The twu-day sympusium held un the campus uf Augustana Cullege, Ruck Island, Illinuis, April 5 and 6, 1967, explured the interrelatiunship between the life sciences and engineering and attempted tu make the scientific cummunity mure aware uf an interdisciplinary appruach tu engineering. The sympusium suught tu stimulate new mechanical engineering cuncepts perhaps nut pussible utilizing data available unly thruugh ideas derived frum the traditiunal physical sciences. Devuted tu clused luup biomechanical systems in which biulugical furces and feedback influence mechanical, physical, and chemical systems, this first Ruck Island Arsenal Biumechanics Sympusium was cuspunsured by Ruck Island Arsenal, u. S. Army Weapuns Cummand, U. S. Army Research Office Durham, and Augustana Cullege. It strived fur academic excellance, and the spunsurs are indebted tu the Advisury Cummittee in pruviding the guidance and participatiun required tu achieve this ubjective as reflected in these pruceedings. Persunal thanks are extended tu Drs. Russ C. Bean, Geurge Bugliarellu, Rubert G. Gesteland, Warren S. MCCulluugh, Lawrence M. Patrick, Ali Seirig, and Heinz Vun Fuerster. The planning cummittee, which included Pruf. Juhn E. Ekblad, Edwin M. Vaughan, Alan G. Galbavy, and the editurs, are also. tu be cummended fur their ef- furts in arranging this successful sympusium.

In recent years concern has been growing ab out the preservation ofworld peace, while over the past few decades there has been a vast increase in the amount of international sporting activity and hence more opportunities to advance international understanding and peace. It is this situation which caused the Congress on Sport and International Understanding to be convened, the idea for it ftrst having arisen after the Helsinki Conference on Security and Co-operation in Europe in 1975. The venue for the Congress was, as for the Conference on Security and Co-operation, Finlandia Hall. It was held under the auspices ofthe International Council ofSport and Physica1 Educa tion (ICSPE) and was organised by the Finnish member organisations, the Finnish Society for Research in Sport and Physica1 Education (organising association), Finnish Central Sport Federation (SVUL) and the Workers' Sport Federation (TUL). The aim ofthe Congress was to analyse the role of sport in advancing international understanding and to promote research in this fteld. In addition, the Congress wished to offer researchers and those involved in sporting activities an opportunity to exchange ideas about the themes under discussion. The aim of the Congress was to fmd the answers to the following questions: 1. What forms does international co-operation take in present-day competitive and top-level sport, sports for all and other forms of physica1 culture? What is its histo rica1 background and future? 2."

The European Organization for Research into Cancer Treatment (OERTC), founded in 1962 initially under the name Groupe Europeen de Chimiotherapie Anti cancereuse (GECA), is an extramural European Institute for collecting, co-ordinating and encouraging the work of scientists researching into cancer treatment at 16 European institutes: 3 in W. Germany, 2 in Italy, 2 in Belgium, 3 in the Netherlands, 2 in the United Kingdom, 1 in Switzerland and 3 in France. The first President of OERTC was Professor GEORGES MATHE, now succeeded by Professor SILVIO GARATTINI of Milan. The organization has a Board of 20 Directors, responsible for co-ordinating the entire range of activities and guiding research and experimental studies on animals, also the first human trials of new therapeutic agents which have been fully tested on animals. The Co-operating Groups carry out com plementary testing involving large numbers of patients. Thus, OER TC is not a "learned society" but an agency for co-ordinating work. OER TC's annual plenary meeting for 1968 was held in Paris on 22nd and 23rd March. It was given over to an intensive study of the scientific basis of chemotherapy in the treatment of cancer in man. These two working sessions brought together members of all groups, both directing and co-operating. The first day was in effect a teaching seminar, open to all practitioners wishing to use chemotherapy in cancer, and explaining the scientific basis of such treatment. This seminar constitutes the present monograph."

