This practical resource provides toxicolgists and scientists with essential information on the regulations that govern the context and the content of their jobs and products. The book also covers the scientific and historical underpinnings of those regulations. Each chapter provides a grounding in the historical events that led to the development of original legislation and major subsequent changes in legislation. The major administrative divisions for regulatory agencies and their main missions and responsibilities are also detailed, as are the basic filing units or documents the agencies require of individuals to meet goals.

eBook available with sample pages: 0203165594

REAL-LIFE CASES, TUTORIAL QUESTIONS, NARRATIVE HISTORY

Intriguing anecdotal pedagogy, like the alleged arsenical poisonings of Napoleon and President Taylor and the probable mercury overdose of Isaac Newton, is one of the things that set Toxicology: A Case-Oriented Approach apart from other toxicology texts. Based on an undergraduate-graduate combined toxicology course at West Chester University, this innovative text captures readers' interest by combining modern case studies, historical cases, and hundreds of illustrations and tables. Each chapter presents several case scenarios that involve the reader with questions about diagnosis, testing methods, treatment, and other pertinent information.

TOXICOLOGY FOR THE LABORATORY AND THE EMERGENCY ROOM

In an easy-to-read style, this book covers the major organ systems and reviews the effects of toxins in each system. Most contemporary books are almost entirely clinical or entirely analytical. Toxicology: A Case-Oriented Approach treats each area extensively to benefit students and professionals who need to know aspects of both. It describes diagnosis and treatment of each specific poisonous exposure and discusses chemical basis and the laboratory testing of toxins. This dual perspective, coupled with the book's interesting narrative approach, lets readers quickly absorb the information they need to understand toxicology in the laboratory and in the Emergency Department.

Addressing the numerous gaps in current information, Target Organ Toxicology in Marine and Freshwater Teleosts is an essential resource for researchers and professionals in aquatic toxicology and environmental risk assessment.
All the chapters are written by researchers who are internationally recognised for their work in mechanistic aspects of aquatic toxicology. Each chapter focuses on a specific target organ or physiological system and describes how various agents disrupt the normal physiological system and processes. This volume provides coverage of toxic effects in the central nervous, immune, neurobehavioural and reproductive systems as well as describing general mechanisms of toxicity. The companion volume, Organs, is devoted to specific organs with coverage of the gill, kidney, skin, liver and gut.

eBook available with sample pages: 0203361415

Addressing the numerous gaps in current information, Target Organ Toxicology in Marine and Freshwater Teleosts is an essential resource for researchers and professionals in aquatic toxicology and environmental risk assessment.
All the chapters are written by researchers who are internationally recognised for their work in mechanistic aspects of aquatic toxicology. Each chapter focuses on a specific target organ or physiological system and describes how various agents disrupt the normal physiological system and processes. This volume is devoted to specific organs with coverage of the gill, kidney, skin, liver and gut. The companion volume, Systems, provides coverage of toxic effects in the central nervous, immune, neurobehavioural and reproductive systems as well as describing general mechanisms of toxicity.

eBook available with sample pages: 0203361407

Contents:
1. Introduction. 2. Determination of Metals in Soils. 3. Determination of Metals in Non-Saline Sediments. 4. Determination of Metals in Marine Sediments. 5. Determination of Metals in Estuarine Sediments. 6. Determination of Metals in Sludges. 7. Determination of Anions in Soil. 8. Determination of Anions in Non-Saline Sediments. 9. Determination of Anions in Sludges 10. Sampling Procedures. 11. Accumulation Processes in Sediments. 12. Disposal of Wastes to Land. 13. Relationship between Metal Content of Soil and Crops Grown on Soil. Index.

