Digital Human Modeling and Medicine: The Digital Twin explores the body of knowledge and state-of-the-art in Digital Human Modeling (DHM) and its applications in medicine. DHM is the science of representing humans with their physical properties, characteristics and behaviors in computerized, virtual models. These models can be used standalone or integrated with other computerized object design systems to both design or study designs of medical devices or medical device products and their relationship with humans. They serve as fast and cost-efficient computer-based tools for the assessment of human functional systems and human-system interaction. This book provides an industry first introductory and practitioner focused overview of human simulation tools, with detailed chapters describing body functional elements and organs, organ interactions and fields of application. Thus, DHM tools and a specific scientific/practical problem - functional study of the human body - are linked in a coherent framework. Eventually the book shows how DHM interfaces with common physical devices in medical practice, answering to a gap in literature and a common practitioner question. Case studies provide the applied knowledge for practitioners to make informed decisions.

A pathbreaking history of the regulatory foundations of America's twentieth-century aerial preeminence. Today, the federal government possesses unparalleled authority over the atmosphere of the United States. Yet when the Wright Brothers inaugurated the air age on December 17, 1903, the sky was an unregulated frontier. As increasing numbers of aircraft threatened public safety in subsequent decades and World War I accentuated national security concerns about aviation, the need for government intervention became increasingly apparent. But where did authority over the airplane reside within America's federalist system? And what should US policy look like for a device that could readily travel over physical barriers and political borders? In Sovereign Skies, Sean Seyer provides a radically new understanding of the origins of American aviation policy in the first decades of the twentieth century. Drawing on the concept of mental models from cognitive science, regime theory from political science, and extensive archival sources, Seyer situates the development, spread, and institutionalization of a distinct American regulatory idea within its proper international context. He illustrates how a relatively small group of bureaucrats, military officers, industry leaders, and engineers drew upon previous regulatory schemes and international principles in their struggle to define government's relationship to the airplane. In so doing, he challenges the current domestic-centered narrative within the literature and delineates the central role of the airplane in the reinterpretation of federal power under the commerce clause. By placing the origins of aviation policy within a broader transnational context, Sovereign Skies highlights the influence of global regimes on US policy and demonstrates the need for continued engagement in world affairs. Filling a major gap in the historiography of aviation, it will be of interest to readers of aviation, diplomatic, and legal history, as well as regulatory policy and American political development.

Every bit of information that circulates the internet across the globe is a pulse of light, that at some point will need to be converted to an electric signal in order to be processed by the electronic circuitry in our data centers, computers, and cell phones. Photodetectors (PD's) perform this conversion with ultra high speed and efficiency, in addition to being ubiquitously present in many other devices ranging from the mundane TV remote controls, to ultra high resolution instrumentation used in Laser Interferometer Gravitational Wave Observatory (LIGO) that reach the edge of the universe and measure gravitational waves. The second edition of "Photodetectors" fully updates the popular first edition with updated information covering the state-of-the-art in modern photodetectors. The 2nd edition starts with basic metrology of photodetectors and common figures-of-merit to compare various devices. It follows with chapters that discuss single-photon detection with Avalanche Photodiodes; organic photodetectors that can be inkjet printed; and silicon-germanium PDs popular in burgeoning field of Silicon Photonics. Internationally recognized experts contribute chapters on one-dimensional, nanowire, PDs as well as high speed zero-dimensional, quantum dot, versions that increase the spectral span as well as speed and sensitivity of PDs and can be produced on various substrates. Solar-blind PDs that operate in harsh environments such as deep space, or rocket engines, are reviewed and new devices in GaN technology . Novel Plasmonic PDs, as well as devices which employ micro-plasma of confined charge in order to make devices that overcome speed limitation of transfer of electronic charge, are covered in other chapters. Using different, novel technologies, CMOS compatible devices are described in two chapters, and ultra high speed PDs that use low-temperature-grown GaAs (LT-GaAs) to detect fast THz signals are reviewed in another chapter. Photodetectors used in application areas of Silicon-Photonics and Microwave-Photonics are reviewed in final chapters of this book. All chapters are of a review nature, providing a perspective of the field before concentrating on particular advancements. As such, the book should appeal to a wide audience that ranges from those with general interest in the topic, to practitioners, graduate students and experts who are interested in the state-of-the-art in photodetection.

