Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

Veterinary Toxicology, in recent years, has acquired greater importance than ever before because of increasing and indiscriminate use of farm chemicals and drugs accompanied by rapid degrading impact of environmental pollution on health of animals. The indiscriminate feeding habits of domestic animals especially in developing countries make them more prone to the impact of natural toxicants especially Phytotoxins and Mycotoxins. Toxicology has been recognized as a separate discipline in veterinary sciences both at undergraduate and post graduate levels for the last four decades and a lot of emphasis has been given on its teaching, research and practical utility from clinical point of view. The book has been prepared in a most comprehensive manner with up-to date reference which offers invaluable, clinically oriented guidance on numerous potentially toxic substances. In addition, to covering traditional and non-traditional areas of toxicology it provides a wealth of quick reference charts and tables that put vital information at your finger tips in seconds

What chemicals are poisonous to the heart and why are they toxic?
Find out by reading Principles of Cardiac Toxicology. Certain chemicals can produce toxicity by interacting with elements of the cardiovascular system. This book presents the anatomical, physiological, biochemical, and pathological basis for this interaction and describes the classes of chemicals known to produce cardiovascular toxicity. Characteristics of potential antidotes are also discussed. Clinicians and researchers will discover that this volume is an essential guide to understanding factors that could contribute to cardiovascular health and disease. Cardiologists, emergency room physicians, intensive care nurses, consulting pharmacists, and basic medical scientists will also benefit from this comprehensive work.

With nanotechnology being a relatively new field, the questions regarding safety and ethics are steadily increasing with the development of the research. This book aims to give an overview on the ethics associated with employing nanoscience for products with everyday applications. The risks as well as the regulations are discussed, and an outlook for the future of nanoscience on a manufacturer's scale and for the society is provided. Handbook of Nanoethics is perfect for , academicians and scientist, as well as all other industry professionals and researchers. It is a good introduction for newcomers in the field who do not want to dive deep into the details but are eager to understand the ethical challenges and possible solution related to nanotechnology and ethics.

Pharmacokinetics and Toxicokinetics provides an overview of pharmacokinetics and toxicokinetics in a comprehensible, interrelated, and applied manner. It integrates the principles held in common by both fields through a logical and systematic approach. The book presents mathematical descriptions of physiological processes employed in different approaches to PK/TK modeling. It focuses on emphasizing general principles and concepts, rather than isolated observations. Above all, the book is an effort to blend the pharmaceutical and toxicological aspects of both fields. The systematic compilation of mathematical concepts and methodologies allows readers to decide on relevant concepts and approaches for their research, scientific or regulatory decisions, or for offering advance courses and seminars. This is an invaluable resource for scientists in the pharmaceutical sciences, clinical sciences, and environmental health sciences, as well as those involved in drug discovery and development.

The field of nanomedicine has risen quickly due to the increasing number of designer-made nanomaterials. These nanomaterials have the potential to manage diseases and change the way medicine is currently studied. However, the increased practice of using nanomaterials has shed light on how many concepts of nanomedicine and nanotoxicity have been overlooked. Nanotoxicology: Toxicity Evaluation of Nanomedicine Applications addresses the existing gaps between nanomedicine and nanotoxicity. This book also brings together up-to-date knowledge on advances toward safe-by-design nanomaterials and existing toxicity challenges. This book delivers a comprehensive coverage in the field with fundamental understanding, serving as a platform to convey essential concepts of nanotoxicology and how these concepts can be employed to develop advanced nanomaterials for a range of biomedical applications. This book is an effort to answer some of the thoughtful nanotoxicological complications and their auspicious probable solutions with new approaches and careful toxicity assessment. Key Features: Reveals novel nanoscale approaches, toxicity assessment, and biomedical applications Includes importance of nanotoxicity concepts in developing smart nanomaterials Highlights unique contributions and "A to Z" aspects on the state-of-the-art from global leaders Offers a complete package to learn fundamentals with recommendations on nanomaterials toxicity and safe-by-design nanomedicines Nanotoxicology: Toxicity Evaluation of Nanomedicine Applications illuminates the high potential of many innovative nanomaterials, ultimately demonstrating them to be promising substitutes for available therapies that can be effectively used in fighting a myriad of biomedical complications. Further, this book reports legal, ethical, safety, and regulatory issues associated with nanomaterials, which have often been neglected, if not overlooked in literature and limiting clinical translation at nanoscale level. It will equip readers with cutting-edge knowledge of promising developments in nanomedicine and nanotoxicology, along with potential future prospects.

