Accurate interpretation of indications for treatment is the cornerstone of success in medicine. This book carefully examines the relation between clinical features, diagnosis, and choice of minimally invasive technique for a range of spine pathologies. It explains how selection of technique is intimately related to clinical and diagnostic aspects and how recognition of this relation forms the foundation for an optimal outcome. In addition to examining the various minimally invasive options, including the latest techniques, careful attention is paid to the role of medical treatment in avoiding recurrence after initial therapy. Nerve blocks, epidural injections, and intradiscal procedures are among the many options available in the armamentarium of the interventionalist, and advice is given on their use in different contexts. This volume will be of great value for neuroradiologists and others responsible for treating patients with spine disorders.

This text evolved as a response to numerous requests to present a simplified approach to the diagnosis and management of most of the common aspects of both cosmetic and medical venous disorders. The authors, representing experienced plebologists from several different primary disciplines, have attempted to present simplistic paradigm-oriented approaches on how to thoughtfully evaluate and manage common vein issues with contemporary solutions. Several areas of phlebology were not addressed in this text. The management of vascular malformations are beyond the scope of this text and were not covered in detail. Although indications for the appropriate use of IVC filters are discussed, the details about the specific devices, their placement and removal are also beyond the scope of this text. Deep venous obstruction from prior thrombosis, venous compression by arteries such as the compression of the left common iliac vein by the right common iliac artery and pelvic venous insufficiency can now be managed with minimally invasive image guided treatments; the technical aspects of such treatments are complex and not discussed in detail in this handbook. This book will increase the therapeutic skill of the practicing phlebologist and thus increase the quality of care for patients faced with problems related to venous disorders.

"Cleft Lip and Palate Primary Repair" introduces the main approaches to cleft lip and palate repaired, including the principles of design, skills and case analysis. Presenting a collection of advanced theories and techniques in this field, richly illustrated and with video clips of the respective operations, it is intended for plastic surgeons, oral surgeons and paediatrics surgeons, as well as for medical students.

Bing Shi is a Professor and surgeon at Department of Cleft Lip and Palate Repair in West China Hospital of Stomatology, Sichuan University, China. Brian C. Sommerlad is a Consultant Plastic Surgeon at the North Thames Cleft Center, Great Ormond Street Hospital for Children, UK.

Surgical Management of Benign Esophageal Disorders: The "Chicago Approach" covers all stages of the diagnosis and treatment of the most common benign esophageal disorders in a concise and easy-to-read format.Indications, patient preparation, operative techniques, and strategies for avoiding and managing complications are included and based both on evidence-based data and the experience of the most famous esophageal surgeons in the United States and abroad. Each chapter includes a summary of the current management strategy for the disease process, and a review of current state of the art techniques provided by world leaders on esophageal disease, surgeons and gastroenterologists alike. A special emphasis is given to emerging procedures in laparoscopy, thoracoscopy, and endoscopy. Surgical Management of Benign Esophageal Disorders: The "Chicago Approach" is illustrated throughout with line diagrams that depict fundamental anatomic or technical principles and is a valuable resource for surgeons and gastroenterologists in residence and training.

This textbook is based on the curriculum for US, UK, Canadian and Australasian Orthopedic trainees. It offers an in-depth summary of the knowledge needed to pass the boards and FRCS examination in Trauma and Orthopedic surgery. The focus is on basic information on every orthopedic subspecialty, including: surgical anatomy, basic sciences, adult reconstruction, pediatric orthopedics, foot and ankle surgery, orthopedic pathology, the spine, sports surgery, upper limb, wrist and hand surgery, and orthopedic traumas. All sections are written by experts in the respective field and utilize a consistent bullet-point format, chosen to facilitate the learning experience and help readers memorize and organize knowledge. A clear and concise "take-home message" section precedes each topic, and key references are highlighted at the end of each chapter.

The 17th volume in this series provides surgeons and trainees with the latest advances in their field. Beginning with a chapter on sepsis biomarkers, the following sections discuss surgical techniques for various diseases, with a focus on different types of cancer. Other chapters cover prenatal surgery, microvascular surgery, and surgical safety. Each topic is explained in a step by step format, explaining preoperative evaluation, imaging and post-operative management, as well as the procedure itself. This new volume is highly illustrated with surgical photographs, figures, flowcharts and tables to assist learning. Key points New volume covering latest advances and techniques in general surgery Topics explained in step by step format Highly illustrated with surgical images, figures and tables Previous volume (9789352708284) published in 2019

