Key features: High quality full color photographs and descriptive texts on the location and removal of the organs from the mouse Instructive methods and clear visuals for trimming and orienting the organs for paraffin histology to obtain the best possible sections for analysis Full color photomicrographs of the resulting section for each organ stained with hematoxylin and eosin demonstrating important features and landmarks for the histologist to ensure the optimal area for analysis is achieved All in one, easy to use guide organized by individual organs of the laboratory mouse Spiralbound for easy reference in the lab This "one-stop" guide offers an essential resource for any academic, research or development operation where mouse necropsy and/or histology are performed. Connecting the reader 'from the mouse to the microscope', it provides a detailed guide for locating, trimming, orientating and embedding of the most frequently investigated tissues collected in the laboratory mouse. It shows where the organs reside in the mouse, how to trim and embed them as well as the resulting optimal sections. This guide brings together the wealth of scattered information into one high-quality text, the emphasis is on providing knowledge that will help histologists and scientists get better results in any downstream assays where ideal sections are needed.

Practitioners of aesthetic medicine and surgery already have a series of textbooks instructing on how to treat the standard patient. Unfortunately, they also have patients who do not conform to the average-those who are of a different age, or sex, ethnicity, or medical history, or who have special social requirements. Aesthetic Rejuvenation Challenges and Solutions: A World Perspective pools the expertise of top aesthetic practitioners who look at those complicated areas that tend to be ignored in the more standard textbooks and provides advice on managing these areas of special challenge that arise in clinical practice. The book contains extensive material on "non-standard" and "non-textbook" patients. It discusses how to evaluate these patients, and when to decide that a patient is not suited for a particular procedure. It discusses the treatment of patients of different ethnic groups, and provides guidance on how to manage patient expectations and deal with dissatisfied patients.

"Engineering for Patient Safety: Issues in Minimally Invasive Procedures" is a brief study of how human factors engineers have worked with medical personnel to improve patient safety and reduce medical error in the newest minimally invasive surgical procedures. In traditional surgery, surgeons had the advantages of three-dimensional vision and hands-on feedback as a result of direct contact with instruments and tissue. While the new surgical techniques have cost benefits and generally reduce patient trauma and recovery time, a whole new cast of potential problems has been introduced and there are greater risks of medical error.
This book features:
*an explanation of new technologies to improve minimally invasive procedures, starting with task analysis, problem assessment, instrument design, and evaluation of the new technologies;
*examples from laparoscopy, arthroscopy, virtual colonoscopy, and cardiovascular catheter interventions; and
*future projects and research fields.
This study is of interest to human factors researchers who focus on health care, designers and manufacturers of medical equipment, and surgeons and technicians.

Facioscapulohumeral muscular dystrophy (FSHD) is a genetic disorder involving slowly progressive muscle degeneration in which the muscles of the face, shoulder blades and upper arms are among the most severely affected. It is the third most common inherited muscular dystrophy, affecting 1 in 20,000. The search for the molecular basis of the disease is of interest to all genetic researchers, involving a deletion outside a coding region resulting in over-expression of adjacent genes. This volume summarizes the current understanding of the disorder, including clinical, molecular and therapeutic aspects.

Recent Advances in Surgery 27 is the latest volume in the successful and well-established Recent Advances series. This title is updated annually, covering the latest trends within surgery and reflecting any changes to the professional examinations for surgeons. Recent Advances in Surgery 27 has contributions on important topics relevant to the management of all surgical patients, providing in-depth reviews of important advancing areas in surgical subspecialties. This wide scope makes this book an ideal choice for the busy consultant as well as an essential read for students of surgery at all levels. Suitable for experienced medical professionals, as well as students and candidates of the MRCS/AFRCS, this edition reviews the latest trends within surgery and forms a useful update of general surgery for candidates of the Intercollegiate examination. Over 30 contributors, who are recognized experts in their particular field, provide in-depth reviews of important topics relevant to the management of all surgical patients and advancing areas in surgical subspecialties.

Artificial hearts are seductive devices. Their promissory nature as a cure for heart failure aligned neatly with the twentieth-century American medical community's view of the body as an entity of replacement parts. In Artificial Hearts, Shelley McKellar traces the controversial history of this imperfect technology beginning in the 1950s and leading up to the present day. McKellar profiles generations of researchers and devices as she traces the heart's development and clinical use. She situates the events of Dr. Michael DeBakey and Dr. Denton Cooley's professional fall-out after the first artificial heart implant case in 1969, as well as the 1982-83 Jarvik-7 heart implant case of Barney Clark, within a larger historical trajectory. She explores how some individuals-like former US Vice President Dick Cheney-affected the public profile of this technology by choosing to be implanted with artificial hearts. Finally, she explains the varied physical experiences, both negative and positive, of numerous artificial heart recipients. McKellar argues that desirability-rather than the feasibility or practicality of artificial hearts-drove the invention of the device. Technical challenges and unsettling clinical experiences produced an ambivalence toward its continued development by many researchers, clinicians, politicians, bioethicists, and the public. But the potential and promise of the artificial heart offset this ambivalence, influencing how success was characterized and by whom. Packed with larger-than-life characters-from dedicated and ardent scientists to feuding Texas surgeons and brave patients-this book is a fascinating case study that speaks to questions of expectations, limitations, and uncertainty in a high-technology medical world.

