Proteomics in Biology Part A, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field, and a focus on proteomics for this updated volume.

J.B.S. Haldane (1892-1964) is widely appreciated as one of the greatest and most influential British scientists of the 20th century, making significant contributions to genetics, physiology, biochemistry, biometry, cosmology, and other sciences. More remarkable, then, is the fact that Haldane had no formal qualification in science. He made frequent appearances in the media, making pronouncements on a variety of poignant topics including mining disasters, meteorites, politics, and the economy, and was a popular scientific essay writer. Haldane also was famed for conducting painful experiments on himself, including several instances in which he permanently himself. A staunch Marxist and convert to Hinduism, Haldane lived a diverse, lively and interesting life that is still revered by today's science community. A biography of Haldane has not been attempted since 1968, and that book provided an incomplete account of the man's scientific achievement. "The Life and Works of J.B.S. Haldane" serves to fix this glaring omission, providing a complete biographical sketch written by Krishna Dronamraju, one of the last living men to have worked personally with Haldane. A new genre of biographies of 20th-century scientists has come into being, and thus far works have been written about men like Einstein, Oppenheimer, Bernal, Galton, and many more; the inclusion of Haldane within this genre is an absolute necessity. Dronamraju evaluates Haldane's social and political background, as well as his scientific creativity and accomplishments. Haldane embodies a generation of intellectuals who believed and promoted knowledge for its own sake, and that spirit of scientific curiosity and passion is captured in this biography.

cryoEM, a new volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods and new developments in recording images, the creation, evaluation and validation of 3D maps from the images, model building into maps and refinement of the resulting atomic structures, and applications of essentially single particle methods to helical structures and to sub-tomogram averaging.

Information literacy-the ability to find, evaluate, and use information resources-is an important skill for future chemists. Students and scientists need to distinguish between information provided by Wikipedia, ChemSpider, research journals, and The New York Times, depending on the intended use of the information sought. Instructors and librarians may often teach these skills through stand-alone database demonstrations, video tutorials, and lectures. However, it is possible to teach these skills in a more contextual and integrated manner by designing chemistry assignments that incorporate information literacy as a learning outcome. This book will prove useful for librarians and chemistry instructors who are designing courses in which students develop information literacy in the context of a chemistry course at two-year colleges, public and private universities, and high schools. The chapters in this book review the current state of information literacy in chemistry and provide concrete examples of assignments and interventions aimed at teaching information literacy skills in chemistry curricula. A wide range of options are offered for integrating information literacy into college-level chemistry courses, including general chemistry, organic chemistry, science courses for students not majoring in science, and chemistry capstone research courses.

Metaphysicians should pay attention to quantum mechanics. Why? Not because it provides definitive answers to many metaphysical questions-the theory itself is remarkably silent on the nature of the physical world, and the various interpretations of the theory on offer present conflicting ontological pictures. Rather, quantum mechanics is essential to the metaphysician because it reshapes standard metaphysical debates and opens up unforeseen new metaphysical possibilities. Even if quantum mechanics provides few clear answers, there are good reasons to think that any adequate understanding of the quantum world will result in a radical reshaping of our classical world-view in some way or other. Whatever the world is like at the atomic scale, it is almost certainly not the swarm of particles pushed around by forces that is often presupposed. This book guides readers through the theory of quantum mechanics and its implications for metaphysics in a clear and accessible way. The theory and its various interpretations are presented with a minimum of technicality. The consequences of these interpretations for metaphysical debates concerning realism, indeterminacy, causation, determinism, holism, and individuality (among other topics) are explored in detail, stressing the novel form that the debates take given the empirical facts in the quantum domain. While quantum mechanics may not deliver unconditional pronouncements on these issues, the range of possibilities consistent with our knowledge of the empirical world is relatively small-and each possibility is metaphysically revisionary in some way. This book will appeal to researchers, students, and anybody else interested in how science informs our world-view.

Now more than ever we are facing pressing world challenges of energy (identifying alternate energy), food (ensuring the food supply), water (providing clean water), and human health (enabling individualized medicine); and to solve these challenges will require chemistry and the related chemical sciences. Integrating sustainability into everything we do from instituting responsible operations, to selecting partners for change and innovating sustainable solutions. Industry needs academe to prepare their graduates to ascend the ladder with skill and agility. This can only be done by integrating sustainability expeditiously into chemistry curricula.

