Handbook of Ecotoxicology, Second Edition focuses on toxic substances and how they effect ecosystems worldwide. It presents methods for quantifying and measuring ecotoxicological effects in the field and in the lab, as well as methods for estimating, predicting, and modeling in ecotoxicology studies.

Completely revised and updated with 18 new chapters, this second edition includes contributions from over 75 international experts. Also, a Technical Review Board reviewed all manuscripts for accuracy and currency.

This authoritative work is the definitive reference for students, researchers, consultants, and other professionals in the environmental sciences, toxicology, chemistry, biology, and ecology - in academia, industry, and government.

Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

Formaldehyde is virtually ubiquitous in the modern environment due to its cost-effective nature, its use in resin formation, and its preservative properties. Though formaldehyde is necessary for many products and processes important to the world's economy, this economic dependence on formaldehyde comes at a cost to public health. Growth and consequent industrialization rely heavily on formaldehyde use. New buildings-residences, public places, and offices-are not only built with timber preserved by formaldehyde, but they are also furnished with wood, wool, and textile products that contain formaldehyde. The general population faces environmental exposure from indoor and outdoor air pollution, food, and even medicine. Scientific inquiry into formaldehyde exposure has grown in response. This book consolidates the new and established body of formaldehyde research in the scholarly community, focusing on exposure, genotoxicity, and adverse health outcomes. Through this resource, we hope to increase awareness of the broad range of health effects posed by formaldehyde exposure, and to encourage interdisciplinary interest, as well as research, into this pervasive compound-especially in the United States and China, where formaldehyde production and usage is high. This book will be useful to researchers of environmental and occupational exposure, students, and government regulators and anyone exposed to formaldehyde in the workplace and/or at home.

Gasotransmitters are gas molecules produced endogenously in prokaryotic and eukaryotic cells for signalling purposes. This book provides, for the first time, a comprehensive description and systematic look at all gasotransmitters, established or proposed, since their detection in 2002. The content and scope covers the production, metabolism, and signalling roles of gasotransmitters. Conceptual advances, scientific discoveries and newly developed techniques described in this book influence our understanding of fundamental molecular and cellular events in biology and medicine. This book serves as the state-of-the-art book for undergraduate and graduate students as well as post-doctoral fellows in biomedical disciplines and toxicologists studying the toxic mechanisms of gasotransmitters in the environment. It will also be welcomed by researchers in university and research institutes, government agencies, pharmaceutical and medical instrument industry, and clinical practice.

Around the World, metal pollution is a major problem. Conventional practices of toxic metal removal can be ineffective and/or expensive, delaying and exacerbating the crisis. Those communities dealing with contamination must be aware of the fundamentals advances of microbe-mediated metal removal practices because these methods can be easily used and require less remedial intervention. This book describes innovations and efficient applications for metal bioremediation for environments polluted by metal contaminates.

A variety of air pollutants are emitted into the atmosphere from human-caused and natural emissions sources throughout the United States and elsewhere. These contaminants impact sensitive natural resources in wilderness, including the national parks. The system of national parks in the United States is among our greatest assets. This book provides a compilation and synthesis of current scientific understanding regarding the causes and effects of these pollutants within national park lands. It describes pollutant emissions, deposition, and exposures; it identifies the critical (tipping point) loads of pollutant deposition at which adverse impacts are manifested.

