Quantal response (sometimes called dose-reponse) data arise in many areas, both through experimental and observational studies. Particular emphasis is placed in this book on applications in bioassay and toxicology. For instance, data for analysis may arise from routine clinical trials, or from studies of safe doses of drugs. Throughout the material is motivated by a wide range of practical examples.

Presenting all preclinical and clinical information available on genetically engineered toxins, this unique, single-source reference provides the most up-to-date methods and practical examples for conducting clinical studies in toxin molecular biology.;Reviewing difficult problems and their solutions, Genetically Engineered Toxins discusses techniques for clo;ning, expressing, and purifying recombinant toxins and genetically modified recombinant toxins; documents structure-function relationships in toxins, including comparative information; supplies theory and illustrations of chimeric toxins; delineates the preclinical assessments of new reagents; and summarizes approaches to drug design.;With over 1100 literature citations, Genetically Engineered Toxins is an invaluable resource for biochemists, molecular biologists, biotechnologists, pharmacologists, toxicologists, X-ray crystallographers, enzymologists, oncologists, hematologists, immunologists, rheumatologists, botanists, and graduate-level students in molecular biology, biotechnology, and clinical oncology courses.

Handbook of Environmental Contaminants: A Guide for Site Assessment is an indispensable working reference for environmental assessment professionals faced with determining potential environmental contaminants that might be found in the soil, groundwater, or air of a property or facility. The book provides a comprehensive listing of potential contaminants associated with hundreds of industries, activities, and processes. The types of properties covered range from agricultural to heavy industrial. The products and processes covered range from the processing of yeast to the constituents of rocket fuel. The book also discusses products associated with the degradation of common chemical solvents in the environment.
Handbook of Environmental Contaminants: A Guide for Site Assessment is an important reference for environmental consultants, workers on Superfund sites, public health and safety professionals, attorneys, educators and students, and lenders.

This textbook presents a comprehensive examination of environmental science and ecotoxicology for undergraduate students. The material provides sufficient related background information leading to a competency to clearly understand ecotoxicology concepts and topics.

This is the final volume in a three-volume work that has addressed the scientific methodologies relevant to clinical neurobehavioral toxicology. Volume I focused on basic concepts and methodologies in Neurobehavioral Toxicology, with Volume II focusing on the peripheral nervous system. Volume III attends to what is known about industrial and environmental chemicals, medicines, and substances of abuse and how these agents affect the central nervous system. All substances have the capacity to be toxic, depending on factors that include the physical properties of the chemical or compound, organism related variables, or interaction between the two. These substances on the other hand and as a result of these same factors might be used therapeutically or even recreationally. The difference between medicine, recreational drug, or poison depends often on a careful balance between adverse and intended effects. How to determine that a specified substance has caused harm is emphasized in the present volume by way of case examples and discussion. Illnesses and behavioral variations that compete with toxicant-induced explanations for findings in a given case, as well as the various controversies that can arise around issues of diagnosis and causal determination, are treated comprehensively in this volume.

Developed from the efforts of a multiyear, international project examining how persistent, bioaccumulative, and toxic (PBT) chemicals are evaluated and managed, Persistent, Bioaccumulative, and Toxic (PBT) Chemicals: Technical Aspects, Policies, and Practices focuses on improving the processes that govern PBTs. Incorporating science and policy literature-as well as interviews and panel discussions featuring experts from around the world-this book provides you with an international perspective of PBT policies (centering on Europe, Asia, and North America), and reveals major findings and recommendations for improving PBT science, laws, and policies. It includes case studies of specific chemicals, provides an introduction to the overall subject of toxic chemicals, and weighs in on science and policy expansion for PBTs. It also provides summary tables of important PBTs, and discussions on the number of PBTs in commerce, weight of evidence approaches, market deselection, and international management. The text: Assesses the history, current practice, and future of PBT management Considers the roles scientific data, modeling, and conventions play in identifying and regulating PBTs Explores the number of PBTs in commerce and the growing role of weight of evidence (WOE) in the making of PBT determinations Identifies issues that are likely to come up in WOE judgments Examines international, national, subnational, and regional PBT policies Includes a comprehensive and easy-to-understand analysis of PBT science and policy This book reviews the current science, policies, and practices surrounding the regulation of PBTs. It also provides relevant research, recommendations, and suggestions for improving the management and oversight of PBTs.

