Most of the developments in perioperative medicine the 20th century were focused on the establishment of standard monitors, biomarkers, and outcomes measures for the cardiovascular and respiratory systems, with marked improvements in perioperative safety. The fields of anesthesiology and perioperative medicine have now shifted to the consideration of the nervous system. Complications such as delirium, cognitive decline, anesthetic neurotoxicity, stroke and other devastating nervous system events are only now developing significant scientific and clinical attention. Yet there has been no single reference to serve as a guide for the clinician or the investigator in this area. Neurologic Outcomes of Surgery and Anesthesia fills this gap in perioperative medicine literature and provides a concise yet thorough overview of adverse outcomes involving the brain, spine, and peripheral nerves. Rather than being organized by type of operation, each chapter in this invaluable resource is devoted to a specific adverse outcome. Every outcome is reviewed in an easy-to-follow format that includes an introduction to the clinical problem, a section on incidence, prevalence, and outcomes, an assessment of risk factors, discussions of preventive strategies, treatment, and current recommendations, a conclusion, and references.

The human lumbopelvic area has become the focus of a considerable amount of new and intriguing research relevant to effective diagnosis and treatment of low back pain. Back function has recently been studied from a broader perspective, including the analysis of the coupled function in spine, pelvis and legs. These approaches lead to new questions about dynamic stability and motor control in general, and specifically about the spine and pelvis. These new insights obviously imply new approaches in the prevention and treatment of low back pain and pelvic pain. Unique to this book is its in-depth coverage of this subject area by a team of international contributors who represent the broad range of professionals involved in clinical research and therapy. These experts cover a vast area of lumbopelvic experience, from effective treatment and rehabilitation to epidemiology, anatomy, biomechanics, pain and motor control, surgery and manual therapy. Evidence -based focus Final conclusions including perspectives with each chapter Each chapter is relevant and up to date New high profile contributors Updated references Introduction and closure for each chapter Special attention given to stability and muscle function

This issue of Foot and Ankle Clinics, guest edited by Dr. Gaston Slullitel, will discuss Current Concepts of Treatment of Metatarsalgia. Under the guidance of long-time series Consulting Editor Dr. Mark Myerson, Dr. Slullitel and his contributing authors will explore topics of interest for practitioners in the field. Articles include, but are not limited to: the role of First ray insufficiency in the development of metatarsalgia; Current evidence in surgical treatment for metatarsalgia; Evolution of The Weil Osteotomy; State of the Art in Lesser MTPJ Instability; MIS options for Metatarsalgia Treatment; Gastroc recession in the setting of Metarsalgia; Freiberg's infraction: surgical options; Resection arthroplasty; and Brachymetatatarsia, among others.

There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy.
Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier.
The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices.
- Provides detailed description of clinical trials in cell transplantation
- Review of current therapeutic approaches
- Coverage of the broad range of diseases addressed by cell therapeutics
- Discussion of stem cell biology and its role in transplantation

This unique how-to atlas presents in-depth, detailed, richly illustrated coverage of cosmetic surgical procedures that apply specifically to the Asian patient. Dr. Park, a pioneer in this field, along with Dr. Toriumi and a host of global experts present procedures for and pitfalls of cosmetic surgery in the Asian population. Inside, you'll find coverage of techniques not typically found in other Asian cosmetic surgery texts, including the single suture technique and the debulking technique for double eyelid surgery . anatomy for maxillofacial surgery . premaxillary reduction . and more. Discusses the anatomic differences between people of European descent and the Asian patient. Covers potential problems specific to Asian patients, including asymmetric eyelid creases * undesirably shaped eyelid crease * hollowness * "Westernization" * overly high eyelid crease * multiple creases * eyelid ptosis * scarring after epicanthal fold surgery * and more. Features augmentation rhinoplasty-covering both the use of alloplastic material and biological grafts LDetails the single suture technique and the debulking technique for double eyelid surgery * anatomy for maxillofacial surgery * premaxillary reduction * mandibulogram * aesthetic facial skeletal surgery * cheek dimple creation * mandible angle reduction * and Botox injection for masseteric hypertrophy. Uses 750 illustrations-most in full color-that depict every nuance of every procedure so you can quickly grasp each concept. With 23 contributors.