The senses can be powerful triggers for memories of our past, eliciting a range of both positive and negative emotions. The smell or taste of a long forgotten sweet can stimulate a rich emotional response connected to our childhood, or a piece of music transport us back to our adolescence. Sense memories can be linked to all the senses - sound, vision, and even touch can also trigger intense and emotional memories of our past.
In The Proust Effect, we learn about why sense memories are special, how they work in the brain, how they can enrich our daily life, and even how they can help those suffering from problems involving memory. A sense memory can be evoked by a smell, a taste, a flavor, a touch, a sound, a melody, a color or a picture, or by some other involuntary sensory stimulus. Any of these can triggers a vivid, emotional reliving of a forgotten event in the past.
Exploring the senses in thought-provoking scientific experiments and artistic projects, this fascinating book offers new insights into memory - drawn from neuroscience, the arts, and professions such as education, elderly care, health care therapy and the culinary profession.

Science is the most reliable means available for understanding the world around us and our place in it. But, since science draws conclusions based on limited empirical evidence, there is always a chance that a scientific inference will be incorrect. That chance, known as inductive risk, is endemic to science. Though inductive risk has always been present in scientific practice, the role of values in responding to it has only recently gained extensive attention from philosophers, scientists, and policy-makers. Exploring Inductive Risk brings together a set of eleven concrete case studies with the goals of illustrating the pervasiveness of inductive risk, assisting scientists and policymakers in responding to it, and moving theoretical discussions of this phenomenon forward. The case studies range over a wide variety of scientific contexts, including the drug approval process, high energy particle physics, dual-use research, climate science, research on gender disparities in employment, clinical trials, and toxicology. The book includes an introductory chapter that provides a conceptual introduction to the topic and a historical overview of the argument that values have an important role to play in responding to inductive risk, as well as a concluding chapter that synthesizes important themes from the book and maps out issues in need of further consideration.

This book describes the profound changes that occurred in the teaching of chemistry in western countries in the years immediately following the Soviet Union's launch of Sputnik, the first artificial Earth satellite, in 1957. With substantial government and private funding, chemistry educators introduced new curricula, developed programs to enhance the knowledge and skills of chemistry teachers, conceived of new models for managing chemistry education, and experimented with a plethora of materials for visualization of concepts and delivery of content. They also began to seriously study and apply findings from the behavioral sciences to the teaching and learning of chemistry. Now, many chemistry educators are contributing original research in the cognitive sciences that relates to chemistry education. While Sputnik seemed to signal the dawn of far-reaching effects that would take place in political, diplomatic, and strategic, as well as in educational spheres, the seeds of these changes were sown decades before, mainly through the insight and actions of one individual, Neil Gordon, who, virtually singlehandedly, launched the ACS Division of Chemical Education and the Journal of Chemical Education. These two institutions provided the impetus for the United States to eventually become the undisputed leader in chemistry education worldwide.

Work with individual atoms and molecules aims to demonstrate that miniaturized electronic, optical, magnetic, and mechanical devices can operate ultimately even at the level of a single atom or molecule. As such, atomic and molecular manipulation has played an emblematic role in the development of the field of nanoscience. New methods based on the use of the scanning tunnelling microscope (STM) have been developed to characterize and manipulate all the degrees of freedom of individual atoms and molecules with an unprecedented precision. In the meantime, new concepts have emerged to design molecules and substrates having specific optical, mechanical and electronic functions, thus opening the way to the fabrication of real nano-machines. Manipulation of individual atoms and molecules has also opened up completely new areas of research and knowledge, raising fundamental questions of "Optics at the atomic scale," "Mechanics at the atomic scale," Electronics at the atomic scale," "Quantum physics at the atomic scale," and "Chemistry at the atomic scale." This book aims to illustrate the main aspects of this ongoing scientific adventure and to anticipate the major challenges for the future in "Atomic and molecular manipulation" from fundamental knowledge to the fabrication of atomic-scale devices.
Provides a broad overview of the field to aid those new and entering into this research areaPresents a review of the historical development and evolution of the fieldOffers a clear personalized view of current scanning probe microscopy research from world experts

