Alcohol, Drugs, and Impaired Driving addresses many theoretical and practical issues related to the role played by alcohol and other psychoactive drugs on driving performance, road-traffic safety, and public health. Several key forensic issues are involved in the enforcement of laws regulating driving under the influence of alcohol and/or other drugs, including analytical toxicology, pharmacology of drug action, as well as the relationships between dose taken, concentration levels in the body, and impairment of performance and behavior. Our knowledge of drunken driving is much more comprehensive than drugged driving, so a large part of this book is devoted to alcohol impairment, as well as impairment caused by use of drugs other than alcohol. For convenience, the book is divided into four main sections. The first section gives some historical background about measuring alcohol in blood and breath as evidence for the prosecution of traffic offenders. The important role of the Breathalyzer instrument in traffic-law enforcement, especially in Australia, Canada, and the USA is presented along with a biographical sketch of its inventor (Professor Robert F. Borkenstein of Indiana University) with focus on the man, his work and his impact. The second section discusses several issues related to forensic blood and breath-alcohol alcohol analysis as evidence for prosecution of traffic offenders. This includes how the results should be interpreted in relation to impairment and an evaluation of common defense challenges. Because most countries have adopted concentration per se laws, the main thrust of the prosecution case is the suspect's measured blood- or breath-alcohol concentration. This legal framework necessitates that the analytical methods used are "fit for purpose" and are subjected to rigorous quality assurance procedures. The third section gives a broad overview of the current state of knowledge about driving under the influence of non-alcohol drugs in various countries. This includes adoption of zero-tolerance laws, concentration per se statutes, and clinical evidence of driver impairment based on field sobriety tests and drug recognition expert evidence. The fourth section deals with epidemiology, enforcement, and countermeasures aimed at reducing the threat of drunken and drugged driving. All articles have appeared previously in the international journal Forensic Science Review, but all are completely updated with current data, references, and the latest research on developments since the articles were published. This book contains a convenient collection of the best articles covering recommendations for blood and breath testing methods, public policy relating to such methods, and forensic and legal implications of the enforcement of measures to counter driving under the influence.

Ecotoxicology of Wild Mammals brings together the latest research on the exposure and effects of environmental contaminants in wild mammal populations.
The underlying theme is encompassed by four questions:

• What exactly do we know about environmental contaminants in wild mammals?
• What are the commonalities and differences between mammal orders/species in the effects that contaminants have?
• How and to what degree of accuracy can we predict the adverse effects of environmental contaminants on mammalian wildlife?
• How significant are contaminant insults compared with other density-independent and -dependent factors such as habitat loss, climatic factors and disease?

Written by a team of international authors who have led the research on contaminants in mammals, the underlying scientific principles and issues raised will have significance throughout the world. This will be invaluable to those studying the effects of environmental pollutants on mammals, regulatory agencies and those carrying out environmental impact assessment.

Tuberculous Meningitis: Manual of Diagnosis and Therapy focuses on the most common and most lethal manifestation of tuberculosis of the central nervous system. It includes up-to-date reviews of the diagnosis, treatment, and management of tuberculous meningitis in adults and children. Extensive guidance is provided for the treatment of drug-sensitive and drug-resistant tuberculosis and tuberculous meningitis. Clinicians and researchers will find the beginning chapters on immunopathology and epidemiology of great use in their efforts to develop new strategies for the diagnosis and treatment of tuberculous meningitis.

Demography in Ecotoxicology focuses on the interface between toxicology, life history and demographic theory. This comprehensive book examines the different ways of adequately assessing the potential impact of toxic stress on populations and discusses how to obtain an insight into the underlying physiological and genetic mechanisms. The theory is illustrated with empiricial observations on a number of species and organisational levels and the book incorporates:

• case studies;
• real data;
• life history models;
• methodologies; and,
• recommendations for risk assessment

Written by an international team of researchers, Demography in Ecotoxicology will be invaluable to ecotoxicologists, ecologists and wildlife conservationists in academia, industry and regulatory bodies wishing to gain a greater understanding into the prediction and effects of natural and man-made toxicants on populations.

