Exploring roles critical to environmental toxicology, Modeling and Simulation in Ecotoxicology with Applications in MATLAB (R) and Simulink (R) covers the steps in modeling and simulation from problem conception to validation and simulation analysis. Using the MATLAB and Simulink programming languages, the book presents examples of mathematical functions and simulations, with special emphasis on how to develop mathematical models and run computer simulations of ecotoxicological processes. Designed for students and professionals with little or no experience in modeling, the book includes: General principles of modeling and simulation and an introduction to MATLAB and Simulink Stochastic modeling where variability and uncertainty are acknowledged by making parameters random variables Toxicological processes from the level of the individual organism, with worked examples of process models in either MATLAB or Simulink Toxicological processes at the level of populations, communities, and ecosystems Parameter estimation using least squares regression methods The design of simulation experiments similar to the experimental design applied to laboratory or field experiments Methods of postsimulation analysis, including stability analysis and sensitivity analysis Different levels of model validation and how they are related to the modeling purpose The book also provides three individual case studies. The first involves a model developed to assess the relative risk of mortality following exposure to insecticides in different avian species. The second explores the role of diving behavior on the inhalation and distribution of oil spill naphthalene in bottlenose dolphins. The final case study looks at the dynamics of mercury in Daphnia that are exposed to simulated thermal plumes from a hypothetical power plant cooling system. Presented in a rigorous yet accessible style, the methodology is versatile enough to be readily applicable not only to environmental toxicology but a range of other biological fields.

1. Discusses the properties, mechanisms, advantages, limitations and promising solutions of different types of membrane technologies 2. Addresses the optimization of process parameters 3. Describes the performance of different membranes 4. Presents the potential of Nanotechnology to improve the treatment efficiency of wastewater treatment plants (WWTPs) 5. Covers the application of membrane and membrane-based hybrid treatment technologies for wastewater treatment

With chapter contributions from more than 30 metal biology experts, Cellular and Molecular Biology of Metals explains the role of key divalent metal ions involved in the molecular and cellular biology of various target cell populations. Although it primarily focuses on homeostatic metals, such as nickel, zinc, and chromium, the text also discusses a few environmentally pertinent, toxic divalent cations, including mercury, cadmium, and arsenic. This authoritative resource reviews the physiological mechanisms underlying the handling of essential and toxic metal ions, including metal ion homeostasis, metals and enzyme activity, metals and transcriptional regulation, and metal ion transport. It also analyzes other functions designed to avoid metal-induced toxicity and mediate the metal enhancement of cellular function. The role of metal ions and their effect on mammalian cells and organs are only beginning to be truly defined. Cellular and Molecular Biology of Metals arms metals toxicologists and cellular and molecular biologists with the necessary knowledge they need to take the research effort to the next level. Key selling features: Presents the most recent advances in the cell and molecular biology of metal ions Provides a complete exploration of transport mechanisms Addresses homeostatic metals as well as several environmentally relevant toxic divalent cations Features contributions from experts in their respective fields

The field of electromagnetic sensitivity is the new epidemic of the 21st century, and can cause disease of the automatic nerve system in any part of the body. This is as a result of chemical sensitivity, in which over 80,000 chemicals are involved, resulting in innumerable combinations. A cursory understanding of the combinations can help clinicians partially understand the associated problems and thus help in the diagnosis and treatment of electromagnetic sensitivities. But a basic understanding of environmentally induced illness and healing must first be understood by the clinicians before diseases occur such as cardiac arrhythmia, muscle spasms, and nerve pain.

The discussion on arsenic in the environment is complex and must grasp the importance of very many, mostly unrelated works on individual aspects. This volume represents one of the first comprehensive and interdisciplinary examinations into arsenic's behaviour in air, water, soils, sediments, plants and the human body. Based on state-of-the-art investigations into the global arsenic cycle, the related human toxicology and available remediation technologies, arsenic is assessed holistically in all the environmental compartments. Using the results of primary research, the authors offer concrete suggestions for risk reduction and management of environmental pollution that allow the reader to successfully tackle similar problems and find sustainable solutions. The book consists of three essential parts: Review of the current knowledge of arsenic behaviour in the environment (global biogeochemical cycles), toxicology, remediation techniques, immobilization technologies and environmental legislation Case studies for mining-related arsenic problems Discussion of mitigation and remediation technologies and approaches such as environmental education, hygiene training, backed by real experience and successful implementation in the study area In a highly coherent manner, the book makes use of 120 tables and figures, a large number of literature citations, and very detailed subject index (that encompasses references) to provide rapid and up-to-date access to all relevant information. Cross-references provide a great manoeuvrability between the chapters. The book delivers very insightful and hands-on approaches for graduate students and professionals working on arsenic questions not only in environmental science, but also in the fields of environmental engineering, medicine and social science.

