Endocrine Disrupting Chemicals (EDCs) have been shown to produce changes in the endocrine system of organisms, leading to increases in cancers and abnormalities in reproductive structure and function. This book presents research on the endocrine-disrupting effects of sewage and industrial effluents, covering the sources, fate, and transport of EDCs, and sludge treatment and disposal options considered in regard to their implications for receiving environments. It also addresses the potential sources and analysis of these substances in waters, sediments, and sludges. In addition, the authors review current legislation and potential management strategies for endocrine disrupters in the environment.

Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, toxicology, chemistry, and material sciences. Particle Toxicology brings together the state of the science in particle physico-chemistry, cell biology, and toxicology in a single volume. While organized around the classical toxicology paradigm of exposure - dose - response, the book is unique in its emphasis on mechanistic toxicology. Preparing the reader with a brief historical overview and a conceptual framework for particle research, the book provides reviews on the mechanisms and properties of pathogenic particles and their effects on target cells at various sites in the body. The text describes how adverse effects are a consequence of deposition, translocation, and the complex issue of "dose" dominates. Contributions from leading researchers address particle-associated pro-inflammatory effects and inflammatory signaling, cellular and extracellular oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects. Exemplar particles include quartz, asbestos, particulate material and nanoparticles. The book also covers mathematical modeling and human studies as avenues for future research. Responding to the evolving trend of consumer applications for particulate matter, Particle Toxicology provides the comprehensive resource for current knowledge from which to develop ne

Difficult to measure accurately and deal with effectively, organic pollutants continue to be a major hazard in the environment. Significantly expanded, the second edition of Organic Pollutants: An Ecotoxicological Perspective describes the mechanistic basis of ecotoxicology, using major groups of pollutants as illustrative examples, and explores the problem of complex mixtures of chemicals. New in the Second Edition: Expanded coverage of complex pollution problems and the exploitation of recent scientific and technological developments to investigate them New chapters: Endocrine Disrupting Chemicals and their Environmental Impacts and Neurotoxicity and Behavioral Effects Additional information on biomarker approaches and new technologies, such as microarrays assays, developed to address complex pollution problems Tried-and-True Format Presents Updated Information Keeping the same format that made the first edition so popular, the text begins with coverage of the basic principles underpinning the environmental behavior and effects of organic pollutants. It then describes the properties and ecotoxicology of major pollutants, discusses some issues that arise after consideration of the material in the second part of the text, and explores future prospects. Mechanistic Approach Provides Basis for Development of New Strategies The book takes a bottom up approach, describing the mechanisms by which pollutants have harmful effects on living organisms and how these effects are translated into adverse changes at the population level. This mechanistic approach supplies the basis for development of new mechanistic biomarker assays, which in turn provide measures of toxic effect and not merely of exposure, and subsequently provide evidence of causality between pollutant levels and ecological changes.

Divided into five parts, Microbial Food Contamination, Second Edition looks at emerging foodborne human pathogens andcomprehensively evaluates the microbiology, biochemistry, detection, risk, and threat of foodborne illness in today's global market. The first section introduces new insights into the pathogenic effect of E. coli, viral diseases, and protozoan parasites, as well as prions and other zoonotic diseases. It discusses mycotoxins and aflatoxins, particularly the carcinogenicity of aflatoxin B1 and the chemoprevention of liver cancer. Detection, Monitoring, and Control Presenting recent advances in the detection and monitoring of foodborne pathogens, section two reviews rapid electrochemical biosensors, new methods to detect prion diseases, and the use of polymerized chain reaction (PCR) for detection, identification, and typing of microorganisms. Section three examines control and prevention measures including Kosher and Halal food laws, and the use of naturally occurring antimicrobials, irradiation, and other physical control strategies. It also considers the genetic and biochemical control of aflatoxigenic fungi. International Regulation and Trade Globalization reduces traditional geographic borders that once prohibited pathogens from spreading and increases the risk of transnational outbreaks. The impact of this trend on international trade is evaluated in section four with a look at the implications of mad cow disease on the beef trade. It also provides an overview of programs to mitigate contamination such as the Codex Alimentarius and the International Food Safety Authorities Network. Bioterrorism Addressing the most frightening aspect of microbial contamination, section five explores bioterrorism and the different chemical, radiological, and biological agents that could be employed to deliberately contaminate food. Contributors take a critical look at present food protection strategie