The living soil is crucial to photosynthesis, biogeochemical cycles, global food production, climate change, biodiversity, and plant and animal health. In the past decade, scientists have made significant advances in soil microbiology research. While the basic principles are now better understood, knowledge has been forthcoming on the best available technologies and methods applied to researching soil microorganisms, their diversity, interactions, biochemistry, survival, gene expression, and their roles in global climate change, plant disease suppression and growth stimulation, and biogeochemical cycles. This knowledge can be applied to better predict the transformation of pollutants in soil and the activities of microbes in the rhizosphere. It will also assist us in fostering crop production in an era with an increasing human population and intensification of agriculture. Following the tradition of its predecessors, Modern Soil Microbiology, Third Edition, is an indispensable source that supports graduate/undergraduate teaching for soil and environmental microbiologists in academia, as well as in government and industrial laboratories. It is a comprehensive collection of chapters on various aspects of soil microbiology, useful for all professionals working with soils. Compiled by internationally renowned educators and research scholars, this textbook contains key tables, figures, and photographs, supported by thousands of references to illustrate the depth of knowledge in soil microbiology. FEATURES Fully updated and expanded to include new key chapters on historical developments, future applications, and soil viruses and proteins Discusses molecular methods applied to soil microbiology, diverse soil microorganisms, and global climate change Emphasizes the role of terrestrial microorganisms and cycles involved in climate change Details the latest molecular methods applied to soil microbiology research User-friendly for students, and containing numerous tables, figures, and illustrations to better understand the current knowledge in soil microbiology

This new volume, Food Safety: Rapid Detection and Effective Prevention of Foodborne Hazards, focuses on the general concepts, mechanisms, and new applications of analytical and molecular biology techniques for detecting, removing, and preventing chemical and biological hazards from food. Edited by a microbiologist and medical officer with over 20 years of laboratory and research experience in bacteriology, molecular biology, infectious disease, and food safety, and who has trained with the U.S. Food and Drug Administration (FDA), the volume provides an abundance of valuable information on food safety and foodborne hazards in our food and drink. Today, food safety is a growing concern not only of food-related professionals and policymakers, but also of the public. Foodborne hazards, including chemical and biological hazards, can cause food intoxication, infectious diseases, cancers, and other health risks. Foodborne diseases are a major public health and economic burden in both the developed and developing countries. In the United States alone, the incidence of foodborne illness is approximately 9.4 million cases with about 56,000 hospitalizations and 1,351 deaths every year. Written in an easy-to-read and user-friend style, each chapter introduces a chemical or biological hazard and addresses: What kinds of disease does the foodborne hazard cause Why is it necessary for us to study it What routes does it take to enter our food and how does it cause us to become sick How do we identify it Chapters then go on to present new technologies employed to detect, isolate, and/or identify the hazard and prevention procedures such as: (ADD BULLETS) How can the current application of new technology be used to detect the foodborne hazards How do we prevent the diseases caused by the foodborne hazards This book will be valuable to professionals and other specialists who work in food preparation, food safety, clinical laboratories, and food manufacturing industry. It will be a resource for food handling trainers as well as to anyone interested in foodborne hazards and their affective detection, reduction, and prevention strategies. This book can also serve as a important reference for more specialized courses in food safety-related courses and training programs.

Wastes: Solutions, Treatments and Opportunities III contains selected papers presented at the 5th edition of the International Conference Wastes: Solutions, Treatments and Opportunities, that took place on 3-6 September 2019, in Costa da Caparica, Portugal. The Wastes conference, which takes place biennially, is a prime forum for sharing innovation, technological development and sustainable solutions for the waste management and recycling sectors around the world, counting with the participation of experts from academia and industry. The papers included in this book cover a wide range of topics, including: Wastes as construction materials; Wastes as fuels; Waste treatment technologies; MSW management; Recycling of wastes and materials recovery; Environmental, economic and social aspects in waste management; Life cycle assessment; Circular economy and wastes refineries; Logistics, policies, regulatory constraints and markets in waste management.