Over the past decade, there has been rapid growth in bioengineering applications in the field of spine implants. This book explains the technical foundation for understanding and expanding the field of spine implants, reviews the major established technologies related to spine implants, and provides reference material for developing and commercializing new spine implants. The editors, who have a track record of collaboration and editing technical books, provide a unified approach to this topic in the most comprehensive and useful book to date.
-Related website provides the latest information on spine technology including articles and research papers on the latest technology and development.
-Major technologies reviewed include devices used for fusion (screws, plates, rods, and cages), disc repair and augmentation, total disc replacement, and vertebral body repair and augmentation.
-Technology landscape, review of published/public domain data currently available, and safety and efficacy of technology discussed in detail.

This issue of Surgical Clinics of North America focuses on Practicing Primary Palliative Care and is edited by Dr. Pringl Miller. Articles will include: Advantages of a Multidisciplinary Team Approach to Surgical Care; Concurrent Palliative Care has Clinical Outcome Benefits; Goals of Care Discussions - Understanding the Outcomes that Matter Most; Prognostic Tools and Shared Decision Making; Peri-Operative Advance Directives - DNR in the OR; Optimizing Pain Control During the Opioid Epidemic; Wound and Stoma Care - Less is More; Image-Guided Palliative Interventions; Palliative Care and the Pregnant Surgical Patient; Tracheostomies, PEGs, and Hemodialysis Vascular Access - When Are They Really Indicated?; Post-Operative Recovery & Survivorship after Acute Hospitalization for Serious Life Limiting Illness; Spiritual Dimensions of Surgical Palliative Care; Transitioning to Comfort-Focused Care at the End-of-Life; Mitigating Burnout; Surgical Palliative Care Education; and more!

This book describes the anatomical knowledge required for the 60 most common general surgical procedures. Throughout the emphasis is on helping the surgeon prepare for, and successfully and safely complete the operation. The choice of operations covered and the level of detail make the book ideal for higher surgical trainees in General Surgery. More experienced surgeons will also use it as a source of reference. Covers approximately 60 of the commonest operations in general surgery that need to be mastered during higher surgical training Each chapter covers the anatomy that will be encountered during the operation Includes notes on anatomical variations that may be encountered Fully illustrated with clear line drawings Matches the knowledge expected of candidates for the General Surgical Fellowship Totally redesigned with new artwork More on endoscopic procedures Greater coverage of anatomical variation that the surgeon will encounter

This issue of Oral and Maxillofacial Surgery Clinics of North America is devoted to Orthodontics for the Oral and Maxillofacial Surgery Patient and is edited by Drs. Michael R. Markiewicz, Sath Allareddy and Michael Miloro. Articles will include: Digital workflow for combined orthodontics and orthognathic surgery; Surgical tooth exposure and bonding: What does the orthodontist want?; Temporary skeletal anchorage techniques; Interceptive dentofacial orthopedics (growth modification); Correction of transverse maxillary deficiency; Comprehensive pre-orthognathic surgery orthodontics; Distraction osteogenesis for the non-craniofacial patient; Surgery-first approach in the orthognathic patient; Idiopathic condylar resorption: What should we do?; Juvenile idiopathic arthritis: Update on management; Comprehensive post-orthognathic surgery orthodontics: complications, misconceptions, and management; Aesthetic facial surgery and orthodontics: Common goals; and more!

This issue of Surgical Clinics of North America focuses on Inflammatory Bowel Disease and is edited by Dr. Sean Langenfeld. Articles will include: IBD presentation and diagnosis; Endoscopy in IBD; Preoperative considerations in IBD; Postoperative Considerations in IBD; IBD and cancer/dysplasia; Elective abdominal surgery for IBD; Abdominal emergencies in IBD; Anorectal Crohn's disease; Other surgeries in IBD patients; Pediatric inflammatory bowel disease; Pouch complications; Genetic and environmental considerations for IBD; IBD and short bowel syndrome; Medical Management of IBD; and more!

