Updating the extremely successful Wildlife Toxicology and Population Modeling (CRC Press, 1994), Wildlife Toxicology: Emerging Contaminant and Biodiversity Issues brings together a distinguished group of international contributors, who provide a global assessment of a range of environmental stressors, including pesticides, environmental contaminants, and other emerging chemical threats, and their impact on wildlife populations.

Addresses Emerging Wildlife Threats in One Concise Volume

A decade ago, many of these threats existed but were either unrecognized or considered minor issues, and all have now snowballed into major challenges for the conservation of wildlife populations. This is the first book to address these dangers in a single volume and recommend proven mitigation techniques to protect and sustain Earth's wildlife populations.

Examines Species Range Shifts, Ocean Acidification, Coral Bleaching, & Impacts of Heightened UV Influx

This comprehensive reference identifies and documents examples of chemical stressor exposures and responses among ecosystem receptors worldwide. Chapters discuss emerging diseases and the expansion of pesticide/contaminant use, as well as agricultural trends and biofuels, and the widespread use of munitions and explosives from military and industrial-related activities. With the aid of several solid case studies, the book also addresses atmospheric contaminants and climate change, population modeling, and emerging transnational issues in ecotoxicology.

Wildlife Toxicology: Emerging Contaminant and Biodiversity Issues stimulates dialogue among the academic and research communities and environmental public policy decision makers. The book challenges these groups to think more globally about environmental contaminants and their potential impacts on biodiversity and environmental degradation.

Check out Ronald J. Kendall's Advances in Biological and Chemical Terrorism Countermeasures.

Professor Kendall has been quoted recently in several news outlets in connection with the Gulf Oil Spill. Check out these articles on the CRC Press Ning page.

The application of molecular biologic methods, recognition of neurogenic inflammatory processes, and utilization of genetic knockout animals are just some of the advances in toxicology of the upper airways in recent years. Toxicology of the Nose and Upper Airways presents a culmination of knowledge gained as a result of both human and experimental animal studies over the past decade. With contributions from internationally recognized leaders in the fields of experimental toxicology, respiratory medicine, otolaryngology, allergy, and sensory science, this volume: Examines the effect of selected pollutants on the upper airways of both humans and experimental animals-emphasizing mechanistic issues in the process Discusses epidemiologic findings from populations exposed occupationally or environmentally, comparing and contrasting alternative risk assessment approaches Features clear chapter organization with sections on structure and function, dosimetry and toxicokinetics, functional and pathologic responses and their measurement, responses to specific agents, risk assessment, and special topics This volume is an essential reference for pharmacologists and toxicologists concerned with the nose and upper airway, as well as clinicians, risk assessors, and sensory scientists.

Wastes: Solutions, Treatments and Opportunities III contains selected papers presented at the 5th edition of the International Conference Wastes: Solutions, Treatments and Opportunities, that took place on 3-6 September 2019, in Costa da Caparica, Portugal. The Wastes conference, which takes place biennially, is a prime forum for sharing innovation, technological development and sustainable solutions for the waste management and recycling sectors around the world, counting with the participation of experts from academia and industry. The papers included in this book cover a wide range of topics, including: Wastes as construction materials; Wastes as fuels; Waste treatment technologies; MSW management; Recycling of wastes and materials recovery; Environmental, economic and social aspects in waste management; Life cycle assessment; Circular economy and wastes refineries; Logistics, policies, regulatory constraints and markets in waste management.

Examines endocrine toxicologya (TM)s increased importance in environmental safety issues due to legislative directives established over the past ten years.

With contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system.

Covering all principal areas of EPA concern, Endocrine Toxicology, Third Edition provides:

• putative endocrine disruptors and mechanisms of endocrine toxicity
• the history and status of the regulatory process
• mechanisms of toxic effects in various hormonal systems
• comparisons of the endocrine responses in humans, livestock, and wildlife
• testing methods in mammalian, fish, avian, and amphibian models
• valuable insight into the approaches of various personnel in the field, including: government officials who make and oversee policy; scientists in charge of development and validation of testing methods; basic researchers who identify toxic mechanisms; and manufacturers responsible for environmentally benign product certification

Due to the high degree of biological similarity between primates and humans, monkeys and apes have been used successfully in medical research for many decades. Medical Primatology: History, Biological Foundations and Applications provides a comprehensive summary linking the use of monkeys and apes in biomedical research to their kinship with humans. The book begins by discussing the history of this research, and then focuses on the biological foundations upon which medical primatology has been built. Primate taxonomy and evolution are reviewed, using not only traditional sources of data, but also recent experimental evidence from molecular biology, genetics, and biomedicine that indicates the need to place higher simians in the family of man. Condensing a broad range of scientific literature into one volume, this will be a useful reference for specialists in the biological sciences and medicine, as well as researchers involved in biological, anthropological, biomedical, clinical, and pharmacological research on primates.