Introduction to Environmental Toxicology is designed as a concise text, introducing students to the fundamentals of this important subject. It covers the origin, characterization and environmental distribution of the major pollutants, and provides an explanation of their implications for human morbidity via the development of cancer, cardiovascular disease, pulmonary dysfunction and neurological conditions. Considering impacts on biodiversity, such as effects from acid rain, heavy metals and selected anthropogenic compounds, this book: - Covers biogenic contaminants, gases and particulates, organic pollutants, petroleum, heavy metals, complex polymers and radiation; - Considers the impact of pollutants across human health, biodiversity, water and food safety; - Includes questions, further reading and case studies to spark discussion in tutorials. Covering all the major biological toxins and pollutants, this book forms a true introduction to the subject for undergraduates studying environmental toxicology and related subjects.

This title presents a detailed overview on the full range of hazard categories and the associated risks of chemicals. It provides a basic introduction into toxicology, ecotoxicology and environmental behavior and enables all who perform precise chemical analysis to handle substances according to their intrinsic properties such as physical-chemical, environmental, ecological and toxicological hazards.

The manufacture of plastic as well as its indiscriminate disposal and destruction by incineration pollutes atmospheric, terrestrial, and aquatic ecosystems. Synthetic plastics do not break down; they accumulate in the environment as macro-, micro-, and nanoplastics. These particulate plastics are a major source of pollutants in soil and marine ecosystems. Particulate Plastics in Terrestrial and Aquatic Environments provides a fundamental understanding of the sources of these plastics and the threats they pose to the environment. The book demonstrates the ecotoxicity of particulate plastics using case studies and offers management practices to mitigate particulate plastic contamination in the environment. Features * Describes physical and chemical properties of particulate plastics in terrestrial and aquatic ecosystems * Presents information on characteristics of particulate plastics as impacted by weathering processes * Provides numerous approaches for managing particulate plastic contamination * Identifies sources of particulate plastics in the environment; distribution and characteristics of particulate plastics; and management strategies of particulate plastics Written by a global team of scientists, this book is for researchers in the fields of environmental safety and waste management or individuals interested in the impact of particulate plastics on environmental health.

Life-cycle assessment is a methodology used to evaluate the environmental impacts of a product, process, or service during its life cycle, and risk assessment is a tool to evaluate potential hazards to human health and the environment introduced by pollutant emissions. The United Nations Sustainable Development Goals call for, among other objectives, responsible consumption and production by decoupling environmental resource use and environmental impacts from economic growth and human well-being. Life-cycle assessment and risk assessment are both analytical system approaches that allow scientists and other decision makers to address these issues and objectives according to the current understanding of environmental mechanisms. This book is the first attempt to illustrate the existing interfaces between life-cycle assessment and risk assessment and to indicate options for further integration of both tools. The second edition: Focuses on sustainability Considers new developments in life-cycle assessment and environmental risk assessment over the last ten years at the international level Introduces broader concepts and discussions on integrative versus the complementary use of life-cycle and risk assessments Extends the scope of integrated life-cycle and risk assessments to critical raw materials Includes more case studies and discusses engineered nanomaterials Featuring contributions from leading experts, Integrated Life-Cycle and Risk Assessment for Industrial Processes and Products is a great reference for graduate students and professionals in environmental management and intends to catalyze communication between life-cycle assessment and risk assessment experts and scientists in academia, industry, and governmental agencies. The practical format of the book-illustrated with flowcharts, examples, exercises, and concrete applications-makes it a useful manual for analyzing situations and making decisions.