The incorporation of nanomaterials into products can improve performance, efficiency, and durability in various fields ranging from construction, energy management, catalysis, microelectronics, plastics, coatings, and paints to consumer articles such as foods and cosmetics. But innovation never comes at zero risk. The potential hazards resulting from human exposure during production, use, or disposal has raised concerns and targeted research early on. Safety of Nanomaterials along Their Lifecycle: Release, Exposure, and Human Hazards presents the state of the art in nanosafety research from a lifecycle perspective. Although major knowledge gaps still exist, solid data are now available to identify scenarios of critical risk as well as those of safe nanomaterial use for our benefit. The book is divided into four parts: characterization, hazard, release and exposure, and real-life case studies. To improve coherence throughout the book, various chapters review the same suite of well-characterized, judiciously chosen, and identical industrial nanomaterials. The book is a helpful resource to professionals in product development, industrial design, regulatory agencies, and materials scientists and engineers involved in the safety of nanomaterials.

The Congress "Arsenic in the Environment" offers an international, multi- and interdisciplinary discussion platform for research aimed towards a holistic solution to the problem posed by the environmental toxin arsenic, with considerable societal impact. The congress has focused on cutting edge and breakthrough research in physical, chemical, toxicological, medical, agricultural and other specific issues on arsenic across a broader environmental realm. The Congress "Arsenic in the Environment" was first organized in Mexico City (As2006) followed by As2008 in Valencia, Spain, As2010 in Tainan, Taiwan and As2012 in Cairns, Australia. The 5th International Congress As2014 was held May 11-16, 2014 in Buenos Aires, Argentina and entitled One Century of the Discovery of Arsenicosis in Latin America (1914-2014). The session topics comprised: Theme 1: Arsenic in environmental matrices (air, water and soil) Theme 2: Arsenic in food Theme 3: Arsenic and health Theme 4: Removal technologies Theme 5: Mitigation management and policy Hosting this Congress in Argentina was especially relevant because 2014, marks 100 years since the discovery of the disease Hidroarsenicismo Cronico Regional Endemico (HACRE) or arsenicosis by Dr. Goyenechea and Dr. Ayerza in the city of Bell Ville, Province of Cordoba, Argentina. Dr. Ayerza was the first person to relate skin disorders to the consumption of groundwater with high concentrations of arsenic. It is estimated that more than 14 million people in Latin America are at risk, of whom nearly 4 million are exposed to drinking water with high arsenic concentration in Argentina, and further in Chile, El Salvador, Mexico, Nicaragua and Peru. A vast area of the Chaco-Pampean Plain in Argentina, mostly in the semi-arid regions, is affected not only by arsenic exposure from drinking water but also through other exposure pathways, e.g. through food and other dietary intake. The Congress has gathered professionals involved in different segments of interdisciplinary research in an open forum, and strengthens relations between academia, industry, research laboratories, government agencies and the private sector to share an optimal atmosphere for exchange of knowledge, discoveries and discussions about the problem of arsenic in the environment.

Air pollution affects every living organism, including all kinds of vegetation on which we depend for survival. The second edition of this standard reference textbook provides a comprehensive and up-to-date overview of the direct and indirect impacts of air pollution on plant life. Written by an international team of experts, the book also covers the main historical aspects and sources of pollutants, atmospheric transport and transformations of pollutants, and issues of global change and the use of science in air pollution policy formulation.

Air Pollution and Plant Life Second Edition is a unique text in several ways:

• covering all the main phytotoxic pollutants with due consideration given to impacts at all levels of plant organisation from molecular to ecological.

• emphasising the effects of air pollutants in altering plant response to common stresses, both abiotic and biotic - fields in which considerable progress has been made since publication of the first edition.

• and including coverage of how research leads to pollution control policy development.