The biological importance of selenium has been firmly established by scientists for its intricate roles in various biochemical and physiological mechanisms related to animal and human health. To evaluate different facets of selenium in today's complex environment and to provide a worldwide platform for multi-disciplinary selenium researchers, the 6th International Conference on Selenium in the Environment and Human Health was held from 27 to 30 October 2019 in Yangling/Xi'an, China. This proceedings volume brings together 103 extended abstracts prepared by contributors from academia, industry, and governmental agencies in 18 countries, including some most recent research findings among different selenium research disciplines from cell molecular and plant biology, geochemistry, biofortification, to environmental and health management. Selenium researchers worldwide provide extraordinary new knowledge on selenium in the peer-reviewed texts contained within this book.

A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk. New aspects, major advances, and new areas in molecular and cellular biology and toxicology demand updated sources of information to elucidate the functional mechanics of human toxicology.

Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition retains the accessible format of the original to present the general principles that link xenobiotic-induced toxicity with the molecular pathways that underlie these toxic effects. Extensively illustrated, this book forms a conceptual bridge between multiple events at the molecular level and the determinants of toxicity at the physiological and cellular level. Specific examples of drugs, environmental pollutants, and other chemicals are carefully chosen to illustrate and highlight the fundamental mechanisms of toxicity at different toxicokinetic and toxicodynamic levels. The book includes references and review articles at the end of each chapter, as well as boxed text for relevant review information on biological, biochemical, molecular, and toxicological background. Linking molecular pathways to more general biomedical contexts, the author ensures that the reader is not lost in the details and instead receives a broad understanding of the processes underlying xenobiotic toxicity.

New in the Second Edition Updated chapters Types of toxic responses Disruption of signal transduction by xenobiotics Disruption of mitochondrial function Novel mechanisms derived from systems toxicology

Highlighting latest advances in genetics and biochemistry, the completely revised Third Edition reviews the field from basic science, clinical, epidemiological, and regulatory perspectives. Contributions from top opinion leaders in the field bring together developments in molecular embryology and cell biology as they apply to problems in developmental toxicology. It covers testing of pharmaceutical and environmental agents and interpretation of developmental toxicology data, highlighting mathematical and statistical techniques, as well as the effects of toxic exposure on the functional development of various organs. The relationship between maternal and developmental toxicology is examined, in addition to current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the regulatory aspects of testing and risk assessment. Pre- and postconceptional clinical care and genetic factors in clinical developmental toxicology are also discussed. Key topics include: the roles of apoptosis and signal transduction pathways in normal and abnormal development the role of epigenetic changes in development the role of nutrition and individual susceptibility the utility of bioinformatics global and targeted gene expression changes

Exploring roles critical to environmental toxicology, Modeling and Simulation in Ecotoxicology with Applications in MATLAB (R) and Simulink (R) covers the steps in modeling and simulation from problem conception to validation and simulation analysis. Using the MATLAB and Simulink programming languages, the book presents examples of mathematical functions and simulations, with special emphasis on how to develop mathematical models and run computer simulations of ecotoxicological processes. Designed for students and professionals with little or no experience in modeling, the book includes: General principles of modeling and simulation and an introduction to MATLAB and Simulink Stochastic modeling where variability and uncertainty are acknowledged by making parameters random variables Toxicological processes from the level of the individual organism, with worked examples of process models in either MATLAB or Simulink Toxicological processes at the level of populations, communities, and ecosystems Parameter estimation using least squares regression methods The design of simulation experiments similar to the experimental design applied to laboratory or field experiments Methods of postsimulation analysis, including stability analysis and sensitivity analysis Different levels of model validation and how they are related to the modeling purpose The book also provides three individual case studies. The first involves a model developed to assess the relative risk of mortality following exposure to insecticides in different avian species. The second explores the role of diving behavior on the inhalation and distribution of oil spill naphthalene in bottlenose dolphins. The final case study looks at the dynamics of mercury in Daphnia that are exposed to simulated thermal plumes from a hypothetical power plant cooling system. Presented in a rigorous yet accessible style, the methodology is versatile enough to be readily applicable not only to environmental toxicology but a range of other biological fields.