Presenting the first database of its kind, this unique reference illustrates the relationships between the chemistry and developmental toxicity of a number of important pharmaceuticals and industrial toxicants. Human Developmental Toxicants contains up-to-date and concise information on the chemical structures, properties, and biological activities for 50 known agents that adversely affect prenatal and postnatal human development in terms of growth, viability, structure, and function. This book presents data linking chemical and structural properties of specific toxicants as they relate to toxic effects, dosage, timing, and route of exposure. Focusing on one compound per chapter, the book also includes associated biological data from animals for each agent covered. Accompanying downloadable resources summarize all of the data discussed in the text within an electronic database. In addition, the CD contains three-dimensional structure representations and 49 calculated physicochemical and topological parameters of the selected molecules. This information is useful for building structure activity relationship (SAR) models linking the chemical properties with observed human developmental toxicity. As scientists continue to explore how chemicals alter human development, Human Developmental Toxicants contains the necessary information to further identify which chemical properties are responsible for adverse effects. This reference provides toxicologists, teratologists, chemists and other scientists with the latest data and information needed to perform risk assessments, predict chemicals that may produce developmental toxicity, and regulate harmful exposure.

Tolerance, the ability of populations to cope with the chemical stress resulting from toxic contaminants, has been described in many organisms from bacteria to fungi, from phytoplankton to terrestrial flowering plants, and from invertebrates such as worms to vertebrates like fish and amphibians. The building of tolerance, be it by physiological acclimation or genetic adaptation, can have great consequences for the local biodiversity, and hence the ecology and ecosystem functioning of many of the world's habitats. Understanding the frequency of the occurrence of tolerance has tremendous implications for the sustainability of biodiversity and ecosystem functioning. Tolerance to Environmental Contaminants takes a multidisciplinary approach across contaminant types, habitats, organisms, biological levels of organization and scientific disciplines. The book examines the general principles governing the acquisition and biological consequences of tolerance, genetically or physiologically based, at different levels of biological organization, taxonomically from bacteria and archaea to flowering plants and vertebrates, and within organisms from molecular biology and biochemistry through physiology to whole organism, community, and ecosystem levels of organization. Presenting a state-of-the-art synthesis of the many aspects of the phenomenon of tolerance to environmental contaminants, this volume covers mechanisms of defense involved in the acquisition of tolerance, different classes of environmental contaminants, positive and negative ecological consequences of tolerance and the impact of tolerance in bacteria, plants, and insects on society. The reviews presented in this book supply the tools for carrying out more informed and therefore more reliable risk-benefit analyses when assessing the ecotoxicological risks to life in any of the contaminated habitats that now surround us in our industrialized society.

Given the essential role that primary producers play in aquatic ecosystems, it is imperative that the potential risk of pesticides to the structure and functioning of aquatic plants is adequately assessed. An integration of regulatory and research information from key specialists in the area of environmental regulation, Aquatic Macrophyte Risk Assessment for Pesticides provides a state-of-the-art guide to ecotoxicological risk assessment. Written by well-known experts in the field of aquatic risk assessment, this book is a practical reference for the assessment of the risk of pesticides with herbicidal activity to aquatic macrophytes. The book supplies a concise, coherent, and science-based view from influential regulators, academics, and industry scientists. They address the selection of additional species, critical regulatory endpoints, and assessing the risk of plant protection products to aquatic macrophytes. They also present a clear description of key issues in macrophyte risk assessment, information on macrophyte test methods, suitable measurement endpoints, and data evaluation and interpretation. Filled with recommendations distilled from existing regulatory experiences of aquatic macrophyte risk assessment, the book includes case studies to identify issues, data gaps, and inadequacies in study design. It also identifies improvements to risk assessment that could be implemented immediately and those for which further research is needed. An authoritative resource, the book points the way to an improved approach to aquatic macrophyte risk assessment.

With growing interest in the safety of foods, knowledge of food toxicology is gaining more importance every day. Introduction to Toxicology and Food provides a concise overview of both the science of toxicology and food toxicology. It presents easy-to-understand explanations of the concepts and principles of toxicology as a science, the toxicants found in foods, and naturally occurring antitoxic/anticarcinogenic substances in foods. It examines the uses, harmful effects, and safety aspects of a variety of toxicants, including natural toxicants, contaminants, and food additives. The book begins with a general overview of the concepts and principles of toxicology. It describes its history and branches, toxic doses, stages of toxication, effect mechanisms of toxins, and toxicity tests. Then it covers the substances in our foods that have toxicological significance, such as natural sources of toxicants, contaminants, and food additives. Finally, the book presents information about "chemopreventers" - those foods and food components that have antimutagenic or anticarcinogenic effects. With its easy-to-read style and its clear discussions of the science of toxicology, food toxicology, and chemopreventers, Introduction to Toxicology and Food is an ideal text for an undergraduate course in food toxicology and a useful guide for food scientists.