Exclusively addressing the region of the upper extremity, this important and practical reference features contributions from 17 leading specialists and supplies state-of-the-art descriptions of diverse fractures, treatment approaches, and surgical options. Includes a chapter on nonunions of the upper extremity.

Considering the epidemiology of COPD, this title collects all available knowledge on the subject, featuring data on the national emphysema treatment trial. It explores the epidemiology of emphysema, the management of complications and surgical controversies in lung volume reduction surgery for emphysema (LVRS).

Advances in Spinal Fusion reveals a new generation of materials and devices for enhanced operations in spinal fusion. This reference showcases emerging research and technologies in areas such as biodegradable implants, drug delivery, stem cell isolation and transfection, cell encapsulation and immobilization, and the design of 2D and 3D scaffolds for cells. It captures a cascade of innovations crucial to increased healing and decreased morbidity in spinal fusion methods and mechanics and addresses current standards in analytical methodology and quality control, it describes the selection of biomaterials for improved biocompatibility, biostability, and structure/function relationships.

In this issue of Foot and Ankle Clinics, guest editor Dr. Don Anderson brings his considerable expertise to the topic of Applied Translational Research in Foot and Ankle Surgery. Applied translational research is designed to ensure the highest possible chance of success, and in this issue, top experts in foot and ankle surgery help you produce more meaningful, applicable results that take both safety and efficacy into consideration. Contains 14 practice-oriented topics including utilizing novel in-clinic assessments to identify aberrant foot biomechanics; foot and ankle alignment and biomechanical implications; patient-specific FE analysis of foot and ankle biomechanics; biomechanics of chronic ankle instability; and more. Provides in-depth clinical reviews on applied translational research in foot and ankle surgery, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

The bestselling author of Complications reveals what you need to be a great surgeon - and shows how everyone can improve at what they doThe struggle to perform well is universal, but nowhere is this drive to do better more important than in medicine. In his new book, Atul Gawande explores how doctors strive to close the gap between best intentions and best performance in the face of obstacles that sometimes seem insurmountable.His vivid stories take us to battlefield surgical tents in Iraq, to a polio outbreak in India and to malpractice courtrooms around the country. He discusses the ethical dilemmas of doctors' participation in lethal injections, examines the influence of money on modern medicine and recounts the astoundingly contentious history of hand-washing. Finally, he gives a brutally honest insight into life as a practising surgeon.Unflinching but compassionate, Gawande's investigation into medical professionals and their progression from good to great provides a detailed blueprint for success that can be used by everyone.

Preoperative imaging is increasingly being adopted for preoperative planning in plastic and reconstructive surgery. Accurate preoperative analysis can reduce the length of operations and maximize surgical design and dissection techniques. Imaging for Plastic Surgery covers the techniques, applications, and potentialities of medical imaging technology in plastic and reconstructive surgery. Presenting state-of-the-art research on evolving imaging modalities, this cutting-edge text: Provides a practical introduction to imaging modalities that can be used during preoperative planning Addresses imaging principles of the face, head, neck, breast, trunk, and extremities Identifies the strengths and weaknesses of all available imaging modalities Demonstrates the added value of imaging in different clinical scenarios Comprised of contributions from world-class experts in the field, Imaging for Plastic Surgery is an essential imaging resource for surgeons, radiologists, and patient care professionals.