Since the discovery of Glutathione S-Transferase (GST) or Glutathione transferase, studies have probed important questions about its pharmacological and physiological significance. Toxicology of Glutathione Transferases is the only text that details the methods used in GST research. With chapters written by experts who have been involved in all areas of GST research and have actively contributed to the progress of this field, the book describes the role of GSTs in toxicology, focusing on their pharmacologic and physiologic roles and their relevance to biological toxicology. The book provides current information on gene families, structure and regulation of gene expression, reaction mechanisms and substrates, three-dimensional structures of GSTs, design of proteins with GST activity, and various approaches to developing inhibitors that overcome drug resistance. It also covers the physiological significance and the mechanisms of activation of microsomal GSTs. carcinogens and possible implications of GST polymorphism in human health and disease, make the volume useful to researchers in the field of pharmacology and toxicology. Chapters cover the possible and exciting role of GSTs in defense mechanisms against chronic oxidative stress-linked disorders such as atherosclerosis and the newly emerging area of GST-mediated modulation of stress-signaling through its catalytic as well as binding activities. They explore an intriguing hypothesis that strongly suggests an important role of the factors that modulate the GSH-electrophile conjugate (GS-E) homeostasis in the regulation of cellular processes. Chapters on known and potential endogenous electrophilic substrates and a major role of GSTs in suppressing stress-induced lipid peroxidation reinforce this newly emerging role of GSTs. These are just a few of the features that make the book helpful to clinicians involved in basic as well as translational research, particularly those studying oxidative stress-related degenerative diseases.

The Congress "Arsenic in the Environment" offers an international, multi- and interdisciplinary discussion platform for research aimed towards a holistic solution to the problem posed by the environmental toxin arsenic, with considerable societal impact. The congress has focused on cutting edge and breakthrough research in physical, chemical, toxicological, medical, agricultural and other specific issues on arsenic across a broader environmental realm. The Congress "Arsenic in the Environment" was first organized in Mexico City (As2006) followed by As2008 in Valencia, Spain, As2010 in Tainan, Taiwan and As2012 in Cairns, Australia. The 5th International Congress As2014 was held May 11-16, 2014 in Buenos Aires, Argentina and entitled One Century of the Discovery of Arsenicosis in Latin America (1914-2014). The session topics comprised: Theme 1: Arsenic in environmental matrices (air, water and soil) Theme 2: Arsenic in food Theme 3: Arsenic and health Theme 4: Removal technologies Theme 5: Mitigation management and policy Hosting this Congress in Argentina was especially relevant because 2014, marks 100 years since the discovery of the disease Hidroarsenicismo Cronico Regional Endemico (HACRE) or arsenicosis by Dr. Goyenechea and Dr. Ayerza in the city of Bell Ville, Province of Cordoba, Argentina. Dr. Ayerza was the first person to relate skin disorders to the consumption of groundwater with high concentrations of arsenic. It is estimated that more than 14 million people in Latin America are at risk, of whom nearly 4 million are exposed to drinking water with high arsenic concentration in Argentina, and further in Chile, El Salvador, Mexico, Nicaragua and Peru. A vast area of the Chaco-Pampean Plain in Argentina, mostly in the semi-arid regions, is affected not only by arsenic exposure from drinking water but also through other exposure pathways, e.g. through food and other dietary intake. The Congress has gathered professionals involved in different segments of interdisciplinary research in an open forum, and strengthens relations between academia, industry, research laboratories, government agencies and the private sector to share an optimal atmosphere for exchange of knowledge, discoveries and discussions about the problem of arsenic in the environment.

