Divided into five parts, Microbial Food Contamination, Second Edition looks at emerging foodborne human pathogens andcomprehensively evaluates the microbiology, biochemistry, detection, risk, and threat of foodborne illness in today's global market. The first section introduces new insights into the pathogenic effect of E. coli, viral diseases, and protozoan parasites, as well as prions and other zoonotic diseases. It discusses mycotoxins and aflatoxins, particularly the carcinogenicity of aflatoxin B1 and the chemoprevention of liver cancer. Detection, Monitoring, and Control Presenting recent advances in the detection and monitoring of foodborne pathogens, section two reviews rapid electrochemical biosensors, new methods to detect prion diseases, and the use of polymerized chain reaction (PCR) for detection, identification, and typing of microorganisms. Section three examines control and prevention measures including Kosher and Halal food laws, and the use of naturally occurring antimicrobials, irradiation, and other physical control strategies. It also considers the genetic and biochemical control of aflatoxigenic fungi. International Regulation and Trade Globalization reduces traditional geographic borders that once prohibited pathogens from spreading and increases the risk of transnational outbreaks. The impact of this trend on international trade is evaluated in section four with a look at the implications of mad cow disease on the beef trade. It also provides an overview of programs to mitigate contamination such as the Codex Alimentarius and the International Food Safety Authorities Network. Bioterrorism Addressing the most frightening aspect of microbial contamination, section five explores bioterrorism and the different chemical, radiological, and biological agents that could be employed to deliberately contaminate food. Contributors take a critical look at present food protection strategie

Given the essential role that primary producers play in aquatic ecosystems, it is imperative that the potential risk of pesticides to the structure and functioning of aquatic plants is adequately assessed. An integration of regulatory and research information from key specialists in the area of environmental regulation, Aquatic Macrophyte Risk Assessment for Pesticides provides a state-of-the-art guide to ecotoxicological risk assessment. Written by well-known experts in the field of aquatic risk assessment, this book is a practical reference for the assessment of the risk of pesticides with herbicidal activity to aquatic macrophytes. The book supplies a concise, coherent, and science-based view from influential regulators, academics, and industry scientists. They address the selection of additional species, critical regulatory endpoints, and assessing the risk of plant protection products to aquatic macrophytes. They also present a clear description of key issues in macrophyte risk assessment, information on macrophyte test methods, suitable measurement endpoints, and data evaluation and interpretation. Filled with recommendations distilled from existing regulatory experiences of aquatic macrophyte risk assessment, the book includes case studies to identify issues, data gaps, and inadequacies in study design. It also identifies improvements to risk assessment that could be implemented immediately and those for which further research is needed. An authoritative resource, the book points the way to an improved approach to aquatic macrophyte risk assessment.

Currently serving as a resource for the National Center for Toxological Research in their work with the Gulf Coast oil spill, this book presents current research conducted primarily by the airforce on the toxic effects of JP-8 jet fuel on the pulmonary, immune, dermal, and nervous systems. In all, the book considers 13 toxicology studies of significance, the results of which are currently shaping US armed services policy. It will enable all of the hydrocarbon industry to make better choices regarding fuel handling. Due to its widespread use, jet fuel is thought to be the largest toxicant exposure risk for U.S. Armed Services personnel. Taking a proactive approach to the potential dangers of repeated human exposure to hydrocarbon fuels, the Air Force Office of Scientific Research (AFOSR) sponsored a number of research projects during the last 20 years investigating health effects resulting from specific exposure to JP-8 (Jet Propellant-8). Jet Fuel Toxicology summarizes the newest and most important results of these extensive research programs carried out by hydrocarbon fuel research groups throughout the U.S. Each book chapter highlights one specific research area from the many topical areas comprising jet fuel toxicology. After examining the contents and general action of JP-8, the book looks at how the fuel affects various body functions highlighted by: Effects on daily inhalation on the respiratory system Acute and long-term neurotoxicological and neurobehavioral effects Both local and systemic toxicity following exposure through the skin Immunotoxicity from pulmonary and dermal exposures Genetic damage, as evidenced in studies of the blood and bone marrow of mice In all, the book considers 13 major toxicology areas of study, the results of which will enable all of the hydrocarbon industry to make

