The contributors provide a rich overview of the strengths and limitations of using risk assessment methods in the occupational health arena. This book brings together a distinguished group of experts in occupational health and risk assessment who express diverse views on the usefulness of risk assessment in the protection of worker health. Representatives from regulatory agencies, labor, industry, and academia consider both policy and technical issues, providing a rich overview of the strengths and limitations of using risk assessment methods in the occupational health arena. Both policy and technical issues are explored. Several contributors focus on the policy implications of regulatory agencies' increasing reliance on risk assessment to guide occupational and environmental risk reduction strategies. Others consider specific methodological issues relating to the application of state-of-the-art scientific developments to the evaluation of occupational risks. Chapters are organized to consider specific aspects of the field including current applications of risk assessment methods by federal regulatory agencies; approaches to improving the use of epidemiological data in risk assessment; the use of animal bioassay data to predict occupational risks; potential uses of cutting-edge scientific data on toxicological mechanisms, toxicokinetics, and biomarkers in risk assessment; specific issues including ethics, values, and sociopolitical aspects of the process, and a concluding chapter discussing future directions to the evaluation and regulation of risks to worker health and safety. Given the range of policy and technical issues explored, this collection will be invaluable to professionals as well as academics in the fields of occupational health and environmental risk assessment.

The major theme of this book is analytical approaches to trace metal and speciation analysis in biological specimens. The emphasis is on the reliable determination of a number of toxicologically and environmentally important metals. It is essentially a handbook based on the practical experience of each individual author. The scope ranges from sampling and sample preparation to the application of various modern and well-documented methods, including quality assessment and control and statistical treatment of data. Practical advice on avoiding sample contamination is included.

In the first part, the reader is offered an introduction into the basic principles and methods, starting with sampling, sample storage and sample treatment, with the emphasis on sample decomposition. This is followed by a description of the potential of atomic absorption spectrometry, atomic emission spectrometry, voltammetry, neutron activation analysis, isotope dilution analysis, and the possibilities for metal speciation in biological specimens. Quality control and all approaches to achieve reliable data are treated in chapters about interlaboratory and intralaboratory surveys and reference methods, reference materials and statistics and data evaluation.

The chapters of the second part provide detailed information on the analysis of thirteen trace metals in the most important biological specimens. The following metals are treated in great detail: Aluminium, arsenic, cadmium, chromium, copper, lead, selenium, manganese, nickel, mercury, thallium, vanadium and zinc.

The book will serve as a valuable aid for practical analysis in biomedical laboratories and for researchers involved with trace metal and species analysis in clinical, biochemical and environmental research.

Evaluates the risks to human health and the environment posed by lindane, an isomer of hexachlorocyclohexane used, for more than four decades, as a broad-spectrum insecticide. Although most lindane is used in agriculture for the treatment of seeds and soils, other important applications include the protection of wood and timber, the treatment of veterinary ectoparasites, and the treatment of scabies and body lice in humans.

Evaluates the risks to human health and the environment posed by the mining, refining, industrial use, and recycling of platinum and selected platinum compounds. Because of its exceptional catalytic properties, resistance to chemical corrosion, and high mechanical strength, platinum is widely used in the chemical and petroleum industries, most notably in the production of catalysts, including devices for reducing hazardous gas emissions. The growing use of catalytic converters to reduce pollution from automobile exhausts has caused a sharp increase in the world demand for this metal. Compounds such as cisplatin also have important therapeutic applications.

Evaluates the risks to human health and the environment posed by two partially halogenated chlorofluorocarbons: dichlorofluoromethane (HCFC 21) and chlorodifluoromethane (HCFC 22). These two methane derivatives were selected for evaluation because of their potential use as substitutes for those fully halogenated chlorofluorocarbons that are being phased out as a result of the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer. The evaluation is intended to assist industry in its urgent search for acceptable substitute chemicals, most notably for use as refrigerants, as propellants in aerosols, and as blowing agents for the production of polystyrene. While data on human toxicity are thoroughly reviewed, the greatest challenge is to find the most accurate models for predicting levels of release to the environment and estimating the potential of these chemicals to deplete the ozone layer.