Since the popular first edition was published more than a decade ago, the number of swine used in toxicity studies has increased as an alternative to commonly used non-rodent species, such as dogs and primates. A volume in the Laboratory Animal Pocket Reference Series, The Laboratory Swine, Second Edition maintains the high standard set by the previous edition and is poised to continue its legacy as the premier laboratory reference on the care and use of swine in the laboratory. Emphasizes Humane Care and Use of Laboratory Swine Addressing the biology, husbandry, management, veterinary care and research applications of both large and miniature swine, this color reference is a complete source of information on the species. It is thoroughly updated and includes a major revision to the anesthetics section. It also places a heightened focus on animal welfare and addresses important considerations related to genetically modified swine. The book is divided into six parts: Important Biological Features examines everything from different breeds and behavior, to anatomical and physiological features, as well as digestive, cardiovascular, and pulmonary systems Husbandry addresses housing, nutrition, sanitation, transportation, and more Management and Quality Assurance looks at the impact of infections on animal research using swine, zoonotic diseases, legal regulations, genetic monitoring, and more Veterinary Care covers a variety of topics, such as clinical examination, diseases, pain recognition, and post-operative management Experimental Techniques addresses restraint, sampling techniques, basic surgical procedures, and other issues Resources provides extensive references for further study, including handbooks, journals, and websites

Praise for the First Edition "This book is easy to read and has many informative illustrations...I would strongly recommend this book to those interested in a broad introduction to the care and use of laboratory guinea pigs as well as to laboratory animal technicians, managers, veterinarians and scientists who do not have direct access to large, well organized animal resource units with extensive library facilities." -John D. Young, Contemporary Topics The Laboratory Guinea Pig provides a compact and well- illustrated introduction to research on the guinea pig. The second edition of this popular handbook facilitates quick reference to the behavioral and physical traits of the guinea pig, as well as practical information on its unique anatomical and biological features. Numerous tables and color illustrations help the reader identify features of anatomy and understand health issues and care requirements. Supplying a stepwise introduction to common laboratory techniques, the new edition of this trusted reference provides guidance that supports the humane care and use of guinea pigs in the laboratory setting.

Highlighting the latest advances in molecular biology, mathematical modeling, quantitative risk assessment, and biopharmaceutical development, this reference presents how current scientific applications and methods impact and revolutionize mainstream toxicological research. Presenting findings from disciplines that will impact the future of toxicology in years to come including proteomics, toxicogenomics, and metabonomics, this expertly conceived guide explores toxicological issues of particular world interest, such as toxicity of nanomaterials, military jet fuels, and genetically-modified foods.

With chapter contributions from more than 30 metal biology experts, Cellular and Molecular Biology of Metals explains the role of key divalent metal ions involved in the molecular and cellular biology of various target cell populations. Although it primarily focuses on homeostatic metals, such as nickel, zinc, and chromium, the text also discusses a few environmentally pertinent, toxic divalent cations, including mercury, cadmium, and arsenic. This authoritative resource reviews the physiological mechanisms underlying the handling of essential and toxic metal ions, including metal ion homeostasis, metals and enzyme activity, metals and transcriptional regulation, and metal ion transport. It also analyzes other functions designed to avoid metal-induced toxicity and mediate the metal enhancement of cellular function. The role of metal ions and their effect on mammalian cells and organs are only beginning to be truly defined. Cellular and Molecular Biology of Metals arms metals toxicologists and cellular and molecular biologists with the necessary knowledge they need to take the research effort to the next level. Key selling features: Presents the most recent advances in the cell and molecular biology of metal ions Provides a complete exploration of transport mechanisms Addresses homeostatic metals as well as several environmentally relevant toxic divalent cations Features contributions from experts in their respective fields

Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. For the first time, the collective sciences involved in the understanding of this mode of drug delivery are brought together in one publication. Non-Clinical Vascular Infusion Technology, Volume I: The Science covers the scientific principles behind the delivery systems, from both physical and physiological standpoints. The book addresses body fluid dynamics, describes the scientific processes necessary to understand the various aspects of the physico-chemical issues relating to vascular infusion delivery, and discusses vascular infusion dynamics. It also considers all the essential elements of the preparation of a formulation intended for vascular delivery as well as assessment of compatibility of the formulation with the dosing apparatus. This volume, along with Volume II: The Techniques, provides a foundation of knowledge on infusion technology and its importance for safe clinical use of substances via this route of delivery. Features Identifies and shares best practices for non-clinical vascular infusion Presents modern practices and procedures in line with up-to-date equipment development Offers recommendations for in-life assessments in order to monitor the success or problems with the vascular infusion delivery Makes comparisons with human data in many areas