This book is a concise guide to basic techniques in dermatologic surgery. Designed as a ‘how to’, quick reference text with a bullet point format and emphasis on demonstration, the book is invaluable for trainee and practising dermatologists. Beginning with instruction on patient evaluation, anaesthesia, instruments and suturing, the following sections cover skin biopsy, and different surgical techniques including cryosurgery, cyst removal, Mohs surgery, and skin grafts. Two chapters are dedicated to laser surgery for lesions and tattoo removal. The final chapters discuss aesthetic procedures such as chemical peels, neuromodulators, fillers, and treatment of rhinophyma, concluding with detail on biopsy and surgery of the nail. Authored by recognised, US-based expert Glenn Goldman, this book is highly illustrated with surgical photographs and diagrams. Key points Guide to basic techniques in dermatologic surgery for trainee and practising dermatologists ‘How to’, quick reference text, presented in bullet point format for easy understanding Authored by recognised, US-based expert in the field Highly illustrated with surgical photographs and diagrams

"Advances in Calcium Phosphate Biomaterials" presents a comprehensive, state-of-the-art review of the latest advances in developing calcium phosphate biomaterials and their applications in medicine. It covers the fundamental structures, synthesis methods, characterization methods, and the physical and chemical properties of calcium phosphate biomaterials, as well as the synthesis and properties of calcium phosphate-based biomaterials in regenerative medicine and their clinical applications. The book brings together these new concepts, mechanisms and methods in contributions by both young and veteran academics, clinicians, and researchers to forward the knowledge and expertise on calcium phosphate and related materials. Accordingly, the book not only covers the fundamentals but also open new avenues for meeting future challenges in research and clinical applications.

Besim Ben-Nissan is a Professor of Chemistry and Forensic Science at the University of Technology, Sydney, Australia"

This volume contains the proceedings of the International Symposium on Growth Factors and Wound Healing: Basic Science and Potential Clinical Applications, held in Boston from September 28-October 1, 1995. The objective of this symposium is to provide basic and clinical investigators state-of-the-art information on the biology of wound healing and tissue repair. Written and edited by eminent experts in the field, the papers herein cover the general concepts of wound healing; the role of nutrients in wound healing responses; endogenous growth factors and wound healing; clinical applications of growth hormone and IGF-1 therapy; and clinical applications of peptide growth factors.

The difference among pluripotent stem cells, multipotent stem cells, and unipotent stem cells is pointed out. Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells. Because of the potential of human embryonic stem cells to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential. Because of their pluripotency, these cells have been used in various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. The formation of embryoid bodies, which are three-dimensional aggregates of embryonic stem cells, is explained as this is the first step in cell differentiation. Such embryoid body culture has been widely used as a trigger for the in vitro differentiation of embryonic stem cells. The basic capacity of self-renewal of human embryogenic stem cells is explained. The role of TGF-beta in the propagation of human embryonic stem cells is discussed. The differentiation of human embryonic stem cells into neurons, hepatocytes, cardiomyocytes, and retinal cells is fully explained. Donor policies for hematopoietic stem cells are also explained.

Colorectal Cancer Screening provides a complete overview of colorectal cancer screening, from epidemiology and molecular abnormalities, to the latest screening techniques such as stool DNA and FIT, Computerized Tomography (CT) Colonography, High Definition Colonoscopes and Narrow Band Imaging. As the text is devoted entirely to CRC screening, it features many facts, principles, guidelines and figures related to screening in an easy access format. This volume provides a complete guide to colorectal cancer screening which will be informative to the subspecialist as well as the primary care practitioner. It represents the only text that provides this up to date information about a subject that is continually changing. For the primary practitioner, information on the guidelines for screening as well as increasing patient participation is presentedd. For the subspecialist, information regarding the latest imaging techniques as well as flat adenomas and chromoendoscopy are covered. The section on the molecular changes in CRC will appeal to both groups. The text includes up to date information about colorectal screening that encompasses the entire spectrum of the topic and features photographs of polyps as well as diagrams of the morphology of polyps as well as photographs of CT colonography images. Algorithms are presented for all the suggested guidelines. Chapters are devoted to patient participation in screening and risk factors as well as new imaging technology. This useful volume explains the rationale behind screening for CRC. In addition, it covers the different screening options as well as the performance characteristics, when available in the literature, for each test. This volume will be used by the sub specialists who perform screening tests as well as primary care practitioners who refer patients to be screened for colorectal cancer.

New research has shown that neuroendocrine tumors are more common than previously thought. Progress in our understanding of the molecular pathogenesis of these not-so-rare cancers has resulted in renewed interest in developinginnovative therapeutic options. In particular, novel molecular targeted agents have been shown to have significant anti-tumor activity, and integration of these therapies has led to critical advances in management.