The journey to find genes responsible for determining sensitivity or resistance to specific insecticides led to the paraoxonase (PON1) gene on human chromosome 7. This gene encodes a 355 amino acid protein that is localized on the high density lipoprotein (HDL) particles in plasma. Characterization of this gene revealed that different individuals expressed both different forms of this enzyme with amino acid substitutions at positions 55 and 192 as well as different levels of this protein. Additional studies showed that mutations in the regulatory region of the PON1 gene contributed to the very different levels of plasma PON1 among individuals. It turned out that both the level of the enzyme as well as the amino acid present at position 192 (glutamine or arginine) are important in determining resistance to the active forms of specific organophosphorus insecticides, especially diazinon and chlorpyrifos. The position 192 amino acid also determined whether an individual's plasma hydrolyzed the nerve agents soman and sarin at high or low rates. It is not yet known whether these different rates of hydrolysis observed in biochemical assays reflect differences in sensitivity of individuals to nerve agents. Taken together, all of the experiments carried out to date indicate that engineered recombinant PON1 is an excellent candidate to use for treating cases of poisoning by specific organophosphorus compounds. The available data on the relationship of PON1 levels and position 192 genotype led us to introduce the term PON1 status to describe an individual's PON1 plasma level as well as their position 192 genotype.

The characterization of the genetic variations of the PON1 gene together withexperiments showing that HDL can protect the lipids in low density lipoprotein particles (LDL) from oxidation and that it was PON1 that was responsible for this protection have opened an entirely new area of investigation, the role of PON1 in protecting against vascular disease.

More recent reports have noted that PON1 also metabolizes a number of drugs, activating some and inactivating others.

This book describes the recent advances in understanding the role of PON1 in both cardiovascular disease and toxicology of insecticide exposure as well as some of the recent information indicating an important possible role in the pharmacokinetics of drug metabolism. The final chapter of the book provides an overview of the areas of PON1 research and suggests future directions for research on PON1 as well as the related, linked genes PON2 and PON3.

Brainstorming Questions in Toxicology is designed to serve as a comprehensive, quick reference supplement for various examinations that include sections on toxicology. It reflects the breadth and multidisciplinary nature of toxicology with an objective approach to the subject. With 3500 short questions and answers, multiple choice questions, true/false or correct/incorrect statements, fill in the blanks, and matching the statements, this book is a helpful tool for students, teachers and toxicologists preparing for licensure and certification exams. It is also a resource or refresher for toxicologists working in pharmacy, medical, clinical and forensic toxicology, veterinary, and other related fields such as environment and eco-toxicology. Key Features: Serves as a refresher for academicians and professionals in the field of toxicology Provides an essential guide for the student who needs a study aid for toxicology and the teacher of toxicology who needs inspiration when composing questions for their students Supplements in-house training courses in toxicology that exist in some pharmaceutical and chemical industries

A wide-ranging compilation of techniques, Extrapolation Practice for Ecotoxicological Effect Characterization of Chemicals describes methods of extrapolation in the framework of ecological risk assessment. The book, informally known as EXPECT, identifies data needs and situations where these extrapolations can be most usefully applied, making it a practical guide to the application of extrapolation procedures. It focuses on the extrapolation of chemical effects and covers the extrapolation of exposures in the context of interactions between toxicants and the matrix.

This volume describes the structure and function of bacterial toxins and presents a comprehensive review of virulence factors, providing recent information concerning cell physiology and biochemistry, as well as new toxin tools for experimental studies and clinical therapy. A wide variety of toxic proteins, including the toxins that cause diptheria, cholera, pertussis, shigellosis, tetanus, botulism and anthrax, are discussed.;The work is aimed at microbiologists, biochemists, endocrinologists, toxicologists, infectious disease specialists, pathologists, public health officials, and upper-level undergraduate and graduate students in these disciplines.