Triennial the Division of Biomedical Engineering of the Institute of Textile Technology and Chemical Engineering, Denkendorf, is organizing conferences on specific topics in the field of polymeric materials for use in the biomedical areas. The aim is to bring together scientists from allover the world working on this speci fic topic, to present the newest state of the art and to discuss their problems in a more concentrated atmosphere and at last to create and intensivate their cooperation. Following two conferences on "Polyurethanes in Biomedical Engi neering" (1983 and 1986), the Institute of Textile Technology and Chemical Engineering set a theme, which is very closely related to its own task: "Medical Textiles for Implantation". As technical materials, textiles can be classified in two fields of application: - first, textiles used for highly flexible, strong, but only tension load bearing systems, e.g. tows; - second, textiles manufactured to flat shaped devices to separate two regions more or less semipermeable, e.g. clothing; - a combination of both are reinforced systems like tubular fabrics e.g.; here pressure load will be transformed to tensile load, the separation may be performed by a coating. In the biological systems the classification can be used in the same manner: - Tension load bearing structures are ligaments and tendons, semipermeable separation is realized by cell membranes as well as by cell layers, for example the skin. - The combination of both of the principles can be found for example in arteries and the trachea.

The subtitle of this book - A Holistic Approach to Rehabilitatio- underscores our fundamental point of view regarding spinal ailments. The patient with his ailments should be at the focus of attention, yet the subtitle combines two important elements, namely, "rehabilitation" and "holistic approach. " It is only by combining both concepts to show that they do belong together that the door to successful treatment of persons with vertebral problems can be opened. Holistic medicine does not require an ideological classification of its own, but should be under stood as a unified, optimal form of medicine which encompasses the whole person: his health and his illnesses in all their aspects. Too often, there is an automatic, senseless separation of the two concepts. Purists in one or the other camp need to recognize the common ground and to eliminate the barriers that have been erected by extreme positions and attacks. When we look back into history, we can see that there have always been schools of medical thought that have promulgated one or another direction. Evaluations and interpretations change in accordance with our knowledge and the times themselves, but that which is most valu able remains in end effect, forming the starting point for following gen erations. It should be noted that the entire body of medical knowledge had its beginnings in empiricism, whose ideas could not be confirmed and supported until much later, parallel with the developments in research technology."

During the past five years there has been a reawakening of interest in the psychotherapy of patients with medical disorders characterized as psychosomatic. For three decades, psychoanalysis and psychoanalytic psychotherapy were used extensively to treat and study psychosomatic disorders. Early in the 1960s, interest in this approach to these conditions faded, and the .Psychosomatic Service. in most hospitals became the .Consultation Liaison Service. (Lipowski, 1967). The recent focus of biofeedback on psychosomatic conditions provides a new technique with which the physician or psychiatrist may treat these patients (Rickles, 1981). In addition, the successful application of biofeedback training to a variety of complaints such as those presented in this volume has heralded the addition of biofeedback to the treatment modalities used for medical complaints. Frequently, psychological factors can still be seen; for example, when biofeedback treatment may require lifestyle changes on the part of the patient, the exploration of secondary gains or resistances before the disorder can be success fully treated, and the establishment of rapport and empathy which is so important for truly effective biofeedback training. Aside from certain psychological dimensions that are always present in biofeed back training, in this case biofeedback is being used in a primarily medical setting for primarily medical complaints."

This monograph analyses all aspects related to the etiopathogenesis, pathomorphology, diagnosis and treatment of lumbar disc herniation. It includes 24 chapters, over 500 illustrations, partly in colour, and 2800 bibliographic entries, going from the historical to the most recent ones. Five chapters are dedicated to biological and pathomorphologic aspects both of lumbar disc herniation and the conditions most often associated with herniation. The etiopathogenesis is analysed in the light of the most significant and recent studies. Five chapters deal with the clinical presentation and diagnostic tests in an extremely wide and detailed way. Large space is reserved to conservative management. The chapters on invasive treatments and on the results and complications of surgery define the advantages and limitations of the old and new percutaneous or surgical treatments. Two chapters are dedicated to surgical management of patients with spinal conditions associated with herniation, and two other deal with the surgical failure. This monograph is aimed at satisfying the requirements of both experts and young doctors. Some chapters are of particular interest to the spine specialist, whilst others are useful to the novice to acquire a general knowledge of the subject.