The discussion on arsenic in the environment is complex and must grasp the importance of very many, mostly unrelated works on individual aspects. This volume represents one of the first comprehensive and interdisciplinary examinations into arsenic's behaviour in air, water, soils, sediments, plants and the human body. Based on state-of-the-art investigations into the global arsenic cycle, the related human toxicology and available remediation technologies, arsenic is assessed holistically in all the environmental compartments. Using the results of primary research, the authors offer concrete suggestions for risk reduction and management of environmental pollution that allow the reader to successfully tackle similar problems and find sustainable solutions. The book consists of three essential parts: Review of the current knowledge of arsenic behaviour in the environment (global biogeochemical cycles), toxicology, remediation techniques, immobilization technologies and environmental legislation Case studies for mining-related arsenic problems Discussion of mitigation and remediation technologies and approaches such as environmental education, hygiene training, backed by real experience and successful implementation in the study area In a highly coherent manner, the book makes use of 120 tables and figures, a large number of literature citations, and very detailed subject index (that encompasses references) to provide rapid and up-to-date access to all relevant information. Cross-references provide a great manoeuvrability between the chapters. The book delivers very insightful and hands-on approaches for graduate students and professionals working on arsenic questions not only in environmental science, but also in the fields of environmental engineering, medicine and social science.

Up to 200 million people in 70 countries are at risk from drinking water contaminated with arsenic, which is a major cause of chronic debilitating illnesses and fatal cancers. Until recently little was known about the mobility of arsenic, and how redox transformations determined its movement into or out of water supplies. Although human activities contribute to the release of arsenic from minerals, it is now clear that bacteria are responsible for most of the redox transformation of arsenic in the environment. Bacterial oxidation of arsenite (to the less mobile arsenate) has been known since 1918, but it was not until 2000 that a bacterium was shown to gain energy from this process. Since then a wide range of arsenite-oxidizing bacteria have been isolated, including aerobes and anaerobes; heterotrophs and autotrophs; thermophiles, mesophiles and psychrophiles. This book reviews recent advances in the study of such bacteria. After a section on background-geology and health issues-the main body of the book concerns the cellular machinery of arsenite oxidation. It concludes by examining possible applications. Topics treated are: The geology and cycling of arsenic Arsenic and disease Arsenite oxidation: physiology, enzymes, genes, and gene regulation. Community genomics and functioning, and the evolution of arsenite oxidation Microbial arsenite oxidation in bioremediation Biosensors for arsenic in drinking water and industrial effluents

Compiling knowledge gained through more than 50 years of experience in environmental engineering technology, this book illustrates the application of fundamental concepts in microbiology to provide a sound basis for the design and operation of various biological systems used in solving environmental challenges in the air, water, and soil. Environmental Pollution Control Microbiology emphasizes the quantitative relationships of microbial growth and metabolism, beginning an examination of the overall metabolism and resulting growth of bacteria, fungi, algae, protozoa, rotifers, and other microorganisms and explains how bacteria bring about the stabilization of biodegradable organic pollutants.

Molecular Toxicology is a concise introduction to the subject, taking the reader through the theoretical principles of toxicology followed by specific examples. In the first section, the concepts behind possible mechanisms of toxicity are described (e.g. the specific enzyme or receptor system) using examples where appropriate. Following this a series of examples are used to show the extension of concept into the real world, in an organ specific manner. The book concludes with a section outlining toxicity assessment methods, where the impact of molecular biology is having a considerable impact, including DNA microarrays, proteomics and bioinformatics. The Advanced Text series is designed for students taking advanced-level courses in life sciences, including final year undergraduates and taught MSc. Titles in this series will also be invaluable to researchers new to the field, and to established researchers as a basic reference.