That the longstanding antagonism between science and religion is irreconcilable has been taken for granted. And in the wake of recent controversies over teaching intelligent design and the ethics of stem-cell research, the divide seems as unbridgeable as ever.
In Science vs. Religion, Elaine Howard Ecklund investigates this unexamined assumption in the first systematic study of what scientists actually think and feel about religion. In the course of her research, Ecklund surveyed nearly 1,700 scientists and interviewed 275 of them. She finds that most of what we believe about the faith lives of elite scientists is wrong. Nearly 50 percent of them are religious. Many others are what she calls "spiritual entrepreneurs," seeking creative ways to work with the tensions between science and faith outside the constraints of traditional religion. The book centers around vivid portraits of 10 representative men and women working in the natural and social sciences at top American research universities. Ecklund's respondents run the gamut from Margaret, a chemist who teaches a Sunday-school class, to Arik, a physicist who chose not to believe in God well before he decided to become a scientist. Only a small minority are actively hostile to religion. Ecklund reveals how scientists-believers and skeptics alike-are struggling to engage the increasing number of religious students in their classrooms and argues that many scientists are searching for "boundary pioneers" to cross the picket lines separating science and religion.
With broad implications for education, science funding, and the thorny ethical questions surrounding stem-cell research, cloning, and other cutting-edge scientific endeavors, Science vs. Religion brings a welcome dose of reality to the science and religion debates.

Compelling evidence exists to support the hypothesis that both formal and informal mentoring practices that provide access to information and resources are effective in promoting career advancement, especially for women. Such associations provide opportunities to improve the status, effectiveness, and visibility of a faculty member via introductions to new colleagues, knowledge of information about the organizational system, and awareness of innovative projects and new challenges.
This volume developed from the symposium "Successful Mentoring Strategies to Facilitate the Advancement of Women Faculty" held at the 239th National Meeting of the American Chemical Society in San Francisco in March 2010. The organizers of the symposium, also serving as the editors of this volume, aimed to feature an array of successful mechanisms for enhancing the leadership, visibility, and recognition of academic women scientists using various mentoring strategies. It was their goal to have contributors share creative approaches to address the challenge of broadening the participation and advancement of women in science and engineering at all career stages and from a wide range of institutional types. Inspired by the successful outcomes of the editors' own NSF-ADVANCE project that involved the formation of horizontal peer mentoring alliances, this book is a collection of valuable practices and insights to both share how their horizontal mentoring strategy has impacted their professional and personal lives and to learn of other effective mechanisms for advancing women faculty.

There are eight columns in the Periodic Table. The eighth column is comprised of the rare gases, so-called because they are the rarest elements on earth. They are also called the inert or noble gases because, like nobility, they do no work. They are colorless, odorless, invisible gases which do not react with anything, and were thought to be unimportant until the early 1960s. Starting in that era, David Fisher has spent roughly fifty years doing research on these gases, publishing nearly a hundred papers in the scientific journals, applying them to problems in geophysics and cosmochemistry, and learning how other scientists have utilized them to change our ideas about the universe, the sun, and our own planet.
Much Ado about (Practically) Nothing will cover this spectrum of ideas, interspersed with the author's own work which will serve to introduce each gas and the important work others have done with them. The rare gases have participated in a wide range of scientific advances-even revolutions-but no book has ever recorded the entire story. Fisher will range from the intricacies of the atomic nucleus and the tiniest of elementary particles, the neutrino, to the energy source of the stars; from the age of the earth to its future energies; from life on Mars to cancer here on earth. A whole panoply that has never before been told as an entity.

Ordinary language and scientific language enable us to speak about, in a singular way (using demonstratives and names), what we recognize not to exist: fictions, the contents of our hallucinations, abstract objects, and various idealized but nonexistent objects that our scientific theories are often couched in terms of. Indeed, references to such nonexistent items-especially in the case of the application of mathematics to the sciences-are indispensable. We cannot avoid talking about such things. Scientific and ordinary languages thus enable us to say things about Pegasus or about hallucinated objects that are true (or false), such as "Pegasus was believed by the ancient Greeks to be a flying horse," or "That elf I'm now hallucinating over there is wearing blue shoes." Standard contemporary metaphysical views and semantic analyses of singular idioms on offer in contemporary philosophy of language have not successfully accommodated these routine practices of saying true and false things about the nonexistent while simultaneously honoring the insight that such things do not exist in any way at all (and have no properties). That is, philosophers often feel driven to claim that such objects do exist, or they claim that all our talk isn't genuine truth-apt talk, but only pretence. This book reconfigures metaphysics (and the role of metaphysics in semantics) in radical ways that allow the accommodation of our ordinary ways of speaking of what does not exist while retaining the absolutely crucial presupposition that such objects exist in no way at all, have no properties, and so are not the truth-makers for the truths and falsities that are about them.