Toxic plants and other natural toxicants have a variety of roles in the fields of human health, medical research and the production of safe food and also represent an economic problem in terms of animal health and crop production. Estimates of economic impact on livestock have ranged in the millions of dollars in countries such as Australia and the United States. This book brings together applied and fundamental research from botanists, chemists, biochemists, agricultural scientists, veterinarians and physicians and advice from regulatory bodies. It consists of more than 100 edited papers from the Fifth International Symposium on Poisonous Plants, held in Texas in May 1997. All aspects of poisonous plants, mycotoxicoses and herbal intoxications are covered. Their adverse effects are described, such as fatalities, reduced or failed reproduction, fetotoxicity, spontaneous abortions, deformities, reduced productivity and organ-specific toxicity. Methods of detection, isolation and identification of the chemical compounds responsible are included. The biochemistry of the plant-associated toxins and elucidation of their mechanism of action is investigated, including the protocols for management or eradication, immunization programs, behaviour modification, withholding periods for metabolic detoxification, regulatory advice concerning human usage of natural products and advice concerning toxin-residue in agricultural produce. The development of non-toxic strains of plants for use as fodder is also discussed. This book is essential reading for toxicologists concerned with animal and human health, food industry regulators and plant scientists.

Toxicology is the study of the adverse effects of chemical, physical, or biological agents on people, animals, and the environment. Toxicologists are trained to investigate, interpret, and communicate the nature of those effects. Over the last ten years the subject of toxicology has changed dramatically, moving from a discipline which was once firmly wedded to traditional methods to one which is keen to embrace the innovative techniques emerging from the developing fields of cell culture and molecular biology. There is an acute need for this to be reflected in a paradigm shift which takes advantage of the opportunities offered by modern developments in the life sciences, including new in vitro and in silico approaches, alternative whole organism (non-mammalian) models and the exploitation of omics methods, high throughput screening (HTS) techniques and molecular imaging technologies. This concise, accessible introduction to the field includes the very latest concepts and methodologies. It provides MSc, PhD and final year undergraduate students in pharmacy, biomedical and life sciences, as well as individuals starting out in the cosmetics, consumer products, pharmaceutical and testing industries, with everything they need to know to get to grips with the fast moving field of toxicology and the current approaches used in the risk assessment of drugs and chemicals.

Hazardous agents are an ongoing concern in the modern workplace, with many examples of workers being severely affected by chemicals as a result of both acute and chronic exposure. Occupational Toxicology, 2nd Edition introduces the basics of toxicology that underpin the application of toxicological information to the workplace environment. The book contains chapters on the most important workplace exposures such as metals, pesticides, solvents, plastics, gases, and particulate matter, as well as the organs likely to be affected. The lungs and the skin are given individual consideration as common sites of injury and disease caused by exposure to chemicals. Genotoxicity and cancer are also singled out for particular attention due to ongoing concern about cancer-related effects of chemicals. Important fields interfacing with occupational toxicology - hygiene, epidemiology, and occupational medicine - are also covered to assist the reader in understanding the necessity of cross-discipline considerations in dealing with workplace exposures. This practical approach makes this book particularly valuable to students of toxicology as well as to occupational health and safety professionals at all levels.

Security sensitive microbes (viruses, bacteria, fungi, and parasites) and toxins, which are often referred to as the select agents and toxins, have the capacity to cause serious illness and death in humans, animals, and plants. Throughout history, these microbes and toxins have been exploited in one form or another as biowarfare and bioterror agents that create fear and panic well beyond any actual physical damages they might cause. Manual of Security Sensitive Microbes and Toxins provides comprehensive, state-of-the-art coverage of microbes and toxins of biosecurity concern. The ultimate goal is to increase our awareness of these agents and enhance our preparedness against any future bio-emergencies. The book begins with an introduction containing a brief overview of the historical aspects of security sensitive microbes and toxins. This is followed by a concise summary of the current status in relation to the regulation of security sensitive microbes and toxins and a discussion of future development trends. The book is divided into seven parts: Microbes and Toxins Affecting Humans and Animals: Viruses Microbes and Toxins Affecting Human and Animals: Bacteria Microbes and Toxins Affecting Human and Animals: Fungus and Parasite Microbes and Toxins Affecting Human and Animals: Toxins Microbes Affecting Animals: Viruses Microbes Affecting Animals: Bacteria Microbes Affecting Plants Written by experts in the relevant areas of research, the chapters are authoritative reviews, each one covering a single microbe or toxin with respect to its classification, biology, epidemiology, pathogenesis, identification, diagnosis, treatment, and prevention. The chapters also discuss the limitations of our current knowledge and challenges relating to improved detection and control of the microbe or toxin.