Endocrine and Hormonal Toxicology Edited by Philip W. Harvey, Kevin C. Rush and Andrew Cockburn AgrEvo UK Ltd, Saffron Walden, UK This is the first book to consider the integrated role of the classical endocrine system and hormones (including those from tissues outside the classical endocrine system) in toxicological responses. Although focusing on the latest knowledge on endocrine glands as target organs and the mechanistic and molecular basis for toxicity in these organs, Endocrine and Hormonal Toxicology has been written to cover toxicological responses at the whole body level mediated by endocrine or hormonal mechanisms. This whole body, multi--organ approach significantly broadens the relevance of this volume to toxicologists. Following an introductory section on the types of endocrine toxicity including primary, secondary and indirect mechanisms, the next section deals with endocrine organs as toxicological targets. International contributions focus on the pituitary, thyroid and parathyroids, adrenals, testes, ovaries and the pancreas, and comparative endocrine carcinogenesis. A third section of the book develops the whole body approach, in which chapters are devoted to hormonal mechanisms of toxicity to the immune, nervous, cardiovascular, gastrointestinal and reproductive systems, as well as to the liver, kidney and skin. The final section covers human and environmental health perspectives discussing endocrine disrupting chemicals, hormonal mechanisms in breast cancer and current regulatory trends in endocrine and hormonal toxicology. The comprehensive nature of Endocrine and Hormonal Toxicology makes it accessible to both specialist and general toxicologists, and to those within the fields of endocrinology, pharmacology and pathology.

Public interest in the health impacts of carbon monoxide (CO) has been increasing rapidly during the past decade. And rightly so: it is the most ubiquitous environmental poison. Car exhaust fumes, furnaces, gas-powered engines, home water heaters, smoke from all types of fire, and tobacco smoke all contribute to carbon monoxide intoxication - the leading cause of poisoning death in the United States. Even when it doesn't cause death, it often produces lasting, deleterious effects on the central nervous system.

From one of the world's top CO experts, Carbon Monoxide Toxicity examines the latest basic science and clinical research from around the world. It addresses the gamut of health-related CO issues, from the history of CO studies to the hidden threat of chronic low-level exposure. The broad themes center on clinical management of various forms of CO poisoning and education of the public on the constant dangers of CO.

Thanks to the success of CO environmental health regulations in the U.S., society is much more aware of the threat of CO poisoning. Increasing numbers of people use CO detectors in public buildings, homes, pleasure boats, and aircraft. Carbon Monoxide Toxicity meets the need for current research on the clinical management of CO poisoning.


Visit the author's Web site at www.coheadquarters.com

Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. With contributions from an international selection of authors who are leaders in commercial infusion technology, Non-Clinical Vascular Infusion Technology, Volume II: The Techniques provides a current account of the techniques involved in all the major laboratory animal species for conducting successful vascular infusion studies with xenobiotics. Following in the footsteps of the highly praised Handbook of Pre-Clinical Continuous Intravenous Infusion, this new volume covers both up-to-date procedures and equipment. It is organized by species, including all those commonly used in pre-clinical studies: rat, mouse, dog, minipig, large primate, and marmoset. There are also chapters on juvenile studies and reproductive toxicity studies. Each section addresses the selection of the best model, surgical and non-surgical best practices, practical techniques, equipment selection, and commonly encountered background pathologies. Using a fresh approach, the authors identify best practices to be shared across the industry, and provide guidance on choices for the most acceptable methodologies from an animal welfare perspective. This volume, along with Volume I: The Science, provides a foundation of knowledge on infusion technology and its importance for safe clinical use of substances via this route of delivery. Features: Emphasizes best practices in accordance with the 3Rs-reduction, refinement, and replacement of animal usage in laboratories Presents step-by-step procedures and practical tips covering a wide range of common animal models, augmented by the liberal use of illustrations Covers modern practices and procedures in accordance with up-to-date equipment development

The environment in which human beings live is complex and we may encounter many different potentially toxic chemical substances during the course of our lives. These xenobiotic agents may invade the living system in the form of environmental pollutants, in the diet, as pharmaceutically administered compounds or even as chemical weapons and it is becoming widely recognised that free radicals are often involved in this toxicity.
The book covers all aspects of toxic agents in the environment from their detection to their effects. Final year undergraduates and postgraduates studying toxicology, biochemistry, cell biology or environmental science will find this book valuable reading, whilst researchers in academia, the pharmaceutical industry, and public health laboratories will appreciate it as a comprehensive reference.