"Bold and compelling... Uniformly excellent, and often wryly amusing."" - The Wall Street Journal "A globetrotting historical adventure, told from the inside of the operating room... Medical writing at its most exhilarating." - Michael Paul Mason "Comprehensively researched, deftly told, and radiating both intellect and passion... Essential reading for anyone interested not only in the history but also in the future of medicine." - Frank Huyler "A history of surgery that is informative, entertaining, and highly readable." Library Journal A fascinating history of the practice of surgery from one of the leading figures in the field, chronicling centuries of scientific breakthroughs by the discipline's most dynamic, pioneering doctors. Written by an author with plenty of experience holding a scalpel, Dr. David Schneider's The Invention of Surgery is an in-depth biography of the practice that has leapt forward over the centuries from the dangerous guesswork of ancient Greek physicians through the world-changing "implant revolution" of the twentieth century. The Invention of Surgery explains this dramatic progress and highlights the personalities of the discipline's most dynamic historical figures. It links together the lives of the pioneering scientists who first understood what causes disease, how organs become infected or cancerous, and how surgery could powerfully intercede in people's lives, and then shows how the rise of surgery intersected with many of the greatest medical breakthroughs of the last century, including the evolution of medical education, the transformation of the hospital from a place of dying to a habitation of healing, the development of antibiotics, and the rise of transistors and polymer science. And as Schneider argues, surgery has not finished transforming; new technologies are constantly reinventing both the practice of surgery and the nature of the objects we are permanently implanting in our bodies. Schneider considers these latest developments, asking "What's next?" and analyzing how our conception of surgery has changed alongside our evolving ideas of medicine, technology, and our bodies.

This new addition to the popular 100 cases series explores common clinical scenarios that will be encountered by the medical student and junior doctor during practical training in the emergency department, in the community and in intensive and critical care settings, and which are likely to feature in qualifying examinations. The book covers a broad range of presentations, organized by sub-specialty area for ease of reference. Comprehensive answers highlight key take home points from each case and provide practical advice on how to deal with the challenges that occur when practising emergency and critical care medicine at all levels.

This volume offers a comprehensive discussion of the stereotactic frames, frameless systems, and radiosurgical procedures utilized in the treatment and control of movement and neurological disorders, Parkinson's disease, chronic pain, spasticity, tumours, epilepsy, and arteriovenous malformations.

This title offers guidelines to avoid complications in the diagnosis, management, repair and rehabilitation of common, complex and multifaceted fractures of the shoulder girdle. It emphasizes critical issues in clinical and radiographic evaluation for optimal surgical outcomes. The text is also illustrated to clarify diagnostic, surgical and therapeutic schemes.

The Manual of Venous and Lymphatic Diseases constitutes a concise but comprehensive and contemporary description of the nature and management of venous and lymphatic diseases. This innovative book instructs the post-graduate trainee in phlebology and is also valuable to undergraduate students wishing to gain a broader knowledge than is available in general surgical texts. Addtionally, it is a useful reference for practising phelebologists, vascular surgeons and imaging specialists. The text covers basic principles, diagnosis and treatment of chronic venous disease, venous thrombo-embolism, lymphoedema and vascular malformations.

Filling a gap in literature, this concise and practical book presents the principles of virtual orthopedic assessment and shares insights into the use of technology for distance patient-physician communication. Offering expert know-how and best practices, it equips readers with essential information on how to best remotely manage the diagnosis, treatment and follow-up of patients.The book starts by defining telemedicine and presenting the basic requirements. The following chapters each focus on a specific joint or compartment, highlighting its peculiarities in terms of remote clinical assessment, and also discussing data security, patient confidentiality and consent as well as medico-legal issues. Moreover, the book features a dedicated chapter that analyzes specific issues related to remote assessment in children, older patients, noncompliant patients, and patients with pain. Covering all the basic and practical aspects of this emerging field, this book is a must-read for orthopedists and other professionals, such as general practitioners and physiotherapists, wanting to gain insights into remote orthopedic patient care.

Endoleaks and Endotension is an authoritative resource for vascular surgeons, interventional radiologists and cardiologists, vascular disease specialists, primary care physicians and internists, and students interested in endovascular aneurysm repair. It contains valuable guidelines from a widely respected team of international authorities on the subject.

Orthopaedic procedures in elderly patients are challenging and costly. As the population ages these costs will continue to escalate. ORTHOPAEDIC ISSUES IN OSTEOPOROSIS weaves together theory and applications to provide the first reference available on the orthopaedic aspects of osteoporosis.

The focus on the management of patients who have had a fracture sets this book apart. Featuring extensive coverage of surgical management of osteoporotic fractures, it highlights the challenges of internal repair in osteoporotic bone. The chapters combine the basic and clinical essentials of osteoporosis with the latest orthopaedic findings in applied research and surgical treatment.

Fractures associated with osteoporosis account for the majority of the money spent on this condition. However, the orthpaedic treatment of osteoporotic bone is a formidable surgical problem, and one not covered explicitly in any book - until now. With over 300 tables, line drawings, equations, and macro or X-ray photographs, ORTHOPAEDIC ISSUES IN OSTEOPOROSIS is a long overdue resource.

