Our understanding of the genetic and developmental mechanisms underlying scoliosis is rapidly evolving, this timely second edition of The Genetics and Development of Scoliosis is to provide researchers, clinicians, and students with the most current views in this field. This volume brings together leaders in understanding congenital and idiopathic scoliosis to present the current state of research, and to compare the genetic etiology of these conditions, in order to identify potential shared developmental mechanisms. This book will summarize the recent advances in studies of spinal development and how disruptions during embryogenesis in embryonic segmentation can lead to congenital vertebral defects. In addition, recent reports of genetic loci predisposing patients to develop juvenile and adolescent idiopathic scoliosis will be presented, and key clinical features are reviewed. Finally, there will be discussion of how genetic heterogeneity and gene-environment interactions may contribute to congenital scoliosis and isolated vertebral malformations.

The kidneys participate in all vital processes of the body to maintain overall homeostasis and health. When kidneys are injured during surgical interventions, metabolic and hemodynamic control is disrupted, leading to dysfunction associated with greater mortality, length of hospital stay and cost.

"Peri-operative Kidney Injury" presents the epidemiology, risk factors, diagnosis, treatment and outcomes associated with kidney injury during the peri-operative period. Concepts and principles of care to prevent kidney complications during surgical procedures are provided to equip health care professionals along with strategies to manage acute kidney injury and associated challenges when they occur. Chapters detail diverse surgical settings, ranging from the more common, such as abdominal, cardiac and vascular surgeries, to the intricately complex, including the use of the left ventricular assist device and organ transplants. This practical and comprehensive text blends the evidence-based standards of care with cutting edge advances in the field, while also providing the reader with a peek into innovations on the horizon.

Problem Based Neurosurgery is a remarkable fusion of recent advances in neuro-imaging and neurosurgery with modern teaching of integrated system based curricula. It approaches each problem systematically from history, and physical examination to differential diagnosis, investigations and management options. The book captures four decades of advances and experiences in diagnosis and management of patients. The problems upon which the book is based are real patients and cover all aspects of neurosurgical practice with up to date modern images. The blend of new scientific discoveries, modern imaging and the art of smart history and physical examinations underpins the book to improve diagnosis, investigation and the care of neurosurgical patients.The main thrust of this book is that it is based on clinical problems faced by fellows, residents and students, rather than traditional topic based. Problem based learning and management is the modern method of teaching in the new curriculum of teaching neurosurgery. It is a practical handbook that will help students, residents and community doctors alike. There is no similar book on the market that fulfills the objectives of this handbook.

The temporal bone is located at the lower sides of the skull and directly underneath the temple. Part of the Clinico Radiological Series, the new edition of this book reviews current techniques in imaging of the temporal bone and associated disorders. Beginning with an introduction to normal anatomy and the various imaging modalities, the following sections discuss various disorders including congenital anomalies and infections of the external and middle ear; inner ear, internal auditory canal and cochlear implant, and tumours. The final sections explore the clinico-radiological approach to hearing loss, vertigo, tinnitus and facial nerve palsy, concluding with an examination section. The second edition has been fully revised to cover the latest advances in the field. Each topic is presented in a step by step format and illustrative cases and reporting templates are provided for each section. Radiological images and tables enhance learning. Key points Comprehensive review of imaging techniques for the temporal bone Fully revised, second edition covering latest advances in the field Each section includes illustrative cases and reporting templates Previous edition (9789385891908) published in 2016

The book will serve as on demand reference for consultation when one is faced with such special scenario in the field of endourology. It s easy to read and easy to understand format should give an easy access to all chapters right from the beginning, so there is no need to read previous chapters for understanding the current one.

Furthermore it will serve as a textbook for problem oriented approach, which will be an interesting and attractive method of teaching. "

Recent years have witnessed a trend toward the use of minimally invasive techniques in all areas of orthopedic surgery, including hip replacement. This book aims to provide a comprehensive guide to the use of minimally invasive surgery in total hip arthroplasty. The four commonly employed approaches anterior, anterolateral OCM, anterolateral supine, and posterior are described in detail with the aid of high-quality illustrations. For each approach, clear guidance is offered on patient selection, patient positioning, surgical procedure, postsurgical care, and rehabilitation. Potential complications and the advantages and disadvantages of each option are carefully weighed up, and experts also present their personal experiences, outcomes, and success rates with the different approaches. The book concludes by discussing future trends in hip arthroplasty."