G. MATHE and R. K. OLDHAM' Institut de Cancerologie et d'Immunogem tique, Hopital Paul Brousse, Villejuif Since the last war, cancer chemotherapy has been the object of very intensive and expensive research. Nevertheless, its development has been very slow, and its ultimate potential is today somewhat in doubt. In doubt because it does not cure any cancer patients except a) females carrying placental choriocarcinoma, a semi-allogenic tumor, in which case, cure may be in fluenced by immune rejection, and b) children suffering from Burkitt's tumor, where the probable reason for the cure is that all the neoplastic cells are in the cycle, which is a unique condition among all the human tumor varieties. Whether the long term survivors in acute leukemia, lymphomas, certain sarcomas and certain testicular tumors are "cures" will require longer follow-up. The idea that chemotherapy does not cure most cancer patients because all their neoplastic cells are not in cycle has led to the use of drug combinations. Whatever they are, "cocktail combinations" which are made up of drugs given according to any timing, or scientific combinations, based on pharmacodynamics, pharmaco kinetics or cell kinetics data, are more toxic than single drugs, and are all the more toxic as the number of drugs in the combination is increased."

The human personality is inextricably bound up with, among other things, the function of the central nervous system. Diseases and malfunctions of the brain, head injuries and neurosurgical operations can all result in permanently altered behaviour patterns. This interrelation between brain and behaviour is most clearly demonstrated in cases involving functional neurosurgery and severe traumatic lesions. Despite the fact that this interrelation represents an everyday challenge to the neurosurgeon, it is a question which receives less attention than it deserves in neurosurgical meetings. Given the scope and complexity of this topic, it is not possible to cover every aspect of it here: hence, discussion is limited to the impact on personality of injuries, language, epilepsy and psychosurgery. However, before considering the medical aspects, it was deemed necessary to try and arrive at a definition of "personality." This question was discussed by a number of philosophers representing various perspectives. Their diversity of viewpoints and conceptions greatly enriched the discussions.

Over the past 10-20 years there has been an explosion of work on the disturbance of motor control that is manifested as "spasticity." This work has been based on new insights from animal experiments into the basis of normal motor control and the development of experimental techniques that could be used in patients with neurological disturbances. For this reason, on the initiative of Alfred Thilmann, the editors of this volume organized a workshop on spasticity, held in Essen, Germany, in November, 1992. The intention of the meeting was to bring together leading scientists in an atmosphere that would generate discussion and hopefully consensus and ideas for future work. The attendance was restricted and deliberately selective, with a mix of basic scientists, clinical scientists and practicing clinicians. The product of their presentations and deliberations is this volume. The book is organized in the same sequence as the workshop, so that the discussion sessions could be summarized by the appropriate chairman.

Up until two decades ago, clinical interest in the etiopathogenetic interpretation of lumbo-radicular syndromes was prevalently concentrated on the pathology of the inter vertebral disc. This vision gradually changed and grew as a result of the affirmation of the concept of pathological narrowing of the osteoligamentous vertebral canal as a cause of compression of the lumbar nervous structures. Finally, in the last ten years, lumbar stenosis has become more and more a subject of current interest not only as a result of problems related to nosography, diagnosis, and therapy, but also as a result of the increasing frequency with which vertebral canal or nerve root canal stenosis syndromes are recognized and treated. At the same time there was a tendency to include in stenotic pathology other pathological conditions responsible for lumbo-radicular syndromes. This led to dilation of the concept of stenosis, which perhaps no longer responded to reality, and which was not useful from a practical point of view. The need to define stenotic pathology and to correctly locate it within the vast field of lumbar pathology inspired the writing of this volume. This monograph gathers many diagnostic and therapeutic concepts matured at our In stitution over the years. Some of these concepts have already been defined in scientific meet ings or in publications."