This book presents a review of the existing literature on natural mycotoxins to create a comprehensive reference for mycotoxin levels. Each entry includes contamination, concentration rate, mostly mean mycotoxin concentration of organs (human and animal) and country of origin of the sample. Due to the serious spoilage and health issues the presence of mycotoxins can cause, it is imperative that corresponding scientists, health institutions and the food and feed industries have a more qualified understanding of mycotoxins in living things. To this end, Natural Mycotoxin Contamination in Humans and Animals provides an excellent resource. The present book complements the series of the author's previous books, Mycotoxins in Feedstuffs and Mycotoxins in Foodstuffs, in that it is a review of the literature to create a comprehensive reference for mycotoxin levels. As with Mycotoxins and their Metabolites in Humans and Animals, the focus remains the same, but the scope now covers natural mycotoxins only. Comprehensive reference of natural mycotoxin levels in humans and animals Easy-to-use database of mycotoxins Each entry is comprehensive

A title in the Emerging Issues in Analytical Chemistry series, Designer Drugs: Chemistry, Analysis, Regulation, Toxicology, Epidemiology, Legislation presents both an overview and a guide to techniques for designer drug analysis. Proliferation of the synthesis and use of designer drugs is a serious public health problem with social, economic, and legal implications. Whether abuse is studied at the population level or the individual level, researchers need both background and highly detailed technical information on specific drugs and drug classes in order to combat the proliferation and highly damaging consequences of these substances. Author Roy Gerona provides a comprehensive discussion that emphasizes the potential threat to society, presents the ongoing challenges confronting the various laboratory approaches to detection and identification of new chemical entities, and informs the development of improved analytical solutions for use in legislation, law enforcement, and treatment. Designer Drugs: Chemistry, Analysis, Regulation, Toxicology, Epidemiology, Legislation offers an introduction to the field and a source of information on specific drugs, drug effects, and analytical tools to a wide audience for anyone studying or engaging in designer drug analysis. Analytical and medical chemists, pharmacologist, toxicologists, and students, researchers, and policy makers in the fields of drug abuse, medicine, public health, and forensics will greatly benefit from this essential text.

Industrial activities like textile processing and mining are typical sources of heavy metal-rich wastewaters. The sulfate reducing process has become an attractive method for the production of sulfide to precipitate metals since most of these streams also contain sulfate, which is the electron acceptor and, in less common cases, chemical oxygen demand which is the electron donor of sulfate reducing bacteria. The inverse fluidized bed (IFB) reactor is a system for the production of biogenic sulfide and metal precipitation in the same unit due to its configuration: the biomass floats on top of the reactor, whereas metal sulfide precipitates settle and thus can be recovered at the bottom. The main objective of this thesis was to elucidate the factors affecting simultaneous sulfate reduction and precipitation of heavy metals in an IFB reactor in order to optimize the metal recovery from wastewaters such as acid mine drainage. Therefore, this thesis focused on varying different operational conditions to study their effect on the solid-liquid separation and purity of the metal sulfide precipitates as well as on their effect on the sulfate reducing process. Furthermore, one chapter was focused on the study of strategies for sulfide control in the IFB reactor. In addition, recommendations for further research to improve the recovery of the metal sulfides in bioreactors are given.

The present work evaluates the toxic effects of some environmental stressors on fish eggs and larvae and describes the biomarker responses of fish from locations with varying levels of pollution. Development of the main groups of biomarkers is discussed. The book demonstrates general trends and specific peculiarities of biomarker induction in early fish life and their association with the animal's developmental stages. It addresses responses of fish eggs and larvae to pollution under experimental conditions and presents information obtained from in situ studies. Chapters describe xenobiotics accumulation, anoxia and hypoxia, increasing temperature, eutrophication, and other unfavorable environmental factors, including biotic and abiotic factors, and their impact on fish embryos. They also examine fluctuations in biomarker levels in fish eggs and larvae that have been impacted by climate changes and discuss possible scenarios, especially for fish population size, reproduction, growth, development and biodiversity.

