Environmental considerations are playing an increasingly important role in determining management strategies for soil and land. Many important environmental issues involve aspects of the biology of soil, and these issues cannot be considered satisfactorily in isolation from a general understanding of soil biology as a whole. This is the second edition of a book first published in 1989 and now thoroughly rewritten to focus on soil ecology and environmental issues. The first part of the book provides an introduction to soils, its inhabitants, and their activities. The second part covers the influence of man on the natural cycles of soil. Topics such as acid rain and nitrogen fertilizers are considered alongside pesticides and genetically modified organisms. A new final chapter has been added which considers how, as we move towards the next millennium, we can apply the concept of sustainability to issues such as global climate change and farming systems. The book is directed at advanced undergraduate and immediate postgraduate students in environmental science and soil ecology, with students of physical geography and earth sciences as an important secondary market.

Genetic toxicology is considered to be an important assessment tool as there is genetic impact of artificial chemicals. Insight on Genotoxicity discusses testing, mechanism, prediction, and bioindicator of genotoxicity taking into consideration recent advances in nano-engineered particles. Corollary of DNA dent is also discussed in detail taking into consideration the impact of ICH guidelines on genotoxicity testing, which is important for drug discovery innovation and development. Perspective review of genotoxicity evaluation in phytopharmaceuticals has been mentioned along with the prevention of genotoxicity in brief viewpoint. Salient Features Presents methods, standard protocols, and guidelines for genotoxicity testing Examines the impact of ICH Guidelines on genetic toxicity testing which is a regulatory requirement for drug discovery and development Defines appropriate strategies about advances in in vivo genotoxicity testing which have been listed along with progress and prospects Discusses advancement in the high-throughput approaches for genotoxicity testing Details computational prediction of genotoxicity with consideration of mutagenicity, chromosomal damage caused and strategies for computational prediction in drug development

This comprehensive treatise offers an in-depth discussion of natural toxicants in plants, emphasizing their effects as defenses against herbivory. Coevolution of plants and her-bivores are covered with a detailed treatment of toxicant metabolism and systemic effects in mammalian tissues. Con-sideration of the economic importance of plant toxins, modi-fication by plant breeding, management of toxico-sis, and toxicant problems in various geographic areas are in-cluded. Each volume offers an extensive description of chemistry, biosynthesis, analysis, distribution in plants, metabolism in mam-mals and insects, and practical problems in humans and livestock.

Ecotoxicology and Chemistry Applications in Environmental Management describes how to set up an integrated, holistic approach to addressing ecotoxicological problems. It provides detailed explanations in answer to questions like "Why is it necessary to apply an integrated approach?" and "How does one apply an integrated environmental management approach?" Highlighted topics of the book include Environmental chemical calculations QSAR estimation methods Toxic substance interference with other environmental problems Using diagnostic ecological subdisciplines for solutions Cleaner production methods and technologies Environmental risk assessment Addressing one of the most difficult tasks today, this book provides a much-needed holistic view for translating scientific knowledge and research results into effective environmental management measures. Rooted in a seven-step method, it integrates examination and quantification of an environmental problem and describes the use of ecological diagnostic tools to develop a diagnosis for ecosystem health. It also presents methods for choosing and using solutions or combinations of solutions to tackle problems.

The public has a great desire for products that prevent the annoyance of biting insects and ticks, but that desire does not always translate into sensible use of those products. Insect Repellents Handbook, Second Edition summarizes evidence-based information on insect repellents to inform decisions by those involved with insect repellent research, development, and use. This authoritative, single-source reference makes it possible for you to quickly gain a working level of expertise about insect repellents, without having to search through the scattered literature. The previous edition was the first comprehensive volume on this subject and quickly became the definitive reference on insect repellents. This second edition reflects the current state of insect repellent science, covers the processes involved in the development and testing of new active ingredients and formulations, and discusses the practical uses of repellents. The book includes thought-provoking discussions on how repellents work, their neuromolecular basis of action, and whether green chemistry can provide effective repellents. It also supplies an in-depth understanding of the development of repellents including testing methods, review of active ingredients, and the use of chemical mixtures as repellents. It provides science-backed chapters on repellent use including best practices for use of personal protection products, criteria for repellent use, and insect repellents for other potential use.

Experimental Toxicology is an important text for undergraduates, post-graduates and professionals involved with studying or teaching this often controversial subject. It addresses the basic issues concerned with the practice of experimental toxicology and discusses in detail the following topics: experimental design; biochemical issues; animal husbandry; species differences; immunological issues; carcinogenesis; reproductive approaches; statistics; genetics; in vitro and molecular approaches; risk assessment; information resources; aspects of legislation; good laboratory practice; and laboratory design. The book has been updated and revised to reflect the many changes that have taken place since the first edition was published five years ago and this 2nd Edition gives special attention to the extensive changes that have taken place in the areas of molecular, genetic and reproductive toxicology and in the knowledge regarding the multiplicity of enzymes involved in foreign compound metabolism. Experimental Toxicology is a must for newcomers to the field who wish to gain an understanding of what toxicology is all about. It will also be of interest to experienced practitioners and to professionals from other areas who need a rapid introduction to the subject.