The volume contains papers presented at a workshop of held from September 28 - October 1st in Eibsee near Munich, Germany.
The aim of the workshop was to present results of interdisciplinary research which aims to help handicapped persons suffering from paraplegia or hemiplegia to regain the capability to stand or walk. The contributions cover both fundamental research and clinical applications.

In-patient treatment for alcoholism going beyond physical withdrawal from the drug has been available in Germany for more than 130 years. Particularly since the Second World War, treatment has broadened and changed in various ways. There are several reasons for this development. The recognition of alcoholism as a disease by the Supreme Court had widespread financial and administrative consequences. Since then in patient treatment has been funded mainly by the pension insurance institutions. Another reason is the strengthened influence of different psychotherapeutic schools on practice in treatment. At the present time in the Federal Republic of Germany there are about 250 treatment facilities (Suchtfachkliniken, or addiction centres), where around 25000 patients a year receive in-patient treatment. In addition to these, there are the addiction units in psychiatric and general hospitals, of which some offer withdrawal treatment, while others also offer rehabilit ation treatment. For out-patient treatment there are about 450 special addiction counselling and treatment centres, out-patient facilities available at local health authorities and university hospitals and, further to all this, there are thousands of self-help groups of various kinds. This system of interlocking treatment facilities of various kinds, from the first contact to the after-care stage, is called a treatment network or chain.

From 21-24 June 1989 the International Federation of Adapted Physical Activity (IF APA) held its 7th International Symposium "Adapted Physical Activity -An Interdisciplinary Approach" in Berlin (West). This was the first time that this symposium has been held in a German speaking country, and it presented unique challenges to the organizers. For example, neither the term nor the field of adapted physical activity was known in Germany before the symposium. Thus, at the outset, the organizers' task was to define the meaning of adapted physical activity as a concept and to identify areas and professionals associated with it. After lengthy and intense discussions we agreed on the following definition: Adapted physical activity refers to movement, physical activity, and sports in which special emphasis is placed on the interests and capabilities of individuals with limiting conditions, such as the disabled, health impaired or aged. Despite the fact that the use of an English term for a symposium in Germany would not be accepted by all German speaking professionals, it was decided to use this term because no translation appeared to be fully adequate. "Sports for the Disabled", "Modified Movement Activites", "Sport Therapy", or "Psychomotor Exercises" would have represented only single aspects of adapted physical activity and were thus incomplete.

The spinal cord has a characteristic structure and functions that are distinct from those of the brain. Its functions are tremendously important since it modulates the peripheral sensory inputs to the dorsal horn, and it gives rise to the ascending pathways transmitting peripheral afferent inputs to the brain, and conveys the descending pathways from the brain both to the lower motor neurons, the final common pathway, and to dorsal horn sensory neurons. In spite of these vital functions, the spinal cord constitutes only a small percent age of the mass of the human central nervous system and is located far from the skin surface, which has obstructed the recording of its electrical activity. Recently, however, important advances have been made in several recording techniques, including epidural recording or averaging methods, allowing both sensory and motor evoked spinal cord potentials in man to be recorded. This volume is based on the papers presented at the Fourth International Symposium on Spinal Cord Monitoring and Electrodiagnosis. Each of these international symposia has brought together many of the specialists involved in this research, with an important increase in the number of participants since the first symposium was held in Toyko in 1981. At the past symposia several attempts were made to standardize data, techniques, and clinical applications and to integrate the new findings into patient care."