This is the third volume of the five-volume book series "Engineering Tools for Environmental Risk Management". The book series deals with the following topics: * Environmental deterioration and pollution, management of environmental problems * Environmental toxicology - a tool for managing chemical substances and contaminated environment * Assessment and monitoring tools, risk assessment * Risk reduction measures and technologies * Case studies for demonstration of the application of engineering tools The authors aim to describe interactions and options in risk management by providing a broad scientific overview of the environment, its human uses and the associated local, regional and global environmental problems; interpreting the holistic approach used in solving environmental protection issues; striking a balance between nature's needs and engineering capabilities; understanding interactions between regulation, management and engineering; obtaining information about novel technologies and innovative engineering tools. This third volume provides an overview on the basic principles, concepts, practices and tools of environmental monitoring and contaminated site assessment. The volume focuses on those engineering tools that enable integrated site assessment and decision making and ensure an efficient control of the environment. Some topics supporting sustainable land use and efficient environmental management are listed below: * Efficient management and regulation of contaminated land and the environment; * Early warning and environmental monitoring; * Assessment of contaminated land: the best practices; * Environmental sampling; * Risk characterization and contaminated matrix assessment; * Integrated application of physical, chemical, biological, ecological and (eco) toxicological characterization methods; * Direct toxicity assessment (DTA) and decision making; * Online analyzers, electrodes and biosensors for assessment and monitoring of waters.; * In situ and real-time measurement tools for soil and contaminated sites; * Rapid on-site methods and contaminant and toxicity assessment kits; * Engineering tools from omics technologies, microsensors to heavy machinery; * Dynamic characterization of subsurface soil and groundwater using membrane interface probes, optical and X-ray fl uorescence and ELCAD wastewater characterization; * Geochemical modeling: methods and applications; * Environmental assessment using cyclodextrins. This book series focuses on the state of knowledge about the environment and its conscious and structured application in environmental engineering, management and decision making.

Despite ongoing efforts to prohibit the production, storage and use of chemical warfare agents recent world events highlight the enduring threat to the population from these agents. Research efforts in various countries have resulted in novel insights into chemical warfare toxicology that has enabled the development of new approaches for the diagnosis and treatment of chemical warfare poisoning. This book provides an up-to-date treatise on the diagnosis and verification of exposure, and the pre- and post-exposure treatment of poisoning. Focussing on the most important representative nerve and blistering agents, whilst also covering other potential chemical warfare agents, this book will give the reader a comprehensive overview of the many different aspects of chemical warfare agent toxicology. The text will appeal to toxicologists, biochemists and weapons specialists working in industry and academia, and anyone with an interest in chemical warfare toxicology or exposure.

Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology. The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next one reviews the biological processes and endpoints involved in reproduction and development. The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods. The book takes a cross-disciplinary approach bringing together developmental, reproductive and systems biology, chemistry, toxicology, pharmacology, biostatistics, information sciences, bioinformatics, and computational approaches. This valuable resource provides those in the field with the necessary knowledge to evaluate both classic and recent approaches to characterize toxicity.

Security sensitive microbes (viruses, bacteria, fungi, and parasites) and toxins, which are often referred to as the select agents and toxins, have the capacity to cause serious illness and death in humans, animals, and plants. Throughout history, these microbes and toxins have been exploited in one form or another as biowarfare and bioterror agents that create fear and panic well beyond any actual physical damages they might cause. Manual of Security Sensitive Microbes and Toxins provides comprehensive, state-of-the-art coverage of microbes and toxins of biosecurity concern. The ultimate goal is to increase our awareness of these agents and enhance our preparedness against any future bio-emergencies. The book begins with an introduction containing a brief overview of the historical aspects of security sensitive microbes and toxins. This is followed by a concise summary of the current status in relation to the regulation of security sensitive microbes and toxins and a discussion of future development trends. The book is divided into seven parts: Microbes and Toxins Affecting Humans and Animals: Viruses Microbes and Toxins Affecting Human and Animals: Bacteria Microbes and Toxins Affecting Human and Animals: Fungus and Parasite Microbes and Toxins Affecting Human and Animals: Toxins Microbes Affecting Animals: Viruses Microbes Affecting Animals: Bacteria Microbes Affecting Plants Written by experts in the relevant areas of research, the chapters are authoritative reviews, each one covering a single microbe or toxin with respect to its classification, biology, epidemiology, pathogenesis, identification, diagnosis, treatment, and prevention. The chapters also discuss the limitations of our current knowledge and challenges relating to improved detection and control of the microbe or toxin.