First published in 1986: The purpose of these volumes is to provide a valuable reference for established investigators and postgraduate students in toxicology.

This important volume-the product of a meeting of a select group of scientists-provides the most recent research results from the world's leaders in the study of toxic pollutants in sediments. It gives practical information on measuring and mapping distributions of concentrations of pollutants and their toxic effects in sediments. Also covered are the use and relative advantages and disadvantages of benthic chambers, sedimentation traps, box corers, "peepers" and other sampling techniques in sediment research and assessment. Important topics covered include: bioassay, elemental speciation, diffuse source problems, nutrient flux, biomethylation, bioavailability, and toxicity assessment. Will help in assessment and monitoring of chemistry, dynamics, bioavailability, and toxicity of pollutants, as well helping to chart courses for remedial action. This book will be of interest to anyone interested in the processes controlling the chemistry and movement of pollutants in sediments, especially: limnologists aquatic toxicologists engineers lake managers ecologists biologists environmental chemists

This is the third volume of the five-volume book series "Engineering Tools for Environmental Risk Management". The book series deals with the following topics: * Environmental deterioration and pollution, management of environmental problems * Environmental toxicology - a tool for managing chemical substances and contaminated environment * Assessment and monitoring tools, risk assessment * Risk reduction measures and technologies * Case studies for demonstration of the application of engineering tools The authors aim to describe interactions and options in risk management by providing a broad scientific overview of the environment, its human uses and the associated local, regional and global environmental problems; interpreting the holistic approach used in solving environmental protection issues; striking a balance between nature's needs and engineering capabilities; understanding interactions between regulation, management and engineering; obtaining information about novel technologies and innovative engineering tools. This third volume provides an overview on the basic principles, concepts, practices and tools of environmental monitoring and contaminated site assessment. The volume focuses on those engineering tools that enable integrated site assessment and decision making and ensure an efficient control of the environment. Some topics supporting sustainable land use and efficient environmental management are listed below: * Efficient management and regulation of contaminated land and the environment; * Early warning and environmental monitoring; * Assessment of contaminated land: the best practices; * Environmental sampling; * Risk characterization and contaminated matrix assessment; * Integrated application of physical, chemical, biological, ecological and (eco) toxicological characterization methods; * Direct toxicity assessment (DTA) and decision making; * Online analyzers, electrodes and biosensors for assessment and monitoring of waters.; * In situ and real-time measurement tools for soil and contaminated sites; * Rapid on-site methods and contaminant and toxicity assessment kits; * Engineering tools from omics technologies, microsensors to heavy machinery; * Dynamic characterization of subsurface soil and groundwater using membrane interface probes, optical and X-ray fl uorescence and ELCAD wastewater characterization; * Geochemical modeling: methods and applications; * Environmental assessment using cyclodextrins. This book series focuses on the state of knowledge about the environment and its conscious and structured application in environmental engineering, management and decision making.

First published in 1986: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

Ecotoxicology offers a comprehensive overview of the science underpinning the recognition and management of environmental contamination. It describes the toxicology of environmental contaminants, the methods used for assessing their toxicity and ecological impacts, and approaches employed to mitigate pollution and ecological health risks globally. Chapters cover the latest advances in research, including genomics, natural toxins, endocrine disruption and the toxicology of radioactive substances. The second half of the book focuses on applications, such as cradle-to-grave effects of selected industries, legal and economic approaches to environmental regulation, ecological risk assessment, and contaminated site remediation. With short capsules written by invited experts, numerous case studies from around the world and further reading lists, this textbook is designed for advanced undergraduate and graduate one-semester courses. It is also a valuable reference for graduate students and professionals. Online resources for instructors and students are also available.