At the beginning of the century the average life span in developed societies was less than 50 years. It is now more than 70 years and will continue to increase in the near future. Aging is a challenge to science and society. There are several theories of aging. The programmed aging hypothesis suggests that aging cannot be altered by any external influence, that aging is programmed from the beginning of life until the end of senescence. Another theory is based on genetic instability, with repair processes correcting errors in the cells that cause aging. Aging processes manifest themselves at the molecular and cellular level, in different organs, and in the whole organism. Most older persons acquire multiple diseases, primarily chronic ones. The multimorbidity of the elderly raises many questions as to nutrition, metabolism, immunity, drug therapy, and rehabilitation. Nutrition may be able to intervene in the aging process. Aging is associated with dec lining immunity and reduced resistance to many diseases, and it is pos sible that nutritional changes in old age contribute to the declining immunity in the elderly. The elderly take 40% of the prescription drugs in Germany and adverse drug reactions are more frequent in geriatric patients. There are not only problems in drug therapy for elderly pa tients, but also in their rehabilitation. The aim of rehabilitation is the restoration of geriatric patients to their former functional and environ mental status."

Effective Technology: Integration for Disabled Children: The Family Perspective explores microcomputer-based special education intervention programs aimed at advancing mildly handicapped children and empowering their parents. The book applies the stress, resources and coping model to families with disabled children, examining specific components of the pro posed model through family surveys and studies, and presenting future directions for research and experimentation. The book also offers an overview of the research related to effective integration of computers into the special education system, with particular attention to a cognitive approach to skill development through various software programs. Effective Technol ogy: Integration For Disabled Children is intended for researchers and practitioners in a wide range of fields interested in family research and parent-empowering interventions as well as for those involved in technology integration within special education contexts."

Biomechanics of Injury, Third Edition, explains the biomechanical principles of injury and how injuries affect the normal function of human anatomy. With a clear, accessible writing style and nearly 400 full-color photos and anatomy illustrations, it guides readers through the mechanical concepts of injuries without a heavy emphasis on mathematics. Previously titled Biomechanics of Musculoskeletal Injury, this third edition expands coverage of injuries beyond those of the musculoskeletal system to include the head, neck, and spine. Joining noted biomechanists Ronald Zernicke and William Whiting is concussion expert and athletic trainer Steven Broglio, who offers insights on head trauma and other neurological injuries. Unique in its evaluation of and appreciation for the intricacies of injury mechanisms, Biomechanics of Injury, Third Edition, comprehensively examines these issues: The mechanical aspects of injury and the concept of injury as a stimulus for beneficial tissue adaptations The effects of injury on the normal function of the human anatomy and joint mechanics Mechanical parameters such as force, stress and strain, stiffness, and elasticity and their application to tissue mechanics and injury How connective tissues respond to mechanical loading and how those tissues are studied to quantify their mechanical behavior Factors such as age, gender, nutrition, and exercise, with an emphasis on how lifestyle choices might lessen the chance or severity of injury How the principles of mechanical load and overload, use and overuse, level and progression of injury, and the many contributory factors involved in injury combine to form a backdrop for viewing specific injuries Updated sidebars present a detailed analysis of anterior cruciate ligament injuries, rotator cuff pathologies, and concussion. In addition, the text discusses topics of current concern such as falls in older populations, throwing-related rotator cuff pathologies, and youth injuries from carrying backpacks. Biomechanics of Injury, Third Edition, also employs learning aids to help readers understand and retain information. Objectives at the start of each chapter highlight the main concepts. Key terms appear in bold in the text and are defined in the glossary. Key Points at the end of each chapter summarize central concepts. Questions to Consider appear at the end of each chapter to test readers’ understanding and ability to apply the information presented. Updated Suggested Readings are included at the end of each chapter for readers who wish to dive deeper into selected topics. Knowledge of the biological responses of tissues to mechanical loading improves our understanding of injury and its consequences. Biomechanics of Injury, Third Edition, will enable students and health professionals to reduce the likelihood that clients, patients, or athletes will experience painful and debilitating physical injury.

