Tellurium, a well-known chalcogen, finds potential applications in various fields from chemistry to other branches of science such as nanotechnology and macromolecular science. However, its safety must also be taken into consideration when exploring its industrial applications. This book explores the breadth of tellurium's applications, outlines strategies for industrial use, and describes the safety concerns of this element.

Present the main anthropological and non-anthropological sources of waste generation containing toxic metals. Demonstrate aspects related to the generation, disposal and valuation of solid waste containing toxic metals. Portray techniques for the treatment and reuse of water contaminated with toxic metals.

The coastal tropics comprise some of the most sensitive and yet the most understudied ecosystems in the world. Coastal plains and river valleys are also home to agriculture on a vast scale and it is not surprising to find that streams and rivers receive the majority of agricultural runoff, carrying the residues of insecticides, fungicides and other pesticides into estuaries and coastal zone. There is a growing awareness of an urgent need to develop strategies that facilitate the coexistence of productive, healthy and economically viable agriculture with the preservation of natural resources.
Pesticide Residues in Tropical Coastal Ecosystems brings together toxicology experts from around the world to assess pesticide burdens in many of the major food-producing tropical countries. It provides a unique set of case studies, chronicling pesticide usage and its ecotoxicological impact in coastal regions.
A practical guide to recent research findings and applications, it is essential reading for environmental professionals, ecotoxicologists, marine chemists and agrochemists.

eBook available with sample pages: 0203165586

This reference comprehensively covers the formation, characteristics, and control of various toxins that occur in the production, storage, handling, and preparation of food-exploring toxin sources, mechanisms, routes of exposure and absorption, and their chemical and biochemical components to prevent contamination of food products and reduce epidemics of foodborne disease. Contains more than 3000 current references to facilitate further research, as well as recent guidelines from the FDA and World Health Organization regarding food hygiene and safety The Handbook of Food Toxicology discusses methods to inhibit toxin formation the effect of manufacturing, pesticide, and drug residues on the tissues, organs, and biological processes of the human body the origins, symptoms, diagnosis, and treatment of diseases caused by food-related microorganisms, viruses, and bacteria biological and industrial contaminants in the air, water, and soil possible environmental factors contributing to cancer, gene mutations, and birth defects potential toxic effects of normal dietary constituents the role of metabolic pathways in xenobiotic toxicity toxicants derived from food processing operations naturally occurring antinutritional components of plants and fungi the impact of additives on food texture, stability, and nutritional value From health and economic consequences to exposure assessment and detoxification, the Handbook of Food Toxicology is an authoritative and timely guide for food toxicologists and mycotoxicologists, nutritionists, food and environmental microbiologists, molecular and cell biologists and biochemists, infectious disease specialists, gastroenterologists, emergency room/poison control physicians, agricultural scientists, phytotoxicologists, food scientists and technologists, food sanitarians, parasitiologists, entomologists, epidemiologists, state and federal regulatory officials, and public health officers.

Agriculture methods that exclude pesticides and other chemical inputs are spreading rapidly all over the world. Commonly known as organic farming, this agriculture model is increasingly recognized by farmers, consumers, environmentalists and policy-makers as a way to improve environmental, social, and economical sustainability in food production. This entry explains the concept of Organic Farming and gives an overview of the current situation, growth factors and dynamics, and basic practices. Dekker will provide subscribers and readers with new content each quarter. The list below indicates titles planned for future quarterly updates (new and revised articles). The alphabetical list below is not intended to specify when an individual article will be available. This timely resource ranges across a broad spectrum of interrelated disciplines-including botany, zoology, agriculture, engineering, environment, public health, and soil and water science-to identify diverse pest species that damage and destroy crops, livestock, and forest products. This user-friendly reference contains: an authoritative and comprehensive writing style that allows experienced professionals to find specific information overviews that enable quick understanding of never before encountered subject matter a flexible cross referencing system and exhaustive index that facilitate easy location