Toxicology is the study of the adverse effects of chemical, physical, or biological agents on people, animals, and the environment. Toxicologists are trained to investigate, interpret, and communicate the nature of those effects. Over the last ten years the subject of toxicology has changed dramatically, moving from a discipline which was once firmly wedded to traditional methods to one which is keen to embrace the innovative techniques emerging from the developing fields of cell culture and molecular biology. There is an acute need for this to be reflected in a paradigm shift which takes advantage of the opportunities offered by modern developments in the life sciences, including new in vitro and in silico approaches, alternative whole organism (non-mammalian) models and the exploitation of omics methods, high throughput screening (HTS) techniques and molecular imaging technologies. This concise, accessible introduction to the field includes the very latest concepts and methodologies. It provides MSc, PhD and final year undergraduate students in pharmacy, biomedical and life sciences, as well as individuals starting out in the cosmetics, consumer products, pharmaceutical and testing industries, with everything they need to know to get to grips with the fast moving field of toxicology and the current approaches used in the risk assessment of drugs and chemicals.

Advances in analytical chemistry methodology now allow us to detect the most minute trace amounts of pesticides. As this capacity grows, so does public concern about toxic contamination, resulting in stricter government regulations and a growing demand for even more sensitive, precise, and reliable analysis.

Addressing the interplay between regulations and the development of analytical technology, this volume presents the first unified treatment of the regulatory and analytical aspects of pesticide residues. Current regulations, existing and emerging methodologies, state-of-the-art instrumentation, and the basic science of analyzing for pesticides in food and other environmental media are all covered.

The book provides step-by-step guidelines to analytical techniques, along with real-world examples from the latest research—showing the reader how to analyze minute traces of pesticides quickly and accurately, using both highly sophisticated and basic, less sensitive techniques. Many safety issues are explored in depth, as are the regulatory aspects of pesticide registration, residue analysis, exposure monitoring, risk assessment, and tolerance enforcement.

Timely, authoritative, and practical throughout, Pesticide Residues in Foods is an invaluable reference for analytical chemists and laboratory managers everywhere—in industry, agriculture, environmental sciences, research, and instrument manufacturing—and for anyone with an interest in the broader environmental, agricultural, and consumer-related implications of pesticide use.

An invaluable resource for analytical chemists and laboratory managers, Pesticide Residues in Foods provides a complete overview of the theory, practice, and regulatory aspects of pesticide residue analysis today, including:

• All regulatory issues, from risk assessment and tolerance to data-quality requirements to laboratory accreditation standards
• State-of-the-art methodologies and instrumentation, including high- performance liquid chromatography and mass spectrometry
• The application of analytical technology to "green chemistry," such as the reduction of solvents and toxic reagents in the laboratory
• Novel solutions to the old problem of keeping the food supply safe from harmful levels of pesticides
• Ample examples to help analytical chemists select the most appropriate method for a given residue analysis
• Easy-to-use tables and figures throughout the text

This book provides a complete coverage of all aspects of the occurrence, toxicity and analysis of toxicants in the aqueous ecosystem. The aqueous ecosystem includes natural waters such as rivers, coastal waters and open seawater. It also includes sedimentary matter present in these waters, creatures (fish, crustacea) and plant life. Chapters dealing with toxicity measurement, control of pollution regulation and toxicity data systematically discuss metals, organometallic compounds and organic compounds. In addition, Chapters 4 and 5 deal with the effects of these types of toxicants in natural waters and water creatures tissues, whilst Chapter 8 deals with the health of such creatures. Contents:

• Toxicity Evaluation - Water Based
• Toxicity Evaluation - Animal Tissue Analysis Based
• Control of Pollution Regulations
• Toxicity Data
• Effects of Dissolved Metals in Water on Creatures
• Effect of Organic and Organometallic Compounds in Water on Creatures
• Pollution of Sedimentary Matter
• Polution of Sea Organisms
• Phytoplankton
• Algae and Weeds - Toxicity, Concentration and Analysis
• Pollution of Potable Water
• Radioactivity in the Environment

Toxicants in the Aqueous Ecosystem is essential reading for all Analytical Chemists, Environmentalists and Toxicologists working in the field.

