional complex plasmas: in one case a determination of the coupling parameter (ratio of mean potential to mean kinetic energy of the particles in an ensemble), and in the other a detailed characterization of the non-equilibrium recrystallization of a two-dimensional system. The latter results are used to establish the connection between structural order parameters and the kinetic energy, which in turn gives novel insights into the underlying physical processes determining the two-dimensional phase transition.

This book presents a comprehensive overview of research on environmentally friendly insulating gases, in response to the urgent calls for developing alternatives to SF6 due to the increasing awareness of the threat it poses as a greenhouse gas. It covers gas dielectrics, SF6 and its mixtures, and potential alternative gases, providing fundamental information on gas discharge and gas insulation and especially focusing on the development of new environmentally friendly insulating gases over the last decade. The book begins by describing the insulating and arcing characteristics of SF6, followed by an introduction to the gas dielectrics performance of SF6 gas mixtures with buffer gases. The latest findings on new environmentally friendly insulating gases are described in detail, and suggestions for practical application are also provided. Graduate students and teachers involved in high-voltage and insulation engineering can use the book as teaching material. Researchers working in plasma science, laser action and related applied physics fields can also benefit from the book's analytical approach and detailed data; engineers from the fields of electric power operation systems and electrical manufacturing will find it a valuable reference work for solving practical problems.

This book provides an overview of solar wind turbulence from both the theoretical and observational perspective. It argues that the interplanetary medium offers the best opportunity to directly study turbulent fluctuations in collisionless plasmas. In fact, during expansion, the solar wind evolves towards a state characterized by large-amplitude fluctuations in all observed parameters, which resembles, at least at large scales, the well-known hydrodynamic turbulence. This text starts with historical references to past observations and experiments on turbulent flows. It then introduces the Navier-Stokes equations for a magnetized plasma whose low-frequency turbulence evolution is described within the framework of the MHD approximation. It also considers the scaling of plasma and magnetic field fluctuations and the study of nonlinear energy cascades within the same framework. It reports observations of turbulence in the ecliptic and at high latitude, treating Alfvenic and compressive fluctuations separately in order to explain the transport of mass, momentum and energy during the expansion. Further, existing models are compared with direct observations in the heliosphere. The problem of self-similar and anomalous fluctuations in the solar wind is then addressed using tools provided by dynamical system theory and discussed on the basis of available models and observations. The book highlights observations of Yaglom's law in solar wind turbulence, which is one of the most important findings in fully developed turbulence and directly related to the long-lasting and still unsolved problem of solar wind plasma heating. Lastly, it includes a short chapter dedicated to the kinetic range of fluctuations, which has recently been receiving more attention from the space plasma community, since this is inherently related to turbulent energy dissipation and consequent plasma heating. It particularly focuses on the nature and role of the fluctuations populating this frequency range, and discusses several model predictions and recent observational findings in this context.

This book is an introduction to contemporary plasma physics that discusses the most relevant recent advances in the field and covers a careful choice of applications to various branches of astrophysics and space science. The purpose of the book is to allow the student to master the basic concepts of plasma physics and to bring him or her up to date in a number of relevant areas of current research. Topics covered include orbit theory, kinetic theory, fluid models, magnetohydrodynamics, MHD turbulence, instabilities, discontinuities, and magnetic reconnection. Some prior knowledge of classical physics is required, in particular fluid mechanics, statistical physics, and electrodynamics. The mathematical developments are self-contained and explicitly detailed in the text. A number of exercises are provided at the end of each chapter, together with suggestions and solutions.

This book presents the theory of gas discharge plasmas in a didactical way. It explains the processes in gas discharge plasmas. A gas discharge plasma is an ionized gas which is supported by an external electric field. Therefore its parameters are determined by processes in it. The properties of a gas discharge plasma depend on its gas component, types of external fields, their geometry and regimes of gas discharge. Fundamentals of a gas discharge plasma include elementary, radiative and transport processes which are included in its kinetics influence. They are represented in this book together with the analysis of simple gas discharges. These general principles are applied to stationary gas discharge plasmas of helium and argon. The analysis of such plasmas under certain conditions is theoretically determined by numerical plasma parameters for given regimes and conditions.

A dense sheet of electrons accelerated to close to the speed of light can act as a tuneable mirror that can generate bright bursts of laser-like radiation in the short wavelength range simply via the reflection of a counter-propagating laser pulse. This thesis investigates the generation of such a relativistic electron mirror structure in a series of experiments accompanied by computer simulations. It is shown that such relativistic mirror can indeed be created from the interaction of a high-intensity laser pulse with a nanometer-scale, ultrathin foil. The reported work gives a intriguing insight into the complex dynamics of high-intensity laser-nanofoil interactions and constitutes a major step towards the development of a relativistic mirror, which could potentially generate bright burst of X-rays on a micro-scale.