Juvenile hormones (JHs) are a group of structurally related sesquiterpenes secreted by the insect corpora allata. They affect most insect life-cycle stages and physiological functions, including embryogenesis, larval and adult development, metamorphosis, reproduction, metabolism, diapause, polyethism, and migration. Juvenoids such as methoprene, hydroprene, kinoprene, pyriproxyfen, and fenoxycarb are man-made chemicals that mimic the structure and/or activity of JHs, selectively targeting and disrupting the endocrine system of insects. They are particularly suited as larvicides for the control of pest and disease vectoring insects such as mosquitoes. Juvenile Hormones and Juvenoids: Modeling Biological Effects and Environmental Fate discusses the various modeling approaches that can be used to study the mechanism of action of JHs in insects and to estimate the adverse effects and the environmental fate of the juvenoids that mimic their activity. This book is the third of the QSAR in Environmental and Health Sciences series, but the first dedicated to the use of QSAR and other in silico techniques to provide these insights into JHs and their analogs. With contributions by an international team of scientists, the book begins with a historical survey of JHs and juvenoids. It then discusses biosynthesis of sesquiterpenoids followed by chapters covering JH activity such as morph-specific JH titers in crickets, and JH analog activity including soldier-specific organ development in termites and the role of methoprene in gene transcription. The book examines modeling approaches applied to resistance to JH analogs, to population dynamics of nontarget species in the presence of juvenoids, and to SAR and QSAR of JH mimics. The book concludes with a discussion on the use of multicriteria analysis for selecting insecticides for vector control.

Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. With contributions from an international selection of authors who are leaders in commercial infusion technology, Non-Clinical Vascular Infusion Technology, Volume II: The Techniques provides a current account of the techniques involved in all the major laboratory animal species for conducting successful vascular infusion studies with xenobiotics. Following in the footsteps of the highly praised Handbook of Pre-Clinical Continuous Intravenous Infusion, this new volume covers both up-to-date procedures and equipment. It is organized by species, including all those commonly used in pre-clinical studies: rat, mouse, dog, minipig, large primate, and marmoset. There are also chapters on juvenile studies and reproductive toxicity studies. Each section addresses the selection of the best model, surgical and non-surgical best practices, practical techniques, equipment selection, and commonly encountered background pathologies. Using a fresh approach, the authors identify best practices to be shared across the industry, and provide guidance on choices for the most acceptable methodologies from an animal welfare perspective. This volume, along with Volume I: The Science, provides a foundation of knowledge on infusion technology and its importance for safe clinical use of substances via this route of delivery. Features: Emphasizes best practices in accordance with the 3Rs-reduction, refinement, and replacement of animal usage in laboratories Presents step-by-step procedures and practical tips covering a wide range of common animal models, augmented by the liberal use of illustrations Covers modern practices and procedures in accordance with up-to-date equipment development

The third edition of the Toxicologist's Pocket Handbook, like the first two editions, is a scaled-down version of the best-selling Handbook of Toxicology. It provides the most frequently used toxicology reference information in a convenient pocket-sized book. The format remains the same as the earlier editions to allow basic reference information to be located quickly, with the information placed in sections specific to subspecialties of toxicology. A detailed table of contents lists all tables and figures contained in the book by section. This expanded edition contains a number of tables not found in the second edition added to sections on lab animals, general toxicology, dermal and ocular toxicology, genetic toxicology/carcinogenesis, neurotoxicology, immunotoxicology, reproductive/developmental toxicology, industrial chemical, and pharmaceutical toxicology. New information is presented for additional laboratory animals such as swine and primates, infusion recommendations, newer methods such as the local lymph node assay, and reference safety pharmacology values for standard species. Additional information on typical genetic toxicology and immunotoxicology assays as well as in vitro assays for eye irritation are provided. Some tables from the second edition have been updated to include new information that has arisen since the earlier edition went to press. Information from the second edition, such as regulatory requirements that are no longer applicable, has been deleted.

The focus of this report is upon information essential to the understanding of the toxic action of cadmium and the relationship between dose (exposure) and effects on human beings and animals. The therapy of cadmium poisoning has not been discussed.This review on cadmium in the environment has been performed under a contract between the U.S. Environmental Protection Agency and the Department of Environmental Hygiene of the Karolinska Institute, Sweden. The report is intended to serve as a background paper for a future Air Quality Criteria document on cadmium. Therefore, particular attention has been given to information relevant for the evaluation of risks due to long-term exposure to low concentrations of cadmium. Acute effects from short-term exposure to high concentrations are dealt with briefly. In vitro studies without bearing on the main problem have not been dealt with.The report is not limited to effects from exposure via inhalation. Newly accessible information, showing that large populations may be exposed considerably via the oral route, can elucidate chronic effects of cadmium in general. Man and animals can be victims of secondary exposure through vehicles such as food and water which have been contaminated by cadmium in air.

Provides the latest information regarding how to evaluate sediment contamination and its effects on aquatic ecosystems]Presents an integrated ecosystem approach]Explains how to integrate assessments]