Handbook on Biological Warfare Preparedness provides detailed information on biological warfare agents and their mode of transmission and spread. In addition, it explains methods of detection and medical countermeasures, including vaccine and post-exposure therapeutics, with specific sections detailing diseases, their transmission, clinical signs and symptoms, diagnosis, treatment, vaccines, prevention and management. This book is useful reading for researchers and advanced students in toxicology, but it will also prove helpful for medical students, civil administration, medical doctors, first responders and security forces. As the highly unpredictable nature of any event involving biological warfare agents has given rise to the need for the rapid development of accurate detection systems, this book is a timely resource on the topic.

Ecotoxicology, New Challenges and New Approaches provides the latest in new challenges for research in ecotoxicology. In six comprehensive chapters, the book deals with the long term effect of stressors on biological communities, the effect of pollutants on the chemical communication among organisms, the impact of multiple stressors and of emerging pollutants (microplastics), and at the use of new technologies (omics) in ecotoxicology.

Nanoparticles have numerous biomedical applications including drug delivery, bone implants and imaging. A protein corona is formed when proteins existing in a biological system cover the nanoparticle surface. The formation of a nanoparticle-protein corona, changes the behaviour of the nanoparticle, resulting in new biological characteristics and influencing the circulation lifetime, accumulation, toxicity, cellular uptake and agglomeration. This book provides a detailed understanding of nanoparticle-protein corona formation, its biological significance and the factors that govern the formation of coronas. It also explains the impact of nanoparticle-protein interactions on biological assays, ecotoxicity studies and proteomics research. It will be of interest to researchers studying the application of nanoparticles as well as toxicologists and pharmaceutical chemists.

Methyl Bromide is a naturally occurring compound but also a man-made product, widely used as a fumigant in agriculture, horticulture and the preservation of structural materials. It is also believed to play a significant role in the depletion of the ozone layer. Since 1991, a fierce debate has raged on the relative merits of scientific, political, environmental and economic arguments for and against the use of this chemical. This book does not set out to convince the reader of a predetermined view point. Its purpose is to set out as much of the scientific debate as is possible to date and let the reader weigh up the available evidence. In this volume are covered the major relevant fields of science including agriculture, atmospheric chemistry, oceanography, environmental sciences, chemistry, biology and toxicology, as well as two chapters on potential alternatives to methyl bromide. The authors who have contributed to this book are international experts who have played pivotal roles in the international debate on methyl bromide.

This book presents a comprehensive review of the most recent studies on the impact of contaminants on the marine environment. Conventional and new information, as well as the latest techniques, are presented, which can be applied to several types of marine organisms from bacteria and fungi to animals and algae. Specific topics discussed include the impact of different contaminants on different organisms as well as different approaches and their outcomes in terms of impact assessment. The integration of these techniques is also discussed in order to attain sentinel species and biomarkers to be applied for assessing ecological quality and impact assessment programs and studies.

This is a comprehensive and up-to-date investigation of a deadly toxin and its impact on ecology and human health. Part 1 contains a thorough treatment of the chemical nature of arsenic, its environmental behaviour and its measurement through contemporary analytical methods. Part 2 deals with the latest findings from a wide range of international research groups into the repercussions of arsenic exposures on human health and the ecosystem.