Monkeys and apes have been used successfully in medical research for many decades due to the high degree of relatedness and biological similarity of these primates to humans. Medical Primatology begins with a discussion of the history of this research, and then focuses on the biological foundations upon which medical primatology has been built. Primate taxonomy and evolution are reviewed using not only traditional sources of data, but also recent experimental evidence from molecular biology, genetics and biomedicine that indicates, in particular, the need to place higher simians in the family of man.
Medical Primatology for the first time provides a comprehensive summary text linking the use of simians in biomedical research to their kinship with humans, and it condenses a wide range of scientific literature into one volume. It will be a useful reference book for those involved in biological, anthropological, biomedical, clinical and pharmacological research on primates, and students and specialists in the biological sciences and medicine.

eBook available with sample pages: 0203298691

This text coherently links biochemical fundamentals and mechanisms with economic and societal problems of environmental pollution. It addresses interdisciplinary topics such as regulatory problems, sampling and pollutant quantifi cation, model organisms and provides a philosophical perspective on the toxin load on a variety of organisms, including humans in the environment in the Anthropocene. Case studies and exercises illustrate current issues and discuss future aspects.

Contents:
1. Electron Paramagnetic Resonance Study for Defining the Mechanism of Irritant Dermatitis Y. Kawasaki, J. Mizushima, R. Cooke and H. Maibach 2. Irritant Patch Testing in Atopic Individuals H. Loeffler and I. Effendy 3. Quantification of Nonerythematous Irritant Dermatitis V. Charbonnier, H. Maibach, B. Morrison and M. Paye 4. Detergents I. Effendy and H. Maibach 5. Permeability of Skin for Metal Compounds J. Hostynek 6. Irritant Dermatitis: Subthreshhold Irritation E. Tur 7. Cytokines and Irritant Dermatitis Syndrome I. Effendy and H. Maibach 8. Assay to Quantify Subjective Irritation Caused by the Pyrethroid Insecticide Alpha-Cypermethrin R. Herbst, R. Strimling and H. Maibach 9. Prediction of Skin Corrosivity Using Quantitative Structure-activity Relationships M. Barratt 10. Contamination and Percutaneous Absorption of Chemicals from Water and Soil R. Wester and H. Maibach 11. Determining an Occupational Dermal Exposure Biomarker for Atrazine Through Measurement of Metabolites in Human Urine by HPLC-accelerator Mass-spectrometry B. Buchholz, J. Vogel, S. Gilman, S. Gee, B. Hammock, X. Hui, R. Wester and H. Maibach 12. Partitioning of Chemicals from Water Into Powdered Human Stratum Corneum (Callus) X. Hui, R. Wester, P. Magee and H. Maibach 13. Dermal Exposure of Hands to Pesticides G. Matthews 14. Iontophoresis A. Anigbogu and H. Maibach 15. Penetration and Barrier Creams H. Zhai and H. Maibach 16. Fiber K. Hatch and H. Maibach 17. Novel Topical Agents for Prevention and Treatment of Allergic and Irritant Contact Dermatitis John Wille and A. Kydonieus 18. Allergic Contact Dermatitis: Clinical Considerations Y. Leow and H. Maibach 19. Pharmacology, Toxicology and Immunology of Experimental Contact Sensitizers W. Hannon, T. Chartier and J. Taylor 20. Modulation of the Dermal Immune Response by Acute Restraint S. Tinkle and M. Flint 21. Textile-dye Allergic Contact Dermatitis Prevalence K. Hatch and H. Maibach 22. Dose-Response Studies in Guinea Pig Allergy Tests S. Frankild 23. Operational Definition of Allergic Contact Dermatitis S. Ale and H. Maibach 24. Predictive Immunotoxicological Risk Assessment B. Horney, P. Lehmann and H. Vohr 25. Allergic Contact Dermatitis From Transdermal Systems C. Levin and H. Maibach 26. Animal Models for Immunologic Contact Urticaria and Nonimmunologic Contact Urticaria A. Lauerma and H. Maibach 27. Diagnostic Tests in Dermatology S. Amin, A. Lauerma and H. Maibach 28. Wound Healing Products D. Hobson 29. Issues of Toxicity With Dermatologic Drugs During Pregnancy B. Reed 30. Roles of Calcium Ions in Skin Barrier H. Tanojo and H. Maibach 31. Nuclear Receptors for Psoralen in Cultured Human Skin Fibroblasts K. Milioni, E. Bloom and H. Maibach 32. In Vitro Viability Assays M. Kwah 33. Dermal Penetration of Calcium Salts and Calcinosis Cutis S. Soileau

Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humans and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitro models has risen. This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and developmental toxicity) and the full spectrum of target organ systems (including the skin, eye, heart, liver, kidney and nervous system). Chapters are devoted to each of these speciality areas from a perspective of presenting the principal models and their uses and limitations.

Cutting across traditional subject boundaries, Principles of Ecotoxicology, Fourth Edition gives readers an integrated view of ecotoxicology, from molecules to ecosystems. This new edition of a bestselling textbook continues to emphasize principles rather than practice, providing the interdisciplinary perspective and grounding required for research. Organized into three sections, the book first describes the molecular structures, properties, and environmental fate of pollutants. It then deals with the effects of pollutants on living organisms at the molecular, cellular, and individual levels. Moving into population biology and population genetics, the third part of the book addresses a question of great interest to ecologists: What effects do pollutants have at the levels of population, community, and the whole ecosystem? The book also looks at how ecotoxicology is used in the biomonitoring of environmental pollution, the investigation of pollution problems, the conducting of field trials, the study of the development of resistance, and the growing area of environmental risk assessments. Throughout, examples and case studies illustrate the principles. This updated fourth edition includes new material on nanoparticle pollution, bioaccumulation, biomarkers, and chemical warfare in nature, as well as a new chapter on the future directions of ecotoxicology. A concise textbook that will also appeal to practicing ecotoxicologists, it provides a solid basis for understanding what happens to chemicals in the real world, where they go, how they ultimately degrade, and how they affect the individuals and populations that encounter them. What's New in This Edition Revised and updated material throughout A chapter on future directions of ecotoxicology New material on nanoparticle pollution and chemical warfare in nature Ex

This book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial applications. However, our understanding of nanomaterial-mediated toxicity under in vivo condition remains limited. The book begins with a chapter on synthesis and characterization of nanoparticles used for various biological, medical and commercial purposes. The rest of the chapters deal with the impact of nanoparticles on different biological aspects like behavior, physiology and metabolic homoeostasis using Drosophila as a model organism. Lastly, the book summarizes how proper characterization and evaluation of safe dosage of nanoparticles can be a boon if incorporated in consumer goods and for biomedical applications. Overall, the book pursues an interdisciplinary approach by connecting nanotechnology and biology from various angles using Drosophila as a model system, so as to develop more efficient, safe and effective use of nanoparticles for human beings.

Practical Toxicology: Evaluation, Prediction, and Risk, Third Edition shows how to conduct a program of safety evaluation and testing and then to interpret and apply the resulting data and information in the real world, beginning with the basic concepts in toxicology and progressing to the interpretation of the resulting data. Revised and updated chapters on risk assessment guide the reader to setting the foundations necessary for submission to regulatory authorities. In addition, a new chapter in the book reviews the errors in toxicology, mistakes, misuse, mismanagement, and misunderstanding with a view to avoiding these in the future. New Chapters in the Third Edition: Toxicology in silico Errors in Toxicology Safety Assessment of Extractables and Leachables. This new edition follows a practical sequence from introducing the basics of toxicology (including the vital concept of normality in controls) to describing a test program and then interpreting the data and translating that to risk assessment that can be used in a number of real world situations where safety and secure risk assessment are essential. Although written primarily from the perspective of pharmaceutical development, the test designs and toxicological problems encountered in that field are entirely relevant to those with other classes of chemicals, the only difference being the regulatory context. Toxicology is an international discipline and the book has been written to take into account some of the differences in regulatory nuance between the main regions of the world. Completely revised and written in an easily accessible style, the text address several audiences-from students and post-graduates coming to the subject for the first time to established professionals who find themselves needing to learn about toxicology, toxicity testing, interpretation of the results, and risk assessment. It is intended primarily as a textbook, with case studies and information on where to go to ask questions, but can also be used as a practical reference book. It covers all the basics of toxicology and the main aspects of safety evaluation testing and risk assessment while reviewing critically the current state of the discipline. It also provides a foundation for those seeking registration or certification.

