Heavy metals and metalloids, singly or in combination, induce toxic
manifestations either through acute or chronic pathology. In
particular, long-term chronic exposure to diverse heavy metals and
metalloids to humans and animals can lead to numerous physical,
muscular, neurological, nephrological, and diverse degenerative
diseases and dysfunctions, including multiple sclerosis, muscular
dystrophy, Parkinson's and Alzheimer's diseases, cardiovascular
disorders, and several others. Recognized heavy metals such as
lead, mercury, arsenic, cadmium, thallium, and hexavalent chromium
are known for enormous toxicity. The immediate vital signs of acute
heavy metal exposure include nausea, vomiting, diarrhea, and acute
abdominal pain. Mercury has been identified as the most toxic heavy
metal, and mercury poisoning is known as acrodynia or pink disease.
Similarly, lead, another toxic heavy metal, was at one time an
integral part of painting. Metal Toxicology Handbook further
explains and discusses the varying attributes of metals, discussing
toxicity, safety, and proper human utilization of metals. Beginning
with a broad overview of metals, metalloids, redox biology, and
neurodegeneration and going further into the roles, benefits, and
toxicity of metals with each section, the text contains 28 chapters
from eminent researchers and scientists in their respective fields
and is a must-have for anyone researching the potential toxicity in
metals. Key Features Discusses the pathology of metal toxicity
Highlights the benefits of metals Explains the mechanism and
salient features of restoring metabolic homeostasis Highlights
dose-dependent beneficial and adverse effects of vanadium safety
and toxicity The initial introductory section provides a broad
overview of metals, metalloids, redox biology, and
neurodegeneration. The second section discusses the pathology of
metal toxicity in two chapters, while the third section highlights
the mechanism and salient features of restoring metabolic
homeostasis in two chapters. The fourth section demonstrates the
aspect of radionuclides toxicity. In a change of pace, the fifth
section discusses the benefits of metals in four chapters. The
sixth section, titled "Toxic Manifestations by Diverse Heavy Metals
and Metalloids," provides fourteen chapters that discuss the
toxicological mechanism and manifestation of individual metals. The
editors have crafted a commentary titled "A Treatise on Metal
Toxicity" and summarized a vivid scenario of metal toxicity and its
consequences.
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