Tolerance, the ability of populations to cope with the chemical stress resulting from toxic contaminants, has been described in many organisms from bacteria to fungi, from phytoplankton to terrestrial flowering plants, and from invertebrates such as worms to vertebrates like fish and amphibians. The building of tolerance, be it by physiological acclimation or genetic adaptation, can have great consequences for the local biodiversity, and hence the ecology and ecosystem functioning of many of the world's habitats. Understanding the frequency of the occurrence of tolerance has tremendous implications for the sustainability of biodiversity and ecosystem functioning. Tolerance to Environmental Contaminants takes a multidisciplinary approach across contaminant types, habitats, organisms, biological levels of organization and scientific disciplines. The book examines the general principles governing the acquisition and biological consequences of tolerance, genetically or physiologically based, at different levels of biological organization, taxonomically from bacteria and archaea to flowering plants and vertebrates, and within organisms from molecular biology and biochemistry through physiology to whole organism, community, and ecosystem levels of organization. Presenting a state-of-the-art synthesis of the many aspects of the phenomenon of tolerance to environmental contaminants, this volume covers mechanisms of defense involved in the acquisition of tolerance, different classes of environmental contaminants, positive and negative ecological consequences of tolerance and the impact of tolerance in bacteria, plants, and insects on society. The reviews presented in this book supply the tools for carrying out more informed and therefore more reliable risk-benefit analyses when assessing the ecotoxicological risks to life in any of the contaminated habitats that now surround us in our industrialized society.

The activities of modern society have unleashed a range of toxic chemicals into the global environment. Many of these toxicants are now being detected in increasing quantities in the tissues of marine mammals, most notably in top predators who acquire relatively large amounts of toxic chemicals by ingesting contaminated prey. Toxicology of Marine Mammals focuses on the effects of natural and introduced toxicants on organs and systems in marine mammals. It provides overviews on health status and contamination, with subsequent chapters devoted to whales, pinnipeds, dolphins, polar bears, manatees, and sea otters. Internationally renowned researchers assess the mounting evidence for adverse effects on reproduction and the chemically-induced increased susceptibility to death from infectious diseases. The concluding chapter addresses perspectives and issues for the future. This compelling book features research from a vast geographic landscape ranging from the tropics to the Arctic, with case studies on intriguing areas of contamination such as the St. Lawrence River and the Baltic Sea. It identifies the severe threats that environmental contaminants pose to the health and future of marine mammals. It also makes an urgent call for legislation to regulate the incessant pollution ravaging our seas and devastating the marine mammal population worldwide. Toxicologists working in marine biology and veterinary medicine, conservation scientists, fisheries scientists, environmental scientists, and wildlife managers will all benefit from this comprehensive resource.

With growing interest in the safety of foods, knowledge of food toxicology is gaining more importance every day. Introduction to Toxicology and Food provides a concise overview of both the science of toxicology and food toxicology. It presents easy-to-understand explanations of the concepts and principles of toxicology as a science, the toxicants found in foods, and naturally occurring antitoxic/anticarcinogenic substances in foods. It examines the uses, harmful effects, and safety aspects of a variety of toxicants, including natural toxicants, contaminants, and food additives. The book begins with a general overview of the concepts and principles of toxicology. It describes its history and branches, toxic doses, stages of toxication, effect mechanisms of toxins, and toxicity tests. Then it covers the substances in our foods that have toxicological significance, such as natural sources of toxicants, contaminants, and food additives. Finally, the book presents information about "chemopreventers" - those foods and food components that have antimutagenic or anticarcinogenic effects. With its easy-to-read style and its clear discussions of the science of toxicology, food toxicology, and chemopreventers, Introduction to Toxicology and Food is an ideal text for an undergraduate course in food toxicology and a useful guide for food scientists.