Responding to the growing need for an aggressive yet conservative approach to evaluating mussel populations, Freshwater Bivalve Ecotoxicology provides a collective review of the techniques and approaches for assessing contaminant impact on freshwater ecosystems. The editors incorporate coverage of research topics and management issues from a cross-section of scientists in the field. They explore current advances in general monitoring of population responses to stressors, fundamental concepts of ecotoxicology specific to burrowing bivalves, and useful insights that offer direction and priority for resolving specific problems challenging protection and conservation efforts. This book lays the groundwork with discussions of topics such as impact assessment, toxicokinetics, biomarkers, and pollution tolerance. The authors then explore fundamental concepts surrounding responses measured in freshwater bivalves as a consequence of chemical exposures or accumulated contaminants in target organs or tissues. They highlight the difficulties encountered with the laboratory culture of these organisms for toxicity testing or other controlled experiments, and examine the use of surrogate test organisms to relate sensitivities of response and reduce pressure on already impacted fauna. The book also reviews innovative field research using in situ bivalve toxicity testing, discusses effects-oriented tissue contaminant assessment, and concludes with threefour specific laboratory or combined field/laboratory ecotoxicology studies. A summary of methods from more than 75 laboratory toxicity studies conducted with freshwater mussels, the book provides an overview of a standardized method for conducting water-only acute and chronic laboratory toxicity tests with glochidia juvenile freshwater mussels. It focuses on studies that report measured contaminant treatments, had robust experimental designs, including replication of control and contaminant treatments, and were publish

This book, the second of three volumes, concentrates on peripheral nervous system disorders. Examining the effects of neurotoxicants on nerve, muscle and the neuromuscular junction, it builds on the scientific principles outlined in volume 1 by looking at the application of the methods discussed, particularly in terms of the evaluation and diagnosis of individual patients and the related process of establishing causation. Neurobehavorial Toxicology, Volume 2 will be of interest to practicing neurologists and neuropsychologists, as well as to occupational medicine physicians and medical toxicologists.

Highlighting activated charcoal's great effectiveness in treating drug overdoses and poisonings in both humans and animals, this comprehensive, single-source reference brings together vital information from every significant study on the use of activated charcoal for medical purposes-describing all available charcoal products and their characteristics. Details activated charcoal's ability to reduce the systemic absorption of a vast array of drugs, chemicals, and biochemical substances-including analgesics, antipyretics, sedatives, alkaloids, snake venoms, and bacterial and fungal toxins.

Currently serving as a resource for the National Center for Toxological Research in their work with the Gulf Coast oil spill, this book presents current research conducted primarily by the airforce on the toxic effects of JP-8 jet fuel on the pulmonary, immune, dermal, and nervous systems. In all, the book considers 13 toxicology studies of significance, the results of which are currently shaping US armed services policy. It will enable all of the hydrocarbon industry to make better choices regarding fuel handling. Due to its widespread use, jet fuel is thought to be the largest toxicant exposure risk for U.S. Armed Services personnel. Taking a proactive approach to the potential dangers of repeated human exposure to hydrocarbon fuels, the Air Force Office of Scientific Research (AFOSR) sponsored a number of research projects during the last 20 years investigating health effects resulting from specific exposure to JP-8 (Jet Propellant-8). Jet Fuel Toxicology summarizes the newest and most important results of these extensive research programs carried out by hydrocarbon fuel research groups throughout the U.S. Each book chapter highlights one specific research area from the many topical areas comprising jet fuel toxicology. After examining the contents and general action of JP-8, the book looks at how the fuel affects various body functions highlighted by: Effects on daily inhalation on the respiratory system Acute and long-term neurotoxicological and neurobehavioral effects Both local and systemic toxicity following exposure through the skin Immunotoxicity from pulmonary and dermal exposures Genetic damage, as evidenced in studies of the blood and bone marrow of mice In all, the book considers 13 major toxicology areas of study, the results of which will enable all of the hydrocarbon industry to make

The activities of modern society have unleashed a range of toxic chemicals into the global environment. Many of these toxicants are now being detected in increasing quantities in the tissues of marine mammals, most notably in top predators who acquire relatively large amounts of toxic chemicals by ingesting contaminated prey. Toxicology of Marine Mammals focuses on the effects of natural and introduced toxicants on organs and systems in marine mammals. It provides overviews on health status and contamination, with subsequent chapters devoted to whales, pinnipeds, dolphins, polar bears, manatees, and sea otters. Internationally renowned researchers assess the mounting evidence for adverse effects on reproduction and the chemically-induced increased susceptibility to death from infectious diseases. The concluding chapter addresses perspectives and issues for the future. This compelling book features research from a vast geographic landscape ranging from the tropics to the Arctic, with case studies on intriguing areas of contamination such as the St. Lawrence River and the Baltic Sea. It identifies the severe threats that environmental contaminants pose to the health and future of marine mammals. It also makes an urgent call for legislation to regulate the incessant pollution ravaging our seas and devastating the marine mammal population worldwide. Toxicologists working in marine biology and veterinary medicine, conservation scientists, fisheries scientists, environmental scientists, and wildlife managers will all benefit from this comprehensive resource.