Illustrated Toxicology: With Study Questions is an essential, practical resource for self-study and guidance catering to a broad spectrum of students. This book covers a range of core toxicological areas, including pesticides, radioactive materials and poisonous plants, also presenting a section on veterinary toxicology. Across 16 chapters, the book presents key concepts with the aid of over 250 detailed, full-color illustrations. Each section is supplemented with practical exercises to support active learning. This combination of clear illustrations and sample testing will help readers gain a deeper understanding of toxicology. This book is useful for toxicology, pharmacy, medical and veterinary students, and also serves as a refresher for academics and professionals in the field, including clinical pharmacists, forensic toxicologists, environmentalists and veterinarians.

Increased awareness surrounding environmental protection has prompted the development of more ecofriendly technologies. This book provides useful information on technologies based upon the use of biological agents for environmental clean-up, including bacteria, yeast, fungi, algae, and plants. Some chapters refer to the direct application of products derived from plants and microorganisms for designing strategies of environmental remediation. The combination of strategies helps in efficient removal of pollutants generated from anthropogenic activities with minimal environmental impact. This book is meant for professionals involved in environmental technology and waste management.

One of the very few - if not only - books written exclusively related to this topic. This book comprehensively outlines the principles governing the accumulation of chemicals from the environment by organisms. Packed with tables and diagrams, this work reviews the experimental data available on both terrestrial and aquatic systems. It describes methods which are used to predict bioaccumulation of chemicals from their physicochemical properties. It also reviews environmental and other factors influencing bioaccumulation. This text also includes previously unpublished theoretical explanations of several bioaccumulation processes, including food chain biomagnification. Information in this exceptional volume is useful to government officials involved with environmental management, chemists, biologists, consultants working with chemical waste control, researchers, and graduate students.

As the application of nanotechnology in the myriad disciplines of science and engineering--from agriculture, pharmaceuticals, material science, and biotechnology to sensors, electronics, and mechanical and electrical engineering--brings benefits it also can produce serious threats to human health and the environment that must be evaluated. The unique properties of nanomaterials make them different from their bulk counterparts. In addition to such unique properties, the nanometric size of nanomaterials can invite some detrimental effects on the health and well-being of living organisms and the environment. Thus, it is important to distinguish nanomaterials with such ill effects from nanomaterials with no or minimum toxicity. Nanotoxicology: Toxicity Evaluation, Risk Assessment and Management covers issues such as the basic principles of nanotoxicity, methods used for nanotoxicity evaluation, risk assessment and its management for nanomaterial toxicity with a focus on current trends, limitations, challenges, and future directions of nanotoxicity evaluation. Various experts from different countries discuss these issues in detail in this book. This will be helpful to researchers, educators, and students who are interested in research opportunities for avoiding the environmental and health hazards of nanomaterials. This book will also be useful for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, drugs, and other regulatory sciences.

Karch's Drug Abuse Handbook, Third Edition remains the quintessential compendium addressing the pharmacological, medical, and legal aspects of drugs and informing the forensic community of the latest scientific advances and emergent practices. For this edition, Dr. Karch has brought on clinical and forensic toxicology expert Dr. Bruce Goldberger, editor-in-chief of the Journal of Analytical Toxicology and president of the American Board of Forensic Toxicology, to serve as co-editor. In addition, world-renowned scientists and medical professionals have contributed their work and expertise in tackling the latest developments in drug testing, drug-related medical emergencies, and the drug toxicology. Topics addressed include genetic testing in drug death investigation, pathology, toxicogenetics, alcohol, post-mortem toxicology, new psychoactive substances, the latest legal issues and challenges as well as drugs and drug testing in sports, and the ethical, legal, and practical issues involved. Vivid pictures and diagrams throughout illustrate the pathological effects of drugs and the chemical make-up and breakdown of abused drugs. With unparalleled detail, the latest research and the highest level of authoritative medical scientific information, The Drug Abuse Handbook, Third Edition remains the definitive resource for drug related issues.

Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development. The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity, among others.

The Indian Nitrogen Assessment: Sources of Reactive Nitrogen, Environmental and Climate Effects, and Management Options and Policies provides a reference for anyone interested in Reactive N, from researchers and students, to environmental managers. Although the main processes that affect the N cycle are well known, this book is focused on the causes and effects of disruption in the N cycle, specifically in India. The book helps readers gain a precise understanding of the scale of nitrogen use, misuse, and release through various agricultural, industrial, vehicular, and other activities, also including discussions on its contribution to the pollution of water and air. Drawing upon the collective work of the Indian Nitrogen Group, this reference book helps solve the challenges associated with providing reliable estimates of nitrogen transfers within different ecosystems, also presenting the next steps that should be taken in the development of balanced, cost-effective, and feasible strategies to reduce the amount of reactive nitrogen.