The congress "Arsenic in the Environment" offers an international, multi- and interdisciplinary discussion platform for arsenic research aimed at short-term solutions of problems with considerable social impact, rather than only focusing on cutting edge and breakthrough research in physical, chemical, toxicological, medical and other specific issues on arsenic on a broader environmental realm. The congress "Arsenic in the Environment" was first organized in Mexico City (As 2006 ) followed by As 2008 in Valencia, Spain. The Third International Congress As 2010 was held in Tainan, Taiwan from May 17-21, 2010 entitled: "Arsenic in Geosphere and Human Diseases". The session topics comprised: 1. Geology + hydrogeology of arsenic; 2. Ecological effects: Arsenic in soils, plants and food chain; 3. Marine + terrestrial biota; 4. Health effects on humans: Epidemiology + biomarkers; 5. Toxicological effects; 6. Assessment and remediation; 7. Analytical methods. Hosting this congress in Taiwan was especially relevant, because the endemic Blackfoot Disease, related to the arsenic uptake from drinking water supplied by artesian wells, was discovered here half a century ago. Since then Taiwan has become an important region specializing in arsenic research. This volume presents the extended abstracts of the congress and will give the latest state of the art knowledge based on current research performed by the global scientific community.

Highlighting latest advances in genetics and biochemistry, the completely revised Third Edition reviews the field from basic science, clinical, epidemiological, and regulatory perspectives. Contributions from top opinion leaders in the field bring together developments in molecular embryology and cell biology as they apply to problems in developmental toxicology. It covers testing of pharmaceutical and environmental agents and interpretation of developmental toxicology data, highlighting mathematical and statistical techniques, as well as the effects of toxic exposure on the functional development of various organs. The relationship between maternal and developmental toxicology is examined, in addition to current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the regulatory aspects of testing and risk assessment. Pre- and postconceptional clinical care and genetic factors in clinical developmental toxicology are also discussed. Key topics include: the roles of apoptosis and signal transduction pathways in normal and abnormal development the role of epigenetic changes in development the role of nutrition and individual susceptibility the utility of bioinformatics global and targeted gene expression changes

Traditional toxicology textbooks tend to be doorstops: tomes filled with important but seemingly abstract chemistry and biology. Meanwhile, magazine and journal articles introduce students to timely topics such as EPA and endocrine disruption or the carcinogenic effects of pesticides, but don't provide the fundamentals needed to understand the science of toxicity. Written by a professor of toxicology, Modern Poisons bridges this gap. This accessible book explains basic principles in plain language while illuminating the most important issues in contemporary toxicology. Kolok begins by exploring age-old precepts of the field such as the dose-response relationship and the concept, first introduced by Ambroise Pare in the sixteenth century, that a chemical's particular action depends on its inherent chemical nature. The author goes on to show exactly how chemicals enter the body and elicit their toxic effect, as well as the body's methods of defence. With the fundamentals established, Kolok digs into advances in toxicology, tracing the field's development from World War II to the present clay. The book examines both technical discoveries and their impacts on public policy. Highlights include studies of endocrine-disrupting chemicals in toiletries and prescriptions, the emerging science on prions, and our growing understanding of epigenetics. Readers learn not only how toxic exposure affects people and wildlife, but about the long-term social and environmental consequences of our chemicals. Whether studying toxicology itself, public health, or environmental science, readers will develop a core understanding of, and curiosity about, this fast-changing field.

This book has been developed over many years from several popular courses taught to students at both Birmingham and London universities. It provides an important step in introducing principles and concepts within the field of toxicology. The underlying mechanisms of toxicity are highlighted through examples taken from gases, minerals, plants, fungi, bacteria, marine creatures, industrial chemicals and pharmacological agents.In this second edition, the text has been completely revised and expanded with the addition of six new chapters - carbon monoxide, hydrofluoric acid, lead, mushroom, toxins, paracetamol, paraquat and diquat. Each chapter is self-sufficient, enabling readers to dip into chapters of interest at random without any lack of understanding. The book is informative, with numerous clinical details, and will appeal to those who wish to delve into this fascinating subject.