Thermodynamics is used increasingly in ecology to understand the system properties of ecosystems because it is a basic science that describes energy transformation from a holistic view. In the last decade, many contributions to ecosystem theory based on thermodynamics have been published, therefore an important step toward integrating these theories and encouraging a more wide spread use of them is to present them in one volume. An ecosystem consists of interdependent living organisms that are also interdependent with their environment, all of which are involved in a constant transfer of energy and mass within a general state of equilibrium or dis-equilibrium. Thermodynamics can quantify exactly how "organized" or "disorganized" a system is - an extremely useful to know when trying to understand how a dynamic ecosystem is behaving. A part of the Environmental and Ecological (Math) Modeling series, Thermodynamics and Ecology is a book-length study - the first of its kind - of the current thinking on how an ecosystem can be explained and predicted in terms of its thermodynamical behavior. After the introductory chapters on the fundamentals of thermodynamics, the book explains how thermodynamic theory can be specifically applied to the "measurement" of an ecosystem, including the assessment of its state of entropy and enthalpy. Additionally, it will show economists how to put these theories to use when trying to quantify the movement of goods and services through another type of complex living system - a human society.

This book outlines the strategies used in the investigation, characterization, management, and restoration and remediation for various contaminated sites. It draws on real-world examples from across the globe to illustrate remediation techniques and discusses their applicability. It provides guidance for the successful corrective action assessment and response programs for any type of contaminated land problem, and at any location. The systematic protocols presented will aid environmental professionals in managing contaminated land and associated problems more efficiently. This new edition adds twelve new chapters, and is fully updated and expanded throughout.

Current procedures used for hazard identification and classification are based on persistence, bioaccumulation, and toxicity measurements. Assessing the Hazard of Metals and Inorganic Metal Substances in Aquatic and Terrestrial Systems provides the basis for improvements to the current model for hazard assessment. The book reviews the scientific underpinnings of the use of persistence as applied to metals, including bioavailability, and the use of bioaccumulation to evaluate aquatic species and aquatic-linked food chains. It also examines toxicity procedures as used within PBT approaches and measurements for metals in terrestrial ecosystems. The book brings together a multidisciplinary and international group of scientists, managers, and policy makers from Australia, Belgium, Canada, Germany, the Netherlands, the United Kingdom, and the United States to discuss various means for assessing the environmental hazard posed by metals and inorganic metal substances. The contributors include representatives from regulatory and nonregulatory government agencies, academia, industry, environmental groups, and consulting firms involved in assessment, management, and basic research of metals and metal substances. They provide a focused discussion of the fate and effects of metals in the environment, incorporating important advances developed over the past decade.

This book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial applications. However, our understanding of nanomaterial-mediated toxicity under in vivo condition remains limited. The book begins with a chapter on synthesis and characterization of nanoparticles used for various biological, medical and commercial purposes. The rest of the chapters deal with the impact of nanoparticles on different biological aspects like behavior, physiology and metabolic homoeostasis using Drosophila as a model organism. Lastly, the book summarizes how proper characterization and evaluation of safe dosage of nanoparticles can be a boon if incorporated in consumer goods and for biomedical applications. Overall, the book pursues an interdisciplinary approach by connecting nanotechnology and biology from various angles using Drosophila as a model system, so as to develop more efficient, safe and effective use of nanoparticles for human beings.

