Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

Information Resources in Toxicology, Third Edition is a sourcebook for anyone who needs to know where to find toxicology information. It provides an up-to-date selective guide to a large variety of sources--books, journals, organizations, audiovisuals, internet and electronic sources, and more. For the Third Edition, the editors have selected, organized, and updated the most relevant information available. New information on grants and other funding opportunities, physical hazards, patent literature, and technical reports have also been added.
This comprehensive, time-saving tool is ideal for toxicologists, pharmacologists, drug companies, testing labs, libraries, poison control centers, physicians, legal and regulatory professionals, and chemists.
Key Features
* Serves as an all-in-one resource for toxicology information
* New edition includes information on publishers, grants and other funding opportunities, physical hazards, patent literature, and technical reports
* Updated to include the latest internet and electronic sources, e-mail addresses, etc.
* Provides valuable data about the new fields that have emerged within toxicological research; namely, the biochemical, cellular, molecular, and genetic aspects

Fiber Crop-Based Phytoremediation: Socio-economic and Environmental Sustainability provides an informative source of information on using fiber crops for phytoremediation. Phytoremediation is gaining attention globally due to ever-increasing numbers and areas of industrially polluted sites. The major challenge is to develop new and cost-effective solutions to decontaminate polluted sites. In this regard, plant-based remediation, especially using fiber crops, is a promising and cost-effective approach for environmental remediation on a large-scale due to its socio-economic and ecological sustainability. Furthermore, changing environmental conditions also cause various biotic and abiotic stresses in fiber crops and thereby negatively affect the fiber crop establishment, growth and yield. This book will be specifically important to these readers who need to be able to select specific fiber crop species according to site-specificity of the contaminated site.

This book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial applications. However, our understanding of nanomaterial-mediated toxicity under in vivo condition remains limited. The book begins with a chapter on synthesis and characterization of nanoparticles used for various biological, medical and commercial purposes. The rest of the chapters deal with the impact of nanoparticles on different biological aspects like behavior, physiology and metabolic homoeostasis using Drosophila as a model organism. Lastly, the book summarizes how proper characterization and evaluation of safe dosage of nanoparticles can be a boon if incorporated in consumer goods and for biomedical applications. Overall, the book pursues an interdisciplinary approach by connecting nanotechnology and biology from various angles using Drosophila as a model system, so as to develop more efficient, safe and effective use of nanoparticles for human beings.

Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

Forensic professionals, particularly medical examiners-often working through heavy caseloads-require quick and easy access to reliable sources of information to help interpret toxicology results. While several in-depth resources are available, they are often large, cumbersome, and contain more information than is often needed. The Handbook of Forensic Toxicology for Medical Examiners is a concise handbook referencing the most common toxic substances and their reported non-toxic, toxic, and lethal concentrations, making it an ideal text for quick reference in the lab or autopsy room. Features of the Second Edition: Explains the principles of postmortem toxicology and the factors which must be considered Provides tables of toxicologic data for over 200 commonly encountered substances, including drugs of abuse, poisons, prescription drugs, and over-the-counter medications Includes discussion and description of the novel psychoactive drugs-including synthetic opioids, cannabinoids, stimulants and hallucinogens Supplemental appendices provide additional information regarding specimen types and selection, testing methodologies, normal laboratory values, and conversion charts The busy forensic professional needs a concise handbook that provides critical information quickly and accurately. This heavily referenced text offers an easy-to-use format allowing for rapid access for both routine daily use and preparation for courtroom testimony.

Environmental Chemistry is a relatively young science. Interest in this subject, however, is growing very rapidly and, although no agreement has been reached as yet about the exact content and limits of this interdisciplinary discipline, there appears to be increasing interest in seeing environmental topics which are based on chemistry embodied in this subject. One of the first objectives of Environ mental Chemistry must be the study of the environment and of natural chemical processes which occur in the environment. A major purpose of this series on Environmental Chemistry, therefore, is to present a reasonably uniform view of various aspects of the chemistry of the environment and chemical reactions occurring in the environment. The industrial activities of man have given a new dimension to Environ mental Chemistry. We have now synthesized and described over five million chemical compounds and chemical industry produces about hundred and fifty million tons of synthetic chemicals annually. We ship billions of tons of oil per year and through mining operations and other geophysical modifications, large quantities of inorganic and organic materials are released from their natural deposits. Cities and metropolitan areas of up to 15 million inhabitants produce large quantities of waste in relatively small and confined areas. Much of the chemical products and waste products of modern society are released into the environment either during production, storage, transport, use or ultimate disposal. These released materials participate in natural cycles and reactions and frequently lead to interference and disturbance of natural systems."

Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk. Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions. The 13 organ system chapters provide the specifics related to pathologic characteristics, differential diagnosis, and interpretation of toxic responses in each organ system. These chapters are specifically important for the bench pathologist but also for the toxicologist who interacts with pathologists and function as study toxicologists and project team representatives in the drug development arena.

Following the original initiative of the International Organisation for Biological Control some 15 years ago, research groups and agrochemical companies have been investigating the effects of pesticides on beneficial organisms, devising laboratory and field test methods and lately developing protocols for regulatory testing requirements in Europe. This work, and the application of agreed protocols for testing, is of crucial importance to the environmentally acceptable use of pesticides and to the further development of Integrated Pest Management systems, and the objective of this book is to review the origins and progress of the research - what has been accomplished, what is the current position and what still needs to be done.

Toxicity Assessment Alternatives: Methods, Issues, Opportunities contains a broad array of critical surveys, contributed by active and respected investigators, describing their research and offering updates on toxicity assessment alternatives, directions determined by current and future grant programs, opportunities for mechanistically based test methods to detect endocrine disruptor activity, the use of alternatives in the Department of Defense hazard assessment initiatives, and the issues and opportunities for validation and regulatory acceptance. Several of these advances make use oftransgenic models that reduce the time and cost of carcinogenicity testing. Others use tissue cultures for the assessment of endocrine disrupting chemicals. Cultures of human epidermal keratinocytes are applicable as models for sulfur mustard lesions, and in vitro protein denaturation is used as a chemical test for assessing the ocular and dermal irritation potential of cosmetic prod ucts. Molecular modeling is applied to explaining chemical toxicity. Commercially developed assay systems have undergone extensive evaluation by their manufacturers. Some of these await external valida tion, and others await acceptance by North American and European regulatory agencies. Toxicity Assessment Alternatives: Methods, Issues, Opportunities provides information from members of the scientific and regulatory communities on what has been achieved and what has been accepted in alternatives to animal testing."

The field of endocrine disruption or endocrine active compounds (EACs), which is just emerging and still controversial, is comprehensively covered by leading experts in Volume 3, Subvolumes L (Part I) and M (the present volume, Part II). The major classes of endocrine active chemicals are discussed, as well as methods for their detection and their association with health disturbances in humans and wildlife. The etiology of several of the human diseases associated with endocrine disruptors, e.g. breast and prostate cancer, decreased fertility and malformations, is still poorly understood, and the current state of knowledge is presented. Since hormonally active agents appear to have the potential of both adverse and beneficial effects, the evidence of health benefits associated with endocrine active compounds in humans is also presented. Basic chapters on the mode of action of EACs and on the etiology of the associated diseases facilitate the understanding of this complex subject for non-medical readers.

Developed from a short course taught at Leeds University, this book covers methods of monitoring emissions of air pollutants from stationary sources. It surveys the techniques and points out their advantages and disadvantages.

This book discusses UV radiation, its effects on ecosystems and the likely evolutionary consequences of changed UV radiation environments, past, present and future. The first two chapters examine the history of the UV radiation climate of earth and the factors that determine organismal and ecosystem exposure. Their purpose is to give the reader a physical perspective on UV radiation and an understanding of the constantly changing UV environment that ecosystems are exposed to over time. Variations in the UV radiation environment occur at the local level (such as boundary layer and plant canopy effects) through to global-scale changes (such as alterations in the column abundance of UV-B protecting ozone). UV radiation regimes also vary over temporal scales. These alterations occur on time scales of seconds (the movement of clouds and plant canopies) to literally billions of years (gross long-term changes in the composition of the Earth's atmosphere). In the chapters that follow five specific biological and ecological topics in photobiology are considered. They are effects of UV radiation on amphibians, plants, corals, aquatic microbial ecosystems and Antarctic ecosystems that are exposed to the anthropogenically generated ozone 'hole'. These chapters consider UV radiation effects at a diversity of levels from the biochemical to the community. Their purpose is to provide the reader with our current understanding of the ecological effects of UV radiation, the areas where questions still remain and to provide a perspective from which the reader can better understand questions in evolutionary photobiology. The final chapter investigates the biological consequences of altered extraterrestrial ultraviolet fluxes, which are quite different from those experienced on the Earth. Our knowledge of the role of UV radiation in shaping ecologies and evolutionary change is still in its infancy. This book brings together a number of authors with the aim of helping to consolidate a better understanding of this interesting area of photobiology.