This book outlines some fields of cell diagnostics applied to allelopathy with several chapters devoted to cellular model systems for allelopathy, new methods of microscopy in cellular diagnostics and methods of analytical biochemistry and biophysics.

Reviews in Food and Nutrition Toxicity, Volume 4 includes the most recent reviews of current issues involved in the toxicity of food and nutrients. With contributors from the fields of medicine, public health, and environmental science, the continuation of this series distills a broad range of research on food safety and food technology.
Volume Four discusses:
The extent to which postnatal metal exposure through breastfeeding can impair an infant's health
Selenium bioavailability and metabolism, effects of selenium exposure, and mechanisms of selenium toxicity
The fate of toxic and nontoxic arsenic compounds in the human body upon ingestion
The biological role of sulfur, sulfur metabolism, deficiencies, and toxicity
The effects on fluoride on teeth, bones, kidneys, arteries, hormones, the brain, and the reproductive system
Food-borne disease outbreaks, microbial quality and risk assessment of food-borne microorganisms in ready to eat foods
Effect of T-2 toxin on DNA and chromosomes, circulatory system, skin, reproductive system, liver and spleen, gastrointestinal tract, brain and neurotransmitters, and more
Investigation of the interference of AFB1 with molecular components of cell cycle checkpoints
Analyzes cycad consumption and its effects on the neurological systems and its manifestations; describes bio-chemical changes and morphological or pathological outcomes through time in detail
Lectins in the human diet, toxicity and biological effects, immunomodulatory effects, modulation of immune function by dietary lectins in disease
This is a valuable resource for anyone involved in the food industry or academics researching food science and food technology.

This book presents refereed and edited papers from the 6th International Symposium on Poisonous Plants, held in Scotland in August 2001. It covers a range of topics from plant biochemistry to toxic effects in animals (particularly grazing farmed animals) and humans. The contents include the evolution of antinutrients and toxins in plants, biomedical applications of toxins in plants, isolation, identification and effects of plant and fungal toxins and the effect of plant toxins on aversion to plants in animal diets.

The Manual of Immunological Methods represents the collaboration of the Canadian Network of Toxicology Centers, a non-profit network of university-based scientists dedicated to research, training, risk assessment, and communication. This manual provides detailed immunological methods that can be utilized by researchers or practitioners who want to enhance the successful application of this science. It emphasizes the need for continuously improving the quality of experiments performed and maintaining consistency in the results obtained.
The Manual of Immunological Methods presents validated assays that are accompanied by a series of tools that will guide readers in performing their own laboratory work in the spirit of the Good Laboratory Practices. It covers specific methodologies including sample collection, preparation of cells, assay conditions, and data evaluation. Discussion of species differences and comparisons of a wide variety of species is an important feature. Both graduate students and practicing researchers in the areas of immunology and immunotoxicology will appreciate the Manual of Immunological Methods as a guide to standard operating procedures in the laboratory.

Covering some of the most important topics in modern toxicology, the Handbook of Human Toxicology is a unique and valuable addition to the current literature. It addresses issues, answers questions, and provides data related to. Within each of these five major sections are several carefully selected topics that reflect the current state of human toxicology. From tissue uptake of mercury to the effects of drugs on immune systems, the text provides much-needed information quickly and easily.

This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.