In this volume, an outstanding group of the world s leaders in the field have assembled to convey their knowledge of the epidemiology, biology, and management of allthemajor types of neuroendocrine tumors. The book takes a multi-modality approach to understanding disease processes and therapeutics, including chapters on medical and surgical treatment as well as a chapter devoted to imaging. Throughout, the authors emphasize recent advances in our understanding of molecular biology and the subsequent emerging therapeutic options.

This book is a practical guide to the basics of surgery for interns, residents and practising surgeons. It serves as an instruction manual on best practice and preparations for surgery. Comprising 45 chapters, the text begins with discussion on duties and responsibilities of house surgeons and residents, before detailing different techniques for best practice in a variety of areas, including sterile hand washing and gloving techniques, resuscitation of a patient, insertion of IV cannula, Ryles tube and Foley Catheter, local anaesthetics and nerve blocks, and minor surgical procedures. Other important chapters include discussion on the MRSA super-bug, and the 'Safe Surgery Saves Lives' initiative from the World Health Organisation. The second edition has been fully revised to present the latest techniques in the field. Additional chapters are included covering informed consent and negligence, surgical knots, intestinal and vascular anastomosis, energy sources in surgery, and surgical nutrition. The new edition features nearly 500 surgical photographs and figures, and includes a DVD ROM demonstrating bandaging techniques, tube thoracostomy, central venous cannulation, and venous cutdown. Key points Practical guide to surgery for trainees and surgeons Fully revised, second edition featuring many new topics Highly illustrated with images and figures, and includes a DVD ROM demonstrating procedures Previous edition (9789351527220) published in 2015

Transplantation of the Heart and HeartLungs (N.E. Shumway). Physiologic Principles and Clinical Use of Hypothermia (L.K. Davis, R.F. Davis). Anesthetic Evaluation and Management in Bloodless Surgery (N.S. Faithfull). Normothermic Mycocardial Preservation, an Optimal Approach for Myocardial Protection During All Forms of OpenHeart Surgery (R.E. Engelman et al.). Pharmacologic Manipulations to Minimize Bloodloss in Cardiac Surgery (A.C. Cernaianu, A.J. DelRossi). Sutureless Intraluminal Ring Grafts for Aortic Replacement (G.M. Lemole). Immunologic Consequences of Transfusion (P.I. Tartter). Traumatic Rupture of the Thoracic Aorta (R.C. Camishion, J.B. Alexander). Cardiomyoplasty (R.C.J. Chiu). Current Status of Autotransfusion (R.A. Vertrees, A.C. Cernaianu). Transesophageal Echocardiology (W.H. O'Connor). The Use of Circulatory Support in Cardiac Surgery (R.L. Kormos). 9 additional articles. Index.

Management of knee trauma has changed rapidly over the past decade, with the acquisition of additional knowledge and new surgical techniques. At present, the optimal management of knee injuries requires the synthesis of multiple approaches drawn from orthopaedics and related surgical fields. The goal of this work is to comprehensively discuss the current state of the art in management of all types of knee trauma, including soft tissue and osteoarticular injuries. In order to take care of the patient with knee trauma, the orthopaedic surgeon must be able to assess and manage injuries of menisci, ligaments, articular surfaces, and bone, as all of these structures must work harmoniously for the knee to function properly. This book has been organized into five major sections. The first section on fundamental principles covers anatomy, articular cartilage injury and repair, osteochondral fractures, soft tissue management, extensile exposure, exter nal fixation, and the use of allografts in the knee. These chapters set the stage for the second section, which covers major fractures of the distal femur and tibial plateau, and the third section, where injuries of the exten sor mechanism are discussed. In section four, injuries of the menisci and ligaments are covered comprehensively, including discussion of multiple liga ment disruptions and knee dislocations. The final section covers late recon structive problems and complications of knee trauma, including knee stiff ness, malunions and nonunions, arthrodesis, total knee replacements for posttraumatic arthritis, fractures about total knee replacement, and extensor mechanism disruption in total knee replacements."

This volume presents a comprehensive overview of the latest advances in basic and translational research in the field of reconstructive transplantation and its potential therapeutic implications. Dr. Thomas E. Starzl and Dr. Raimund Margreiter, both pioneers in the field of transplantation, have written the foreword for the book. The volume spans such topics as skin rejection, immune monitoring, stem cell-based immunomodulatory strategies, costimulatory blockade, tolerance induction, chronic rejection, ischemia reperfusion injury, nerve regeneration, cortical reintegration, and small and large animal models for reconstructive transplantation. The book is intended for biomedical researchers and basic scientists in the field of reconstructive transplantation, transplant immunology and regenerative medicine, as well as clinicians, surgeons and multidisciplinary specialists, who are practicing or interested in this novel and exciting field. Postgraduate fellows and students will also find it a valuable reference.