"Reviews a wide range of methods for soil physical analysis. Considers applications, accuracy, measurement time, and cost of equipment. Provides examples of applications."

Brainstorming Questions in Toxicology is designed to serve as a comprehensive, quick reference supplement for various examinations that include sections on toxicology. It reflects the breadth and multidisciplinary nature of toxicology with an objective approach to the subject. With 3500 short questions and answers, multiple choice questions, true/false or correct/incorrect statements, fill in the blanks, and matching the statements, this book is a helpful tool for students, teachers and toxicologists preparing for licensure and certification exams. It is also a resource or refresher for toxicologists working in pharmacy, medical, clinical and forensic toxicology, veterinary, and other related fields such as environment and eco-toxicology. Key Features: Serves as a refresher for academicians and professionals in the field of toxicology Provides an essential guide for the student who needs a study aid for toxicology and the teacher of toxicology who needs inspiration when composing questions for their students Supplements in-house training courses in toxicology that exist in some pharmaceutical and chemical industries

Managing sites contaminated with munitions constituents is an international challenge. Although the choice of approach and the use of Ecological Risk Assessment (ERA) tools may vary from country to country, the assurance of quality and the direction of ecotoxicological research are universally recognized as shared concerns. Drawing on a multidisciplinary team of contributors, Ecotoxicology of Explosives provides comprehenisve and critical reviews available to date on fate, transport, and effects of explosives. The book delineates the state of the science of the ecotoxicology of explosives, past, present, and recently developed. It reviews the accessible fate and ecotoxicological data for energetic materials (EMs) and the methods for their development. The chapters characterize the fate of explosives in the environment, then provide information on their ecological effects in key environmental media, including aquatic, sedimentary, and terrestrial habitats. The book also discusses approaches for assembling these lines of evidence for risk assessment purposes. The chapter authors have critically examined the peer-reviewed literature to identify and prioritize the knowledge gaps and to recommend future areas of research. The editors include a review of the genotoxic effects of the EMs and the cellular and molecular mechanisms underlying the toxicity of these chemicals. They also discuss the transport, transformation, and degradation pathways of these chemicals in the environment that underlie the potential hazardous impact and bioaccumulation of EMs in different terrestrial and aquatic ecologiocal receptors. This information translates into practical applications for the environmental risk assessment of EM-contaminated sites and into recommendations for the sustainable use of defense installations.

Since the dawn of the industrial age, we have unleashed a bewildering number of potentially harmful chemicals. But out of this vast array, how do we identify the actual threats? What does it take to prove that a certain chemical causes cancer? How do we translate academic knowledge of the toxic effects of particular substances into understanding real-world health consequences? The science that answers these questions is toxicology. In The Alchemy of Disease, John Whysner offers an accessible and compelling history of toxicology and its key findings. He details the experiments and discoveries that revealed the causal connections between chemical exposures and diseases. Balancing clear accounts of groundbreaking science with human drama and public-policy relevance, Whysner describes key moments in the development of toxicology and their thorny social and political implications. The book features discussions of toxicological problems past and present, including DDT, cigarettes and other carcinogens, lead poisoning, fossil fuels, chemical warfare, pharmaceuticals-including opioids-and the efficacy of animal testing. Offering valuable insight into the science and politics of crucial public-health concerns, The Alchemy of Disease shows that toxicology's task-pinpointing the chemical cause of an illness-is as compelling as any detective story.