Since the historieal conference held in Alma Ata in 1978, it has been possible to observe a reorientation of the medical profession. More and more, issues of health enter the stage and curative medicine is not just loosing ground but some interest. 'How effective is health education?' and 'Whose task is primary pre vention?' are questions which stimulate great concern and public debate. It seems also to be the first time since the last decades of the 19th century that the social dimension of health receives adequate consideration. Thus the reeent publication of the so-called Black Report on Inequalities in Health (Penguin 1982) led to a heated discussion in Great Britain, certainly of relevance to many other countries. The 6 years since 1978 are much too short a time to proceed far towards 'Health for All', as the slogan of the World Health Organization puts it, but the concepts are spelled out, vaguely but convincing to many of us. It is the right time to discuss first experiences and to move from philosophy to empiri eal work. This work - as it relates to the process evolving since Alma Ata - is characterized by participation, cooperation and prevention: Participation, because 'disease' concerns only the individual patient, his or her family and immediate social environment, while 'health' concerns everyone and should involve everyone. It is a task of the whole of society rather than the domaine of a single profession or party."

Back in September of 1974, I acquired much valuable information while attending the International Conference on Total Knee Replacement in London, which was organized by The Medical Engineering Working Party and the Tribology Group of the Institution of Mechanical Engineers, and the British Orthopaedic Association. I was greatly inspired by the conference, and it formed the beginning of my studies on total knee replacement. The co-editors of this proceedings, Prof. J. Paul and Dr. S. Yamamoto, are both acquaintances made originally at that conference. The International Symposium on Total Knee Replacement held in Nagoya, Japan, on 18-19 May 1987 was attended by many participants, including Prof. Walker, who had presented his studies earlier in London. During the past decade and a half, remarkable technical progress has been made in total knee prostheses. In this symposium, cemented total knee replacement (TKR), noncemented TKR, design considerations of total knee prostheses, problems concerning the patello femoral joint, and the newly developed total knee prosthesis were the main topics discussed. I believe that much new information, including that about the challenges which still remain, along with a fresh view towards continuing studies, are presented here for the reader. I would like to express my sincere gratitude to the support of the Knee Joint Research Society in Japan and to the participants in the symposium for their great help in publishing this book."

Language depends on a normally functioning left hemisphere. This central fact of human cerebral dominance was well established by 19th century aphasiologists and has been repeatedly confirmed by subsequent investiga tions. Predominance, however, does not imply exclusivity. As demonstrated by the commissurotomy patients studied by Eran Zaidel and associates, the right hemisphere is also capable of subserving some linguistic functions. The question, then, is not whether the right hemisphere can process language, but how and when it does so. This volume focuses on the right hemisphere's contribution to one important aspect oflanguage, lexical semantics. Although the right hemisphere may well be involved in other linguistic functions, such as prosody, the greatest evidence for right hemisphere language competence has been obtained for the processing of word meanings. In addition, cognitive psychology and psycho linguistics have provided us with well-developed models of the lexicon and lexical access to guide our inquiry. Finally, there are techniques available for studying lateralized lexical processing in the normal as well as in the brain injured hemispheres. For these reasons, a focus on the lexicon is likely to yield the greatest number of insights about right-hemisphere language processing."

In many cases of neuromuscular disorders the physician is faced with a complete lack of therapeutic approaches. This helplessness places the doctor in a position of conflict between his desire to help and his awareness that there is no treatment. In this situation it is tempting to indiscriminately use any procedure that avoids an admission of medical helplessness while satisfying the patient's demand for treatment. Electrical interventions are often used to avoid this situation. Due to the random use of therapeutic approaches it is not known what really happens. Presumptions and biased empirical observations have led to the exten sive use of different forms of electrical stimulation regimes in neuromuscular diseases. Due to this unsatisfactory situation it is necessary to know more about appropriate methods that are being used in particular disorders. The search for a better understanding of nerve-muscle interaction has shown that certain activity patterns can influence muscle. These experi mental results provide a rational basis for a possible therapeutic use of electrical stimulation of nerve and muscle. Previously most research has been conducted in normal tissue, and little is known regarding the re sponses of diseased muscle. In an interdisciplinary approach to this, it is our intention to present the current knowledge about basic principles of electrical stimulation in normal muscle. Before electrical stimulation can be accepted as a therapeutic tool, we felt it necessary to summarize the effects of activity in normal and diseased muscle and nerve."