This book is part of a series covering surgical specialties. The volumes are multi-authored, containing brief chapters, each of which are devoted to one or two specific questions or decisions within that specialty that are difficult or controversial. The volumes are intended as a current and timely reference source for practicing surgeons, surgeons in training, and educators that describe the recommended ideal approach, rather than customary care, in selected clinical situations.

This book comprises the proceedings of the second International Conference, AsiaHaptics 2016, held in Kashiwanoha, Japan. The book treats the state of the art of the diverse haptics (touch)-related research, including scientific research of haptics perception and illusion, development of haptics devices, and applications to a wide variety of fields such as education, medicine, telecommunication, navigation, and entertainment. This work helps not only active haptic researchers, but also general readers to understand what is going on in this interdisciplinary area of science and technology.

Dr. Leonard Swischuk has revised his outstanding work on imaging the cervical spine in children. He draws upon his extensive experience to provide practitioners with an insightful approach to pediatric cervical spine injuries. The text covers developmental anatomy, normal variants, congenital anomalies, abnormalities of the dens, trauma, and miscellaneous abnormalities of the cervical spine. The book has several strengths that appeal to radiology residents, such as its succinct overview of the topic and helpful reference lists that guide readers to additional resources. Dr. Swischuk illustrates conditions he discusses with excellent plain film examples that help residents identify cases they are likely to encounter during board exams and in practice. Accompanying CT and MR images clarify and qualify the findings. Dr. Swischuk's direct writing style makes the complex content highly accessible, providing imaging residents with an invaluable introduction to pediatric cervical spine radiology.

This book examines the position of children who provide tissue to potentially save the life of another. It questions whether child donors of all ages have been treated appropriately and whether they are sufficiently protected in acting as tissue donors, and ultimately considers whether a new regulatory response is needed to benefit donor children. The book couples a legal exposition of the donor child's position with the medico-ethical reality of clinical practice. In recent years, a growing body of literature concerning the clinical experiences and outcomes for child donors has emerged. This book adds to this by examining another dimension - the regulatory frameworks at play. It examines the ethical arguments for and against children acting as tissue donors and provides an original analysis of the legal and non-legal regulatory frameworks governing children's participation in the United Kingdom, United States and Australia. It combines these doctrinal and theoretical approaches with insights into clinical practice gained from the results of qualitative research conducted with health professionals. The analysis inevitably explores the more general issues of children's right to make medical decisions, the role of parents in decision-making, the value of the best interests test and alternative (legal and ethical) standards, rights of participation of children before the courts, and the role of law and other forms of regulation in a clinical context.

This book aims to equip readers with a better understanding of neuroendocrine tumors of the abdomen and explains how to manage them optimally by making use of novel therapeutic options that represent major advances on previous treatments. The most recent advances in epidemiology, genetics, molecular biology, biomarkers, pathology, diagnostics, clinical assessment, medical therapy, and surgical treatment are presented. The information and data provided will stimulate readers to develop their personal opinions on significant issues and assist in decision making in individual patients during routine clinical practice. The book features a multidisciplinary approach and is designed to meet the needs of all physicians seeking comprehensive guidance from experts on the management of patients with neuroendocrine tumors. It will also be of value for researchers wishing to acquaint themselves with the state of the art in the field and emerging research avenues. Abdominal Neuroendocrine Tumors is published in Springer's highly successful Updates in Surgery series, which now comprises more than 20 titles.

This unique text/reference discusses in depth the two integral components of reconstructive surgery; fracture detection, and reconstruction from broken bone fragments. In addition to supporting its application-oriented viewpoint with detailed coverage of theoretical issues, the work incorporates useful algorithms and relevant concepts from both graph theory and statistics. Topics and features: presents practical solutions for virtual craniofacial reconstruction and computer-aided fracture detection; discusses issues of image registration, object reconstruction, combinatorial pattern matching, and detection of salient points and regions in an image; investigates the concepts of maximum-weight graph matching, maximum-cardinality minimum-weight matching for a bipartite graph, determination of minimum cut in a flow network, and construction of automorphs of a cycle graph; examines the techniques of Markov random fields, hierarchical Bayesian restoration, Gibbs sampling, and Bayesian inference.