Environmental Metabolomics Applications in Field and Laboratory Studies: From the Exposome to the Metabolome presents an overview of the current state of aquatic environments and problems caused by human pressure and daily life. The presence of contaminants in nature and their effects are evaluated, along with recommendations for preservation. This book not only shows readers how to implement techniques, it also guides them through the process. As metabolomics becomes a more routine technique for environmental studies and future perspectives, a guide for validation and globalization of current approaches is needed.

Evaluates the carcinogenic risk to humans posed by exposure to Wood, Leather and Some Associated Industries.

Evaluates the carcinogenic risk to humans posed by exposure to some Pharmaceutical Drugs.

Evaluates the carcinogenic risk to humans posed by exposure to some Non-Nutritive Sweetening Agents.

This practical guide presents a road map for safety assessment as an integral part of the development of new drugs and therapeutics. * Helps readers solve scientific, technical, and regulatory issues in preclinical safety assessment and early clinical drug development * Explains scientific and philosophical bases for evaluation of specific concerns including local tissue tolerance, target organ toxicity and carcinogenicity, developmental toxicity, immunogenicity, and immunotoxicity * Covers the development of new small and large molecules, generics, 505(b)(2) route NDAs, and biosimilars * Revises material to reflect new drug products (small synthetic, large proteins and cells, and tissues), harmonized global and national regulations, and new technologies for safety evaluation * Adds almost 20% new and thoroughly updates existing content from the last edition

Determination of Toxic Organic Chemicals in Natural Waters, Sediments and Soils: Determination and Analysis reviews the latest techniques for the determination and assessment of both current and emerging organic compounds in a range of important environmental contexts. A wide range of organic compounds in non-saline waters are discussed in the opening chapters, including hydrocarbons, surface active agents and volatile organic compounds. This is followed by multiorganics, pesticides and organometallic compounds in non-saline waters. Organic compounds in aqueous precipitation are then explored before the book goes on to discuss compounds in soils, including extraction techniques, insecticides, herbicides and fungicides, and organometallic compounds. Finally, the concluding chapters focus on compounds in sediments, providing readers with the latest information in the field and supporting them as they address the important issue surrounding organic material throughout ecosystems.

A xenobiotic is a chemical which is found in an organism but which is not normally produced or expected to be present in it. Specifically, drugs such as antibiotics are xenobiotics in humans because the human body does not produce them itself. In this new book, the authors present current research on xenobiotics including the potential effects of toxic agents on immune system function; medical strategies to prevent adverse effects of PAH-like anthropogenic xenobiotics; organophosphorus pesticides as dangerous xenobiotics for aquatic environments and phytoremediation for removal of organic xenobiotics from water.

With the expansion of human settlements and the environmental changes brought on by human activity and pollutants toxicology and risk assessment of mammal species is becoming increasingly of interest to toxicologists involved in environmental research. This book focuses specifically on environmental risk assessment in marsupial and placental mammals. Marsupial ecotoxicology is poorly understood in scientific research and as such environmental risk assessment in marsupials is an area of rapidly growing interest. This book will be an ideal companion to toxicologists and ecologists interested in risk assessment in the environments of mammals. Particularly those with an interest in the impact introduced by human activity. The book will also be of interest to those working in conservation biology, biological invasion, biocontrol and habitat management.

Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.

Heavy Metals in the Environment: Impact, Assessment, and Remediation synthesizes both fundamental concepts of heavy metal pollutants and state-of-the-art techniques and technologies for assessment and remediation. The book discusses the sources, origin and health risk assessment of heavy metals as well as the application of GIS, remote sensing and multivariate techniques in the assessment of heavy metals. The various contamination indices like contamination factor, geoaccumulation index, enrichment factor, and pollution index ecological risk index are also included to provide further context on the state of heavy metals in the environment. Covering a variety of approaches, techniques, and scenarios, this book is a key resource for environmental scientists and policymakers working to address environmental pollutants.

This glossary expands upon the Comprehensive Glossary of Terms Used in Toxicology. Like its predecessor, it addresses the need for harmonized toxicology terminology, and has undergone a full, comprehensive and rigorous review by IUPAC Committees. It serves as the reference glossary for students and researchers studying the chemical and molecular biological bases of toxicology, and for those involved in chemicals legislation, regulation and risk assessment. Toxicology uses terminology from many disciplines that have been revolutionized by recent developments in molecular biology and biochemistry, and this glossary provides a compilation of definitions of molecular entities that impact on toxicology. Extensive Notes are included to provide context for many of the proteins and important genes defined, with disambiguation where entities are referred to by different names in the literature. We hope that this will be helpful to students and professionals alike.