In summary, considerable controversy and research have been generated from the automatic/effortful distinction. Hasher and Zacks (1979) initially stated that all manipulations (e. g. , practice, individual differences such as age, orienting instructions) must produce null effects in order to satisfy the criteria that a process is "automatic. " However, Zacks et al. (1984) have more recently noted that automatic processes may range in degree from relative insensitivity to task and subject variables (e. g. , frequency processing) to those that are more vulnera- ble to disruptive effects (e. g. , temporal processing). A review of the literature reveals that individuals are sensitive to frequency information even if manipUla- tions alter the slope of the judgments. Perhaps the application of dual-task metho- dology to the measurement of capacity demands will be useful in classifying processes along an attentional continuum. Moreover, there has been a tendency to dichotomize automatic/effortful processes rather than to characterize them as ranging from low to high attentional demands. Recent evidence (Maki & Ostby, 1987) suggests that attention may be important only in the initial (early) stages of processing frequency information. Therefore, a major difference that may emerge between automatic and effortful processing could be the degree of sus- tained attention required from individuals. In the following section, we review the findings obtained in the application of the automatic/effortful framework to the elderly and neurological/psychiatric populations.

As a graduate student a decade ago, I recall vividly reading the inaugural issue of the Journal of Behavioral Medicine when it appeared in 1978. Its purpose was described as "a broadly conceived interdisciplinary publication devoted to fur thering our understanding of physical health and illness through knowledge and techniques of behavioral science: ' The articles in that first issue addressed such topics as the biofeedback treatment of neuromuscular disorders, anxiety manage ment of Type A behavior, and premorbid psychological factors related to cancer incidence. At that time, coursework in behavioral medicine was in its infancy at my university, and I, along with many classmates, was eager to learn more of this "new and emerging field: ' Thinking back to those times, it is astonishing for one to reflect on the rapid evolution of behavioral medicine and its current status as a clinical and scientific discipline. Organizations such as the Society of Behavioral Medicine now include a broad-based membership that is convened yeady at a major convention. In addition to the Journal of Behavioral Medicine, professionals can avail them selves of several other specialty journals (Annals of Behavioral Medicine, Behavioral Medicine Abstracts, Journal of Developmental and Behavioral Pedi atrics) as well as the numerous articles on behavioral medicine that appear regu larly in the clinical psychology, psychiatry, rehabilitation, and behavior therapy literature. And behavioral medicine services and training programs are encoun tered with increasing frequency within clinic, hospital, and academic settings."

Here is a book for clinicians, clinical investigators, trainees, and graduates who wish to develop their proficiency in the planning, execution, and interpretation of clinical and epidemiological research. Emphasis is placed on the design and analysis of research studies involving human subjects where the primary interest concerns principles of analytic (cause-and- effect) inference. The topic is presented from the standpoint of the clinician and assumes no previous knowledge of epidemiology, research design or statistics. Extensive use is made of illustrative examples from a variety of clinical specialties and subspecialties. The book is divided into three parts. Part I deals with epidemiological research design and analytic inference, including such issues as measurement, rates, analytic bias, and the main forms of observational and experimental epidemiological studies. Part II presents the principles and applications of biostatistics, with emphasis on statistical inference. Part III comprises four chapters covering such topics as diagnostic tests, decision analysis, survival (life-table) analysis, and causality.