Neurotoxicology: Approaches and Methods provides a unique and comprehensive presentation of the current concepts and state-of-the-art methods for the assessment of neurotoxicity. The book analyzes various techniques available and discusses their strengths and weaknesses. This volume will serve as an excellent desk companion and laboratory guide for all investigators, researchers, clinicians, and students interested in neurotoxicology. The internationally knowngroup of editors divide the book into seven sections: "Neuromorphological and Neuropathological Approaches; Neurophysiological Approaches; Neurobehavioral Toxicology; Neurochemical and Biomolecular Approaches; In-Vitro Models; Clinical Neurotoxicology; and Risk Assessment of Neurotoxicity." Each section yields the most up-to-date information by experts in their fields. Meticulously organized and edited, Neurotoxicology: Approaches and Methods is the most authoritative and well-planned neurotoxicology book on the market.
Key Features
* Discusses neurobehavioral testing methods for assessment of neural dysfunctions
* Explains state-of-the-art diagnostic methods, such as clinico-neuropsychological and neurophysiological methods, for patients confronted by neurotoxic problems
* Discusses "In Vitro" methods, including aggregating brain cell methods, organotypic cultures, and the use of human neuronal cell lines for the assessment of neurotoxicity
* Presents step-by-step procedures for many methods
* Provides state-of-the-art neuromorphological and biomolecular methods and approaches for neurotoxicity investigation

In this book, editor G Rasul Chaudhry presents a wide range of topics authored by researchers at the cutting edge of biodegradation and bioremediation. The book includes recent research describing how microorganisms clean soil and water, and how they remove toxic substances. It also presents information on how genetics and molecular biological methods are used to improve the ability of microorganisms to degrade a variety of substances.

For investigators engaged in the study of toxins generally, and host-specific toxins in particular, it is a rare treat to attend a meeting in which toxins involved in plant pathogenesis are emphasized. A gathering of this type provides opportunity to consider the discovery of new toxins, their chemical structures, genes encoding enzymes that control their biosyntheses, their sites of action and physiological effects on plants, and their roles (if any) in pathological processes. Having acknowledged the inspiration fostered by a 'toxin meeting', however, it is important to point out that the program of this symposium was generously sprinkled with 'nontoxin' talks. These contributions generated cross-disciplinary discussion and promoted new ways of thinking about relationships among factors required for plant disease development. The point can be illustrated by considering just one example. We have in the past often regarded diseases mediated by host-specific toxins and diseases involving 'gene-for-gene' relationships as representing two different classes of fungal/plant interaction. This is largely because the key molecular recognition event in so-called 'toxin' diseases leads to compatibility, whereas the corresponding event in 'gene-for-gene' diseases leads to incompatibility. Yet the race specific elicitors produced by the 'gene-for-gene' fungi Cladosporium fulvum (De Wit, Adv. Bot. Res. 21:147- 185, 1995) and Rhynchosporium secalis (Rohe et a1. , EMBO J.

Molecular Toxicology Protocols, Second Edition aims to bring together a series of articles describing validated methods to elucidate specific molecular aspects of toxicology, the emphasis being on the application of molecular methods to genetic toxicology. The volume is divided into ten parts, roughly corresponding to the spectrum of biomarkers intermediate between exposure and disease outcomes as proposed in molecular epidemiology models. Subjects of these new chapters range from preparation of fluid specimens for analysis of cellular inflammatory responses to genotoxic insults to sensitive methods for proteomic analysis and aberrant DNA methylation patterns. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Molecular Toxicology Protocols, Second Edition addresses not only the needs of molecular biologists and toxicologists, but also those of individuals interested in applying molecular methods to clinical applications, such as geneticists, pathologists, biochemists, and epidemiologists.