Gasotransmitters are gas molecules produced endogenously in prokaryotic and eukaryotic cells for signalling purposes. This book provides, for the first time, a comprehensive description and systematic look at all gasotransmitters, established or proposed, since their detection in 2002. The content and scope covers the production, metabolism, and signalling roles of gasotransmitters. Conceptual advances, scientific discoveries and newly developed techniques described in this book influence our understanding of fundamental molecular and cellular events in biology and medicine. This book serves as the state-of-the-art book for undergraduate and graduate students as well as post-doctoral fellows in biomedical disciplines and toxicologists studying the toxic mechanisms of gasotransmitters in the environment. It will also be welcomed by researchers in university and research institutes, government agencies, pharmaceutical and medical instrument industry, and clinical practice.

The potential impact of anthropogenic pollutants such as agrochemicals on the environment is of global concern. Increasing use of certain compounds can result in contamination of food, water and atmospheric systems and in order to combat this pollution it is important to be able to accurately monitor the short and long term effects. This two-volume set of books describes the latest non-traditional aquatic and terrestrial species models used as indicators of the toxic effects of environmental pollutants. The set enables understanding of the effects of pollutants in non-target species, and therefore enables analysis of the effects on ecosystems. This book will be of interest to anyone interested in developing new biomarker species with high degrees of ecological relevance. It will serve as a useful resource for regulatory and research toxicologists.

Arsenic is a naturally occurring element and, as such, it is present in the environment and in our food and drink. It can even be involved in supporting life processes. However, due to its toxicity, there is concern about its presence in our diet. This book examines the real risks and impacts of arsenic in our lives. Looking at arsenic and its compounds, this book explores the presence of arsenic in food and water, the need to clarify its toxicity, and current scientific and public misconceptions about arsenic. It also looks at the use of arsenic in medicine, from cancer treatments to alternative therapies such as homeopathy. Following on from "Is Arsenic an Aphrodisiac?: The Sociochemistry of an Element", this book continues the authors work in addressing the issues surrounding arsenic. It is a fascinating read for general readers as it unveils the reality of our exposure to arsenic in our daily lives.

The US Environmental Protection Agency (EPA) Integrated Risk Information System (IRIS) program develops toxicologic assessments of environmental contaminants. IRIS assessments provide hazard identification and dose-response assessment information. The information is then used in conjunction with exposure information to characterize risks to public health and may be used in risk-based decisionmaking, in regulatory actions, and for other risk-management purposes. Since the middle 1990s, EPA has been in the process of updating the IRIS assessment of inorganic arsenic. In response to a congressional mandate for an independent review of the IRIS assessment of inorganic arsenic, EPA requested that the National Research Council convene a committee to conduct a two-phase study. Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic is the report of the first phase of that study. This report evaluates critical scientific issues in assessing cancer and noncancer effects of oral exposure to inorganic arsenic and offers recommendations on how the issues could be addressed in EPA's IRIS assessment.

The tools for detecting false positives, false negatives, and interference in interactions when testing and monitoring therapeutic drug use For physicians monitoring a patient's progress, efficacy of treatment is often linked to a patient's response to medication. Determining whether a patient is taking the prescribed amount, the drug or dosage is effective, or the prescribed medication is interacting with other drugs can be determined through drug testing. Written as a guide for toxicologists, chemists, and health professionals involved in patient care, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring provides an up-to-date introduction to the tests and methodologies used in a toxicology lab as well as the sources of testing error that can lead to false positives, false negatives, and unreliable conclusions of drug abuse or under use. Covering a host of common therapeutic drugs as well as specific types of interference in immunoassays used in drug testing, the book details a number of possible testing scenarios and problems as well as solutions: * False positive results in immunoassays for drugs in abuse testing * Interferences in immunoassays used for monitoring anticonvulsants, tricyclic antidepressants, and digoxin * False positive alcohol tests using breath analyzers and automated analyzers * When a toxicology report is negative in a suspected overdose patient: the world of designer drugs * Effects of drug-herb interactions on therapeutic drug monitoring * Pharmacogenomics and the general principles of genetic analysis * Approaches for eliminating interference/discordant specimen in therapeutic drug monitoring and drugs in abuse testing * What to do in case there is no readily available method for testing Complete with easy-to-read tables and flowcharts, this book helps toxicologists, clinical chemists, clinical pathologists, and forensic pathologists develop accurate, unbiased drug monitoring and toxicology reports. Health care professionals involved in patient care, especially of critically ill patients, will find this guide indispensable in making sure lab tests are reliable enough to provide high-quality care. An indispensable handbook to the entire suite of toxicology lab tests, as well as all the possible sources of testing error, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring offers clear remedies for eliminating and preventing testing error.