Perioperative care is the care that is given before and after surgery. This textbook is a complete guide to the anaesthetic and critical care management of patients undergoing complex surgeries in all organ systems of the body. Topics cover all age groups - neonates, children, and adults. Divided into 11 sections, the book begins with a general overview of critical care in the perioperative period discussing airway management, pain, fluid and electrolyte therapy, shock, arterial blood gas analysis, respiratory failure and mechanical ventilation, and thromboembolism. The following sections cover surgeries in different organ systems and patient groups - cardiothoracic and vascular, neurosciences, paediatrics, obstetrics and gynaecology, gastrointestinal, genitourinary, orthopaedics, head and neck, and transplantation. The final section explains selected miscellaneous topics including nutrition, haemodynamic monitoring, echocardiography, renal replacement therapy, and antibiotics. Compiling 700 pages, the comprehensive text is further enhanced by clinical photographs, diagrams and tables. Key points Comprehensive guide to perioperative critical care in neonates, children and adults Covers complex surgeries in all organ systems Includes discussion on imaging, airway management, and ventilation Highly illustrated with clinical photographs, diagrams and tables

There are a variety of protocols that are used in infected total joint arthroplasty. This book outlines and details the best possible course of treatment and formulate custom algorithms for every possible case, based on current evidence. It reviews current concepts and "recipes" for the diagnostic and therapeutic procedures (surgical and antibiotic) based on the type of implant, infection and the patient. This book is an essential resource on infected total joint arthroplasty, containing a series of logical and highly detailed instructions that will serve to educate orthopedic surgeons operating in this field on the best approaches, according to detailed and careful research conducted over the last decade.

In the past two decades we have seen a surge forward in understanding the genetics and biochemistry underlying many pediatric orthopaedic disorders. A few projects have even progressed into the realm of clinical trials that are primarily aimed at controlling progressive disease. Meanwhile, genomic technology development has outpaced expectations and is enabling gene discovery for disorders that were previously intractable with traditional genetic methods. Included in this latter category are common disorders that display multigenic inheritance, sporadic disorders, and very rare conditions that are difficult to ascertain. Simultaneously, the study of pediatric orthopaedic disorders has been continuously refined and updated, highlighting a number of likely genetic conditions that are as yet unsolved. Molecular Genetics of Pediatric Orthopaedic Disorders updates researchers and clinicians of new developments of pediatric orthopaedic genetics. The chapters inform the audience on the revolution in new genomic methods and the impact this is having on potential study designs and the potential to discover genetic causes of many unsolved orthopaedic conditions. Recent examples have been included of pediatric orthopaedic conditions, both rare and common, that are being solved with these new methods. The book also educates pediatric orthopedic clinicians and geneticists on our understanding of the biology of "classic" genetic diseases that were derived from prior genetic studies. Chapters include biobanks and strategies for studying very rare disorders, genes and pathways causing primordial dwarfism, and notch signaling in congenital scoliosis, and more.

CARDIAC VALVE ALLOGRAFTS (HOMOGRAFTS) highlights the current controversy about freehand subcoronary aortic valve and root replacement with regard to postoperative morbidity and long term durability. It discusses particular implantation techniques of preference in young patients and in different root pathology. Other chapters address intermediate- and long-term results on cardiac valve and vascular homografts for treating complicating cardiac valve and aortic infections. The chapter on basic science additionally makes this book a highly authoritative reference source for cardiac surgeons, physicians and scientists. This work provides a current survey of the state-of-the-art.

Protocols for Enhancing Function of Fetal Islets in vitro and following Transplantation (A. Hayek, G.M. Beattie). Expression of Two Nonallelic Reg Genes in the Developing Human Pancreas: Effects in vitro of Nicotinamide and Maternal Growth Factors (B. Formby et al.). Preparation of Fetal Islets for Transplantation: Importance of Growth Factors (D.A. Hullet et al.). Studies of Fetal Porcine Isletlike Cell Clusters-A Tissue Source for Xenotransplantation in Insulindependent Diabetes Mellitus? (S. Sandler). Basic Biology of Pig Fetal Pancreas and Its Use as an Allograft (B.E. Tuch et al.). Combined Transplantation of Adult and Fetal Islets for Improvement of Graft Function (Y. Mullen). Studies on Pretreatment of Human Fetal Islet in Vitro and Clinical Islet Transplantation in China (Y.F. Hu et al.). The Use of Human Fetal Islet Tissue for Adjunctive Treatment in Insulindependent Diabetic Patients: The Case for 'Partial Success' (L. JovanovicPeterson et al.). Longterm Studies with Cultured and Cryopreserved Human Fetal Islets for Islet Transplantation in Hungary (G. Farkas). Fetal Islet Transplantation and Pregnancy (C.M. Peterson et al.). Encapsulated Human Islet Transplant Trials in Type I Diabetic Patients (P. SoonShiong). 4 additional articles. Index.