Chemical substances, physical agents and built structures exhibit various types of hazard due to their inherent toxic, mutagenic, carcinogenic, reprotoxic and sensitizing character or damaging to the immune and hormone system. The first steps in managing an environment contaminated by chemical substances are characterization of hazards and quantification of their risks. Chemical models - using only analytical data - are still the most widely used applications for assessing potential adverse effects and the fate and behavior of chemicals in the environment. Chemical models rely on the assumption that the adverse effect is proportional to the concentration, which in most cases is incorrect. In this volume, other models such as biological and ecological or regression models are discussed in detail and compared. Environmental risk management has two subsections: risk assessment and risk reduction. Environmental risk, to a large extent, arises from the adverse effects of chemicals and contaminated land; that is why measuring and testing these effects plays a key role in risk management. "Environmental Toxicology" deals with direct measurement of adverse effects of pure chemicals or environmental samples. This book has therefore been created specifically for engineers and gives a general overview of environmental toxicology. It provides an overview of hundreds of standardized and nonstandardized, generic and site-specific, conventional and innovative, animal and alternative test methods, and demonstrates how to apply these results to the regulation and management of environmental risk. In addition to human, aquatic and terrestrial methods for measuring toxicity, new trends in environmental analytics and the integration and complementary use of chemical analyses and the testing of effects are described. Bioavailability and accessibility as key parameters are detailed and the interactive and dynamic characterization of contaminants in soil is introduced. Emphasis is placed on the evaluation and interpretation of environmental fate and adverse effect data as well as the simulation of environmental processes and effects in microcosms and mesocosms.

Plants depend on physiological mechanisms to combat adverse environmental conditions, such as pathogen attack, wounding, drought, cold, freezing, salt, UV, intense light, heavy metals and SO2. Many of these cause excess production of active oxygen species in plant cells. Plants have evolved complex defense systems against such oxidative stress. The study of these mechanisms has become a fast-moving, important field to many biologists. Written and edited by world-leading scientists, Oxidative Stress in Plants explores the current knowledge of the mechanisms by which various biotic and abiotic environmental stress conditions produce oxygen radicals. The text considers the biochemistry and molecular biology of both non-enzymatic (vitamin C, glutathione) and enzymatic systems which eliminate active oxygen species. In addition, the book discusses evidence that active oxygen species and antioxidants act as signals which trigger defense reactions.

The use of drugs as remedies for various types of diseases has a long tradition; however, it has only been recently recognized that the value of any given compound must be evaluated in light of its benefit to risk ratio. When prescribing drugs, physicians must look at the big picture of the drug's benefits in relation to its side effects and possible toxicity. The aim of this handbook is to compile data from various authors, providing clinicians with data that will optimize their decision making in selecting effective, low-risk drug treatments. It also provides research workers, including physicians, pharmacists, and basic scientists, with a sound basis for increasing knowledge of the risk/benefit ratios of various drugs. Includes detailed assessments of the following types of drugs: Antihypertensive agents Diuretics Anti-diabetic drugs Anticonvulsant drugs Drugs for Parkinson's disease Antihistamines and antiserotonins Cytokines and immunomodulators Non-opioid analgesics and anti-inflammatory agents Antibacterial agents Antiviral agents Drugs used in reproductive endocrinology Systemic drugs for skin diseases Topical liposome drugs Topical glucocorticoids

A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk. New aspects, major advances, and new areas in molecular and cellular biology and toxicology demand updated sources of information to elucidate the functional mechanics of human toxicology.

Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition retains the accessible format of the original to present the general principles that link xenobiotic-induced toxicity with the molecular pathways that underlie these toxic effects. Extensively illustrated, this book forms a conceptual bridge between multiple events at the molecular level and the determinants of toxicity at the physiological and cellular level. Specific examples of drugs, environmental pollutants, and other chemicals are carefully chosen to illustrate and highlight the fundamental mechanisms of toxicity at different toxicokinetic and toxicodynamic levels. The book includes references and review articles at the end of each chapter, as well as boxed text for relevant review information on biological, biochemical, molecular, and toxicological background. Linking molecular pathways to more general biomedical contexts, the author ensures that the reader is not lost in the details and instead receives a broad understanding of the processes underlying xenobiotic toxicity.

New in the Second Edition Updated chapters Types of toxic responses Disruption of signal transduction by xenobiotics Disruption of mitochondrial function Novel mechanisms derived from systems toxicology

Since the discovery of Glutathione S-Transferase (GST) or Glutathione transferase, studies have probed important questions about its pharmacological and physiological significance. Toxicology of Glutathione Transferases is the only text that details the methods used in GST research. With chapters written by experts who have been involved in all areas of GST research and have actively contributed to the progress of this field, the book describes the role of GSTs in toxicology, focusing on their pharmacologic and physiologic roles and their relevance to biological toxicology. The book provides current information on gene families, structure and regulation of gene expression, reaction mechanisms and substrates, three-dimensional structures of GSTs, design of proteins with GST activity, and various approaches to developing inhibitors that overcome drug resistance. It also covers the physiological significance and the mechanisms of activation of microsomal GSTs. carcinogens and possible implications of GST polymorphism in human health and disease, make the volume useful to researchers in the field of pharmacology and toxicology. Chapters cover the possible and exciting role of GSTs in defense mechanisms against chronic oxidative stress-linked disorders such as atherosclerosis and the newly emerging area of GST-mediated modulation of stress-signaling through its catalytic as well as binding activities. They explore an intriguing hypothesis that strongly suggests an important role of the factors that modulate the GSH-electrophile conjugate (GS-E) homeostasis in the regulation of cellular processes. Chapters on known and potential endogenous electrophilic substrates and a major role of GSTs in suppressing stress-induced lipid peroxidation reinforce this newly emerging role of GSTs. These are just a few of the features that make the book helpful to clinicians involved in basic as well as translational research, particularly those studying oxidative stress-related degenerative diseases.