This book examines the history and fundamentals of the physical organic chemistry discipline. With the recent flowering of the organic synthesis field, physical organic chemistry has seemed to be shrinking or perhaps is just being absorbed into the toolkit of the synthetic chemist. The only Nobel Prize that can be reasonably attributed to a physical organic chemist is the 1994 award to George Olah, although Jeffrey I. Seeman has recently made a strong case that R. B. Woodward was actually a physical organic chemist in disguise (I). 2014 saw the awarding of the 50th James Flack Norris Award in Physical Organic Chemistry. James Flack Norris was an early physical organic chemist, before the discipline received its name. This book provides insight into the fundamentals of the field, and each chapter is devoted to a major discovery or to noted physical organic chemists, including Paul Schleyer, William Doering, and Glen A. Russell.

Collaborations between scientists often transcend borders and cultural differences. The fundamental nature of science allows scientists to communicate using knowledge of their field but the institutions that support them are often hindered by financial and cultural barriers. As a result, science suffers. This book evolved from an August 2009 symposium at the 238th annual meeting of the American Chemical Society in Washington, DC. Its focus is on chemistry students and professors interested in developing a global approach to teaching chemistry, by participating in an international exchange program or incorporating culturally inclusive techniques into their classroom. The book has three broad themes; education research with a globalized perspective, experiences of teaching and learning in different countries, and organizations that support a global view of chemical education and chemistry.

Aimed at academics, academic managers and administrators, professionals in scientometrics, information scientists and science policy makers at all levels. This book reviews the principles, methods and indicators of scientometric evaluation of information processes in science and assessment of the publication activity of individuals, teams, institutes and countries. It provides scientists, science officers, librarians and students with basic and advanced knowledge on evaluative scientometrics. Especially great stress is laid on the methods applicable in practice and on the clarification of quantitative aspects of impact of scientific publications measured by citation indicators.
Written by a highly knowledgeable and well-respected scientist in the fieldProvides practical and realistic quantitative methods for evaluating scientific publication activities of individuals, teams, countries and journalsGives standardized descriptions and classification of the main categories of evaluative scientometrics

Dr. Marie Maynard Daly received her PhD in Chemistry from Columbia University in 1947. Although she was hardly the first of her race and gender to engage in the field, she was the first African American woman to receive a PhD in chemistry in the United States. In this book, Jeannette Brown, an African American woman chemist herself, will present a wide-ranging historical introduction to the relatively new presence of African American women in the field of chemistry. It will detail their struggles to obtain an education and their efforts to succeed in a field in which there were few African American men, much less African American women.
The book contains sketches of the lives of African America women chemists from the earliest pioneers up until the late 1960's when the Civil Rights Acts were passed and greater career opportunities began to emerge. In each sketch, Brown will explore women's motivation to study the field and detail their often quite significant accomplishments. Chapters focus on chemists in academia, industry, and government, as well as chemical engineers, whose career path is very different from that of the tradition chemist. The book concludes with a chapter on the future of African American women chemists, which will be of interest to all women interested in science.

There is nothing more essential to our health and wellbeing than breathing: take air in, let it out, repeat 25,000 times a day. Yet, as a species, humans have lost the ability to breathe correctly, with grave consequences.

In Breath, journalist James Nestor travels the world to discover the hidden science behind ancient breathing practices to figure out what went wrong and how to fix it.

Modern research is showing us that making even slight adjustments to the way we inhale and exhale can:

• improve our exercise techniques
• restore healthy sleep patterns and minimise snoring
• halt allergies, asthma and even autoimmune disease

Drawing on thousands of years of ancient wisdom and cutting-edge studies, Breath is full of revelations, turning what we thought we knew about our most basic biological function on its head.

You will never breathe the same again.

This is the first book to bring together both the basic theory and proven process engineering practice of AFM. It is presented in a way that is accessible and valuable to practising engineers as well as to those who are improving their AFM skills and knowledge, and to researchers who are developing new products and solutions using AFM.