It has by now been established that carpal ligamentary lesions may lead to instability and ultimately to carpal arthritis. However, the variety of anatomopathological classifications and the multiplicity of surgical repair techniques reflect the difficulty of grasping this ligamentary pathology. Clinical analysis and traditional investigation techniques must successfully address the complexity of the wrist, which is largely due to the number of synchronized bones involved in every movement of the hand. The clinical analysis of the wrist is insufficient to precisely measure the mobility of each carpal bone, making paraclinical examinations also significant for clinical diagnosis. The tools available today range from X-rays to arthroscopy, including arthroCTscans and soon MRI. As for repair techniques, their diversity must not hide the fact that a biomechanical and physiological principle is involved and must be identified. This book presents the findings of an expert group in the field of wrist pathology. It seeks to analyze, understand, explain and make comprehensible, if not obvious, the reflections that each practitioner should employ during the diagnosis and treatment of carpal ligamentary lesions. The focus is consciously not on degenerative carpal pathology, which usually enjoys more visibility. We hope that readers will benefit from the fact that fragmented pieces of knowledge are gathered in a single work, that they will find in this initial synthesis an inspiration to rethink a difficult and sometimes thankless surgery and to further the surgical advances of the 21st century.

A brain-computer interface (BCI) establishes a direct output channel between the human brain and external devices. BCIs infer user intent via direct measures of brain activity and thus enable communication and control without movement. This book, authored by experts in the field, provides an accessible introduction to the neurophysiological and signal-processing background required for BCI, presents state-of-the-art non-invasive and invasive approaches, gives an overview of current hardware and software solutions, and reviews the most interesting as well as new, emerging BCI applications. The book is intended not only for students and young researchers, but also for newcomers and other readers from diverse backgrounds keen to learn about this vital scientific endeavour.

Biomedical Optics in Otorhinolaryngology: Head and Neck Surgery gives an overview of current technology in biomedical optics relevant to the field of Otorhinolaryngology and head and neck surgery. It provides a comprehensive source of knowledge for researchers and active clinicians seeking information on the principles and practical use of novel diagnostic and therapeutic technology. While most books focus exclusively on laser surgery, which has been largely unchanged for the past 15 years, optical diagnostics and head and neck PDT (photodynamic therapy) are usually entirely overlooked. This book contains a basic introduction into the physics of light and its propagation, lasers and low-coherent light sources, and photon-tissue interaction in relation to therapeutic and diagnostic use. The principles of various imaging techniques are also discussed ( i.e. optical coherence tomography in its variations), as well as the principles and practice of lasers for surgical use on the therapeutic side.