Protection of human health by prevention of environmental hazards has become a major concern in all European countries. This concern is reflected in the regional strategy of Health for All by the Year 2000, as developed in 1984, and in the 1989 European Charter on Environment and Health. However, despite considerable progress, most efforts are related to single sources of exposure and to a small number of 'priority' chemicals. In protecting the population against chemical hazards, attention must also be paid to the fact that subgroups are particularly susceptible to the adverse effects of certain chemicals. This hypersusceptibility may be genetically determined. Such individual predisposition to toxic effects must be taken into account in the efforts to prevent adverse effects of environmental exposures to toxic chemicals. To help address these problems the Regional Office, in co-operation with the Institute of Human Genetics and Anthropology of the Univer sity of Dusseldorf and with financial support from the Federal Ministry for the Environment, Nature Conservation and Nuclear Safety of the Federal Republic of Germany, organized a consultation in Krefeld in October 1989. The meeting was attended by 17 experts from 12 coun tries, three representatives of the host government, two representatives of other organizations and five staff members from the WHO Regional Office for Europe and WHO Headquarters. The list of participants is included as an appendix to the present volume."

International concern in scientific, industrial, and governmental communities of xenobiotics in foods and in both abiotic and biotic environments over traces has justified the present triumvirate of specialized publications in this field: comprehensive reviews, rapidly published research papers and progress reports, and archival documentations. These three international publications are inte grated and scheduled to provide the coherency essential for nonduplicative and current progress in a field as dynamic and complex as environmental contamina tion and toxicology. This series is reserved exclusively for the diversified litera ture on "toxic" chemicals in our food, our feeds, our homes, recreational and working surroundings, our domestic animals, our wildlife and ourselves. Tre mendous efforts worldwide have been mobilized to evaluate the nature, pres ence, magnitude, fate, and toxicology of the chemicals loosed upon the earth. Among the sequelae of this broad new emphasis is an undeniable need for an articulated set of authoritative publications, where one can find the latest impor tant world literature produced by these emerging areas of science together with documentation of pertinent ancillary legislation. Research directors and legislative or administrative advisers do not have the time to scan the escalating number of technical publications that may contain articles important to current responsibility. Rather, these individuals need the background provided by detailed reviews and the assurance that the latest infor mation is made available to them, all with minimal literature searching."

The aim of this book is to give an overview of the most important aspects of physiological and biochemical basis for metal toxicity and tolerance in plants. The book is expected to serve as a reference to university and college teachers, students of plant sciences, environmental biology, environmental biotechnology, agriculture, horticulture, forestry, plant molecular biology, and genetics.

Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy, and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

The concern over the entry of agrochemicals and other xenobiotics into drinking water resources and over the general quality of drinking water is increasing. The topic of water quality and water supply will continue to be of great interest during the next two decades in developed as well as in developing countries. The new volume discusses in an authoritative way the key issues of drinking water and its often necessary treatment.

Pesticides have contributed impressively to our present-day agricultural productivity, but at the same time they are at the center of serious concerns about safety, health, and the environment. Increasingly, the public wonders whether the benefits of pesticides - the perfect red apple' - outweigh the costs of environmental pollution, human illness, and the destruction of animals and our habitat. Scientists and government officials are suspected of promoting commercial interests rather than protecting human welfare.

This volume presents a broad compendium of techniques used in biodegradation and toxicological research. Through both legacy and up-to-date approaches to practical methodologies with proven results, the book examines the role and applications of analytical biodegradation quantification as it applies to the environmental sciences, particularly in the range of byproducts that are usually linked to toxicology, and the test organisms most often used in toxicity testing. Topics include scientific and technical feasibility studies, contaminant impacts evaluation, study design and analytical techniques, key methodologies required to prepare the biodegradation and toxicology protocols, as well as the handling of microbial communities related to such processes. Written for the Methods in Pharmacology and Toxicology series, chapters deal with a critical discussion of laboratory scale experiments, as well as full scale in situ and ex situ apparatus, with each chapter containing both a discursive section along with a detailed methods section. Detailed and authoritative, Toxicity and Biodegradation Testing is primarily focused toward the environmental sciences researcher, while the range of techniques also provides an introduction to biodegradation and toxicology methods for researchers outside of the field.

Applications of nanoparticles to the human life and tools in diagnosis and therapy in field of clinical medicine holds importance and has been an prime focus of biomedical and clinical research for quite sometime, though their application in veterinary medicine is a relatively new focus area of research. Prior to human applications, studies are initially conducted on animals models. Thus toxicity based studies and study of impact of nanoparticles on animal immune system finds importance. In the second volume of the book we discuss the immune system in animals across invertebrates and vertebrate phylas and discuss the impact of nanoparticles in animals life, health, survival and immune system. The book highlights the toxic effects of nanoparticles as environmental pollutants and their adverse impact on animal life forms. Both volumes are also included in a set ISBN 978-3-11-065666-4.