The field of electromagnetic sensitivity is the new epidemic of the 21st century, and can cause disease of the automatic nerve system in any part of the body. This is as a result of chemical sensitivity, in which over 80,000 chemicals are involved, resulting in innumerable combinations. A cursory understanding of the combinations can help clinicians partially understand the associated problems and thus help in the diagnosis and treatment of electromagnetic sensitivities. But a basic understanding of environmentally induced illness and healing must first be understood by the clinicians before diseases occur such as cardiac arrhythmia, muscle spasms, and nerve pain. Key Features: Describes how an understanding of the vast combinations of electrical and chemical sensitivities will help in the diagnosis and treatment of electromagnetic sensitivities Reveals the complexity and multi-faceted presentation often seen in chemical sensitivity and chronic degenerative disease cases Provides information backed up by rigorous scientific data including hundreds of tables and figures as online resources Features a Dedication to Robert Becker, MD, an orthopedic surgeon who was one of the first clinicians to recognize the significance of EMF in medicine and surgery, and also to his assistant Andrew Marino, PhD, who helped develop the basic science of orthopedic electromagnet healing

Exploring roles critical to environmental toxicology, Modeling and Simulation in Ecotoxicology with Applications in MATLAB (R) and Simulink (R) covers the steps in modeling and simulation from problem conception to validation and simulation analysis. Using the MATLAB and Simulink programming languages, the book presents examples of mathematical functions and simulations, with special emphasis on how to develop mathematical models and run computer simulations of ecotoxicological processes. Designed for students and professionals with little or no experience in modeling, the book includes: General principles of modeling and simulation and an introduction to MATLAB and Simulink Stochastic modeling where variability and uncertainty are acknowledged by making parameters random variables Toxicological processes from the level of the individual organism, with worked examples of process models in either MATLAB or Simulink Toxicological processes at the level of populations, communities, and ecosystems Parameter estimation using least squares regression methods The design of simulation experiments similar to the experimental design applied to laboratory or field experiments Methods of postsimulation analysis, including stability analysis and sensitivity analysis Different levels of model validation and how they are related to the modeling purpose The book also provides three individual case studies. The first involves a model developed to assess the relative risk of mortality following exposure to insecticides in different avian species. The second explores the role of diving behavior on the inhalation and distribution of oil spill naphthalene in bottlenose dolphins. The final case study looks at the dynamics of mercury in Daphnia that are exposed to simulated thermal plumes from a hypothetical power plant cooling system. Presented in a rigorous yet accessible style, the methodology is versatile enough to be readily applicable not only to environmental toxicology but a range of other biological fields.

Principles of Animal Extrapolation addresses the conceptual basis for animal extrapolation and provides an abundance of documentation that illustrates how these principles may be applied in the selection of the more appropriate models and in the interpretation of toxicological studies. The book analyzes and documents each specific biological cause of interspecies differences in susceptibility to toxic agents, including differences in absorption, gut flora, tissue distribution, metabolism, mechanisms and efficiencies of repair, and excretion. The problem of the heterogenicity of the human population is addressed through several chapters that assess the availability and prospects of developing predictive animal models for normal humans, as well as selected potential high-risk groups. Other topics presented in this book include the biological basis of regulatory actions involving attempts to extrapolate from exceptionally high exposure levels to realistic values, especially carcinogens; an assessment of genotoxicity tests, their ability to predict carcinogenicity in whole animals, and the manner in which they should be used by regulatory agencies; birth defects; and predicting the risk of human teratogenesis. Principle of Animal Extrapolation is essential for environmental toxicologists. It also provides valuable information to biomedical scientists (especially those involved in drug development and testing) and regulatory personnel in agencies such as the EPA, the OSHA, the NIOSH, and the FDA.

The discussion on arsenic in the environment is complex and must grasp the importance of very many, mostly unrelated works on individual aspects. This volume represents one of the first comprehensive and interdisciplinary examinations into arsenic's behaviour in air, water, soils, sediments, plants and the human body. Based on state-of-the-art investigations into the global arsenic cycle, the related human toxicology and available remediation technologies, arsenic is assessed holistically in all the environmental compartments. Using the results of primary research, the authors offer concrete suggestions for risk reduction and management of environmental pollution that allow the reader to successfully tackle similar problems and find sustainable solutions. The book consists of three essential parts: Review of the current knowledge of arsenic behaviour in the environment (global biogeochemical cycles), toxicology, remediation techniques, immobilization technologies and environmental legislation Case studies for mining-related arsenic problems Discussion of mitigation and remediation technologies and approaches such as environmental education, hygiene training, backed by real experience and successful implementation in the study area In a highly coherent manner, the book makes use of 120 tables and figures, a large number of literature citations, and very detailed subject index (that encompasses references) to provide rapid and up-to-date access to all relevant information. Cross-references provide a great manoeuvrability between the chapters. The book delivers very insightful and hands-on approaches for graduate students and professionals working on arsenic questions not only in environmental science, but also in the fields of environmental engineering, medicine and social science.