Since the second edition of this text was published, many new environmental incidents have occurred, including another nuclear disaster, a mine disaster in the United States, and the Gulf of Mexico oil spill. Updated throughout the text, Ecosystems and Human Health: Toxicology and Environmental Hazards, Third Edition explores the broad range of environmental and human health aspects of chemical and biological hazards-from natural toxins and disasters to man-made pollutants and environmental crises. The book begins with the basic principles of pharmacology and toxicology, risk analysis, and air, water, and soil pollution. It then examines various toxicants and hazards, such as airborne hazards, halogenated hydrocarbons, metals, and organic solvents. Chapters also discuss food additives and contaminants, pesticides, hormone disrupters, radiation hazards, and natural environmental hazards such as venomous and toxic animals. The text reviews the Chernobyl nuclear crisis and the Walkerton drinking water tragedy, as well as other disasters, assessing some of their long-term effects, now that sufficient time has elapsed since their occurrence. With updates in every chapter, this third edition contains significant expansion of information on the genetics of chemical carcinogenesis, global warming, food additives, invasive species in the Great Lakes, nuclear accidents, and more. The book describes how chemical toxins and biological hazards can impact the environment and the people who live in it. The author presents numerous examples of the relationship between ecosystem health and human health. He emphasizes the need to consider the environmental impact of human activities and includes many real-world examples and new case studies.

Among the vast array of methods available for biochemical analysis, chromatography occupies a venerable station. Few analytical methods have had such vital impact on the development of clinical chemistry and toxicology. In this book, the editors have assembled a cross-section of contemporary applications of chromatographic methods used in clinical chemistry and toxicology. The opening chapter focuses on QA and QC, emphasizing the importance of validating analytical methods that are used for clinical and forensic purposes Chapters 2 to 6 discuss applications of chromatographic methods in the detection of anabolic steroids in urine; the detection and measurement of popular nutritional supplements; measurement of L-dopa and L-tyrosine as markers of malignant melanoma; capillary zone electrophoresis combined with LC and MS to measure proteins in plasma; use of HPLC to detect abnormally glycosolated transferrin; and the measurement of catecholamines, which are specific markers of neuroendocrine tumors. Chapters 7 to 11 focus on toxicology applications, including a description of the analysis of alcohols and inhalants; LC methods for measuring organophosphate pesticides, and the detection and identification of neurotoxins used as biochemical weapons; and a GC/MS method for measuring g-hydroxybutyrate and analogues. The final two chapters present chromatographic methods adapted to the analysis of heavy metals in biological specimens: LC and ICP to measure arsenic, mercury, selenium, and platinum in a variety of biological matrices; and measurement of heavy metals by generating volatile chelates that are separated by GC and detected by MS.

The twelve applications described in this bookillustrate the versatility of chromatographic methods, and the range of applications to clinical chemistry and toxicology available with this powerful analytical technique. The book provides an overview of useful methods, while emphasizing the contributions that chromatography continues to make in clinical laboratory medicine.

Named after Selene, Greek goddess of the moon, selenium (Se) has moved has moved from being thought of as a toxicant to being considered an essential nutrient with the potential to reduce cancer risk in the span of seven decades. Diversity of Selenium Functions in Health and Disease focuses on current knowledge of aspects of Se research relevant to its medical use, and particularly to chemoprevention of cancer. It covers how Se is integrated into selenoproteins, selenium compounds with individual functions and dual functions, and unexpected links to Se such as with diabetes. The text ends with a discussion of polymorphisms and mutations in genes of selenoproteins. The chapters elucidate why studies undertaken to prevent diseases with selenium ended with disappointing outcomes and often with the opposite result, i.e. disease promotion. They show that benefit, failure, or side effects depend on: The chemical form and dose of selenium The selenium status of the individual ingesting selenium The capacity of selenium form to serve as a source for selenoprotein biosynthesis The function of selenoproteins reacting to a change in the selenium status The stage of the disease (mainly cancer) at the time point of intervention The genetic background of individuals to be treated Bringing together the accumulated evidence regarding selenium biochemistry, the book covers aspects not found in available general monographs. The narrow focus on medical uses of Se helps resolve the present confusion about potential benefits and hazards of selenium in human health. The book gives you a solid scientific basis for optimum use of selenium in preventing or treating human diseases and answering the questions: Why is selenium essential? How much is required? What are the health consequences of low selenium and can selenium reduce cancer risk?