Names like Love Canal, Chernobyl, and the Exxon Valdez have come to symbolize our anxiety over toxic substances in the environment and their effects on human health and the ecology. Yet, as toxins continue to accumulate rapidly in our air, water, and soil, major environmental disasters are only the most obvious manifestation of a complex and growing problem - the tip of the iceberg, so to speak. The need for scientists and nonscientists who are well versed in the fundamentals of environmental toxicology has never been greater, so too, the need for introductory texts in the field. Based on a groundbreaking course given at the University of Illinois for the past two decades, Toxic Substances in the Environment is a superb introduction to the field of environmental toxicology. While the majority of texts and references on toxins in the environment suffer from either a dearth of careful examination or an overabundance of ponderous detail, this book offers just the right balance of accessibility and scientific rigor. It is basic enough to serve as an advanced undergraduate introduction to environmental toxicology and its two most prominent subgroups - the ecological impact of pollutants, and the effect of pollutants on human health. Yet, at the same time, it is unstinting in scientific detail. While the range of topics is broad, this book offers concise and engaging discussions of diverse subjects such as air pollution and global ecosystems; neurotoxicity; genetic toxicology; social issues associated with environmental toxins; and many others. Supported by more than 100 tables and illustrations, the text is organized around a series of case studies that illustrate the hazards associated withparticular substances and demonstrate the multidisciplinary approach that is essential to any effective effort to clean up or prevent contamination. This case study orientation, along with an annotated bibliography and a unique chapter on policy and policy issues, in which the author offers a rundown of the major public and civic environment action groups, makes Toxic Substances in the Environment a useful professional reference. Reflecting a number of the major concerns and interests voiced by students majoring in a variety of disciplines, including biology, chemistry, agriculture, economics, and engineering, this superb didactic tool is destined to become the environmental toxicological bible of future generations.

Chromium and its compounds are widely used by modern industries resulting in large quantities of this element being discharged into the environment and there is now a growing concern about the effects of chromium in the environment. This volume provides a comprehensive assessment of the uses of chromium, its sources and occurrence in the air, water and soils. It gives a detailed and expert description of chromium chemistry, analytical chemistry, biochemistry and known health effects. It also contains a comprehensive compendium of epidemiological data listed according to exposure type along with models of toxicity. Most of the known environmental and health effects of chromium are treated here along with a discussion of dose-response relationships. A key aspect of the book and one of its most useful features is that it serves as a guide to the analytical procedures and their limitations that are suitable for use in environmental and biological monitoring.

This new edition is revised throughout and includes new and expanded information on natural resource damage assessment, the latest emerging contaminants and issues, and adds new international coverage, including case studies and rules and regulations. The text details key environmental contaminants, explores their fates in the biosphere, and discusses bioaccumulation and the effects of contaminants at increasing levels of ecological organization. Vignettes written by experts illustrate key themes or highlight especially pertinent examples. This edition offers an instructors' solution manual, PowerPoint slides, and supplemental images. Features: Adds all new discussions of natural resource damage assessment concepts and approaches Includes new vignettes written by leading guest authors Draws on materials from 2,500 cited sources, including 400+ new to this edition Adds numerous new entries to a useful glossary of 800+ terms Includes a new appendix discussing Brazilian environmental laws and regulations added to existing appendices outlining U.S., E.U., Chinese, Australian, and Indian environmental laws Fundamentals of Ecotoxicology: The Science of Pollution, Fifth Edition contains a broad overview of ecotoxicology and provides a basic understanding of the field. Designed as a textbook for use in introductory graduate or upper-level undergraduate courses in ecotoxicology, applied ecology, environmental pollution, and environmental science, it can also be used as a general reference for practicing environmental toxicologists.