Ecotoxicology offers a comprehensive overview of the science underpinning the recognition and management of environmental contamination. It describes the toxicology of environmental contaminants, the methods used for assessing their toxicity and ecological impacts, and approaches employed to mitigate pollution and ecological health risks globally. Chapters cover the latest advances in research, including genomics, natural toxins, endocrine disruption and the toxicology of radioactive substances. The second half of the book focuses on applications, such as cradle-to-grave effects of selected industries, legal and economic approaches to environmental regulation, ecological risk assessment, and contaminated site remediation. With short capsules written by invited experts, numerous case studies from around the world and further reading lists, this textbook is designed for advanced undergraduate and graduate one-semester courses. It is also a valuable reference for graduate students and professionals. Online resources for instructors and students are also available.

Microplastics in Urban Water Management Enables readers to understand the true occurrence and fate of microplastics in drinking water, wastewater and sludge, and receiving water Microplastics in Urban Water Management focuses on the occurrence, fate, effect, and removal of microplastics in the urban water management systems, summarizing relevant methods for enhancing microplastics removal and degradation, providing comprehensive data from source to sink (including occurrence and fate of microplastics in urban water management), and covering practical applications, which are expected to provide some theoretical guidance for controlling or mitigating microplastics pollution and its environmental risks. The work also includes detailed multidisciplinary information on the way in which microplastics behave in urban water management, plus recent advances of nanoplastics, i.e., nano-sized microplastics, in the aquatic environment. In Microplastics in Urban Water Management, readers can expect to find detailed information on sample topics such as: Techniques for microplastics detection, including sample collection, purification, identification, and quantitation, plus the definition, emergence, occurrence, and removal of microplastics Elements of microplastics in wastewater treatment plants; for instance, the ecotoxicological effect on the biological treatment of wastewater and sludge Why the discharge of microplastics from wastewater treatment plants is the important source of microplastics in the receiving waters Potential environmental risks of microplastic contamination in receiving water systems and evidence that microplastics can absorb, collect and transport environmental contaminants as vectors For practicing toxicologists, biologists, environmental and chemical engineers, and ecology professionals, as well as researchers and graduate students in these disciplines, Microplastics in Urban Water Management is an essential all-in-one guide to understanding the current state of microplastics in our world and potential solutions for the future.

Difficult to measure accurately and deal with effectively, organic pollutants continue to be a major hazard in the environment. Significantly expanded, the second edition of Organic Pollutants: An Ecotoxicological Perspective describes the mechanistic basis of ecotoxicology, using major groups of pollutants as illustrative examples, and explores the problem of complex mixtures of chemicals. New in the Second Edition: Expanded coverage of complex pollution problems and the exploitation of recent scientific and technological developments to investigate them New chapters: Endocrine Disrupting Chemicals and their Environmental Impacts and Neurotoxicity and Behavioral Effects Additional information on biomarker approaches and new technologies, such as microarrays assays, developed to address complex pollution problems Tried-and-True Format Presents Updated Information Keeping the same format that made the first edition so popular, the text begins with coverage of the basic principles underpinning the environmental behavior and effects of organic pollutants. It then describes the properties and ecotoxicology of major pollutants, discusses some issues that arise after consideration of the material in the second part of the text, and explores future prospects. Mechanistic Approach Provides Basis for Development of New Strategies The book takes a bottom up approach, describing the mechanisms by which pollutants have harmful effects on living organisms and how these effects are translated into adverse changes at the population level. This mechanistic approach supplies the basis for development of new mechanistic biomarker assays, which in turn provide measures of toxic effect and not merely of exposure, and subsequently provide evidence of causality between pollutant levels and ecological changes.