The book takes a rigorous and practical approach that ensures it is directly applicable to process engineering problems. Fundamentals and techniques are concisely described, while specific benefits for process engineering are clearly defined and illustrated. Key content includes: particle-particle, and particle-bubble interactions; characterization of membrane surfaces; the development of fouling resistant membranes; nanoscale pharmaceutical analysis; nanoengineering for cellular sensing; polymers on surfaces; micro and nanoscale rheometry.
Atomic force microscopy (AFM) is an important tool for process engineers and scientists as it enables improved processes and productsThe only book dealing with the theory and practical applications of atomic force microscopy in process engineeringProvides best-practice guidance and experience on using AFM for process and product improvement

An exciting challenge to how the internet and ICT have been understood in academia and popular culture and shows how important cultural assumptions are in how we understand technology. The Internet, Power and Society argues that the way in which we view technology such as the internet owes much to older, historic views of the media and to issues in contemporary society. Such perspectives are deeply rooted in a Western view of technology and the book concludes by offering a radically new perspective as to how the internet can change a society that is truly global in its application.
An original approach to ICT and the Internet that challenges the orthodoxyVery topical subject matter - the book addresses many of the issues regarded of key import in high level political discussions (such as the World Summit on the Information Society); the current understanding of ICT and how to move beyond this interpretationAn approach that moves the debate forward and offers a truly global way of understanding the Internet and ICT"

This book brings together the latest perspectives and ideas on teaching modern physical chemistry. It includes perspectives from experienced and well-known physical chemists, a thorough review of the education literature pertaining to physical chemistry, a thorough review of advances in undergraduate laboratory experiments from the past decade, in-depth descriptions of using computers to aid student learning, and innovative ideas for teaching the fundamentals of physical chemistry. This book will provide valuable insight and information to all teachers of physical chemistry.

Written by an immunologist, this book traces the concept of immunity from ancient times up to the present day, examining how changing concepts and technologies have affected the course of the science. It shows how the personalities of scientists and even political and social factors influenced both theory and practice in the field. With fascinating stories of scientific disputes and shifting scientific trends, each chapter examines an important facet of this discipline that has been so central to the development of modern biomedicine. With its biographical dictionary of important scientists and its lists of significant discoveries and books, this volume will provide the most complete historical reference in the field.
Written in an elegant style by long-time practicing immunologist
Discusses the changing theories and technologies that guided the field
Tells of the exciting disputes among prominent scientists
Lists all the important discoveries and books in the field
Explains in detail the many Nobel prize-winning contributions of immunologists"

Throughout history, people have tried to construct 'theories of everything': highly ambitious attempts to understand nature in its totality. This account presents these theories in their historical contexts, from little known hypotheses from the past to modern developments such as the theory of superstrings, the anthropic principle and ideas of many universes, and uses them to problematize the limits of scientific knowledge. Do claims to theories of everything belong to science at all? Which are the epistemic standards on which an alleged scientific theory of the universe - or the multiverse - is to be judged?
Such questions are currently being discussed by physicists and cosmologists, but rarely within a historical perspective. This book argues that these questions have a history and that knowledge of the historical development of 'higher speculations' may inform and qualify the current debate of the nature and limits of scientific explanation.

New Publication! Based on years of experience and prior publications, the NEW two-volume book, STEM RESEARCH for STUDENTS, is a vital resource for K-12 teachers, higher education faculty, and their students. In Volume One, students acquire the fundamentals and apply them to their investigations: Conduct experiments and refine the design and procedures; Construct data tables and graphs, use descriptive statistics, and make sense of an experiment; Meet a human need by designing, building, and testing a model; Communicate findings through reports and interactions with peers; Apply mathematical concepts to data including ratio and proportional relationships, geometry and measurement, algebra, and statistics. STEM Research for Students, Volume 1, is: Student friendly! Chapters contain investigations with readily available materials, explanations of major concepts, practice sets, and formative assessment tools. Use as a sequence or as individual units of study for specific content. STEM encompassing! For each core experiment, students have multiple options for making connections to various scientific disciplines, engineering, and mathematics. Teacher enhanced! Each chapter contains learning objectives and assessment tools checklists or rubrics. Answers to the practice sets are available on a secure Kendall Hunt web site. Standards aligned! All chapters are aligned with the Next Generation Science Standards, Common Core Standards for Mathematics and Literacy in Science and Technical Subjects, and the International Standards for Technology in Education Standards for Students. Available in print and e-Book formats, STEM Research for Students, Volume 1, may be used: As a supplemental text in upper elementary, middle, and senior high classrooms; As a core text for introductory research courses and STEM research clubs; For pre-service and in-service teachers of science, mathematics, career and technical courses, and gifted students; As a resource for all teachers involved with experiments, engineering designs, mathematical investigations, and competitive STEM projects. The companion volume, STEM Research for Students, Volume 2 enables students to build upon this strong foundation and create effective science experiments, engineering designs, and mathematical investigations.