Highlighting latest advances in genetics and biochemistry, the completely revised Third Edition reviews the field from basic science, clinical, epidemiological, and regulatory perspectives. Contributions from top opinion leaders in the field bring together developments in molecular embryology and cell biology as they apply to problems in developmental toxicology. It covers testing of pharmaceutical and environmental agents and interpretation of developmental toxicology data, highlighting mathematical and statistical techniques, as well as the effects of toxic exposure on the functional development of various organs. The relationship between maternal and developmental toxicology is examined, in addition to current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the regulatory aspects of testing and risk assessment. Pre- and postconceptional clinical care and genetic factors in clinical developmental toxicology are also discussed. Key topics include: the roles of apoptosis and signal transduction pathways in normal and abnormal development the role of epigenetic changes in development the role of nutrition and individual susceptibility the utility of bioinformatics global and targeted gene expression changes

This work contributes to a better understanding of the growing subnational involvement in foreign affairs. It offers a general view of the most prominent aspects in the development of subnational foreign action around the world, dealing with topics such as the repercussions upon subnational autonomy of the progressive constitution of diverse international regimes like the European Union, NAFTA, and APEC, or the complex relation between the growing subnational foreign action and the contemporary conditions for the formulation and implementation of foreign policy in federal and quasifederal states.

This work contributes to a better understanding of the growing subnational involvement in foreign affairs. It offers a general view of the most prominent aspects in the development of subnational foreign action around the world, dealing with topics such as the repercussions upon subnational autonomy of the progressive constitution of diverse international regimes like the European Union, NAFTA, and APEC, or the complex relation between the growing subnational foreign action and the contemporary conditions for the formulation and implementation of foreign policy in federal and quasifederal states.

The third edition of the Toxicologist's Pocket Handbook, like the first two editions, is a scaled-down version of the best-selling Handbook of Toxicology. It provides the most frequently used toxicology reference information in a convenient pocket-sized book. The format remains the same as the earlier editions to allow basic reference information to be located quickly, with the information placed in sections specific to subspecialties of toxicology. A detailed table of contents lists all tables and figures contained in the book by section. This expanded edition contains a number of tables not found in the second edition added to sections on lab animals, general toxicology, dermal and ocular toxicology, genetic toxicology/carcinogenesis, neurotoxicology, immunotoxicology, reproductive/developmental toxicology, industrial chemical, and pharmaceutical toxicology. New information is presented for additional laboratory animals such as swine and primates, infusion recommendations, newer methods such as the local lymph node assay, and reference safety pharmacology values for standard species. Additional information on typical genetic toxicology and immunotoxicology assays as well as in vitro assays for eye irritation are provided. Some tables from the second edition have been updated to include new information that has arisen since the earlier edition went to press. Information from the second edition, such as regulatory requirements that are no longer applicable, has been deleted.

Up to 200 million people in 70 countries are at risk from drinking water contaminated with arsenic, which is a major cause of chronic debilitating illnesses and fatal cancers. Until recently little was known about the mobility of arsenic, and how redox transformations determined its movement into or out of water supplies. Although human activities contribute to the release of arsenic from minerals, it is now clear that bacteria are responsible for most of the redox transformation of arsenic in the environment. Bacterial oxidation of arsenite (to the less mobile arsenate) has been known since 1918, but it was not until 2000 that a bacterium was shown to gain energy from this process. Since then a wide range of arsenite-oxidizing bacteria have been isolated, including aerobes and anaerobes; heterotrophs and autotrophs; thermophiles, mesophiles and psychrophiles. This book reviews recent advances in the study of such bacteria. After a section on background-geology and health issues-the main body of the book concerns the cellular machinery of arsenite oxidation. It concludes by examining possible applications. Topics treated are: The geology and cycling of arsenic Arsenic and disease Arsenite oxidation: physiology, enzymes, genes, and gene regulation. Community genomics and functioning, and the evolution of arsenite oxidation Microbial arsenite oxidation in bioremediation Biosensors for arsenic in drinking water and industrial effluents