This book outlines the strategies used in the investigation, characterization, management, and restoration and remediation for various contaminated sites. It draws on real-world examples from across the globe to illustrate remediation techniques and discusses their applicability. It provides guidance for the successful corrective action assessment and response programs for any type of contaminated land problem, and at any location. The systematic protocols presented will aid environmental professionals in managing contaminated land and associated problems more efficiently. This new edition adds twelve new chapters, and is fully updated and expanded throughout.

Environmental issues such as ozone layer depletion, overpopulation, biodiversity loss, global warming, natural resource depletion, and so on affect every organism on the planet somehow. Environmental biotechnology applications can help to protect and restore the quality of the environment. The goal is to use biotechnology with other technologies and safety procedures to prevent, arrest, and reverse environmental degradation. Environmental biotechnology is one of the most rapidly expanding and practically useful scientific fields. Biochemistry, physiology and genetic research of microorganisms can be converted into commercially available technologies for reversing and preventing further deterioration of the earth's environment. Solid, liquid, and gaseous wastes can be altered either by recycling new by-products or by purifying to make the end product less harmful to the environment. Biotechnology for Toxic Remediation and Environmental Sustainability discusses the removal of pollutants by absorption techniques and recycling wastewater into valuable by-products and biofuels by microorganisms. Moreover, this book also addresses corrosion prevention by green inhibitors, uses electrochemical systems for renewable energy and waste recycling using microbes, and recent food safety and security trends in the food microbiome. On the other hand, this book also discusses therapy and treatments against antibiotic-resistant bacteria, anti-cancer and pharmacological properties of thymoquinone and preventive properties of zinc nanoparticles against stress-mediated apoptosis in epithelial cells. Features Covers all aspects of Biotechnological application in the environment Discusses sustainable technology for the wastewater treatment and value-added products from wastewater Focuses on research activities Green corrosion inhibitors, bio-electrochemical systems, food safety and security, and antimicrobial resistance The book is a valuable resource for the undergrad and graduate students, doctoral and post-doctoral scholars, industrial personnel, academicians, scientists, researchers, and policymakers involved in understanding and implementing applications of biotechnology for environmental toxic remediation.

This volume describes the structure and function of bacterial toxins and presents a comprehensive review of virulence factors, providing recent information concerning cell physiology and biochemistry, as well as new toxin tools for experimental studies and clinical therapy. A wide variety of toxic proteins, including the toxins that cause diptheria, cholera, pertussis, shigellosis, tetanus, botulism and anthrax, are discussed.;The work is aimed at microbiologists, biochemists, endocrinologists, toxicologists, infectious disease specialists, pathologists, public health officials, and upper-level undergraduate and graduate students in these disciplines.

Comprehensive coverage of the field of toxicology which illustrates its importance to and impact on society; Uses pertinent examples, tables and diagrams to aid understanding with learning objectives, and summaries, questions and answers for each chapter; Clearly and concisely written and presented concepts for easy comprehension by toxicology, biomedical, and health science students; Examines the complex interactions associated with toxicological events; Covers effect of toxins on biological and physiological systems;

This book, the second of three volumes, concentrates on peripheral nervous system disorders. Examining the effects of neurotoxicants on nerve, muscle and the neuromuscular junction, it builds on the scientific principles outlined in volume 1 by looking at the application of the methods discussed, particularly in terms of the evaluation and diagnosis of individual patients and the related process of establishing causation. Neurobehavorial Toxicology, Volume 2 will be of interest to practicing neurologists and neuropsychologists, as well as to occupational medicine physicians and medical toxicologists.

Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.