Nanotechnology in Agriculture and Agroecosystems presents the latest research on the role of nanotechnology in agriculture and agroecosystems, offering innovations and many potential benefits in terms of plant growth, food production, crop protection and ecosystem management. Sections introduce new perspectives on the use of nanotechnology in agroecosystems and sustainable agriculture. Subsequent chapters focus on specific areas of innovation, covering a wide range of applications, including plant disease and protection, food processing and packaging, soil quality, precision farming, and groundwater treatment. This is a valuable resource for researchers and advanced students across a range of disciplines, but it is also ideal for industrial scientists, engineers and R&D professionals with an interest in nanotechnology and sustainable technologies for agriculture and agro-industries.

Nano-scale materials have unique electronic, optical, and chemical properties that make them attractive for a new generation of devices. In the second edition of Modeling, Characterization, and Production of Nanomaterials: Electronics, Photonics, and Energy Applications, leading experts review the latest advances in research in the understanding, prediction, and methods of production of current and emerging nanomaterials for key applications. The chapters in the first half of the book cover applications of different modeling techniques, such as Green's function-based multiscale modeling and density functional theory, to simulate nanomaterials and their structures, properties, and devices. The chapters in the second half describe the characterization of nanomaterials using advanced material characterization techniques, such as high-resolution electron microscopy, near-field scanning microwave microscopy, confocal micro-Raman spectroscopy, thermal analysis of nanoparticles, and applications of nanomaterials in areas such as electronics, solar energy, catalysis, and sensing. The second edition includes emerging relevant nanomaterials, applications, and updated modeling and characterization techniques and new understanding of nanomaterials.

Management and Engineering of Critical Infrastructures focuses on two important aspects of CIS, management and engineering. The book provides an ontological foundation for the models and methods needed to design a set of systems, networks and assets that are essential for a society's functioning, and for ensuring the security, safety and economy of a nation. Various examples in agriculture, the water supply, public health, transportation, security services, electricity generation, telecommunication, and financial services can be used to substantiate dangers. Disruptions of CIS can have serious cascading consequences that would stop society from functioning properly and result in loss of life. Malicious software (a.k.a., malware), for example, can disrupt the distribution of electricity across a region, which in turn can lead to the forced shutdown of communication, health and financial sectors. Subsequently, proper engineering and management are important to anticipate possible risks and threats and provide resilient CIS. Although the problem of CIS has been broadly acknowledged and discussed, to date, no unifying theory nor systematic design methods, techniques and tools exist for such CIS.

The Lockheed P-80/F-80 Shooting Star was the first American operational jet fighter. David McLarens new book chronicles the development and early trials of the aircraft during Lockheeds groundbreaking attempts to create a viable jet fighter, in a period when jet propulsion was still an innovative unknown. This period also saw engineers and test pilots like Kelly Johnson and Tony LeVier facing many challenges, incidents and accidents as they attempted to create a new fighter from yet untested aerodynamic theories, and engines that were still under development. Also discussed are the record breaking transcontinental and absoulte speed records set by the Shooting Star. Detailed analysis of the Shooting Stars combat record in Korea shows why the F-80 flew more combat missions than any aircraft in the war theater. Also presented is a summation of all USAF, USAFR, and foreign countries that flew the P-80/F-80. David McLaren is also the author of Lockheed F-94 Starfire(with Marty Isham), and Beware the Thunderbolt!: The 56th Fighter Group in World War II (both titles are available from Schiffer Publishing Ltd.).

Towards 4D Printing presents the current state of three-dimensional (3D) bioprinting and its recent offspring, 4D bioprinting. These are attractive approaches to tissue engineering because they hold the promise of building bulky tissue constructs with incorporated vasculature. Starting with the discussion of 3D and 4D printing of inanimate objects, the book presents several 3D bioprinting techniques and points out the challenges imposed by living cells on the bioprinting process. It argues that, in order to fine-tune the bioprinter, one needs a quantitative analysis of the conditions experienced by cells during printing. Once the printing is over, the construct evolves according to mechanisms known from developmental biology. These are described in the book along with computer simulations that aim to predict the outcome of 3D bioprinting. In addition, the book provides the latest information on the principles and applications of 4D bioprinting, such as for medical devices and assistive technology. The last chapter discusses the perspectives of the field. This book provides an up-to date description of the theoretical tools developed for the optimization of 3D bioprinting, presents the morphogenetic mechanisms responsible for the post-printing evolution of the bioprinted construct and describing computational methods for simulating this evolution, and discusses the leap from 3D to 4D bioprinting in the light of the latest developments in the field. Most importantly, Towards 4D Printing explains the importance of theoretical modeling for the progress of 3D and 4D bioprinting.