This first volume in the series provides a detailed treatment in ecotoxicology and stresses why genetics is important in understanding if and how chemical contaminants affect populations. Written by an array of international contributors from various fields covering mammals, invertebrates, fish, plants, as well as molecular ecotoxicology, this book considers both ecological/evolutionary consequences and practical implications of the interplay between chemical toxicants and the genetic population.
In broadening the understanding of ecological response, this resource ranges from molecular to classical genetics, from plant to animal, from asexual to sexual, touching on some fundamental issues of evolutionary biology. In addition, gaps in our present understanding of genetic and ecotoxicological processes and future research directions have been identified.

This text provides a concise and comprehensive introduction to key immunotoxicological issues for all those interested in, but with no prior knowledge of, this area of toxicology. The first section explores the health consequences of immunotoxicity, namely the adverse effects related to chemically-induced immunosuppression and immunostimulation, hypersensitivity reactions and autoimmune diseases, with an overview of major immunotixicants. The second part describes the latest methods used to detect and evaluate, preclinically and clinically, the unexpected immunotoxic effects of xenobiotics. Trends in implementing strategies and recent changes to the regulatory aspects are also considered. The third section examines possible future developments, including "in vitro" methods, biomarkers of immunotixicity and risk assessment.

This book is about poison and poisonings; it explores the facts, fears and fictions that surround this fascinating topic. Poisons attract attention because they are both dangerous and hard to discover. Secretive and invisible, they are a challenging object of representation. How do science studies, literature, and especially film-the medium of the visible-explain and show what is hidden? How can we deal with uncertainties emerging from the ambivalence of dangerous substances? These considerations lead the editors of this volume to the notion of "precarious identities" as a key discursive marker of poisons and related substances. This book is unique in facilitating a multi-faceted conversation between disciplines. It draws on examples from historical cases of poisoning; figurations of uncertainty and blurred boundaries in literature; and cinematic examples, from early cinema and arthouse to documentary and blockbuster. The contributions work with concepts from gender studies, new materialism, post-colonialism, deconstructivism, motif studies, and discourse analysis.

This text provides a concise and comprehensive introduction to key immunotoxicological issues for all those interested in, but with no prior knowledge of, this area of toxicology. The first section explores the health consequences of immunotoxicity, namely the adverse effects related to chemically-induced immunosuppression and immunostimulation, hypersensitivity reactions and autoimmune diseases, with an overview of Major Immunotoxicants. The Second Part Describes The Latest Methods Used to detect and evaluate, preclinically and clinically, the unexpected Immunotoxic Effects Of Xenobiotics. Trends In Implementing Strategies And recent changes to the regulatory aspects are also considered. The third section examines possible future developments, including In Vitro Methods, Biomarkers Of Immunotixicity And Risk Assessment.

eBook available with sample pages: 0203362551

Exposure to Contaminants in Drinking Water: Estimating Uptake through the Skin and by Inhalation examines the current state of science in this field by identifying and reviewing the available information resources; evaluating various models and approaches; and demonstrating the feasibility of developing estimates of the distribution of absorbed doses of contaminants in drinking water through contact with the skin and by inhalation. This book, the product of a fifteen-member expert working group convened by the Risk Science Institute of the International Life Sciences Institute under a cooperative agreement with the U.S. Environmental Protection Agency's Office of Water, includes contributions from experts in exposure modeling and measurement; water chemistry; time-activity patterns; dermal and respiratory uptake; and the use of probability distributions in characterizing exposures.

and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive and developmental effects, effects on the nervous system and lungs, and cancer. Their reports convey both the current state of scientific understanding of response variability and the genetic basis for such observations. This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community and others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed and illustrated with published data. This authoritative work indicates that, in the case of certain chemicals and in the context of certain specific toxic effects, we have considerable ability to predictively and quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity and quality of information available on response variability and increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.