The field of electromagnetic sensitivity is the new epidemic of the 21st century, and can cause disease of the automatic nerve system in any part of the body. This is as a result of chemical sensitivity, in which over 80,000 chemicals are involved, resulting in innumerable combinations. A cursory understanding of the combinations can help clinicians partially understand the associated problems and thus help in the diagnosis and treatment of electromagnetic sensitivities. But a basic understanding of environmentally induced illness and healing must first be understood by the clinicians before diseases occur such as cardiac arrhythmia, muscle spasms, and nerve pain. Key Features: Describes how an understanding of the vast combinations of electrical and chemical sensitivities will help in the diagnosis and treatment of electromagnetic sensitivities Reveals the complexity and multi-faceted presentation often seen in chemical sensitivity and chronic degenerative disease cases Provides information backed up by rigorous scientific data including hundreds of tables and figures as online resources Features a Dedication to Robert Becker, MD, an orthopedic surgeon who was one of the first clinicians to recognize the significance of EMF in medicine and surgery, and also to his assistant Andrew Marino, PhD, who helped develop the basic science of orthopedic electromagnet healing

This practical book provides toxicologists with essential information on the regulations that govern their jobs and products. Regulatory Toxicology, Third Edition is an up-to-date guide to required safety assessment for the entire range of man-made marketed products. Individual chapters written by experts with extensive experience in the field address requirements not only for human pharmaceuticals and medical devices (for which there are available guidances), but for the full range of man-made products. New in this edition are three chapters addressing Safety Data Sheet Preparation, Regulatory Requirements for GMOs, and Regulatory Requirements for Tobacco and Marijuana. The major administrative divisions for regulatory agencies and their main responsibilities are also detailed, as are the basic filing documents the agencies require. Coverage includes food additives, dietary supplements, cosmetics, over-the-counter drugs, personal care and consumer products, agriculture and GMO products, industrial chemicals, air and drinking water regulations and the special cases of California's Proposition 65, requirements for safety data sheets, and oversight regulations. Both US and international requirements are clearly presented and referenced. In one volume, those who have regulatory responsibility in companies, lawyers, educators, and those selling these materials in the marketplace can learn about regulatory requirements and how to meet them.

Forensic professionals, particularly medical examiners-often working through heavy caseloads-require quick and easy access to reliable sources of information to help interpret toxicology results. While several in-depth resources are available, they are often large, cumbersome, and contain more information than is often needed. The Handbook of Forensic Toxicology for Medical Examiners is a concise handbook referencing the most common toxic substances and their reported non-toxic, toxic, and lethal concentrations, making it an ideal text for quick reference in the lab or autopsy room. Features of the Second Edition: Explains the principles of postmortem toxicology and the factors which must be considered Provides tables of toxicologic data for over 200 commonly encountered substances, including drugs of abuse, poisons, prescription drugs, and over-the-counter medications Includes discussion and description of the novel psychoactive drugs-including synthetic opioids, cannabinoids, stimulants and hallucinogens Supplemental appendices provide additional information regarding specimen types and selection, testing methodologies, normal laboratory values, and conversion charts The busy forensic professional needs a concise handbook that provides critical information quickly and accurately. This heavily referenced text offers an easy-to-use format allowing for rapid access for both routine daily use and preparation for courtroom testimony.

The field of electromagnetic sensitivity is the new epidemic of the 21st century, and can cause disease of the automatic nerve system in any part of the body. This is as a result of chemical sensitivity, in which over 80,000 chemicals are involved, resulting in innumerable combinations. A cursory understanding of the combinations can help clinicians partially understand the associated problems and thus help in the diagnosis and treatment of electromagnetic sensitivities. But a basic understanding of environmentally induced illness and healing must first be understood by the clinicians before diseases occur such as cardiac arrhythmia, muscle spasms, and nerve pain.

As the application of nanotechnology in the myriad disciplines of science and engineering--from agriculture, pharmaceuticals, material science, and biotechnology to sensors, electronics, and mechanical and electrical engineering--brings benefits it also can produce serious threats to human health and the environment that must be evaluated. The unique properties of nanomaterials make them different from their bulk counterparts. In addition to such unique properties, the nanometric size of nanomaterials can invite some detrimental effects on the health and well-being of living organisms and the environment. Thus, it is important to distinguish nanomaterials with such ill effects from nanomaterials with no or minimum toxicity. Nanotoxicology: Toxicity Evaluation, Risk Assessment and Management covers issues such as the basic principles of nanotoxicity, methods used for nanotoxicity evaluation, risk assessment and its management for nanomaterial toxicity with a focus on current trends, limitations, challenges, and future directions of nanotoxicity evaluation. Various experts from different countries discuss these issues in detail in this book. This will be helpful to researchers, educators, and students who are interested in research opportunities for avoiding the environmental and health hazards of nanomaterials. This book will also be useful for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, drugs, and other regulatory sciences.