Highlighting the latest advances in molecular biology, mathematical modeling, quantitative risk assessment, and biopharmaceutical development, this reference presents how current scientific applications and methods impact and revolutionize mainstream toxicological research. Presenting findings from disciplines that will impact the future of toxicology in years to come including proteomics, toxicogenomics, and metabonomics, this expertly conceived guide explores toxicological issues of particular world interest, such as toxicity of nanomaterials, military jet fuels, and genetically-modified foods.

During the recent decades, social, political and academic endeavours have been made to improve environmental quality and reduce pollution. In particular, the ocean, sea and coastal areas show varying degrees of impact from the multiple human activities carried out in the terrestrial as well as in the aquatic environment. Ecology is a science which studies the relationship between organisms and the surrounding environment and in the modern era, the marine world is getting increasing attention. For centuries it has been the final reservoir of human garbage; later it became an oil farm with a concomitant increase of coastal population growth and unplanned growth of the fishing industry and the increasing use of sea routes for cargo transport and recreational uses (cruises). All this led to rising contamination with negative effects on biota and even human health. It is then imperative to know the current situation of the world's oceans: that is the main purpose of this book, to document at a glance the latest research in the field of ocean pollution.

Due to the high degree of biological similarity between primates and humans, monkeys and apes have been used successfully in medical research for many decades. Medical Primatology: History, Biological Foundations and Applications provides a comprehensive summary linking the use of monkeys and apes in biomedical research to their kinship with humans. The book begins by discussing the history of this research, and then focuses on the biological foundations upon which medical primatology has been built. Primate taxonomy and evolution are reviewed, using not only traditional sources of data, but also recent experimental evidence from molecular biology, genetics, and biomedicine that indicates the need to place higher simians in the family of man. Condensing a broad range of scientific literature into one volume, this will be a useful reference for specialists in the biological sciences and medicine, as well as researchers involved in biological, anthropological, biomedical, clinical, and pharmacological research on primates.

This monograph summarizes the current knowledge on potential health hazards induced by nanomaterials from different sources and sort such as food, drugs and silver nanoparticles. Methods to assess toxicity as well as known effects on the genome, neuronal and respiratory system are discussed. Besides the impact on human and animal life the books also addresses aquatic toxicity.

This book aims to set out the political, social, legal and scientific underpinning of risk assessment and risk management for toxic substances. It describes the principles and processes the practitioners undertake when looking at the regulatory risk implications of their work.

This book focuses on an important aspect of the methods in laboratory animal inhalation toxicology. It is targeted to students in toxicology programs and scientists contemplating performing inhalation studies.

Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery - Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery - Written and edited by leading researchers in phytochemistry, medicinal chemistry, analytical chemistry, toxicology, and more - Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career

Compiling knowledge gained through more than 50 years of experience in environmental engineering technology, this book illustrates the application of fundamental concepts in microbiology to provide a sound basis for the design and operation of various biological systems used in solving environmental challenges in the air, water, and soil. Environmental Pollution Control Microbiology emphasizes the quantitative relationships of microbial growth and metabolism, beginning an examination of the overall metabolism and resulting growth of bacteria, fungi, algae, protozoa, rotifers, and other microorganisms and explains how bacteria bring about the stabilization of biodegradable organic pollutants.

Distilling the available knowledge on ethanol-induced liver damage and directly complementing the available bio-medical literature, Ethanol and the Liver covers pathogenic and clinical aspects of alcoholic liver disease. Providing broader coverage of the subject than any available monograph, the editors and their panel of experts relate basic science to pathogenesis and treatment modalities and explore future developments. Coverage includes: Histopathology-fatty liver, alcoholic hepatitis, and cirrhosis Ethanol metabolism and its consequences Mechanisms in the pathogenesis of ALD, including genetics, immunology, and insulin-like growth factors Extrahepatic effects of ALD and the role of alcohol in potentiating liver damage due to other etiologies Interaction of alcohol with viral hepatitis Epidemiology, diagnosis, and treatment Management strategies, including transplantation The vast amount of knowledge and expertise gathered in this book make it an unparalleled resource.