Piperonyl Butoxide contains 20 chapters contributed by world experts in the field on the properties, uses, plant metabolism, and mammalian and environmental toxicology of piperonyl butoxide. The mode of action of piperonyl butoxide is discussed as well as many other specialist topics, including the measurement of synergism in the laboratory, and the potential use of this chemical alone for the control of whiteflies, as well as with insect growth regulators.
This book will prove to be a valuable reference for all concerned with the designing of safe and cost-effective insecticide formulations, particularly those used in the home, industry, or on or near animals and food.

This timely resource offers extensive discussions on the pharmacological, environmental, endocrinological, and natural factors that alter reproductive or developmental processes-elucidating the effects of toxicants on mechanisms of reproduction. Describing biological actions common to both genders as well as gender-specific processes, Reproductive and Developmental Toxicology -provides an overview of the basic biology and physiology of organ systems affected by toxicants -furnishes detailed examples of developmental toxicology -analyzes germ cell toxicity and infertility -covers the developmental effects of neurotoxicity -considers periods of exposure and long-term toxicological consequences -explains how gonadal processes may be susceptible to toxicants in other reproductive organ systems -and more! With over 3700 bibliographic citations and more than 100 photographs, drawings, and tables, Reproductive and Developmental Toxicology is a useful reference for toxicologists; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; obstetricians/gynecologists; pediatricians; pharmacists and pharmacologists; physiologists; geneticists; poison control specialists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

Environmental toxicology is the study of the action of chemicals upon ecosystems. Understanding the effects of exogenous chemicals upon the inhabitants of an ecosystem may enable us to predict and possibly prevent their deleterious effects. This textbook provides a good general introduction to all the major areas of environmental toxicology, including the fate of chemicals in the environment, environmental toxicity testing, risk assessment, radioactivity in the environment, legislation, environmental monitoring and the future impact of industrial development on the environment. It is written in an informal, accessible style with many examples of environmental issues taken from the author's personal experience and will provide students and other interested individuals with a broad overview of the science of environmental toxicology.

Our world is widely contaminated with damaging chemicals, and companies create thousands of new, potentially dangerous chemicals each year. Due to the difficulty and expense of obtaining accurate measurements and the unreliability of reported values, we know surprisingly little about the properties of these contaminants. Determining the properties of chemicals is critical to judging their impact on environmental quality and in making decisions about emission rates, clean-up, and other important public health issues. Chemical Property Estimation describes modern methods of estimating chemical properties, methods which cost much less than traditional laboratory techniques and are sufficiently accurate for most environmental applications. Estimation methods are used to screen chemicals for testing, design monitoring and analysis methods, design clean-up procedures, and verify experimental measurements. The book discusses key methods for estimating chemical properties and considers their relative strengths and weaknesses. Several chapters are devoted to the partitioning of chemicals between air, water, soil, and biota; and properties such as solubility, vapor pressure, and chemical transport. Each chapter begins with a review of relevant theory and background information explaining the applications and limitations of each method. Sample calculations and practical advice on how and when to use each method are included as well. Each method is evaluated for accuracy and reliability. Computer software, databases, and internet resources are evaluated, as well as other supplementary material, such as fundamental constants, units of measure, and more.

Bioassays are among the ecotoxicologist's most effective weapons in the evaluation of water quality and the assessment of ecological impacts of effluents, chemicals, discharges, and emissions on the aquatic environment. Information on these assessment aids is needed throughout the international scientific and environmental management community. This comprehensive reference provides an excellent overview of the small-scale aquatic bioassay techniques and applications currently in use around the world.
This special volume is the result of several years of collaboration between Environment Canada and Fisheries and Oceans Canada. Internationally recognized research scientists at many institutions have contributed to this state-of-the-art examination of the exciting, environmentally important field of microscale testing in aquatic toxicology.
Microscale Testing in Aquatic Toxicology contains over forty chapters covering relevant principles, new techniques and recent advancements, and applications in scientific research, environmental management, academia, and the private sector.