Ecotoxicology Essentials: Environmental Contaminants and Their Biological Effects on Animals and Plants provides a fundamental understanding of this area for students and professionals in ecotoxicology, ecology, conservation, chemistry, public health, wildlife management, fisheries, and many other disciplines. Although new chemicals and potential problems are developed every year, a basic education is essential to address these new challenges, and this work gives such training. Written with the regulatory framework in mind, the material guides readers on modelling, how to conduct assessments, and human and wildlife risk, focusing on effects on animals rather than transport of chemicals. Simple discussions of chemistry are complemented by coverage on the behavior of the animal, dynamics of the ecosystem, real-life situations like drought, and predators in the system - i.e., the natural system versus the lab setting. The book's first section contains chapters on the principles of contaminant toxicology including a brief history of the science of ecotoxicology, basic principles of the science, testing methods, and ways of determining if animals have been exposed to either acute or chronic concentrations of contaminants. The second section deals with the primary classes of contaminants including their chemical characteristics, sources, uses, and effects on organisms. The third section focuses on more complex issues such as the regulation of pollution, population and community effects, risk assessment and modelling.

Toxicology—the scientific study of environmental factors that are harmful to living organisms—was established more than 400 years ago by the Swiss physician Paracelsus. Yet, despite its long lineage, this fascinating discipline continues to evolve sophisticated new tools and techniques for identifying toxins and the means by which they impair health.

This book provides environmental technology students with an enjoyable and effective way to acquire the solid working knowledge of toxicology basics they'll need to make informed decisions as professionals. Features that make Basics of Toxicology an ideal introduction to the subject for two-year and four-year environmental technology students, include:

• Acclaimed, user-friendly, modular format found in all the books in the Preserving the Legacy series
• Basic anatomy, physiology, and chemistry concepts that help clarify how toxins interact with living tissue
• Rapid-learning chapter structure, featuring clear, concise objectives, concept statements, and summaries, as well as practice questions
• Helpful sidebars that highlight critical concepts
• More than 150 high-quality line-drawings, photographs, diagrams, charts, and tables
• Numerous easy-to-perform, skill-building activities
• A glossary of more than 800 essential terms
• Extensive bibliography of recommended readings in all key subject areas
• Basic anatomy, physiology, and chemistry concepts that help clarify how toxins interact with living tissue

Its comprehensive scope along with its quick-reference design also makes Basics of Toxicology a handy working reference for practicing environmental technicians.

Recent developments clearly indicate that speciation studies in biological and environmental matrices are much more important than the total element determination due to the tremendous difference in bioavailability and toxicity of various chemical forms of a particular element. Different separation-detection techniques and hyphenated systems-each with its own advantages and disadvantages with respect to precision, sensitivity and detection limit-have been developed for the identification and quantification of the species present in systems at ultra-trace levels. This book aims to evaluate the speciation analysis in depth and present a comprehensive review of state-of-the-art analytical approaches used for the speciation of elements in environmental samples.

"A Textbook of Modern Toxicology" is a unique resource that provides both students and practitioners with a wide-ranging, accessible overview of the discipline. Suitable for courses in environmental, pharmacological, medical, and veterinary toxicology, this essential text features chapters written by experts who address a range of key topics.

The Fourth Edition includes additional chapters on new approaches to toxicology - molecular methods (-omics: toxicogenomics, proteomics, and metabolomics), bioinformatics, and systems biology - and continues the legacy of its predecessors to provide up-to-date insights into acute toxicity and chemical carcinogenesis, organ toxicity, in vitro and in vivo toxicity testing, ecological risk assessment, and many other areas of toxicology that help foster a solid comprehension of the field.

Also featured in the Fourth Edition are end-of-chapter questions and a Solutions Manual available separately for academic adopters.

Air pollution affects every living organism, including all kinds of vegetation on which we depend for survival. The second edition of this standard reference textbook provides a comprehensive and up-to-date overview of the direct and indirect impacts of air pollution on plant life. Written by an international team of experts, the book also covers the main historical aspects and sources of pollutants, atmospheric transport and transformations of pollutants, and issues of global change and the use of science in air pollution policy formulation.