Increased awareness surrounding environmental protection has prompted the development of more ecofriendly technologies. This book provides useful information on technologies based upon the use of biological agents for environmental clean-up, including bacteria, yeast, fungi, algae, and plants. Some chapters refer to the direct application of products derived from plants and microorganisms for designing strategies of environmental remediation. The combination of strategies helps in efficient removal of pollutants generated from anthropogenic activities with minimal environmental impact. This book is meant for professionals involved in environmental technology and waste management.

The most talked about metalloid in the modern world, arsenic affects the liver, kidney, and lungs; leads to cardiovascular diseases, cancer, and diabetes; and may cause blindness with long-time exposure. With naturally occurring arsenic boosted by mining and other industrial processes contaminating soil and drinking water, arsenic toxicity is a major challenge to health professionals and scientists around the world. Arsenic Toxicity: Prevention and Treatment reviews current understanding of arsenic poisoning and the health consequences resulting from exposure. The book paints a vivid picture of the sources of arsenic toxicity including ground water; food such as rice, fruits and vegetables, fish, and chicken as well as occupational exposures from industries using inorganic arsenic such as glass production, non-ferrous alloy, wood preservation, and semiconductor manufacturing units. The text details the health hazards of arsenic toxicity and then examines removal, mainly from soil and water, highlighting eco-friendly bioremediation techniques. It discusses classical and modern treatment methods for arsenic toxicity, emphasizing the use of nutraceuticals and functional foods. With its focus on the remediation of arsenic toxicity using nutraceutical and functional food, the book provides a unique resource for combatting this global scourge. It provides strategies for defending arsenic toxicity naturally without causing any additional adverse effects.

During the recent decades, social, political and academic endeavours have been made to improve environmental quality and reduce pollution. In particular, the ocean, sea and coastal areas show varying degrees of impact from the multiple human activities carried out in the terrestrial as well as in the aquatic environment. Ecology is a science which studies the relationship between organisms and the surrounding environment and in the modern era, the marine world is getting increasing attention. For centuries it has been the final reservoir of human garbage; later it became an oil farm with a concomitant increase of coastal population growth and unplanned growth of the fishing industry and the increasing use of sea routes for cargo transport and recreational uses (cruises). All this led to rising contamination with negative effects on biota and even human health. It is then imperative to know the current situation of the world's oceans: that is the main purpose of this book, to document at a glance the latest research in the field of ocean pollution.

This book critically examines the available literature on oceanic acidification: including a historical review of pH and atmospheric CO2 levels over the millennia; natural and anthropogenic sources of CO2 to the atmosphere and sea surface; chemical, physical, and biological mode of action; biological effects of acidification to marine plants and animals under laboratory conditions; field observations on seawater chemistry and effects of declining pH; and various technical and political mitigation strategies. Written by Dr. Ronald Eisler, a noted authority on chemical risk assessment, the book summarizes real and projected effects of oceanic acidification.

Green pesticides, also called ecological pesticides, are pesticides derived from organic sources which are considered environmentally friendly and are causing less harm to human and animal health and to habitats and the ecosystem. Essential oils based insecticides started have amazing features. This book gives a full spectrum of the whole range of essential oil based pesticides that may be used in pest control. It discusses the uses and limitations, including the recent advances in this area. It describes the metabolism and mode of action, and provides the present status of essential oil based pesticide residues in foodstuffs, soil and water.

