For many years, it has been known that when rats and mice are given
a reduced amount of food, their life span is increased and they
remain healthy and vigorous at advanced ages.
What is the reason for this change in the usual pattern of
aging? The evidence is overwhelming that the life extension results
from a slowing of aging processes. And the factor responsible is
the decrease in caloric intake. The obvious question: How does this
factor work? A good question - and the reason that research on the
anti-aging action of caloric restriction is today one of the most
studied research areas in biological gerontology. For it is felt
that if the biological mechanisms of the anti-aging action of
caloric restriction can be uncovered, we would gain an
understanding of the basic nature of aging processes, which would,
in turn, yield possible interventions in human aging. This book
aims to provide the growing number of researchers in this field
(faculty, postdoctoral trainees, and graduate students) with a
detailed knowledge of what is known about caloric restriction
within the frame of gerontology, as well as insights on future of
this field.
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