Applications of Nanotechnology in Drug Discovery and Delivery, in the Drug Discovery Update series, presents complete coverage of the application of nanotechnology in the discovery of new drugs and efficient target delivery of drugs. The book highlights recent advances of nanotechnology applications in the biomedical sciences, starting with chapters that provide the basics of nanotechnology, nanoparticles and nanocarriers. Part II deals with the application of nanotechnology in drug discovery, with an emphasis on enhanced delivery of pharmaceutical products, with Part III discussing toxicological and safety issues arising from the use of nanomaterials. This book brings together a global team of experts, making it an essential resource for researchers, drug developers, medicinal chemists, toxicologists and analytical chemists.

Microfluidic Biosensors provides a comprehensive overview of the most recent and emerging technologies in the design, fabrication and integration of microfluidics with transducers. The book discusses the design and principle of microfluidic systems and how to use them for lab-on-a-chip applications. The microfluidic fabrication technologies covered in this book provide an up-to-date view, allowing the community to think of new ways to overcome challenges faced in this field. The book's focus is on existing and emerging technologies not currently being analyzed extensively elsewhere, thus providing a unique perspective and much needed content. The editors have crafted this book to be accessible to all levels of academics, from graduate students, researchers and professors working in the fields of biosensors, microfluidics design, analytical chemistry, biomedical devices and biomedical engineering. It will also be useful for industry professionals working for microfluidic device manufacturers, or in the biosensor and biomedical devices industry.

How the Chicago International Livestock Exposition leveraged the eugenics movement to transform animals into machines and industrialize American agriculture. In 1900, the Chicago International Livestock Exposition became the epicenter of agricultural reform that focused on reinventing animals' bodies to fit a modern, industrial design. Chicago meatpackers partnered with land-grant university professors to create the International--a spectacle on the scale of a world's fair--with the intention of setting the standard for animal quality and, in doing so, transformed American agriculture. In Making Machines of Animals, Neal A. Knapp explains the motivations of both the meatpackers and the professors, describing how they deployed the International to redefine animality itself. Both professors and packers hoped to replace so-called scrub livestock with "improved" animals and created a new taxonomy of animal quality based on the burgeoning eugenics movement. The International created novel definitions of animal superiority and codified new norms, resulting in a dramatic shift in animal weight, body size, and market age. These changes transformed the animals from multipurpose to single-purpose products. These standardized animals and their dependence on off-the-farm inputs and exchanges limited farmers' choices regarding husbandry and marketing, ultimately undermining any goals for balanced farming or the maintenance and regeneration of soil fertility. Drawing on land-grant university research and publications, meatpacker records and propaganda, and newspaper and agricultural journal articles, Knapp critiques the supposed market-oriented, efficiency-driven industrial reforms proffered by the International, which were underpinned by irrational, racist ideologies. The livestock reform movement not only resulted in cruel and violent outcomes for animals but also led to twentieth-century crops and animal husbandry that were rife with inefficiencies and agricultural vulnerabilities.

Biosensors for Emerging and Re-Emerging Infectious Diseases provides a review of how cornerstone optical, electronic, nanomaterial and data processing technologies can address detection issues occurring in a pandemic event. This book gives insights into the fundamental physical, chemical and biological mechanisms needed for such a type of detection. The content covers potential biomarkers which can be used for the infectious disease diagnostic, helping readers find the appropriate approach for the diagnosis of infectious diseases. It presents a novel approach to transferring the sensing platform from lab to application in clinics and to point of care detection. The book then moves on to discuss the function and efficiency of the biosensing platform in early diagnosis of infectious diseases compared to the standard methods. The required time, the technician skills and the steps which must be performed are other key factors of the biosensing platform which are well explained.

Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance focuses on recent and emerging trends surrounding nanomaterials and nano-drug delivery approaches to combat antimicrobial resistance. The relationship between nanomaterials and antimicrobial activity needs to be deeply explored to meet the challenges of combating antimicrobial resistance. The content of this book is divided into three main topic areas, including (i) how to overcome the existing traditional approaches to combat antimicrobial resistance, (ii) applying multiple drug delivery mechanisms to target multi-drug resistant microbes, and (iii) how nanomaterials can be used as drug carriers. This is an important reference source for those looking to understand how nanotechnology plays an important role in combatting disease and infection. As antimicrobial resistance threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi, this is a timely resource.