In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing. Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials.

The present work is the first major attempt at reviewing comprehensively all the available information about the environmental fate and behaviour of the xenobiotic chemicals.

This book critically examines the available literature on oceanic acidification: including a historical review of pH and atmospheric CO2 levels over the millennia; natural and anthropogenic sources of CO2 to the atmosphere and sea surface; chemical, physical, and biological mode of action; biological effects of acidification to marine plants and animals under laboratory conditions; field observations on seawater chemistry and effects of declining pH; and various technical and political mitigation strategies. Written by Dr. Ronald Eisler, a noted authority on chemical risk assessment, the book summarizes real and projected effects of oceanic acidification.

Metal Metabolism in Aquatic Environments is a synthesis of recent developments in the field of metal ecotoxicology and features a number of contemporary issues arising from the interaction of metals and biota, such as pathways of assimilation and food chain transfer, metal accumulation and detoxification in humans and biotransformation of elements such as mercury and arsenic.

The Handbook of Histopathological Practices in Aquatic Environments: Guide to Histology for Environmental Toxicology offers readers in aquatic biology and other water-based environmental sciences a comprehensive resource on histopathology, which is a key tool in the growing field of ecotoxicology. This work brings together the necessary knowledge, from sample preparation, to trait identification, and scoring and data treatment. Furthermore, with examples from several groups of organisms (from worms to fish), these practices can be applied across a wide array of aquatic ecosystems. This book provides a step-by-step approach to solving the questions researchers encounter in aquatic biology and related fields.

Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.

Recent Advances in the Analysis of Marine Toxins, Volume 78, the newest release in the Comprehensive Analytical Chemistry series, presents chapters from the best authors in the field, making it an essential resource. Updated sections in this new volume include topics such as The importance of toxin detection and quantification: environmental issues, public health, food safety, animal health, bioterrorism, bioactive compounds, medical approach, an LC-MS/MS analysis of marine toxins, Animal bioassays: identification of toxins and mechanism of action, Receptor binding assays for the analysis of marine toxins, Immunoassays and optical biosensors (visual, SPR, fluorescence) for marine toxins, and Electrochemical biosensors for marine toxins. Chapters in this ongoing series contain practical and useful information, describing real advantages and limitations. Experts in this field contribute based on their research and personal point-of-view.

Assessment, Restoration and Reclamation of Mining Influenced Soils covers processes operating in the environment as a result of mining activity, including the whole spectra of negative effects of anthropopressure and the environment, from changes in soil chemistry, changes in soil physical properties, geomechanical disturbances, and mine water discharges. Mining activity and its waste are an environmental concern. Knowledge of the fate of potentially harmful elements and their effect on plants and the food chain, and ultimately on human health, is still being understood. Therefore, there is a need for better knowledge on the origin, distribution, and management of mine waste on a global level. This book provides information on hazard assessment and remediation of the disturbed environment, including stabilization of contaminated soils and phytoremediation, and will help scientists and public authorities formulate answers to the daily challenges related to the restoration of contaminated land.

Environmental Fate and Transport Analysis with Compartment Modeling explains how to use the powerful, highly flexible, and intuitive compartment approach to estimate the distribution of chemical contaminants in environmental media in time and space. Add this Easy-to-Use Approach to Your Environmental Modeling Toolbox This numerical technique enables readers to easily develop the equations that describe complex environmental problems by assembling the equations out of compartmental building blocks. The compartments may describe spatial subunits of single- or multi-environmental media, and the way one hooks them together implicitly provides the dimensionality of the problem. With this approach, assembling the equations to describe chemical fate and transport in a three-dimensional, multimedia system is fundamentally no more challenging than a one-dimensional, single-medium problem. Go Beyond "Black Box" Modeling with the Flexible GEM Software The book includes access to the Generic Environmental Model (GEM), a new software package developed by the author. This software implements the compartment approach based on user-prepared input files and solves the resulting mathematical equations. It allows readers to solve linear, nonlinear, and steady-state problems and offers four methods for solving dynamic problems. Each solution technique is reviewed, along with the error properties and the criteria for avoiding or minimizing numerical errors. The book also describes solution techniques and the underlying mathematical theory for solving nonlinear systems. Compartment Modeling from the Ground Up, Made Accessible to Non-Mathematicians A user-friendly introduction to environmental compartment modeling for the beginning modeler, this is also a useful resource for the experienced modeler. It combines a reference on compartment modeling with a user's guide to the GEM. Throughout, the GEM is used to illustrate the theory with numerous examples, while the theoretical discussions illuminate the GEM's functionality.