Ecotoxicology offers a comprehensive overview of the science underpinning the recognition and management of environmental contamination. It describes the toxicology of environmental contaminants, the methods used for assessing their toxicity and ecological impacts, and approaches employed to mitigate pollution and ecological health risks globally. Chapters cover the latest advances in research, including genomics, natural toxins, endocrine disruption and the toxicology of radioactive substances. The second half of the book focuses on applications, such as cradle-to-grave effects of selected industries, legal and economic approaches to environmental regulation, ecological risk assessment, and contaminated site remediation. With short capsules written by invited experts, numerous case studies from around the world and further reading lists, this textbook is designed for advanced undergraduate and graduate one-semester courses. It is also a valuable reference for graduate students and professionals. Online resources for instructors and students are also available.

Reflecting the broad and interdisciplinary nature of toxicology, this third edition of Principles of Toxicology explores the biochemical, physiological, and environmental aspects of the subject. This new edition is updated and revised to include reference to several major new directions in the science of toxicology, including significant changes in thinking about cancer and carcinogenesis as well as the rapid expansion of toxicogenomics. The book also includes new chapters on topics of timely interest such as radiation, food safety, and natural toxins. As in previous editions, chapters combine background material in the appropriate discipline-which helps readers review and remember the basics-with new information on toxicology to stress key principles and concepts. Also included is a selection of updated case studies through which principles and concepts are applied to real-world issues. The book features an extensive cross-referencing system linking all sections and enhancing the integration of material, thus helping readers tie it all together. It also includes an appendix of selected toxicants that describes chemical structure, category of use, and toxicity. These features make specific information quick and easy to find. The easy-to-follow format and clear presentation of information in this book will make this one of the most useful references on your shelf.

Dioxin - Environmental Fate and Health/Ecological Consequences offers a unique, and comprehensive coverage of dioxins and their congeners once they are released to the environment. The book provides readers with a systematic understanding of past and emerging sources of dioxins, current dioxins inventories and historical trends, fate and long-range transboundary atmospheric transport, human health, and ecological risk and regulatory perspective. Providing an excellent analysis of dioxin exposure through the food chain and impact on human health, it also documents the environmental implications of dioxins on ecological flora and fauna. The book offers readers a holistic understanding about dioxins, their atmospheric fate and transport, distribution in various environmental matrices and various routes and exposure pathways through which human beings are exposed to this persistent organic pollutant. It further offers an insight into the toxicological profile and mechanistic analysis of the onset of cancer, remediation technologies, and existing regulatory framework to deal with the problems associated with dioxins. The book will serve as an excellent resource to environmental professionals, particularly environmental toxicologists, environmental health professionals, remediation engineers, environmental regulatory agencies, policymakers, and environmental law professionals.

Written in such a way as to make it accessible to toxicologists who do not have English as a first language, this book focuses on evaluating, interpreting and reporting results of regulatory toxicology studies.