This book provides an in-depth discussion of various aspects of metal ecotoxicology. State-of-the-art information and techniques in areas ranging from metal behavior in surface waters to bioaccumulation kinetics and toxicokinetics to community effects are presented in a hierarchical arrangement. Specific topics discussed include metals in abiotic components of ecosystems, autecology (effects of metals relative to the individual or a single species), and metals in marine and freshwater systems in the context of synecology (species associated and interacting as a unit). This is an important book that will be useful to researchers, risk assessment consultants, regulatory personnel, and teachers and students.

This up-to-date reference includes the most recent available data and detailed case studies concerning the potential health risks of aflatoxin in the human population. It covers everything from acute toxic effects of aflatoxin in men to original observations concerning occupational health hazards due to aflatoxin exposure via the respiratory tract. This work places special emphasis on the potential etiological role of aflatoxin in Reye's syndrome. The presence of aflatoxins in the biological material indicates that the possible carcinogenic hazard due to aflatoxin ingestion is not limited to certain areas but exists all over the world. This informative book is a must for all researchers involved in environmental pathology, food science, mycology, toxicology, and industrial safety.

Radionuclide distribution and transport in terrestrial and aquatic ecosystems is Volume 5 of a critical review of data (Prepared for the Commission of the European Communities) in 1984.

Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. For the first time, the collective sciences involved in the understanding of this mode of drug delivery are brought together in one publication.
Non-Clinical Vascular Infusion Technology, Volume I: The Science covers the scientific principles behind the delivery systems, from both physical and physiological standpoints. The book addresses body fluid dynamics, describes the scientific processes necessary to understand the various aspects of the physico-chemical issues relating to vascular infusion delivery, and discusses vascular infusion dynamics. It also considers all the essential elements of the preparation of a formulation intended for vascular delivery as well as assessment of compatibility of the formulation with the dosing apparatus. This volume, along with "Volume II: The Techniques," provides a foundation of knowledge on infusion technology and its importance for safe clinical use of substances via this route of delivery.
Features

• Identifies and shares best practices for non-clinical vascular infusion
• Presents modern practices and procedures in line with up-to-date equipment development
• Offers recommendations for in-life assessments in order to monitor the success or problems with the vascular infusion delivery
• Makes comparisons with human data in many areas

The congress "Arsenic in the Environment" offers an international, multi- and interdisciplinary discussion platform for arsenic research aimed at practical solutions of problems with considerable social impact, as well as focusing on cutting edge and breakthrough research in physical, chemical, toxicological, medical and other specific issues on arsenic on a broader environmental realm. The congress "Arsenic in the Environment" was first organized in Mexico City (As 2006) followed by As 2008 in Valencia, Spain and As 2010 in Tainan, Taiwan. The 4th International Congress As 2012 was held in Cairns, Australia from July 22-27, 2012 entitled Understanding the Geological and Medical Interface of Arsenic. The session topics comprised: 1. Geology and hydrogeology of arsenic; 2. Medical and health issues of arsenic; 3. Remediation and policy; 4. Analytical methods for arsenic; and 5. Special topics on "Risk assessment of arsenic from mining", "Geomicrobiology of arsenic", "Geothermal arsenic", "Rice arsenic and health perspectives", "Sustainable mitigation of arsenic: from field trials to policy implications", and "Biogeochemical processes of high arsenic groundwater in inland basins" Hosting this congress in Australia was welcome and valued by the local scientific communities. Australia is a mineral rich country where mining has generated significant economic benefit to its people. Unfortunately historical mining for base metals, gold and arsenic had led to environmental contamination of arsenic. Locally produced arsenical compounds were widely used as pesticides and in timber preservation. It is known that there are several thousands of cattle- and sheep-dip sites contaminated with arsenic in Australia. However, commonly observed symptoms of chronic arsenic poisonings such as those found in endemic-blackfoot areas are seemingly absent from these types of environmental contamination due to good quality of potable water supply. Does this fall in the classic argument of "the dose makes the poison"? This congress theme of "understanding the geological and medical interface of arsenic" will advance our knowledge in minimising the risk posted by this so-called number one prioritised contaminant - arsenic.