Based on the "go to" book in the field of ecological risk assessment, this shorter, principles-based, updated textbook is essential for students and new practitioners who want to understand the purposes of environmental assessments and how to achieve them. It includes environmental risks to humans as well as nonhuman populations and ecosystems, and most types of environmental assessments. Drawing upon the author’s extensive experience in the field, first as a senior research staff member in the Environmental Sciences Division at Oak Ridge Laboratory and then as science adviser in the United States Environmental Protection Agency’s National Center for Environmental Assessment, the book explains fundamental principles and basic techniques and illustrates them with example applications which carry through multiple chapters and make this book a practical and hands-on guide. Both the content and the style are inviting and approachable to different levels of students. Features 1. Integrates human health and ecological assessments. 2. Includes epidemiological, risk, causal, impact, and outcome assessments. 3. Focuses on fundamental principles that are applicable in all nations and legal contexts. 4. Employs an engaging style and draws on the author’s practical experience. 5. Explains fundamental concepts in short chapters, making it perfect for beginners in the field. 6. Explains the challenges and rewards of a career in environmental assessment. This book is a practical guide for senior and graduate students in environmental sciences and management, as well as new practitioners of assessment who want to understand the purposes of environmental assessments and how to achieve them.

While an ever-present and familiar toxin, carbon monoxide (CO) remains the number one poison in our environment. This silent killer is responsible for over 2,000 deaths a year in the United States alone. The public and healthcare communities need quality information about the many risks presented by carbon monoxide exposure. Edited by a leading expert in the field, Carbon Monoxide Poisoning delineates the successful means to prevent, identify, and manage the effects of CO poisoning.

This volume explores new information on CO toxicity, including rehabilitation, the dissemination of information to the public, litigation involving CO poisoning, economic loss assessment, and firefighting. A series of chapters detail the risk of CO poisoning from kitchen ranges, recreational vehicles, and power boats. Expert contributors survey diagnostic procedures and devices, incorporating advances in brain SPECT imaging and non-invasive pulse-oximetry. The book includes chapters that specifically addressthe pros and cons of hyperbaric oxygen therapy and thoroughly review the physiological effects of acute and long term exposure to CO, as well as the neurocognitive and neurobehavioral sequelae.

Whether you are a healthcare professional who treats CO poisoning, a lawyer involved in litigation for loss of life or property due to CO poisoning, or an engineer developing a well-insulated structure with sufficient ventilation; you will face the challenges raised by CO toxicology. Offering the only comprehensive reference on the subject, this multi-faceted guide takes an innovative look at how we can identify, treat, and prevent harmful exposure to carbon monoxide.

This title is an excellent resource to help indentify poisonous plants in the home and garden and contains the most current information about plant toxicity in dogs and cats. This essential reference allows veterinarians to not only identify poisonous plants, but also includes the toxic properties of the plant and the clinical signs that can be expected in animals that ingest the plants. This instrumental guide contains detailed discussions on the plant toxins, the plant parts that are most dangerous and the first aid that should be considered. The title includes 192 domestic and exotic plant species, with an emphasis on plants typically found in and around the home. This user friendly guide is organized alphabetically by the plant's botanical name, while the index includes common names listed to help find the specific plant in question. The 350 high quality color photos also assist the practitioner in accurate plant identification. The highly visual, easily accessible format make this title an ideal toxically reference for small animal practitioners.

Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, toxicology, chemistry, and material sciences. Particle Toxicology brings together the state of the science in particle physico-chemistry, cell biology, and toxicology in a single volume. While organized around the classical toxicology paradigm of exposure - dose - response, the book is unique in its emphasis on mechanistic toxicology. Preparing the reader with a brief historical overview and a conceptual framework for particle research, the book provides reviews on the mechanisms and properties of pathogenic particles and their effects on target cells at various sites in the body. The text describes how adverse effects are a consequence of deposition, translocation, and the complex issue of "dose" dominates. Contributions from leading researchers address particle-associated pro-inflammatory effects and inflammatory signaling, cellular and extracellular oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects. Exemplar particles include quartz, asbestos, particulate material and nanoparticles. The book also covers mathematical modeling and human studies as avenues for future research. Responding to the evolving trend of consumer applications for particulate matter, Particle Toxicology provides the comprehensive resource for current knowledge from which to develop ne

There is no current book is available in the market explaining medicinal values, toxicity responses, and other potential uses of poisonous plants exclusively. In recent years, extensive attention has been paid towards the up-gradation of medicinal and herbal plants therefore; this book includes important chapters on relevant topics. Audience - Those who are working on or have an interest in modern research especially in medicinal, herbal, and poisonous plants and is also useful for some pharmaceutical companies involved in herbal drug preparation.