1 Methoden.- 1.1 Elektroenzephalographie (EEG).- 1.1.1 Einfuhrung.- 1.1.2 Entstehungsmechanismen des EEG.- 1.1.3 Methodik der EEG-Ableitung.- 1.1.4 Das normale EEG.- 1.1.5 Pathologische EEG-Veranderungen.- 1.1.6 Diagnostisch relevante EEG-Befunde.- 1.1.7 EEG-Indikationen im Intensivbereich.- 1.2 Ultraschalldiagnostik.- 1.2.1 Physikalische und apparative Voraussetzungen.- 1.2.2 Anatomische und physiologische Voraussetzungen.- 1.2.3 Untersuchungsgang.- 1.2.4 Indikationen der Ultraschalldiagnostik in der Intensivmedizin.- 1.3 Somatosensibel evozierte Potentiale (SEP).- 1.3.1 Einfuhrung.- 1.3.2 Methodik.- 1.3.3 Ursprungsorte der SEP-Komponenten.- 1.3.4 Auswertung und Normwerte.- 1.3.5 Ausfallsmuster bei typischen Schadigungsorten.- 1.3.6 Indikationen zur Ableitung von SEP.- 1.4 Fruhe akustisch evozierte Potentiale (FAEP).- 1.4.1 Einfuhrung.- 1.4.2 Methodik.- 1.4.3 Generatoren des FAEP.- 1.4.4 Auswertung und Normwerte.- 1.4.5 Lokalisationsdiagnostische Bedeutung der FAEP.- 1.4.6 Indikationen zur Ableitung von FAEP.- 1.5 Motorisch evozierte Potentiale (MEP).- 1.5.1 Einfuhrung.- 1.5.2 Wirkungsweise der Magnetstimulation.- 1.5.3 Methodik.- 1.5.4 Auswertung.- 1.5.5 Kontraindikationen.- 1.5.6 Besonderheiten der MEP-Untersuchung auf der Intensivstation.- 1.5.7 Einsatz der MEP auf der neurologischen Intensivstation und im Neuromonitoring.- 1.6 Visuell evozierte Potentiale (VEP).- 1.6.1 Einfuhrung.- 1.6.2 Anatomische und physiologische Grundlagen.- 1.6.3 Technische Durchfuhrung.- 1.6.4 Auswertung.- 1.6.5 Beeinflussung der VEP.- 1.6.6 Indikationen fur VEP-Ableitung in der Intensivmedizin.- 1.7 Elektromyographie (EMG) und Neurographie.- 1.7.1 Einfuhrung.- 1.7.2 Elektromyographie.- 1.7.3 Motorische Neurographie.- 1.7.4 Sensible Neurographie.- 1.7.5 Prufung der neuromuskularen UEberleitung.- 1.7.6 F-Antworten.- 1.7.7 Reflexmessungen.- 1.8 Untersuchung des autonomen Nervensystems.- 1.8.1 Anatomie.- 1.8.2 Physiologie.- 1.8.3 Methodik: Grundlagen.- 1.8.4 Pathophysiologie.- 1.8.5 Methodik: Analyse der Herzfrequenzvariabilitat.- 1.8.6 Allgemeine Befunde.- 1.8.7 Blutdruckmonitoring.- 1.8.8 Methodik: Sympathische Hautreaktion.- 1.9 Exogene und endogene Einflusse auf neurophysiologische Parameter.- 1.9.1 Einfuhrung.- 1.9.2 Exogene Einflusse.- 1.9.3 Endogene Einflusse.- 2 Neuromonitoring bei Intensivtherapiepflichtigen Erkrankungen.- 2.1 Schadel-Hirn-Trauma.- 2.1.1 Einfuhrung.- 2.1.2 Pathophysiologie.- 2.1.3 Klinische Diagnostik.- 2.1.4 Radiologische Diagnostik.- 2.1.5 Neurophysiologische Diagnostik.- 2.2 Hypoxisch-ischamische Hirnschadigung.- 2.2.1 Einfuhrung.- 2.2.2 Ursachen und Pathophysiologie.- 2.2.3 Klinisches Erscheinungsbild.- 2.2.4 Prognose aufgrund der klinischen Untersuchung.- 2.2.5 Bedeutung neurophysiologischer Methoden fur Diagnostik, Verlauf und Prognose.- 2.2.6 Andere Untersuchungen.- 2.3 Intrakranielle Blutungen.- 2.3.1 Einfuhrung.- 2.3.2 Infratentorielle intrazerebrale Blutungen.- 2.3.3 Supratentorielle intrazerebrale Blutungen.- 2.3.4 Subarachnoidalblutungen.- 2.4 Hirninfarkt.- 2.4.1 Einfuhrung.- 2.4.2 Klinische und radiologische Klassifikation der Hirninfarkte.- 2.4.3 Ultraschalldiagnostik.- 2.4.4 Elektroenzephalographie (EEG).- 2.4.5 Fruhe akustisch evozierte Potentiale (FAEP).- 2.4.6 Motorisch evozierte Potentiale (MEP).- 2.4.7 Somatosensibel evozierte Potentiale (SEP).- 2.5 Meningoenzephalitis.- 2.5.1 Einfuhrung.- 2.5.2 Bedeutung neurophysiologischer Methoden fur Verlauf und Prognose.- 2.6 Metabolische und septische Enzephalopathien.- 2.6.1 Einfuhrung.- 2.6.2 Hepatische Enzephalopathie.- 2.6.3 Uramische Enzephalopathie und Dysequilibrium-Syndrom.- 2.6.4 Hypoglykamie.- 2.6.5 Hyperglykamie und hyperosmolares Koma.- 2.6.6 Elektrolytstoerungen.- 2.6.7 Schilddrusenfunktionsstoerungen.- 2.6.8 Weitere metabolische Enzephalopathien.- 2.6.9 Septische Enzephalopathie.- 2.7 Toxische Enzephalopathien.- 2.7.1 Einfuhrung.- 2.7.2 Intoxikation mit Barbituraten und Benzodiazepinen.- 2.7.3 Intoxikation mit Neurol