About the Editor: Yuehuei H. (Huey) An, MD, graduated from the Harbin Medical University, Harbin, Northeast China in 1983 and was trained in orthopaedic surgery at the Beijing Ji Shui Tan Hospital (Residency), and in hand surgery at Sydney Hospital (Clinical Fellow), Australia. In 1991, Dr. An joined with Dr. Richard J. Friedman in the Department of Orthopaedic Surgery at the Medical University of South Carolina to establish the MUSC Orthopaedic Research Laboratory, which is now a multifunctional orthopaedic research center. Dr. An has published more than 100 scientific papers and book chapters and more than 100 abstracts and edited 6 books, including Animal Models in Orthopaedic Research (CRC Press 1999) and Mechanical Testing of Bone and the Bone-Implant Interface (CRC Press 2000). He is an active member of eight academic societies in the fields of orthopaedics, biomaterials, biomechanics, and tissue engineering.

Focuses on individualized spinal injury assessments, immobilization techniques, nonoperative and operative indications, operative fixation strategies, and prognoses. Fractures of the Cervical, Thoracic, and Lumbar Spine surveys the anatomy and physiology of the spinal cord injury designation and analysis using force vectors the spinal cord injury without radiographic abnormality reduction and alignment of the spine in emergency management pharmacological intervention prior to surgery imaging in spinal trauma classification of cervical spine trauma Containing over 1900 references, Fractures of the Cervical, Thoracic, and Lumbar Spine is an invaluable resource for orthopedic, spinal, and trauma surgeons; neurosurgeons; emergency medicine physicians; and neurologists; and residents, nurses, and medical school students in these disciplines.

The novice to the advanced practitioner will find value in having this handy reference on parenteral nutrition. It contains sections on order review, compounding, and drug shortage management. This latest edition is expanded to 13 chapters and is updated with ASPEN safety consensus recommendations and clinical guidelines. It features comprehensive information to help practitioners safely, effectively, and confidently care for patients receiving parenteral nutrition. The third edition includes new chapters on: Competency Multichamber-bags Electronic health records >br> A quick-reference handbook with interdisciplinary guidance on: Access devices, formulations, and prescriptions Treatment for common mechanical, metabolic, and infectious complications Order review, compounding, and drug shortage management Management of patients outside the hospital Considerations for pediatric patients

This comprehensive reference details the techniques for establishing vascular access for hemodialysis and other acute and chronic conditions that require access to the circulation along with peritoneal dialysis access methods. Includes over 960 references and more than 160 tables, figures, and photographs. Vascular Access in Clinical Practice contains the latest material on -autogenous AV fistula formation and maintenance methods -diagnosis of fistula problems prior to thrombosis -salvaging acutely thrombosed grafts -percutaneous methods of salvaging access sites -preoperative assessment of the access patient -materials used for vascular access and their healing responses -access techniques for pediatric patients and features extensive coverage of central venous catheters including -catheter selection -catheter placement techniques -catheter related complications -operative imaging -catheter care and maintenance Vascular Access in Clinical Practice is an essential reference for general and vascular surgeons, residents, and fellows; nephrologists; dialysis practitioners; intravenous infusion practices; and medical, physician assistant, and nursing students who have contact with dialysis and other critically ill patients.

This new edition reflects the explosion of knowledge in basic science and clinical care for athletes with mild traumatic brain injury or concussion. Interest in management and methodology for making diagnoses and improving the clinical outcomes have changed dramatically. All U.S. states have laws dictating how sports concussion patients are cared for and require return to play decisions be coordinated with best practice methods. Epidemiology, classification, and biology of sports concussion, as well as, brain imaging,assessment tests, neuropsychological measures, and management strategies are covered. Illustrative clinical cases, correlative examples, and historical insights are featured.

Research on bone remodeling has resulted in much new information and has led to improvements in design and biomedical practices. Mechanics of Cellular Bone Remodeling: Coupled Thermal, Electrical, and Mechanical Field Effects presents a unified exploration of recent advances, giving readers a sound understanding of bone remodeling and its mathematical representation. Beginning with a description of the basic concept of bone remodeling from a mathematical point of view, the book details the development of each of the techniques and ideas. From there it progresses to the derivation and construction of multifield and cellular bone remodeling and shows how they arise naturally in response to external multifield loads. Topics include: Fundamental concepts and basic formulations for bone remodeling Applications of formulations to multifield internal bone remodeling of inhomogeneous long cylindrical bone Theory and solution of multifield surface bone remodeling A hypothetical regulation mechanism on growth factors for bone modeling and remodeling under multifield loading The RANK-RANKL-OPG pathway and formulation for analyzing the bone remodeling process A model of bone cell population dynamics for cortical bone remodeling under mechanical and pulsed electromagnetic stimulus Recent developments in experiments with bone materials Readers will benefit from the thorough coverage of general principles for each topic, followed by detailed mathematical derivations and worked examples, as well as tables and figures where appropriate. The book not only serves as a reliable reference but is also destined to attract interested readers and researchers to a field that offers fascinating and technologically important challenges.