Today, we are surrounded by a multitude of different chemicals that are essential components of our everyday life. As a consequence, there are various hazardous substances like dioxins, phthalates and flame-retardants circulating in the environment. These have an impact on ecosystems, wildlife and possibly human health. In recent years, the phenomenon called endocrine disruption has raised considerable concern. This book discusses the scientific basis of this issue using epidemiological and experimental in vitro and in vivo data about chemicals targeting the hormonal systems. It also provides an up-to-date review of international initiatives (including high-throughput screening, use of model organisms and in silico applications) aiming to screen, detect and functionally test these chemicals. The authors are highly experienced academics and acknowledged experts with both multidisciplinary and international expertise. The book provides an up-to-date, in-depth review of the current field of food safety research describing many of the "hot topics" currently debated. Recent media attention concerning, for example, dioxins in meat and bisphenol A in baby bottles has created a growing interest in food safety-related issues from both consumers and authorities. In addition, European legislation REACH, which requires industry to extensively test chemicals, has led to new initiatives within this area. This book presents a comprehensive overview of the recent international initiatives formed to meet the challenges of environmental pollutants in our food.

This book discusses basic principles of pharmacology and toxicology and their application to environmental problems. Topics covered include air pollution, alteration of the earth's atmosphere, water and land pollution, health and environmental effects of ionizing radiation, and the environmental and social impact of rapidly growing population. It concludes with a chapter on environmental regulatory policy.

Das Buch Chemometrics and Cheminformatics in Aquatic Toxicology befasst sich mit den bestehenden und neu auftretenden Problemen der Verschmutzung der aquatischen Umwelt durch verschiedene metallische und organische Schadstoffe, insbesondere Industriechemikalien, Pharmazeutika, Kosmetika, Biozide, Nanomaterialien, Pestizide, Tenside, Farbstoffe und viele weitere. Es werden verschiedene chemometrische und cheminformatische Instrumente fur Laien beschrieben mitsamt ihrer Anwendung auf die Analyse und Modellierung der Toxizitatsdaten von Chemikalien in Bezug auf unterschiedliche aquatische Organismen. Eine Reihe von Datenbanken zur aquatischen Toxizitat sowie chemometrische Softwaretools und Webserver werden vorgestellt und praktische Beispiele fur die Modellentwicklung gegeben, einschliesslich der entsprechenden Abbildungen. Daruber hinaus enthalt das Werk Fallstudien und Literaturberichte, um das Verstandnis des Themas abzurunden. Ausserdem lernen die Leserinnen und Leser Werkzeuge und Protokolle wie maschinelles Lernen, Data Mining sowie Methoden des QSAR-basierten und ligandenbasierten chemischen Designs kennen. Daruber hinaus bietet das Werk: * Eine umfassende Einfuhrung in chemometrische und cheminformatische Instrumente und Techniken, insbesondere maschinelles Lernen und Data Mining * Eine Darstellung von Datenbanken zur aquatischen Toxizitat, chemometrischen Softwaretools und Webservern * Praktische Beispiele und Fallstudien zur Verdeutlichung und Veranschaulichung der im Buch enthaltenen Konzepte * Eine kompakte Erlauterung der chemometrischen und cheminformatischen Instrumente sowie ihrer Anwendung auf die Analyse und Modellierung von Toxizitatsdaten Chemometrics and Cheminformatics in Aquatic Toxicology ist ideal fur Forschende und Studierende der Chemie sowie der Umwelt- und Pharmawissenschaften und sollte auch in den Bibliotheken von Fachleuten in der chemischen Industrie sowie Aufsichtsbehoerden, die sich mit Chemometrie beschaftigen, einen Platz finden.