This book presents the neurobiology of orthodontics according to the most recently acquired knowledge on the interaction of the brain activity with the senses. In particular, it highlights the ability of orofacial sensory input to modulate and change the brain activity underlying functions of the stomatognathic system, such as chewing, biting, speech, and occlusal feedback. The approach adopted thereby represents a significant departure from traditional orthodontics, in which malocclusions of the teeth have been interpreted as deriving from DNA coding errors. The described new conceptualization of the etiology and diagnosis of malocclusions has profound implications for orthodontic therapy, as is clearly explained. Orthodontic therapy in turn has significant effects on the brain, which are documented in a chapter devoted to neuroimaging methods. By opening up new and creative pathways in the world of orthodontics, this book will hopefully both educate and excite the practitioner. It is recommended reading for all orthodontists.

Hypermobility of Joints 4th Edition follows the same format as its successful predecessors. The aim of which was to provide an overview of hyperlaxity of joints and this edition follows that aim by describing the most recent research and new developments in biochemistry, as well as providing practical advice on clinical features and management.

Hypermobility of Joints 4th Edition provides illustrative case histories, a review of hypermobility in the performing arts and sports and an outline of heritable hypermobility syndromes. This book is a valuable reference tool for a wide number of specialties, although it will particularly be of interest to rheumatologists, orthopedic surgeons and medical geneticists.

Behavioral neuroscience encompasses the disciplines of neurobiology and psychology to study mechanisms of behavior. This volume provides a contemporary overview of the current state of how ethics informs behavioral neuroscience research. There is dual emphasis on ethical challenges in experimental animal approaches and in clinical and nonclinical research involving human participants.

This book provides an in-depth review of state-of-the-art orthopaedic techniques and basic mechanical operations (drilling, boring, cutting, grinding/milling) involved in present day orthopaedic surgery. Casting a light on exploratory hybrid operations, as well as non-conventional techniques such as laser assisted operations, this book further extends the discussion to include physical aspects of the surgery in view of material (bone) and process parameters. Featuring detailed discussion of the computational modeling of forces (mechanical and thermal) involved in surgical procedures for the planning and optimization of the process/procedure and system development, this book lays the foundations for efforts towards the future development of improved orthopaedic surgery. With topics including the role of bone machining during surgical operations; the physical properties of the bone which influence the response to any machining operation, and robotic automation, this book will be a valuable and comprehensive literature source for years to come.

Presenting a multidisciplinary approach to the prevention and management of injuries to young tennis players, this unique book considers multiple factors contributing to the increasing numbers of such sports-related injuries, such as increased young athlete participation in tennis, the pre-professionalization of younger players and misconceptions surrounding treating children in the same manner as adults. Beginning with the essentials for developing tennis players and their physical and mental growth with the sport, the text then turns to prevention and management techniques and strategies covering the upper and lower extremities, shoulder and elbow, hip and knee, and spine, as well as other acute medical conditions. Further consideration is given to proper nutrition, strength and conditioning, and rehabilitation and return to play. Edited by clinicians directly involved in the care of young tennis players and including contributions from physical therapists, nutritionists, sports psychologists, and physicians, it is an invaluable and comprehensive resource for any professional seeing and treating young tennis players.

There are growing questions regarding the safety, quality, risk management, and costs of PCC teams, their training and preparedness, and their implications on the welfare of patients and families. This innovative book, authored by an international authorship, will highlight the best practices in improving survival while paving a roadmap for the expected changes in the next 10 years as healthcare undergoes major transformation and reform. An invited group of experts in the field will participate in this project to provide the timeliest and informative approaches to how to deal with this global health challenge. The book will be indispensable to all who treat pediatric cardiac disease and will provide important information about managing the risk of patients with pediatric and congenital cardiac disease in the three domains of: the analysis of outcomes, the improvement of quality, and the safety of patients.