This issue of the Atlas of the Oral and Maxillofacial Surgery Clinics of North America focuses on Trauma Surgery, and is edited by Drs. Robert Strauss and Alaaaldin Radwan. Articles will include: Management of panfacial, NOE and frontal sinus fractures; Management of ballistic injuries in the maxillofacial trauma patient; Management of nasal fractures; Temporomandibular joint trauma; Rigid fixation techniques; Complicated maxillofacial fractures: Pediatric and geriatric; Diagnostic imaging of the maxillofacial trauma patient; Post-traumatic injuries of the trigeminal and facial nerve; Avulsive soft tissue injuries; Virtual surgical planning in maxillofacial trauma; Management of orbital fractures; Traumatic ear injuries; Delaying Soft Tissue Repair; and more!

This issue of Surgical Clinics of North America focuses on Surgical Management of Endocrine Disease and is edited by Drs. Rebecca S. Sippel and David F. Schneider. Articles will include: Evaluation of Thyroid Nodules; Decision Making in Indeterminate Thyroid Nodules and the Role of Molecular Testing; Extent of Thyroidectomy for Thyroid Cancer; Management of Nodal Disease in Thyroid Cancer; The Role of Surgery in Inflammatory Conditions of the Thyroid; Diagnosis and Evaluation of Primary Hyperparathyroidism; Who Benefits from Treatment of Primary Hyperparathyroidism?; Intra-operative Decision Making in Parathyroid Surgery; Surgical Management of MEN-1 and MEN-2; The Importance of Family History in the Management of Endocrine Disease; Evaluation of an Adrenal Incidentaloma; Evaluation and Management of Primary Hyperaldosteronism; When to Intervene for Subclinical Cushing's Syndrome; Adrenocortical Cancer Treatment; Surgical Approaches to the Adrenal Gland; Evaluation and Management of Neuroendocrine Tumors of the Pancreas; and more!

. Clinical cases provide a visual resource of surgical options . Procedural videos direct from the Operating Room . Easy to follow format shows step by step each technique

This issue of Clinics in Plastic Surgery, guest edited by Dr. Lee L.Q. Pu, is devoted to Fat Grafting to the Face for Rejuvenation, Contouring, or Regenerative Surgery. This issue will include an overview of current concepts and techniques of facial fat grafting, discuss personal approaches from the experts in fat grafting for facial rejuvenation, and show techniques for fat grafting for facial rejuvenation with nanofat grafts, cryopreserved fat grafts, and SVF-gel. Articles will further discuss fat grafting for facial contouring of the temporal region and midface, nose and chin, and unilateral face with SVF. Pan-facial fat injection approach to facial contouring in young Asian patients and fat grafting for the treatment of facial burns and burn scars, facial scleroderma, facial scars, and secondary facial deformity will also be discussed.

Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science... we assembled experts from all over the world and asked them to focus on the current state of knowledge and the prospects for new knowledge in their area of expertise. To this end, Principles of Bone Biology was conceived." - John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan Praise for the previous edition: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine For over two decades, "Big Gray" has been the go-to repository of knowledge in the disciplines related to bone and mineral metabolism. The fourth edition is a must-have for students new to the field; young investigators at the graduate or postgraduate level beginning their research careers; established scientists who need to keep up with the changing nature of the field, looking to enrich their own research programs, or who are changing their career direction; clinicians who want ready access to up-to-date relevant basic science. This new edition builds on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. Principles of Bone Biology, Fourth Edition provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. Bone research continues to generate enormous attention, due to the broad public health implications of osteoporosis and related bone disorders. This classic, fully updated, two volume reference is designed for anyone involved in the study of bone biology.