How does mercury get out of the ground and into our food? Is tuna safe to eat? What was the Minamata Disaster? Mercury Pollution: A Transdisciplinary Treatment addresses these questions and more. The editors weave interdisciplinary threads into a tapestry that presents a more complete picture of the effects of mercury pollution and provides new ways to think about the environment. The remarkable features that make mercury so useful-and poisonous-have given rise to many stories laid out in rich objective detail, carefully detailing medical, epidemiological, or historical insight, but sidestepping the human experience. A technically rich book that only touches on the human consequences of mercury poisoning cannot fully portray the anguish, confusion, and painful deaths that are the consequence of mercury pollution. Therefore, the editors purposely step out of the conventional scientific framework for discussing mercury pollution to explore the wider human experience. This book clarifies how we are all connected to mercury, how we absorb it through the food we eat and the air we breathe, and how we release it as a consequence of our new technologies. It tackles interesting environmental issues without being overly technical and uses mercury as a case study and model for studying environmental problems. The book uses discussions of the issues surrounding mercury pollution to illustrate how an interdisciplinary vantage is necessary to solve environmental problems. Read an article in the SETAC Globe by Michael C. Newman and Sharon L. Zuber at http://www.setac.org/globe/2011/november/mercury-pollution.html

Catastrophic events such as the Bhopal, India tragedy and rising incidences of cancer in areas neighboring industrial facilities have heightened concern over the use of toxic chemicals in manufacturing and industry, particularly with respect to long-term exposure. While legislation and publicity have reduced the use of some chemicals, risks remain that continue to threaten the health of individuals worldwide. Based on the authors' research conducted through their development of a program in Sao Paulo, Brazil, Toxic Chemicals: Risk Prevention Through Use Reduction examines various toxicity factors and proposes a plan to reduce the toxic impact of these hazardous substances. Explores all factors that contribute to toxicity The book begins by exploring the history of toxic chemical release reporting programs, a trend growing out of the Bhopal tragedy. It surveys their impact both in the United States through the Toxics Release Inventory (TRI) program and in the 29 other countries that maintain similar programs. Then, with the goal of developing a rational method of prioritizing toxic chemicals for reduction, the authors discuss mobility, persistence, and bioconcentration adjustment factors and present a method for integrating all of these factors to estimate the relative impact of chemical release. Compares alternate emphases in existing programs The book describes programs that concentrate on reducing the release of chemicals with the greatest adverse toxic impact and those that require companies to prepare pollution prevention plans and set goals for reducing use or release. It also examines technical assistance programs that help companies search for alternative chemicals to use or process changes that eliminate the use of toxic chemicals. In addition, it explores alternative market-based approaches for achieving environmental protection. Presents a workable plan for the future In the final chapters, the authors lay out their proposed program for reducing the use of toxic chemicals. This plan builds on the existing TRI program and uses lessons learned from this and other programs. The combined research assembled by the authors and their multifaceted approach to the issue of chemical toxicity enables companies and policy makers to move to the next level of toxic chemical use reduction, resulting in a safer environment for future generations.

The first edition of Asbestos: Risk Assessment, Epidemiology, and Health Effects received critical acclaim due to the interdisciplinary nature of its content. Editors Ronald Dodson and Samuel Hammar have carefully kept this popular focus while updating and expanding the topics covered in the first edition with the help of internationally known experts. While there are hundreds of books available on many different aspects of asbestos, none contain the encyclopedic, comprehensive coverage you will find here. See What's New in the Second Edition: Definitions of asbestos by different methodologies and the potential impact that those forms have on health Internationally accepted sampling/analytical schemes Findings of major asbestos-related diseases that continue to increase in most industrialized countries where asbestos is widely used Information on asbestos-induced diseases in biological systems Expanded regulations chapter Copiously illustrated with diagrams, tables, and photographs, including some in color, the book remains an interdisciplinary resource on the major issues in asbestos exposure and human health, with coverage that spans history, pathology, and epidemiology as well as sampling, analysis, and regulatory issues. The editors' expertise and careful updating set this book apart, making it a comprehensive resource that interlinks diverse specialties. They provide an updated and expanded state-of-the-art discussion of important interdisciplinary factors associated with asbestos-related issues in an easy-to-use reference.