Air Pollution and Plant Life Second Edition is a unique text in several ways:

• covering all the main phytotoxic pollutants with due consideration given to impacts at all levels of plant organisation from molecular to ecological.

• emphasising the effects of air pollutants in altering plant response to common stresses, both abiotic and biotic - fields in which considerable progress has been made since publication of the first edition.

• and including coverage of how research leads to pollution control policy development.

Air Pollution and Plant Life Second Edition is essential reading for students in Environmental Science, Biological Science and Agriculture, as well as environmental consultants and professionals involved in air quality research and the application of air quality guidelines and advice.

Gasotransmitters are gas molecules produced endogenously in prokaryotic and eukaryotic cells for signalling purposes. This book provides, for the first time, a comprehensive description and systematic look at all gasotransmitters, established or proposed, since their detection in 2002. The content and scope covers the production, metabolism, and signalling roles of gasotransmitters. Conceptual advances, scientific discoveries and newly developed techniques described in this book influence our understanding of fundamental molecular and cellular events in biology and medicine. This book serves as the state-of-the-art book for undergraduate and graduate students as well as post-doctoral fellows in biomedical disciplines and toxicologists studying the toxic mechanisms of gasotransmitters in the environment. It will also be welcomed by researchers in university and research institutes, government agencies, pharmaceutical and medical instrument industry, and clinical practice.

A basic understanding of statistical concepts and methodology is essential for every research scientist. Statistics in Ecotoxicology is a comprehensive, well-illustrated text, tailored to meet the needs of all ecotoxicologists from undergraduates to professionals. Avoiding mathematical jargon, the book uses worked examples to enable the reader to understand the potential of, and limitations of, statistical analysis in both the planning and operation of laboratory and field ecotoxicological experiments. This informative and highly practical guide:

• provides an invaluable introduction to the quantitative methods for the analysis of ecotoxicological data;
• covers field experimentation, laboratory experimentation, regression methodology, multivariate methods and monitoring:
• incorporates essential tips to prevent many of the common design and analytical failings in ecotoxicology; and,
• includes case studies comprising of terrestrial, freshwater and marine examples.

Written by an international team of scientists, Statistics in Ecotoxicology will be essential reading for all ecotoxicologists.

Arsenic is a naturally occurring element and, as such, it is present in the environment and in our food and drink. It can even be involved in supporting life processes. However, due to its toxicity, there is concern about its presence in our diet. This book examines the real risks and impacts of arsenic in our lives. Looking at arsenic and its compounds, this book explores the presence of arsenic in food and water, the need to clarify its toxicity, and current scientific and public misconceptions about arsenic. It also looks at the use of arsenic in medicine, from cancer treatments to alternative therapies such as homeopathy. Following on from "Is Arsenic an Aphrodisiac?: The Sociochemistry of an Element", this book continues the authors work in addressing the issues surrounding arsenic. It is a fascinating read for general readers as it unveils the reality of our exposure to arsenic in our daily lives.

A Handbook of Environmental Toxicology focuses on two key aspects: human disorders and ecotoxicology as affected by major toxins originating from biological sources and pollutants, as well as radiation generated spontaneously or as a result of anthropogenic activity. A diverse array of these potentially harmful agents regularly appear in the atmosphere, soil, water and food, compromising both human health and biodiversity in natural and managed ecosystems. This book: - provides authoritative reviews together with specialist short communications to complement the main chapters and address contemporary issues with important case studies; - explores the cutting edge of research and also indicates the likely direction of future developments; - contains extensive coverage of toxicants that are of significant current interest and will be of increasing concern for many years to come; and - encourages international cooperation in future research on pollution and other environmental agents causing harm to human health and degradation of natural habitats in the ecosystem. Written by an international team of authors from a range of educational, medical and research establishments, this book is an essential reference for advanced students and researchers in the areas of environmental sciences, ecology, agriculture, environmental health and medicine, in addition to industry and government personnel responsible for environmental regulations and directives.