This detailed book provides an accessible compendium of up-to-date methods in the fields of environmental toxicology, molecular toxicology, and toxicogenomics. Organized into four major sections, the volume examines methods utilizing model animal species, such as nematode, fruit fly, mice, chicken, and amphibians, methods using plants to study chemical toxicity, applying the Ames assay to chemical mutagenicity study, as well as methods for environmental chemical analysis. Although this book is divided into these parts, the methods can be used across species. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Environmental Toxicology and Toxicogenomics: Principles, Methods, and Applications serves as a valuable resource for the scientific community, particularly for young scientists and graduate and undergraduate students, inspiring more research in the vitally important field of environmental toxicity, molecular toxicology, and toxicogenomics.

Contaminants and Clean Technologies provides valuable information on environmental contaminants such as industrial pollutants, micropollutants, pesticides, endocrine disruptors, pharmaceuticals, toxins, and hormones. It focuses on the various types of environmental contaminants discharged from various sources; their toxicological effects in environments, humans, animals, and plants; and their removal methods. It also covers, comprehensively, information on the contaminants released by various industries and agricultural practices, which cause severe threats to the environment. Features of the book: Elucidates systematic information on various types of environmental contaminants, and their fate and consequences Discusses contaminants such as endocrine disruptors, pharmaceutical waste, and personal care products Provides an overview of physicochemical and biological treatment technologies for sustainable development Details recent research finding in the area of environmental contaminants and their future challenges

This text focuses on research procedures in toxicology, aiming to illustrate toxicological concepts and types of toxicity from a mechanistic point of view. Mechanistic research in toxicology leads not only to a greater understanding of the biology involved, but also the means to design substances with selectivity between species and minimal undesirable side effects. Examples of chemical intoxicants are used to illustrate mechanisms in each stage of developing toxicity.

Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation.

Placental Toxicology examines placental transfer and toxicology of drugs and environmental agents to placenta, as well as to fetus. For the first time in a single volume, placental and fetal consequences of exposure of pregnant women to drugs, environmental chemicals, and infections, such as HIV, are discussed. Topics include:
The art of in vitro perfusion of human placenta
Abuse of alcohol, nicotine, morphine, and cocaine during pregnancy, their placental transfer and fetal growth retardation
Placental transfer and fetal toxicities of environmental insecticides
Placental hormones and fetal well-being
Placental transfer of HIV and treatment of pregnant women with anti-HIV drugs

Toxicology, in recent years, has acquired greater importance than ever before because of increasing and indiscriminate use of farm chemicals and drugs accompanied by rapid degrading impact of environmental pollution on health of animals. The indiscriminate feeding habits of domestic animals especially in developing countries make them more prone to the impact of natural toxicants like Phytotoxins and Mycotoxins. Toxicology has been recognized as a separate discipline in all sciences both at undergraduate and post graduate levels for the last four decades and lot of emphasis has been given on its teaching, research and practical utility from clinical point of view. This book was written with two goals in mind i to provide a textbook for students that would supplement their classroom instruction and ii to supply a valuable aid to practioneThe book has been prepared in a most comprehensive manner with up to date references which offers invaluable, clinically oriented guidance on numerous potentially toxic substances. In addition, to covering traditional and non-traditional areas of toxicology it provides a wealth of quick reference charts and tables that gives vital information at your finger tips.

The book summarizes and reviews the environmental and human safety of two classes of nonionic surfactants-alcohol ethoxylates (AE) and alkylphenol ethoxylates (APE). This unique resource contains critical data from published sources as well as from unpublished studies submitted by Soap and Detergent Association member companies. It reviews information on product chemistry and analysis, biodegradation, environmental levels (including fate and distribution), aquatic toxicity, and human safety. Recently developed analytical techniques for the extraction, separation, detection, and measurement of nonionic surfactants and their metabolites in environmental samples are described.
Results of biodegradation studies performed with a variety of test systems are tabulated, as are results of field studies at wastewater treatment plants. Reported comparisons of environmental levels with results of acute and chronic aquatic toxicity tests are provided. The information on the toxicity and irritation potential of AE and APE surfactants includes data from in vitro, mammalian, and human studies.