Presents concrete and extensive information about a basic and applied aspect of plant oxylipins as well as expanded coverage of signaling mechanisms. Highlights the fundamental concepts of the biosynthesis, metabolism, structural biochemistry, and signaling pathway of oxylipins. Details the state-of-the-art methods and techniques in metabolic profiling of oxylipins in plants. Presents insights on computational applications in the evaluation and study of oxylipins in plants

The 2nd edition of book entitled "Principles of Meat Technology" has been designed and modified as per the recent requirement of the Veterinary Professionals and is entirely based on recent course-curriculum of Veterinary Council of India. All the topics included in VCI syllabus for Meat Science subject have been illustrated and discussed in detail with the supplementation of previous edition. The reference material and current scientific information on the subject has been updated which will be of immense value for meat processing industry and persons having some stakes in this subject. This book is broadly covering fresh meat and aquatic foods, their processing, preservation, packaging, standards and biotechnological applications in this specialized field with recent innovations. In this edition book will serve the purpose of impartation of knowledge, skill and update material to acquaint the students of Veterinary Science. It is also due to upgradation of each and every of the book with recent knowledge and innovations. The themes mentioned in the syllabus of VCI is very well covered particularly meat structure, product's quality, handling and processing is very well documented. So authors believe that efforts put in this edition of book in form of material, scientific facts and language will help in understanding the meat science to the students of veterinary science, food science and technology, fish technology, meat technologists, academicians of this field, technicians engaged and the processors of animals and fish products.

Thermoregulation is vital for survival but the interplay between toxic insults and thermoregulatory mechanisms is often poorly understood. Temperature and Toxicology: An Integrative, Comparative, and Environmental Approach is the first major text to study the integrative thermoregulatory responses of mammals that are exposed to toxicants. Because environmental physiology is also crucial in toxicological responses, this volume also examines the role of environmental temperature in the modulation of cellular mechanisms of toxicity.The book begins by explaining the importance of temperature in toxicological studies, and how all biological processes are dependent on temperature. It then reviews the basics of temperature regulation in homeotherms and poikilotherms, and addresses whole-animal and in vitro studies related to the effects of temperature on toxicity. The text examines thermoregulatory response to toxic insult, and how responses affect recovery and potential survival. reactions in humans, and discusses the relevance of heat and cold stress on human exposures to airborne pollutants and other toxicants. This volume provides an extensive comparison of physiological responses of invertebrates, fish, amphibians, and mammals, and focuses on the impact of endocrine disruption. It then considers how toxicants and thermal stress cause the expression of stress proteins, followed by a study of the impact of genetic variability. The book concludes with an examination of thermoregulatory response to natural toxins and venoms.FeaturesExplores how human health and susceptibility to toxicants can be strongly linked to environmental temperatureProvides more than 100 figures and 500 references that illustrate mechanisms though which toxicants affect various speciesInvestigates integrative thermoregulatory responses to toxicants, including effects on behavior and motor outputs

Whether considering toxicant exposure in zebrafish, or the application of cellular diagnostics to marine toxicology, or the ecotoxicology of coral reef ecosystems, or the amount of metalloids in water, this reference offers the protocols for specimen collection that researchers need. Following up on his popular Techniques in Aquatic Toxicology with a second volume, now nine years later, Dr. Ostrander has once again called on the top aquatic toxicologists from across the world to present 39 chapters of unique collection and testing procedures. Updating five techniques from the first volume, the authors have gone on to add over two dozen new techniques. Like the first volume, this text divides the chapters into four broad areas: Techniques for the Assessment of Toxicity in Whole Organisms, Cellular and Subcellular Toxicity, Contaminant Identification, and Impacts in Aquatic Ecosystems, and ends with a General Techniques section that anyone working in the field should find useful. Every chapter covers a specific procedure that can easily be reproduced by any competent technician with basic knowledge. Each of the chapter authors provides and interprets typical as well as anomalous results, false positives, and artifacts. Data is provided either from recently published experiments or from work being published for the first time.