This book features papers presented at a workshop discussing current knowledge about the biological effects of low level exposures (BELLE). The book is designed to help establish a scientific base for future BELLE initiatives and is focused on the issue of the toxicological implications of biological adaptations. Hormesis is considered in a broad, conceptual manner, as well as at molecular and biochemical levels. Other topics covered include the effects of low levels of radiation on biological systems, how the liver adapts to genetic insults, biostatistical considerations when designing studies that address issues associated with biological responses to low doses of chemicals and radiation, and the issues that surround the interpretation of findings from such studies.

Estuaries in every country exemplify the same paradox - they are among the most productive ecosystems and also among the most impacted by anthropogenic activities. And although estuarine biodiversity is key to the ecological and economic health of coastal regions, estuaries are exposed to toxic effluents transported by rivers from remote and nearby conurbations and industrial and agricultural concerns, putting them at risk. Increased attention to environmental issues highlights the fragility and importance of estuaries and brings to the forefront the need for an up-to-date assessment of techniques. Environmental Assessment of Estuarine Ecosystems: A Case Study describes a comparative, multidisciplinary ecotoxicological study of two contrasting estuaries in France. Based on the results of this study, the book presents generalizations about how different techniques might be applied and interpreted in future, similar studies assessing the ecotoxicological status of these vital coastal systems. With contributions from international experts, this reference covers all aspects of estuaries from the physiological to the economical. It introduces the state-of-the-art science required to investigate ecotoxicological problems in many estuaries all over the world. Although carefully focused on a specific region, this book covers a broad range of environmental issues and solutions, demonstrating how various pieces of information can be integrated into a sound assessment. Understanding the observations about this region and the techniques used for its assessment provide a benchmark for assessing, remediating, and applying new developments to other estuaries.

How does mercury get out of the ground and into our food? Is tuna safe to eat? What was the Minamata Disaster? Mercury Pollution: A Transdisciplinary Treatment addresses these questions and more. The editors weave interdisciplinary threads into a tapestry that presents a more complete picture of the effects of mercury pollution and provides new ways to think about the environment. The remarkable features that make mercury so useful-and poisonous-have given rise to many stories laid out in rich objective detail, carefully detailing medical, epidemiological, or historical insight, but sidestepping the human experience. A technically rich book that only touches on the human consequences of mercury poisoning cannot fully portray the anguish, confusion, and painful deaths that are the consequence of mercury pollution. Therefore, the editors purposely step out of the conventional scientific framework for discussing mercury pollution to explore the wider human experience. This book clarifies how we are all connected to mercury, how we absorb it through the food we eat and the air we breathe, and how we release it as a consequence of our new technologies. It tackles interesting environmental issues without being overly technical and uses mercury as a case study and model for studying environmental problems. The book uses discussions of the issues surrounding mercury pollution to illustrate how an interdisciplinary vantage is necessary to solve environmental problems. Read an article in the SETAC Globe by Michael C. Newman and Sharon L. Zuber at http://www.setac.org/globe/2011/november/mercury-pollution.html

Catastrophic events such as the Bhopal, India tragedy and rising incidences of cancer in areas neighboring industrial facilities have heightened concern over the use of toxic chemicals in manufacturing and industry, particularly with respect to long-term exposure. While legislation and publicity have reduced the use of some chemicals, risks remain that continue to threaten the health of individuals worldwide. Based on the authors' research conducted through their development of a program in Sao Paulo, Brazil, Toxic Chemicals: Risk Prevention Through Use Reduction examines various toxicity factors and proposes a plan to reduce the toxic impact of these hazardous substances. Explores all factors that contribute to toxicity The book begins by exploring the history of toxic chemical release reporting programs, a trend growing out of the Bhopal tragedy. It surveys their impact both in the United States through the Toxics Release Inventory (TRI) program and in the 29 other countries that maintain similar programs. Then, with the goal of developing a rational method of prioritizing toxic chemicals for reduction, the authors discuss mobility, persistence, and bioconcentration adjustment factors and present a method for integrating all of these factors to estimate the relative impact of chemical release. Compares alternate emphases in existing programs The book describes programs that concentrate on reducing the release of chemicals with the greatest adverse toxic impact and those that require companies to prepare pollution prevention plans and set goals for reducing use or release. It also examines technical assistance programs that help companies search for alternative chemicals to use or process changes that eliminate the use of toxic chemicals. In addition, it explores alternative market-based approaches for achieving environmental protection. Presents a workable plan for the future In the final chapters, the authors lay out their proposed program for reducing the use of toxic chemicals. This plan builds on the existing TRI program and uses lessons learned from this and other programs. The combined research assembled by the authors and their multifaceted approach to the issue of chemical toxicity enables companies and policy makers to move to the next level of toxic chemical use reduction, resulting in a safer environment for future generations.